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71. 发明授权

US07417021B2 Biologically active conjugate of a biopolymer and therapeutic agent 有权
标题翻译：生物聚合物和治疗剂的生物活性缀合物
公开(公告)号：US07417021B2
公开(公告)日：2008-08-26
申请号：US10841081
申请日：2004-05-07
申请人： Pericles Calias , Robert J. Miller
发明人： Pericles Calias , Robert J. Miller
IPC分类号： A61K38/00 , A61K38/46 , A61K9/00 , C12N11/02 , C07K17/02
CPC分类号： A61K47/645 , A61K47/61 , Y10S530/812 , Y10S530/816
摘要： A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a suitable carrier, has improved in vivo stability and activity, and can be targeted to a variety of cells, tissues and organs.
摘要翻译：公开了包含通过二硫键连接的生物聚合物和治疗剂的生物活性缀合物。当配制在具有合适载体的药物组合物中时，缀合物具有改善的体内稳定性和活性，并且可以靶向各种细胞，组织和器官。

72. 发明授权

US07387836B2 Aziridine compounds and their use in medical devices 有权
标题翻译：氮丙啶化合物及其在医疗器械中的应用
公开(公告)号：US07387836B2
公开(公告)日：2008-06-17
申请号：US10511425
申请日：2003-04-17
申请人： Diego A. Gianolio , Erika E. Johnston , Robert J. Miller
发明人： Diego A. Gianolio , Erika E. Johnston , Robert J. Miller
IPC分类号： B05D5/00 , C08F2/34 , C08F2/52 , C08J7/18 , B32B9/00
CPC分类号： A61L33/0029 , A61L29/085 , A61L31/10 , A61L33/0094 , Y10T428/31504
摘要： There are disclosed novel uses of aziridine compounds. The aziridine compounds can be formed into films by plasma deposition on a wide variety of substrates. The films prevent biofouling, impart biocompatible or antithrombotic properties, and can immobilize therapeutic and pharmaceutical agents to provide a drug delivery system.
摘要翻译：公开了氮丙啶化合物的新用途。氮丙啶化合物可以通过在各种基材上的等离子体沉积形成膜。该膜防止生物污损，赋予生物相容性或抗血栓性质，并且可以固定治疗剂和药剂以提供药物递送系统。

73. 发明授权

US07370846B2 Parallel flow fractionation tray 有权
$Parallel flow fractionation tray$
标题翻译：平行流分离塔
公开(公告)号：US07370846B2
公开(公告)日：2008-05-13
申请号：US11550179
申请日：2006-10-17
申请人： Zhanping Xu , Daniel R. Monkelbaan , Brian J. Nowak , Robert J. Miller
发明人： Zhanping Xu , Daniel R. Monkelbaan , Brian J. Nowak , Robert J. Miller
IPC分类号： B01F3/04
CPC分类号： B01D3/008 , B01D3/20
摘要： The invention comprises multiple configurations of downcomers in a parallel flow multiple downcomer tray for vapor-liquid contacting processes such as the separation of chemical compounds via fractional distillation or the removal of a component of a gas stream with a treating liquid. In one embodiment, side downcomers are incorporated into a parallel flow multiple downcomer tray. In another embodiment, the downcomers have an inclined side wall that directs liquid onto the deck below the downcomer. The inclined side wall also provides additional volume above the inferior downcomer inlet to reduce pinching at this inlet without the need for a stilling deck.
摘要翻译：本发明包括用于气 - 液接触方法的并行流多重降液管的多个构造的降液管，例如通过分馏分离化合物或用处理液除去气流的组分。在一个实施例中，侧向下导管并入到并行流多个下降管托盘中。在另一个实施例中，降液管具有将液体引导到降液管下方的甲板上的倾斜侧壁。倾斜的侧壁还在下部降液管入口之上提供额外的体积，以减少在该入口处的挤压，而不需要静止甲板。

74. 发明授权

US07052586B2 Apparatus for making particulates of controlled dimension 失效
标题翻译：用于制造受控尺寸颗粒的装置
公开(公告)号：US07052586B2
公开(公告)日：2006-05-30
申请号：US10365724
申请日：2003-02-11
申请人： Glen L. Rasmussen , Micheal E. Dickson , Robert J. Miller , Mary J. Nelson , Jonathan C. Hughes , Diane C. Rawlings
发明人： Glen L. Rasmussen , Micheal E. Dickson , Robert J. Miller , Mary J. Nelson , Jonathan C. Hughes , Diane C. Rawlings
IPC分类号： C25B11/03
CPC分类号： C22C33/0278 , B22F1/0055 , C25C5/02 , C25D1/00 , C25D1/20 , H01F1/0027 , H01F1/20 , H01F1/442 , H01F41/16 , H01F41/26 , Y10S428/925 , Y10S428/926 , Y10S428/935 , Y10T428/256 , Y10T428/2982 , Y10T428/2991
摘要： We make particulates, especially magnetic Fe—Co alloys having high magnetic permeability, of controlled dimensions, especially those having a narrow thickness size distribution centered around a median or target thickness in the range of about 0.1–1.0 μm, using electrodeposition typically on a smooth (polished) titanium cathode. Our preferred continuous process uses a rotating drum cathode inside a fixed anode to grow flakes and to produce them automatically by inherent instability in the deposited film. The drum preferably rotates about a substantially vertical axis. The particulates shed (slough off) into the electrolyte (because of mismatch between the cathode surface and the plated metal or alloy at the molecular level) where they are separated in a magnetic separator or other suitable device. If the flakes are soft iron or iron-cobalt alloys, the drum generally is titanium or titanium alloy.
摘要翻译：我们制造颗粒，特别是具有高磁导率的磁性Fe-Co合金，具有受控的尺寸，特别是具有以约0.1-1.0μm范围内的中值或目标厚度为中心的窄厚度尺寸分布的那些，通常使用电沉积（抛光）钛阴极。我们优选的连续方法是在固定阳极内使用旋转鼓形阴极来生长薄片，并通过沉积薄膜的固有不稳定性自动生成薄片。滚筒优选围绕基本垂直的轴线旋转。颗粒物（电解液脱落）进入电解液（由于阴极表面和电子分子级别的电镀金属或合金之间的不匹配），它们在磁选机或其他合适的装置中分离。如果薄片是软铁或铁钴合金，则滚筒一般为钛或钛合金。

75. 发明授权

US06694383B2 Handling service requests 有权
公开(公告)号：US06694383B2
公开(公告)日：2004-02-17
申请号：US10008595
申请日：2001-12-06
申请人： Thai Q. Nguyen , Robert J. Miller , Kenneth C. Creta
发明人： Thai Q. Nguyen , Robert J. Miller , Kenneth C. Creta
IPC分类号： G06F300
CPC分类号： G06F13/4031 , G06F2213/0024
摘要： A first component that stores information about requests for information directed to an interface (e.g., a bus of a computer system connected to components), receives an indication of a request sent by a second component to the interface. The first component sends an identifier for a subsequent request to the second component.

76. 发明授权

US06560682B1 System and method for terminating lock-step sequences in a multiprocessor system 失效
标题翻译：用于在多处理器系统中终止锁步序列的系统和方法
公开(公告)号：US06560682B1
公开(公告)日：2003-05-06
申请号：US08943676
申请日：1997-10-03
申请人： Robert J. Miller , Edward A. McDonald
发明人： Robert J. Miller , Edward A. McDonald
IPC分类号： G06F1200
CPC分类号： G06F11/0793 , G06F9/52 , G06F11/0724 , G06F13/1663
摘要： There is provided, for use in a processing system containing a plurality of processors coupled to a main memory, a control circuit for perturbing a lock-step sequence of memory requests received from the processors. The control circuit comprises a memory request generator for generating at least one memory request operable to terminate the lock-step sequence of memory requests.
摘要翻译：提供了一种用于包含耦合到主存储器的多个处理器的处理系统中的控制电路，用于扰乱从处理器接收到的锁步骤序列的存储器请求。控制电路包括存储器请求发生器，用于产生至少一个可操作以终止锁定步骤序列的存储器请求的存储器请求。

77. 发明授权

US5766306A Continuous process for making nanoscale amorphous magnetic metals 失效
标题翻译：制备纳米级无定形磁性金属的连续工艺
公开(公告)号：US5766306A
公开(公告)日：1998-06-16
申请号：US657992
申请日：1996-06-04
申请人： Larry K. Olli , Patrice K. Ackerman , Robert J. Miller , Diane C. Rawlings
发明人： Larry K. Olli , Patrice K. Ackerman , Robert J. Miller , Diane C. Rawlings
IPC分类号： B22F1/00 , B22F9/30 , H01F1/36 , B22F9/18
CPC分类号： H01F1/36 , B22F1/0096 , B22F9/305 , B22F2998/00 , B22F2999/00 , Y10S977/777 , Y10S977/838 , Y10S977/896
摘要： Sononochemistry permits extremely rapid cooling to produce nanoscale particles. If magnetic, these particles are valuable for magnetic recording media, manufacture of permanent magnets, and other uses. In the present invention, we sonicate neat metal carbonyl to produce particles which we separate, generally magnetically, from the metal carbonyl, thereby making the production process as simple as possible and continuous.
摘要翻译：声子化学允许极快速冷却以产生纳米级颗粒。如果是磁性的，这些颗粒对于磁记录介质，永磁体的制造和其他用途是有价值的。在本发明中，我们将纯金属羰基超声波处理以产生通常磁性地从金属羰基分离的颗粒，从而使生产过程尽可能简单和连续。

78. 发明授权

US5495077A Object position and proximity detector 失效
标题翻译：物体位置和接近检测器
公开(公告)号：US5495077A
公开(公告)日：1996-02-27
申请号：US252969
申请日：1994-06-02
申请人： Robert J. Miller , Stephen Bisset , Timothy P. Allen , Gunter Steinbach
发明人： Robert J. Miller , Stephen Bisset , Timothy P. Allen , Gunter Steinbach
IPC分类号： G06F1/16 , G06F3/033 , G06F3/041 , G06F3/044 , G06F3/048 , G08C21/00 , H03M11/00
CPC分类号： G06F3/041 , G06F1/1626 , G06F3/03547 , G06F3/044 , G06F2203/04101
摘要： A proximity sensor system includes a sensor matrix array having a characteristic capacitance on horizontal and vertical conductors connected to sensor pads. The capacitance changes as a function of the proximity of an object or objects to the sensor matrix. The change in capacitance of each node in both the X and Y directions of the matrix due to the approach of an object is converted to a set of voltages in the X and Y directions. These voltages are processed by analog circuitry to develop electrical signals representative of the centroid of the profile of the object, i.e, its position in the X and Y dimensions. The profile of position may also be integrated to provide Z-axis (pressure) information.
摘要翻译：接近传感器系统包括具有连接到传感器焊盘的水平和垂直导体上的特征电容的传感器矩阵阵列。电容根据物体或传感器矩阵的接近度而变化。由于物体的接近，矩阵的X和Y方向上的每个节点的电容的变化被转换成在X和Y方向上的一组电压。这些电压由模拟电路处理，以开发代表物体轮廓的质心的电信号，即其在X和Y尺寸中的位置。位置的轮廓也可以被集成以提供Z轴（压力）信息。

79. 发明授权

US5380336A Method and apparatus for stereotactic radiosurgery and fractionated radiation therapy 失效
$Method and apparatus for stereotactic radiosurgery and fractionated radiation therapy$
标题翻译：用于立体定向放射外科和分次放射治疗的方法和装置
公开(公告)号：US5380336A
公开(公告)日：1995-01-10
申请号：US48384
申请日：1993-04-16
申请人： John Misko , Robert J. Miller , Stan Heard
发明人： John Misko , Robert J. Miller , Stan Heard
IPC分类号： A61B19/00 , A61N5/10 , A61B17/00
CPC分类号： A61N5/1049 , A61B2090/101 , A61N2005/1097
摘要： The invention includes a rigid frame that is positioned around the skull to define a multi-dimensional coordinate system. Multiple arms are coupled to the frame, each arm having an attachment assembly movable along a longitudinal axis directed toward the center of the rigid frame assembly. Multiple receptors are either attached to the skull or drilled into the skull for receiving an associated attachment assembly. The receptors provide a mounting base upon which the frame is repeatedly attached and detached from the skull at the same reproducible reference location. Each arm has a multi-station receptacle that receives various attachments used for mounting and attaching the receptors. Special bushings are used to lock the attachment assembly in a preset longitudinal position in relation to the arm. The locked attachment assembly can then be removed from the arm allowing the frame to be removed from the skull while maintaining frame position information.
摘要翻译：本发明包括一个围绕颅骨定位以定义多维坐标系的刚性框架。多个臂联接到框架，每个臂具有可沿着指向刚性框架组件的中心的纵向轴线移动的附接组件。多个受体或者连接到颅骨或钻进颅骨以接收相关联的附件组件。这些受体提供了一个安装基座，框架在同一可重复的参考位置上重复地连接并从颅骨上拆下。每个臂具有多站插座，其接收用于安装和附接受体的各种附件。使用特殊衬套将附件组件相对于臂锁定在预设的纵向位置。然后可以将锁定的附接组件从臂移除，从而允许框架从颅骨移除，同时保持框架位置信息。

80. 发明授权

US5322799A Observation cell and mixing chamber 失效
标题翻译：观察池和混合室
公开(公告)号：US5322799A
公开(公告)日：1994-06-21
申请号：US733753
申请日：1991-07-23
申请人： Robert J. Miller , James D. Ingle, Jr.
发明人： Robert J. Miller , James D. Ingle, Jr.
IPC分类号： G01N21/05 , G01N30/34 , G01N30/74 , G01N35/00 , G01N35/08 , B01L3/00
CPC分类号： G01N21/05 , G01N2021/0346 , G01N2030/347 , G01N2035/00514 , G01N35/085 , Y10S436/909
摘要： A device for detecting substances in a liquid film by measuring chemiluminescence, fluorescence or absorption using techniques such as flow-injection analysis schemes, liquid chromatographies, and gas chromatographies. The device can be used as a micro-volume mixing or reaction substrate for a variety of measurements. The device comprises at least two film supports that are separated by a small gap. One or more applicators are positioned along the gap to supply fluids to the gap. The applicators are positioned near the gap at a spacing that is near the necking length of the fluid supplied by the applicator. A thin, continuous film of the mixture of fluids to be examined is supported in the gap between the film supports. The film extends through the examining chamber and through drop and overflow detection probes. Also disclosed is a mixing or reaction chamber which comprises an enclosable mainframe into which a plurality of applicators are butted near a gap defined between two film supports. The chamber communicates with an inlet port and an exit port for controlling the pressure and other aspects of the environment in the chamber.
摘要翻译：用于通过使用诸如流动注射分析方案，液相色谱和气相色谱的技术测量化学发光，荧光或吸收来检测液膜中的物质的装置。该装置可用作微体积混合或反应底物进行各种测量。该装置包括由小间隙分开的至少两个膜支撑件。一个或多个施加器沿着间隙定位以将流体供应到间隙。施加器以接近由施加器供应的流体的缩颈长度的间隔定位在间隙附近。要检查的流体混合物的薄的连续膜被支撑在膜支撑件之间的间隙中。胶片延伸穿过检查室，并通过液滴和溢流检测探针。还公开了一种混合或反应室，其包括可封闭的主机，多个施加器在两个胶片支撑件之间限定的间隙附近对接在其中。该室与入口端口和出口连通，用于控制室内的压力和其它方面的环境。

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