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    • 71. 发明申请
    • ORGANIC COMPOUNDS
    • 有机化合物
    • US20130338124A1
    • 2013-12-19
    • US13701284
    • 2011-05-31
    • Peng LiJun Zhao
    • Peng LiJun Zhao
    • C07D487/04A61K45/06A61K31/519
    • C07D487/04A61K31/519A61K45/06
    • The present invention relates to (1- or 2- and/or 5 and/or 7-substituted)-(3-oxy)-(4H, 4-imino, 4-thioxo or 4-oxo)-pyrazolo[3,4-d]pyrimidin-6-ones, e.g., a compound of formula II as described below, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them. Of particular interest are novel compounds useful as inhibitors of phosphodiesterase 1 (PDE1), e.g., in the treatment of diseases involving disorders of the dopamine D1 receptor intracellular pathway, such as Parkinson's disease, depression, narcolepsy, damage to cognitive function, e.g., in schizophrenia, or disorders that may be ameliorated through enhanced progesterone-signaling pathway, e.g., female sexual dysfunction.
    • 本发明涉及(1-或2-和/或5和/或7-取代的) - (3-氧) - (4H,4-亚氨基,4-硫代或4-氧代) - 吡唑并[3,4 -d]嘧啶-6-酮,例如下述的式II化合物,其制备方法,它们作为药物的用途和包含它们的药物组合物。 特别令人感兴趣的是可用作磷酸二酯酶1(PDE1)抑制剂的新化合物,例如用于治疗涉及多巴胺D1受体细胞内途径紊乱的疾病,例如帕金森病,抑郁症,发作性睡病,对认知功能的损害,例如 精神分裂症或可通过增强的孕激素信号传导途径改善的疾病,例如女​​性性功能障碍。
    • 75. 发明申请
    • NECK MASSAGER
    • US20130184621A1
    • 2013-07-18
    • US13515485
    • 2012-02-22
    • Xuejun MaXuliang WuJun Zhao
    • Xuejun MaXuliang WuJun Zhao
    • A61H7/00
    • A61H7/004A61H2201/0192A61H2201/1215A61H2201/1463A61H2201/1609A61H2201/1671A61H2205/04
    • The present invention relates to a health massage apparatus, providing a neck massager including a U-shaped neck pillow capable of being hungon a neck of a person, an inside of the U-shaped neck pillow corresponding to the neck has at least one massage component, the at least one massage component include at least two massage heads from the top down along the inside of the U-shaped neck pillow, a height of the upper massage head is lower than the adjacent lower massage head in sequence. According to the human neck characteristics involving the protrusion of the upper neck and the depression of the lower neck, in the present invention the upper massage head is set a low position and the lower massage head is set at a high position, advantageously, each of the massage heads respectively massages the corresponding neck part, the good massage effect can be obtained.
    • 本发明涉及一种健康按摩装置,提供一种颈部按摩器,该颈部按摩器包括能够在人的颈部悬挂的U形颈枕,与颈部相对应的U形颈枕的内部具有至少一个按摩部件 所述至少一个按摩部件包括沿着所述U形颈枕的内部的从上至下的至少两个按摩头,所述上部按摩头的高度依次低于所述相邻的下部按摩头。 根据涉及上颈部的突起和下颈部凹陷的人体颈部特征,在本发明中,上部按摩头被设定在低位置,下部按摩头被设定在高位置,有利地, 按摩头分别按摩对应的颈部,可以获得良好的按摩效果。
    • 77. 发明授权
    • Self healing andon system and method
    • 自愈与系统和方法
    • US08195533B1
    • 2012-06-05
    • US12329944
    • 2008-12-08
    • Devesh MishraEric C. YoungSameer Vinod ShahTimothy Jesse TienJun Zhao
    • Devesh MishraEric C. YoungSameer Vinod ShahTimothy Jesse TienJun Zhao
    • G06Q10/00
    • G06Q10/087G06Q20/203G06Q40/00G06Q40/04
    • Disclosed are various embodiments of a self healing andon system. One embodiment of the present disclosure includes a system comprising at least one server. The system further includes logic executed on the at least one server that retrieves a defect history associated with a vendor and at least one product from an inbound shipment from a memory. The at least one product is stocked in a materials handling facility, and the defect history is associated with a specified time period. The at least one server extracts at least one inventory defect from the defect history in a computer system and calculates an inventory defect rate. The at least one server imposes remedial measures if the inventory defect rate exceeds a specified threshold of the inventory defect rate.
    • 公开了自愈和系统的各种实施例。 本公开的一个实施例包括包括至少一个服务器的系统。 该系统还包括在至少一个服务器上执行的逻辑,其检索与供应商相关联的缺陷历史记录以及至少一个来自存储器的入库货物的产品。 至少一个产品存放在材料处理设备中,并且缺陷历史与指定的时间段相关联。 至少一个服务器从计算机系统中的缺陷历史中提取至少一个库存缺陷并计算库存缺陷率。 如果库存缺陷率超过库存缺陷率的指定阈值,则至少一个服务器施加补救措施。
    • 78. 发明授权
    • Power-aware debugging
    • 电源感知调试
    • US08176453B2
    • 2012-05-08
    • US12558259
    • 2009-09-11
    • Kai YangTayung LiuFurshing TsaiTing Shih AngChih Neng HsuJun Zhao
    • Kai YangTayung LiuFurshing TsaiTing Shih AngChih Neng HsuJun Zhao
    • G06F17/50
    • G06F17/5022G06F2217/78
    • A debugging system produces displays in response to an IC design and results of a logic simulation of IC behavior based on the IC design. The IC design includes a hardware description language (HDL) model of the IC describing the IC as comprising cell instances communicating via data signals and power sources for supplying power to the cell instances. The IC design also includes power definition markup language (PDML) model describing a power intent of the IC design. The debugging system generates displays representing HDL code that are annotated to indicate how the power intent of the IC design described by the PDML model relates to the portion of the HDL model represented by the display. The debugging system also generates signals trace displays indicating how both the logic and power intent of the IC design affect the value of a user-selected signal at a user-selected time during the logic simulation.
    • 调试系统根据IC设计和基于IC设计的IC行为的逻辑仿真结果生成显示器。 该IC设计包括描述IC的IC的硬件描述语言(HDL)模型,其包括经由数据信号进行通信的小区实例和用于向小区实例供电的电源。 IC设计还包括描述IC设计的功率意图的功率定义标记语言(PDML)模型。 调试系统产生表示HDL代码的显示器,其被注释以指示由PDML模型描述的IC设计的功率意图与由显示器表示的HDL模型的部分有关。 调试系统还生成信号跟踪显示,指示IC设计的逻辑和电源意图如何在逻辑模拟期间在用户选择的时间影响用户选择的信号的值。