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71. 发明申请

US20140081012A1 NANOPARTICLE, LIPOSOMES, POLYMERS, AGENTS AND PROTEINS MODIFIED WITH REVERSIBLE LINKERS 审中-公开
标题翻译：纳米颗粒，脂质体，聚合物，代用品和蛋白质，用可逆连接剂修饰
公开(公告)号：US20140081012A1
公开(公告)日：2014-03-20
申请号：US13985491
申请日：2012-02-15
申请人： Joseph M. DeSimone , Mary Napier , Jin Wang , Jing Xu , Shaomin Tian , Stuart Dunn
发明人： Joseph M. DeSimone , Mary Napier , Jin Wang , Jing Xu , Shaomin Tian , Stuart Dunn
IPC分类号： C07D207/46 , C12N15/113
CPC分类号： C07D207/46 , A61K9/0019 , A61K9/06 , A61K9/08 , A61K47/54 , A61K47/543 , A61K47/60 , A61K47/6929 , C07D233/90 , C07D403/12 , C12N15/113
摘要： Pharmaceutical, chemical and biological agents containing a reversible disulfide linker are described. These agents can also be covalently bound or contained in delivery vehicles for delivering the agents to desired targets or areas. Also described are delivery vehicles which contain an agent having a reversible disulfide linker and to vehicles that are covalently linked to the agent containing a reversible disulfide linker. The modifications described herein can modify properties of the agents and vehicles, thereby providing desired solubility, stability, hydrophobicity and targeting while the reversibility of the linker can leave the agent to which it is attached free from residual chemical groups after being reduced.
摘要翻译：描述了含有可逆二硫键的制药，化学和生物制剂。这些试剂也可以共价结合或包含在递送载体中，以将试剂递送到期望的靶或区域。还描述了含有具有可逆二硫键接头的试剂和与含有可逆二硫键接头的试剂共价连接的载体的载体。本文所述的修饰可以改变试剂和载体的性质，从而提供所需的溶解性，稳定性，疏水性和靶向性，而连接物的可逆性可以在其被还原后离开残留化学基团的试剂离开。

72. 发明申请

US20120256354A1 METHODS AND MATERIALS FOR FABRICATING MICROFLUIDIC DEVICES 有权
标题翻译：制备微流体装置的方法和材料
公开(公告)号：US20120256354A1
公开(公告)日：2012-10-11
申请号：US13438431
申请日：2012-04-03
申请人： Joseph M. DeSimone , Jason P. Rolland , Ginger M. Denison Rothrock , Paul Resnick
发明人： Joseph M. DeSimone , Jason P. Rolland , Ginger M. Denison Rothrock , Paul Resnick
IPC分类号： B29C59/02 , B29C59/16
CPC分类号： B29C59/005 , B01L3/502707 , B01L2300/0887 , B01L2300/12 , B29C33/3878 , B29C33/405 , B29C65/48 , B29C65/4835 , B29C65/4845 , B29C65/485 , B29C65/521 , B29C66/54 , B29C66/543 , B29C66/71 , B29C66/723 , B29C66/727 , B29C66/91431 , B29C66/919 , B29C66/949 , B29C66/9534 , B29K2883/00 , B29L2031/756 , B81B2201/051 , B81C99/0085 , C08G18/10 , C08G18/5015 , C08G18/8175 , C08G59/30 , C08G65/007 , C08L71/02 , C08L75/16 , Y10T137/0318 , Y10T137/2224 , C08G18/50 , B29C65/00 , B29K2027/18 , B29K2027/12
摘要： Materials and Methods are provided for fabricating microfluidic devices. The materials include low surface energy fluoropolymer compositions having multiple cure functional groups. The materials can include multiple photocurable and/or thermal-curable functional groups such that laminate devices can be fabricated. The materials also substantially do not swell in the presence of hydrocarbon solvents.
摘要翻译：提供材料和方法用于制造微流体装置。这些材料包括具有多个固化官能团的低表面能含氟聚合物组合物。这些材料可以包括多个可光固化和/或热固化的官能团，使得可以制造层压装置。所述材料在烃溶剂存在下也基本上不溶胀。

73. 发明申请

US20100256734A1 Endoprostheses and methods of manufacture 失效
公开(公告)号：US20100256734A1
公开(公告)日：2010-10-07
申请号：US12660753
申请日：2010-03-03
申请人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
发明人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
IPC分类号： A61F2/82
CPC分类号： A61F2/90 , A61F2/848 , A61F2002/825 , A61F2210/0004 , A61F2250/0014 , A61F2250/0036 , A61F2250/0039 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00
摘要： A woven tubular endoprosthesis comprising means for locking the endoprosthesis in a deployed configuration is disclosed. The means for locking the endoprosthesis may comprise locking protrusions, notches, a chemical bond, a curable bond, or other mechanism. The woven fibers comprising the endoprosthesis may be hollow and comprise circumferentially oriented polymeric chains, and may be filled with a curable material. A method of treatment using an endoprosthesis according to the invention is also disclosed.

74. 发明授权

US07704276B2 Endoprostheses and methods of manufacture 失效
标题翻译：内假体和制造方法
公开(公告)号：US07704276B2
公开(公告)日：2010-04-27
申请号：US11541196
申请日：2006-09-30
申请人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
发明人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
IPC分类号： A61F2/90
CPC分类号： A61F2/90 , A61F2/848 , A61F2002/825 , A61F2210/0004 , A61F2250/0014 , A61F2250/0036 , A61F2250/0039 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00
摘要： A woven tubular endoprosthesis comprising means for locking the endoprosthesis in a deployed configuration is disclosed. The means for locking the endoprosthesis may comprise locking protrusions, notches, a chemical bond, a curable bond, or other mechanism. The woven fibers comprising the endoprosthesis may be hollow and comprise circumferentially oriented polymeric chains, and may be filled with a curable material. A method of treatment using an endoprosthesis according to the invention is also disclosed.
摘要翻译：公开了一种编织管状内假体，其包括用于将内置假体锁定在展开构造中的装置。用于锁定内假体的装置可以包括锁定突起，凹口，化学键，可固化键或其它机构。包含内用假体的编织纤维可以是中空的并且包括周向取向的聚合物链，并且可以用可固化材料填充。还公开了使用根据本发明的内置假体的治疗方法。

75. 发明授权

US07641828B2 Methods of making orthodontic appliances 有权
标题翻译：制造矫正器具的方法
公开(公告)号：US07641828B2
公开(公告)日：2010-01-05
申请号：US10963252
申请日：2004-10-12
申请人： Joseph M. DeSimone , Robert E. Tricca
发明人： Joseph M. DeSimone , Robert E. Tricca
IPC分类号： B29C59/00
CPC分类号： A61C7/08 , C08F2/46
摘要： Methods of making a removable dental positioning appliance include forming a sheet of transparent crystalline polymeric material into a shell having cavities shaped to receive and reposition teeth from a first orientation to a successive orientation. The polymeric material may then be annealed at a temperature above its glass transition temperature or cured if a curable material to enhance characteristics of the polymeric material. The polymeric material may be coated with a second transparent material.
摘要翻译：制造可移除牙齿定位装置的方法包括将透明结晶聚合物材料片形成为具有成形为容纳和重新定位牙齿从第一取向到连续取向的空腔的外壳。然后可以在高于其玻璃化转变温度的温度下对聚合物材料进行退火，或者如果是可固化的材料固化以增强聚合物材料的特性，则可以进行退火。聚合物材料可以用第二透明材料涂覆。

76. 发明申请

US20090281250A1 METHODS AND MATERIALS FOR FABRICATING MICROFLUIDIC DEVICES 有权
标题翻译：制备微流体装置的方法和材料
公开(公告)号：US20090281250A1
公开(公告)日：2009-11-12
申请号：US12063284
申请日：2006-08-09
申请人： Joseph M. DeSimone , Jason P. Rolland , Ginger M. Dennison Rothrock , Paul Resnick
发明人： Joseph M. DeSimone , Jason P. Rolland , Ginger M. Dennison Rothrock , Paul Resnick
IPC分类号： C08L67/00 , C08G18/71 , B05D3/00 , C08F2/48 , B44C1/22 , B29C33/40 , G03F7/00 , F15C3/00 , F15C5/00 , G05D7/00
CPC分类号： B29C59/005 , B01L3/502707 , B01L2300/0887 , B01L2300/12 , B29C33/3878 , B29C33/405 , B29C65/48 , B29C65/4835 , B29C65/4845 , B29C65/485 , B29C65/521 , B29C66/54 , B29C66/543 , B29C66/71 , B29C66/723 , B29C66/727 , B29C66/91431 , B29C66/919 , B29C66/949 , B29C66/9534 , B29K2883/00 , B29L2031/756 , B81B2201/051 , B81C99/0085 , C08G18/10 , C08G18/5015 , C08G18/8175 , C08G59/30 , C08G65/007 , C08L71/02 , C08L75/16 , Y10T137/0318 , Y10T137/2224 , C08G18/50 , B29C65/00 , B29K2027/18 , B29K2027/12
摘要： Materials and Methods are provided for fabricating microfluidic devices. The materials include low surface energy fluoropolymer compositions having multiple cure functional groups. The materials can include multiple photocurable and/or thermal-curable functional groups such that laminate devices can be fabricated. The materials also substantially do not swell in the presence of hydrocarbon solvents.
摘要翻译：提供材料和方法用于制造微流体装置。这些材料包括具有多个固化官能团的低表面能含氟聚合物组合物。这些材料可以包括多个可光固化和/或热固化的官能团，使得可以制造层压装置。所述材料在烃溶剂存在下也基本上不溶胀。

77. 发明授权

US07285287B2 Carbon dioxide-assisted methods of providing biocompatible intraluminal prostheses 有权
标题翻译：提供生物相容性管腔内假体的二氧化碳辅助方法
公开(公告)号：US07285287B2
公开(公告)日：2007-10-23
申请号：US10662621
申请日：2003-09-15
申请人： Michael S. Williams , Joseph M. DeSimone
发明人： Michael S. Williams , Joseph M. DeSimone
IPC分类号： A61L29/00
CPC分类号： A61L31/14 , A61L27/34 , A61L27/50 , A61L31/10
摘要： Methods of producing biocompatible intraluminal prostheses are provided and include immersing polymeric material of an intraluminal prosthesis in a densified carbon dioxide composition under controlled conditions such that toxic materials are absorbed by the densified carbon dioxide composition.
摘要翻译：提供了生产生物相容性管腔内假体的方法，包括将腔内假体的聚合材料浸入致密化二氧化碳组合物的受控条件下，使有毒物质被致密二氧化碳组合物吸收。

78. 发明授权

US06929904B2 Positive tone lithography with carbon dioxide development systems 失效
标题翻译：正音光刻与二氧化碳开发系统
公开(公告)号：US06929904B2
公开(公告)日：2005-08-16
申请号：US10294223
申请日：2002-11-14
申请人： Joseph M. DeSimone
发明人： Joseph M. DeSimone
IPC分类号： G03F7/004 , G03F7/039 , G03F7/32 , G03F7/30
CPC分类号： G03F7/0392 , G03F7/0046 , G03F7/32
摘要： A process of forming a resist image in a microelectronic substrate, the process comprises the steps of: (a) providing a substrate having a polymer coating thereon, wherein the polymer is insoluble in water having a pH less than or equal to a specified pH (e.g., 7.0, 6, 5, or 4); then (b) imagewise exposing the coating to radiation such that exposed and unexposed coating portions are formed, with said exposed coating portions being soluble in water having a pH less than or equal to said specified pH7.0; and then (c) contacting said coating to a developing composition comprising carbon dioxide and water, said water having a specified pH less than or equal to 7.0 (and preferably a pH of about 2 or 3 to 4, 5 or 6; i.e. a specified pH less than or equal to 6, 5, or 4), so that said exposed coating portions are preferentially removed from the substrate as compared to said unexposed coating portions to form an image thereon.
摘要翻译：一种在微电子衬底中形成抗蚀剂图像的方法，该方法包括以下步骤：（a）提供其上具有聚合物涂层的基底，其中聚合物不溶于pH小于或等于特定pH的水中例如，7.0,6,5或4）; 然后（b）将涂层成像曝光到辐射，使得形成暴露和未曝光的涂布部分，所述暴露的涂布部分可溶于pH小于或等于所述指定pH7.0的水中; 然后（c）使所述涂层与包含二氧化碳和水的显影组合物接触，所述水的特定pH小于或等于7.0（优选pH为约2或3至4，5或6;即指定的 pH小于或等于6,5或4），使得与所述未曝光的涂布部分相比，所述暴露的涂布部分优先从基底去除以在其上形成图像。

79. 发明授权

US06887266B2 Endoprostheses and methods of manufacture 失效
标题翻译：内假体和制造方法
公开(公告)号：US06887266B2
公开(公告)日：2005-05-03
申请号：US10342622
申请日：2003-01-15
申请人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
发明人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
IPC分类号： A61F2/00 , A61F2/82 , A61F2/90 , A61L27/34 , A61L27/50 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61F2/06
CPC分类号： A61F2/90 , A61F2/848 , A61F2002/825 , A61F2220/005 , A61F2220/0058 , A61F2250/0014 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00
摘要： Improved endoprostheses comprising a delivery configuration and a deployed configuration and methods of manufacture are disclosed. Some embodiments according to the invention comprise woven tubular structures and means for maintaining said structures in their expanded configurations. In one embodiment of the invention, locking elements disposed on one or more fibers maintain said endoprosthesis in its deployed configuration. In alternative embodiments, one or more axial members may maintain said endoprosthesis in its deployed configuration. In yet additional alternative embodiments, a chemical bond or thermocouple may maintain said endoprosthesis in its deployed configuration. Some embodiments according to the invention may comprise erodible material.
摘要翻译：公开了包括输送配置和部署配置和制造方法的改进的内假体。根据本发明的一些实施例包括织造管状结构和用于将所述结构保持在其扩展构型中的装置。在本发明的一个实施例中，设置在一个或多个纤维上的锁定元件将所述内部假体保持在其展开构型中。在替代实施例中，一个或多个轴向构件可以将所述内假体保持在其展开构造中。在另外的替代实施例中，化学键或热电偶可以将所述内假体保持在其展开的构型中。根据本发明的一些实施例可以包括可侵蚀的材料。

80. 发明授权

US06716945B2 Multimodal fluoropolymers and methods of making the same 失效
标题翻译：多峰含氟聚合物及其制备方法
公开(公告)号：US06716945B2
公开(公告)日：2004-04-06
申请号：US09860413
申请日：2001-05-18
申请人： Joseph M. DeSimone , George W. Roberts , Paul A. Charpentier
发明人： Joseph M. DeSimone , George W. Roberts , Paul A. Charpentier
IPC分类号： C08F21422
CPC分类号： C08F14/18 , C08F14/22 , C08F2/04
摘要： A method for forming a fluoropolymer comprises providing a reaction mixture comprising carbon dioxide, at least one fluoromonomer, and an initiator; and reacting the at least one fluoromonomer in the reaction mixture to form a fluoropolymer. The fluoropolymer has a multimodal molecular weight distribution.
摘要翻译：形成含氟聚合物的方法包括提供包含二氧化碳，至少一种含氟单体和引发剂的反应混合物; 并使反应混合物中的至少一种含氟单体反应形成含氟聚合物。含氟聚合物具有多峰分子量分布。

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