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71. 发明授权

US07389778B2 Variable magnetic moment MR navigation 失效
标题翻译：可变磁矩MR导航
公开(公告)号：US07389778B2
公开(公告)日：2008-06-24
申请号：US10834579
申请日：2004-04-29
申请人： Michael E. Sabo , Rogers C. Ritter , Roger N. Hastings , Raju R. Viswanathan
发明人： Michael E. Sabo , Rogers C. Ritter , Roger N. Hastings , Raju R. Viswanathan
IPC分类号： A61B19/00 , A61B17/00
CPC分类号： A61B5/055 , A61B5/06
摘要： A method of navigating a medical device in an operating region in a subject. The method includes applying a magnetic field to the operating region and changing the magnetic moment of the medical device by selectively changing a physical condition of at least one magnet element in the medical device to change the orientation of the device with respect to the applied magnetic field.
摘要翻译：一种在受试者的操作区域中导航医疗装置的方法。该方法包括通过选择性地改变医疗装置中的至少一个磁体元件的物理状态来改变医疗装置的磁矩并改变相对于所施加的磁场的装置的取向来改变操作区域的磁场。

72. 发明授权

US06572579B1 Drug delivery and catheter systems, apparatus and processes 有权
公开(公告)号：US06572579B1
公开(公告)日：2003-06-03
申请号：US09661232
申请日：2000-09-13
申请人： Raghu Raghavan , Raju R. Viswanathan , Timothy Poston
发明人： Raghu Raghavan , Raju R. Viswanathan , Timothy Poston
IPC分类号： A61M100
CPC分类号： A61M25/00 , A61M25/0009 , A61M25/007 , Y10S977/906
摘要： A class of customizable injection devices or delivery instruments whose basic form is a stiff tube with holes of user-selectable size at several user-selectable places is described. The use of this device includes a method of selection and construction of a particular device from such a class of devices for a particular treatment procedure using computer-assisted means. Thus, the user may make selections among available or creatable choices (such as selection of hole size, selection of hole location, number of holes, etc.), and a method can be practiced for making such user-selection serve the goals of delivery of materials such as drugs, cells, or of devices sufficiently small and numerous to be delivered in fluid suspension. The tube should be relatively stiff in the sense that it deflects by no more than an amount between 0° and 15° under the stresses of insertion and placement at the end of a catheter, and varies less than 5 or less than 10% per cent in cross-sectional area when so deflected to the maximum of about 15 degrees.

73. 发明授权

US06464662B1 Drug delivery and catheter systems, apparatus and processes 有权
标题翻译：药物输送和导管系统，装置和过程
公开(公告)号：US06464662B1
公开(公告)日：2002-10-15
申请号：US09626059
申请日：2000-07-26
申请人： Raghu Raghavan , Raju R. Viswanathan , Timothy Poston
发明人： Raghu Raghavan , Raju R. Viswanathan , Timothy Poston
IPC分类号： A61M100
CPC分类号： A61M25/007 , Y10S977/906
摘要： A class of customizable injection devices or delivery instruments whose basic form is a stiff tube with holes of user-selectable size at several user-selectable places is described. The use of this device includes a method of selection and construction of a particular device from such a class of devices for a particular treatment procedure using computer-assisted means. Thus, the user may make selections among available or creatable choices (such as selection of hole size, selection of hole location, number of holes, etc.), and a method can be practiced for making such user-selection serve the goals of delivery of materials such as drugs, cells, or of devices sufficiently small and numerous to be delivered in fluid suspension. The tube should be relatively stiff in the sense that it deflects by no more than an amount between 0° and 15° under the stresses of insertion and placement at the end of a catheter, and varies less than 5 or less than 10% per cent in cross-sectional area when so deflected to the maximum of about 15 degrees.
摘要翻译：描述了一类可定制的注射装置或输送装置，其基本形式是具有用户可选尺寸的孔的刚性管，其在几个用户可选择的位置。该设备的使用包括使用计算机辅助装置从特定处理程序的这类设备中选择和构建特定设备的方法。因此，用户可以在可用或可创建的选择之中进行选择（例如选择孔尺寸，孔位选择，孔数等），并且可以实施用于使这样的用户选择服务于递送目标的方法的材料，例如药物，细胞或足够小和许多以流体悬浮液递送的装置。管子应该是比较僵硬的，因为它在插入和放置在导管末端的应力下偏转不超过0°和15°之间的量，变化小于5或小于10％在横截面积如此偏转到最大约15度时。

74. 发明授权

US08551109B2 Electrostriction devices and methods for assisted magnetic navigation 有权
标题翻译：用于辅助磁导航的电致伸缩装置和方法
公开(公告)号：US08551109B2
公开(公告)日：2013-10-08
申请号：US11770547
申请日：2007-06-28
申请人： Raju R. Viswanathan , Rogers C. Ritter , Peter R. Werp
发明人： Raju R. Viswanathan , Rogers C. Ritter , Peter R. Werp
IPC分类号： A61F11/00
CPC分类号： A61B19/22 , A61B34/70 , A61B34/73 , A61B2017/00106 , A61B2017/003
摘要： An apparatus and method for interventional navigation within a subject's body is provided in which a medical device having at least one electrostrictive element is adapted to cause the distal end of the medical device to bend in a given direction for improving navigation. The medical device may further comprise at least one magnetically responsive element on the distal end, which may be oriented in the approximate direction of a magnetic field that is applied to the subjects body. At least one method for navigating a medical device though a subject's body is provided, by changing the direction of an applied magnetic field to align a magnetically responsive element on the distal end for orienting the distal end, and by applying a voltage to at least one electrostrictive element disposed in the distal portion of the device for causing the distal end to change orientation from that achieved by application of the magnetic field alone.
摘要翻译：提供了一种用于受试者身体内的介入导航的装置和方法，其中具有至少一个电致伸缩元件的医疗装置适于使医疗装置的远端沿给定方向弯曲以改善导航。医疗装置还可以包括远端上的至少一个磁响应元件，其可以被施加到受试者身体的磁场的近似方向定向。通过改变所施加的磁场的方向以使远端上的磁响应元件对准以使远端定向，并且通过向至少一个电极施加电压，提供至少一种用于通过受试者身体导航医疗装置的方法电致伸缩元件设置在装置的远端部分中，用于使远端改变方向与通过仅施加磁场实现的方向。

75. 发明授权

US08273081B2 Impedance-based cardiac therapy planning method with a remote surgical navigation system 有权
标题翻译：基于阻抗的心脏治疗计划方法与远程手术导航系统
公开(公告)号：US08273081B2
公开(公告)日：2012-09-25
申请号：US11852950
申请日：2007-09-10
申请人： Raju R. Viswanathan
发明人： Raju R. Viswanathan
IPC分类号： A61B18/12
CPC分类号： A61B5/0536 , A61B5/042 , A61B18/1492 , A61B34/10 , A61B34/20 , A61B2018/00577 , A61B2018/00839 , A61B2018/00875 , A61B2034/2051 , A61B2090/376
摘要： A method is disclosed for planning the treatment of cardiac arrhythmias by RF ablation with a remote navigation system, including the identification of ablation lines around the pulmonary veins ostia—atrial junctions based on impedance measurements. When used by itself or in conjunction with electro-anatomical approaches, the impedance method therein disclosed enables safe and effective arrhythmia treatment.
摘要翻译：公开了一种通过远程导航系统通过RF消融来规划心律失常治疗的方法，其中包括基于阻抗测量识别围绕肺静脉心房结的消融线。当其本身使用或与电解方法结合使用时，其中所公开的阻抗方法可实现安全有效的心律失常治疗。

76. 发明授权

US08162920B2 Magnetic navigation of medical devices in magnetic fields 有权
标题翻译：医疗器械在磁场中的磁导航
公开(公告)号：US08162920B2
公开(公告)日：2012-04-24
申请号：US10831533
申请日：2004-04-23
申请人： Rogers C. Ritter , Raju R. Viswanathan , Roger N. Hastings
发明人： Rogers C. Ritter , Raju R. Viswanathan , Roger N. Hastings
IPC分类号： A61M31/00 , A61M25/00
CPC分类号： A61B1/00147 , A61M25/0127
摘要： A method of turning a medical device with the assistance of an externally applied magnetic field, in a direction with a component in a plane perpendicular to the direction of the externally applied magnetic field. The method includes applying first torque to the distal end of the medical device by creating magnetic moment at the distal end of the medical device, and applying a second torque to the distal end of the medical device. The second torque may be created by creating a second magnetic moment at the distal end of the device spaced from the first, by using an electrostrictive device, by using a stylette inserted into the device, by using a fluid-driven shaped tube, or otherwise.
摘要翻译：在外部施加的磁场的帮助下，沿与垂直于外部施加的磁场的方向的平面中的分量的方向转动医疗装置的方法。该方法包括通过在医疗装置的远端产生磁矩并将第二扭矩施加到医疗装置的远端，将第一扭矩施加到医疗装置的远端。第二扭矩可以通过使用电致伸缩装置通过使用插入到装置中的通孔，通过使用流体驱动的成形管或以其他方式通过使用流动驱动的成形管产生与装置的远端隔开的第二磁矩来产生。

77. 发明授权

US07983733B2 Surgical navigation using a three-dimensional user interface 有权
标题翻译：手术导航使用三维用户界面
公开(公告)号：US07983733B2
公开(公告)日：2011-07-19
申请号：US10975029
申请日：2004-10-26
申请人： Raju R. Viswanathan
发明人： Raju R. Viswanathan
IPC分类号： A61B5/05
CPC分类号： A61B90/36 , A61B5/06 , A61B34/20 , A61B34/76 , A61B2034/2068 , A61B2090/365
摘要： A system for controlling a medical device in a patient. A display system displays an image of a volume of the patient in a virtual three-dimensional space. A stylus is controllable to actuate a virtual element in the virtual space. A navigation system controls the medical device in the patient volume based on a position of the actuated virtual element. This inherently three-dimensional interface allows a physician to actuate the medical device more intuitively than possible using a two-dimensional interface.
摘要翻译：一种用于控制患者中的医疗装置的系统。显示系统在虚拟三维空间中显示患者体积的图像。触控笔是可控制的，以驱动虚拟空间中的虚拟元件。导航系统基于所致动的虚拟元件的位置来控制患者体积中的医疗装置。这种固有的三维界面允许医生使用二维界面更可靠地致动医疗装置。

78. 发明申请

US20110028989A1 NAVIGATION USING SENSED PHYSIOLOGICAL DATA AS FEEDBACK 审中-公开
标题翻译：使用感觉生理数据作为反馈的导航
公开(公告)号：US20110028989A1
公开(公告)日：2011-02-03
申请号：US12773443
申请日：2010-05-04
申请人： Rogers C. Ritter , Raju R. Viswanathan
发明人： Rogers C. Ritter , Raju R. Viswanathan
IPC分类号： A61B19/00
CPC分类号： A61B5/026 , A61B5/028 , A61B5/04011 , A61B5/04012 , A61B5/042 , A61B5/06 , A61B5/062 , A61B5/065 , A61B5/068 , A61B8/06 , A61B8/12 , A61B34/73 , A61B90/06 , A61B2017/00044 , A61B2034/2051 , A61N1/08
摘要： A method for controlling a remote navigation system to navigate a medical device in an operating region in a subject is provided, comprising operating the remote navigation system to bring a sensor carried on a medical device successively into a plurality of locations in a predetermined pattern, and using the sensor to sense a physiological property of the subject in each location. At least once thereafter, the method operates the remote navigation system to bring a sensor carried on a medical device successively into a series of locations in a predetermined pattern relative to at least one location selected from the predetermined pattern in the immediately preceding step based upon the sensed physiological property value, and uses the sensor to sense the physiological property in each location. The method automatically determines the location of a local extreme value of the sensed physiological property, and may be selectively used to locate a maximum value of the sensed physiological property or a minimum of the sensed physiological property. The method may be utilized for sensing one or more physiological properties such as a magnitude of an electrical signal, a conductivity, a temperature, a fluid flow rate or a fluid velocity, or a range of motion of a surface.
摘要翻译：提供了一种用于控制远程导航系统导航对象中的操作区域中的医疗设备的方法，包括：操作所述远程导航系统，使医疗设备上承载的传感器以预定模式连续地进入多个位置;以及使用传感器来感测每个位置的受试者的生理特性。至少在此之后，该方法操作远程导航系统，以使基于医疗设备的传感器相对于在前一步骤中的预定模式中选择的至少一个位置，以预定模式连续地进入一系列位置，基于感测生理特性值，并使用传感器感测每个位置的生理特性。该方法自动地确定所感测的生理特征的局部极值的位置，并且可以选择性地用于定位所感测的生理特性的最大值或感测到的生理特性的最小值。该方法可以用于感测一个或多个生理特性，例如电信号的大小，电导率，温度，流体流速或流体速度或表面的运动范围。

79. 发明授权

US07818076B2 Method and apparatus for multi-system remote surgical navigation from a single control center 失效
标题翻译：从单一控制中心进行多系统远程手术导航的方法和装置
公开(公告)号：US07818076B2
公开(公告)日：2010-10-19
申请号：US11672358
申请日：2007-02-07
申请人： Raju R. Viswanathan
发明人： Raju R. Viswanathan
IPC分类号： G06F17/00 , G05B19/18 , G08B1/08 , A61B5/00 , A61B3/16
CPC分类号： A61B34/70 , A61B34/35
摘要： A system and method are provided for performing remote surgical navigation in multiple systems from a single control center, where there are at least two remote navigation systems in separate procedure rooms having respective control computers. The system includes a Control Center separate from each procedure room that has a set of displays and interface input devices. A switch may also be included for connecting the Control Center to the set of displays, interface input devices, and remote navigation systems. A method is provided for performing multiple simultaneous remote medical procedures that includes displaying information transmitted from a remote navigation system to the Control Center, and accepting user input from a remote navigation system. The method provides for establishing an encryption key with the remote system, converting the user input to a script data and encrypting the data. The transmitted script command is then transmitted to the remote navigation system.
摘要翻译：提供了一种用于在单个控制中心执行多个系统中的远程手术导航的系统和方法，其中至少两个远程导航系统在具有相应控制计算机的分离的程序室中。该系统包括一个独立于每个过程室的控制中心，它具有一组显示和接口输入设备。还可以包括用于将控制中心连接到一组显示器，接口输入设备和远程导航系统的开关。提供了一种用于执行多个同时远程医疗程序的方法，其包括将从远程导航系统发送的信息显示到控制中心，以及接受来自远程导航系统的用户输入。该方法提供与远程系统建立加密密钥，将用户输入转换为脚本数据并加密数据。然后将发送的脚本命令发送到远程导航系统。

80. 发明授权

US07815580B2 Magnetic guidewire for lesion crossing 失效
标题翻译：磁导丝用于病变穿越
公开(公告)号：US07815580B2
公开(公告)日：2010-10-19
申请号：US11220383
申请日：2005-09-06
申请人： Raju R. Viswanathan
发明人： Raju R. Viswanathan
IPC分类号： A61M25/092 , A61M25/09 , A61M25/00 , A61M5/00
CPC分类号： A61M25/09 , A61M2025/09133
摘要： The invented guidewire relates to improvements in a magnetically navigable medical guidewire to enable passage through an occluded or partially occluded vessel. The guidewire comprises an elongate wire having a proximal end and a distal end, wherein the distal end further comprises a magnetically responsive element and a helical thread formed on the tip. The distal end of the guidewire may be preferably aligned substantially in the direction of an applied magnetic field, after which the proximal end of the guidewire may be torqued to rotate the threaded tip while remaining aligned with the applied magnetic field and cause the tip to screw through the blockage in the occluded vessel.
摘要翻译：本发明的导丝涉及导磁导管的改进，以使得能够穿过封闭或部分闭塞的血管。导丝包括具有近端和远端的细长线，其中远端还包括形成在尖端上的磁响应元件和螺旋形线。导丝的远端可以优选地基本上沿所施加的磁场的方向排列，之后可以将导丝的近端扭转以旋转螺纹尖端，同时保持与所施加的磁场对齐并使尖端螺旋通过闭塞的血管堵塞。

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