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71. 发明申请

US20100189718A1 MOLECULES WITH EXTENDED HALF-LIVES, COMPOSITIONS AND USES THEREOF 有权
标题翻译：具有扩展的半衰期，组合物和其用途的分子
公开(公告)号：US20100189718A1
公开(公告)日：2010-07-29
申请号：US12691433
申请日：2010-01-21
申请人： William Dall'Acqua , Leslie S. Johnson , Elizabeth Sally Ward
发明人： William Dall'Acqua , Leslie S. Johnson , Elizabeth Sally Ward
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N5/10 , A61P31/12 , C12Q1/70
CPC分类号： C07K16/283 , A61K38/00 , A61K39/00 , A61K47/48507 , A61K47/6835 , A61K49/0002 , A61K49/0004 , A61K2039/505 , C07K2/00 , C07K14/70503 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/94 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules.
摘要翻译：本发明提供了由于存在IgG恒定结构域或其结合FcRn的部分而具有增加的体内半衰期的IgG，非IgG免疫球蛋白，蛋白质和非蛋白质试剂的分子，其具有一个或更多的氨基酸修饰，其增加FcRn的恒定结构域或片段的亲和力。具有增加的半衰期的这种蛋白质和分子具有在这种分子的治疗，预防或诊断使用中需要更少量和/或更低频率给药的优点。

72. 发明授权

US07704497B2 Molecules with extended half-lives, compositions and uses thereof 有权
标题翻译：具有延长半衰期，组成和用途的分子
公开(公告)号：US07704497B2
公开(公告)日：2010-04-27
申请号：US11649455
申请日：2007-01-03
申请人： William Dall'Acqua , Leslie S. Johnson , Elizabeth Sally Ward
发明人： William Dall'Acqua , Leslie S. Johnson , Elizabeth Sally Ward
IPC分类号： C07K16/00 , A61K39/395 , C12P21/08 , C12N1/00
CPC分类号： C07K16/283 , A61K38/00 , A61K39/00 , A61K47/48507 , A61K47/6835 , A61K49/0002 , A61K49/0004 , A61K2039/505 , C07K2/00 , C07K14/70503 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/94 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules.
摘要翻译：本发明提供了由于存在IgG恒定结构域或其结合FcRn的部分而具有增加的体内半衰期的IgG，非IgG免疫球蛋白，蛋白质和非蛋白质试剂的分子，其具有一个或更多的氨基酸修饰，其增加FcRn的恒定结构域或片段的亲和力。具有增加的半衰期的这种蛋白质和分子具有在这种分子的治疗，预防或诊断使用中需要更少量和/或更低频率给药的优点。

73. 发明授权

US07435421B2 Derivatives of choline binding proteins for vaccines 失效
标题翻译：用于疫苗的胆碱结合蛋白的衍生物
公开(公告)号：US07435421B2
公开(公告)日：2008-10-14
申请号：US11062080
申请日：2005-02-18
申请人： Theresa M. Wizemann , Scott Koenig , Leslie S. Johnson
发明人： Theresa M. Wizemann , Scott Koenig , Leslie S. Johnson
IPC分类号： A61K39/00 , A61K39/38 , A61K39/02 , A61K39/085 , A61K39/09 , A61K38/00 , A61K38/16 , A01N37/18
CPC分类号： C07K14/3156 , A61K39/00
摘要： The present invention provides bacterial immunogenic agents for administration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of mammalian species with pneumococcal derived polypeptides that include an alpha helix but exclude a choline binding region as a mechanism for stimulating production of antibodies that protect the vaccine recipient against infection by pathogenic bacterial species. In another aspect the invention provides antibodies against such proteins and protein complexes that may be used as diagnostics and/or as protective/treatment agents for pathogenic bacterial species.
摘要翻译：本发明提供用于给予人和非人动物以刺激免疫应答的细菌免疫原性试剂。其特别涉及哺乳动物物种与肺炎球菌来源的多肽的免疫接种，包括α螺旋，但不排除胆碱结合区域，作为刺激保护疫苗接受者免受病原菌种感染的抗体产生的机制。在另一方面，本发明提供了抗这种蛋白质和蛋白质复合物的抗体，其可以用作诊断和/或作为病原菌种的保护/治疗剂。

74. 发明授权

US07122194B2 Vaccine compositions comprising Streptococcus pneumoniae polypeptides having selected structural motifs 有权
标题翻译：包含具有选定结构基序的肺炎链球菌多肽的疫苗组合物
公开(公告)号：US07122194B2
公开(公告)日：2006-10-17
申请号：US10412850
申请日：2003-04-14
申请人： Leslie S. Johnson , John E. Adamou
发明人： Leslie S. Johnson , John E. Adamou
IPC分类号： A61K39/02 , A61K49/00
CPC分类号： A61K39/092 , A61K2039/505 , C07K14/3156 , C07K16/1275
摘要： A vaccine composition is disclosed that comprises polypeptides and fragments of polypeptides containing histidine triad residues or coiled-coil regions, some of which polypeptides or fragments lie between 80 and 680 residues in length. Also disclosed are processes for preventing infection caused by S. pneumoniae comprising administering of vaccine compositions.
摘要翻译：公开了包含多肽和含有组氨酸三联体残基或螺旋卷曲区域的多肽片段的疫苗组合物，其中一些多肽或片段长度在80至680个残基之间。还公开了防止由肺炎链球菌引起的感染的方法，包括施用疫苗组合物。

75. 发明授权

US06863893B2 Derivatives of choline binding proteins for vaccines 失效
公开(公告)号：US06863893B2
公开(公告)日：2005-03-08
申请号：US10254995
申请日：2002-09-25
申请人： Theresa M. Wizemann , Scott Koenig , Leslie S. Johnson
发明人： Theresa M. Wizemann , Scott Koenig , Leslie S. Johnson
IPC分类号： C12N15/09 , A61K39/00 , A61K39/09 , A61K39/395 , A61K39/40 , A61P31/04 , A61P37/04 , C07K14/315 , C07K16/12 , A61K39/02 , A61K39/085 , C07K14/00 , A16K38/00 , A16K38/16
CPC分类号： C07K14/3156 , A61K39/00
摘要： The present invention provides bacterial immunogenic agents for administration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of mammalian species with pneumococcal derived polypeptides that include an alpha helix but exclude a choline binding region as a mechanism for stimulating production of antibodies that protect the vaccine recipient against infection by pathogenic bacterial species. In another aspect the invention provides antibodies against such proteins and protein complexes that may be used as diagnositics and/or as protective/treatment agents for pathogenic bacterial species.

76. 发明授权

US06833356B1 Pneumococcal protein homologs and fragments for vaccines 失效
标题翻译：肺炎球菌蛋白同源物和疫苗片段
公开(公告)号：US06833356B1
公开(公告)日：2004-12-21
申请号：US09645835
申请日：2000-08-25
申请人： Scott Koenig , Jon Heinrichs , Leslie S. Johnson , John E. Adamou
发明人： Scott Koenig , Jon Heinrichs , Leslie S. Johnson , John E. Adamou
IPC分类号： C07K1400
CPC分类号： C07K14/3156
摘要： The invention is directed to isolated polypeptides bearing sequence homology to the Sp36 protein found in pneumococcal organisms, such as Streptococcus pneumoniae. Polynucleotides encoding such polypeptides are also disclosed. The invention also relates to antibodies specific for the disclosed polypeptides and to uses of such antibodies in the treatment of diseases caused by staphylococci as well as group A and B streptococci. In addition, the invention relates to the use of the disclosed polypeptides in compositions and as vaccines and for prophylactic uses such as in vaccination of animals, especially humans, against a wide variety of streptococcal, staphylococcal and other diseases.
摘要翻译：本发明涉及与肺炎球菌生物体如肺炎链球菌中发现的Sp36蛋白具有序列同源性的分离的多肽。还公开了编码这种多肽的多核苷酸。本发明还涉及对于所公开的多肽具有特异性的抗体以及此类抗体用于治疗由葡萄球菌以及A和B组链球菌引起的疾病的用途。此外，本发明涉及所公开的多肽在组合物中的用途，以及作为预防用途的预防用途，例如针对各种链球菌，葡萄球菌和其它疾病的动物，特别是人类的疫苗接种。

77. 发明授权

US06689369B2 Immunogenic pneumococcal protein and vaccine compositions thereof 有权
标题翻译：免疫原性肺炎球菌蛋白及其疫苗组合物
公开(公告)号：US06689369B2
公开(公告)日：2004-02-10
申请号：US09844124
申请日：2001-04-27
申请人： Scott Koenig , Leslie S. Johnson , John E. Adamou
发明人： Scott Koenig , Leslie S. Johnson , John E. Adamou
IPC分类号： A61K3909
CPC分类号： C07K14/3156 , A61K39/00 , A61K2035/11 , A61K2039/505 , A61K2039/53
摘要： The present invention relates to novel immunogenic polypeptides, and therapeutically active fragments thereof, and vaccines, and vaccine compositions, for the prevention and treatment of streptococcal infection, especially by Streptococcus pneumoniae. The invention also relates to antibodies against the disclosed polypeptides, as well as methods of disease prevention and/or treatment.
摘要翻译：本发明涉及用于预防和治疗链球菌感染的新型免疫原性多肽及其治疗活性片段，疫苗和疫苗组合物，特别是由肺炎链球菌（Streptococcus pneumoniae）。本发明还涉及针对所公开的多肽的抗体，以及疾病预防和/或治疗的方法。

78. 发明授权

US06503511B1 Derivatives of choline binding proteins for vaccines 有权
标题翻译：用于疫苗的胆碱结合蛋白的衍生物
公开(公告)号：US06503511B1
公开(公告)日：2003-01-07
申请号：US09286981
申请日：1999-04-06
申请人： Theresa M. Wizemann , Scott Koenig , Leslie S. Johnson
发明人： Theresa M. Wizemann , Scott Koenig , Leslie S. Johnson
IPC分类号： A61K3902
CPC分类号： C07K14/3156 , A61K39/00
摘要： The present invention provides bacterial immunogenic agents for administration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of mammalian species with pneumococcal derived polypeptides that include an alpha helix but exclude a choline binding region as a mechanism for stimulating production of antibodies that protect the vaccine recipient against infection by pathogenic bacterial species. In another aspect the invention provides antibodies against such proteins and protein complexes that may be used as diagnositics and/or as protective/treatment agents for pathogenic bacterial species.
摘要翻译：本发明提供用于给予人和非人动物以刺激免疫应答的细菌免疫原性试剂。其特别涉及哺乳动物物种与肺炎球菌来源的多肽的免疫接种，包括α螺旋，但不排除胆碱结合区域，作为刺激保护疫苗接受者免受病原菌种感染的抗体产生的机制。在另一方面，本发明提供抗这种蛋白质和蛋白质复合物的抗体，其可以用作诊断和/或作为病原菌物种的保护/治疗剂。

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