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71. 发明授权

US4075346A CNS depressant .gamma.-(secondary amino)-ortho-nitro-butyrophenones 失效
标题翻译： CNS DEPRESSANT“ - （二级氨基） - 硝基 - 丁基
公开(公告)号：US4075346A
公开(公告)日：1978-02-21
申请号：US705840
申请日：1976-07-16
申请人： Kikuo Sasajima , Keiichi Ono , Yasuo Motoike , Shigeho Inaba , Hisao Yamamoto
发明人： Kikuo Sasajima , Keiichi Ono , Yasuo Motoike , Shigeho Inaba , Hisao Yamamoto
IPC分类号： C07D211/08 , C07D211/14 , C07D211/18 , C07D211/36 , C07D211/48 , C07D211/52 , C07D295/04 , C07D295/108 , C07D295/12 , C07D307/33 , C07D317/16 , C07D401/04 , C07D471/10 , C07D211/28 , A61K31/445
CPC分类号： C07D295/108 , C07C205/45 , C07D211/14 , C07D211/18 , C07D211/52 , C07D307/33 , C07D317/16
摘要： Novel compounds of the formula: ##STR1## wherein R is a hydrogen or fluorine atom, W is an oxygen atom or an ethylenedioxy or ethylenedithio group and Z is a certain secondary amino group, which are useful as central nervous system depressants, can be prepared by the reaction of a compound of the formula: ##STR2## wherein X is a halogen atom and R and W are each as defined above with a secondary amine of the formula: H--Z wherein Z is as defined above, in case of W being ethylenedioxy or ethylenedithio, optionally followed by hydrolysis and can be reduced to give a compound of the formula: ##STR3## wherein R and Z are each as defined above, which are useful as antipsychotic and/or analgesic agents.

72. 发明授权

US4060550A Novel n'-acylated phenyl-hydrazine and -hydrazone derivatives 失效
标题翻译：新型n {40-酰基苯基 - 肼和腙衍生物
公开(公告)号：US4060550A
公开(公告)日：1977-11-29
申请号：US651831
申请日：1976-01-23
申请人： Michio Kimura , Shigeho Inaba , Hisao Yamamoto
发明人： Michio Kimura , Shigeho Inaba , Hisao Yamamoto
IPC分类号： C07D209/60 , C07D209/70 , C07D307/54 , C07D317/66 , C07D317/68 , C07D319/18 , C07C103/133
CPC分类号： C07D317/66 , C07D209/60 , C07D209/70 , C07D307/54 , C07D317/68 , C07D319/18
摘要： Indolylacetic acid derivatives, which have excellent anti-inflammatory, antipyretic and analgesic activities, represented by the formula, ##STR1## wherein X.sub.1 and X.sub.2 are each methylene; A is an unsubstituted ethylenically unsaturated hydrocarbon chain having up to 5 carbon atoms; m is 0 or 1; n is 1 or 2; R.sub.3 is alkyl having up to 4 carbon atoms; cycloalkyl having 3 to 7 carbon atoms, unsubstituted or C.sub.1 -C.sub.4 alkyl-, nitro-, trifluoromethyl-, methylenedioxy-, ethylenedioxy- or halogen-substituted phenyl, or halogen-, C.sub.1 -C.sub.4 alkyl- or phenyl-substituted or benzene ring-condensed C.sub.3 -C.sub.7 cycloalkyl, or unsubstituted or halogen-, C.sub.1 -C.sub.4 alkyl- or phenyl-substituted or benzene ring-condensed C.sub.5 -C.sub.6 cycloalkenyl; and B is ##STR2## .
摘要翻译：吲哚乙酸衍生物，其具有优异的抗炎，解热和止痛活性，由下式表示，其中X1和X2各自为亚甲基; A是具有至多5个碳原子的未取代的烯属不饱和烃链; m为0或1; n为1或2; R3是具有至多4个碳原子的烷基; 具有3-7个碳原子的环烷基，未取代的或C 1 -C 4烷基 - ，硝基 - ，三氟甲基 - ，亚甲二氧基 - ，亚乙二氧基或卤素取代的苯基，或卤素 - ，C 1 -C 4烷基 - 或苯基取代的或苯环 - 或未取代的或卤素的，C 1 -C 4烷基或苯基取代的或苯环稠合的C 5 -C 6环烯基; 而B是

73. 发明授权

US4044003A Process for preparing 1,4-benzodiazepines 失效
标题翻译：制备1,4-苯并二氮杂卓的方法
公开(公告)号：US4044003A
公开(公告)日：1977-08-23
申请号：US598621
申请日：1975-07-24
申请人： Kikuo Ishizumi , Kazuo Mori , Tadashi Okamoto , Takeshi Akase , Takahiro Izumi , Mitsuhiro Akatsu , Yoshiharu Kume , Shigeho Inaba , Hisao Yamamoto
发明人： Kikuo Ishizumi , Kazuo Mori , Tadashi Okamoto , Takeshi Akase , Takahiro Izumi , Mitsuhiro Akatsu , Yoshiharu Kume , Shigeho Inaba , Hisao Yamamoto
IPC分类号： C07D243/16
CPC分类号： C07D243/16
摘要： 1,4-Benzodiazepine derivatives of the formula, ##STR1## wherein R.sub.1 is hydrogen, a lower alkyl, a haloalkyl, a cycloalkylalkyl, an alkoxyalkyl, an acyloxyalkyl, an alkylthioalkyl, an alkylaminoalkyl, a dialkylaminoalkyl, a hydroxyalkyl, carbamoyl, or an N-alkylcarbamoyl; R.sub.2 is hydrogen or a lower alkyl; X is hydrogen, a halogen, nitro, or trifluoromethyl; A is a group of the formula, ##STR2## (wherein Y and Z each represent hydrogen, a halogen, a lower alkyl, or nitro) and a salt thereof, are prepared by reacting a 1,4-benzodiazepin-2-one compound of the formula, ##STR3## wherein R.sub.1, R.sub.2, X, Y and Z are the same as defined above, with diborane in an inert solvent.
摘要翻译：其中R1是氢，低级烷基，卤代烷基，环烷基烷基，烷氧基烷基，酰氧基烷基，烷基硫代烷基，烷基氨基烷基，二烷基氨基烷基，羟基烷基，氨基甲酰基或 N-烷基氨基甲酰基; R2是氢或低级烷基; X是氢，卤素，硝基或三氟甲基; A是通过使1,4-苯并二氮杂-2-酮化合物（其中Y和Z各自表示氢，卤素，低级烷基或硝基）及其盐的式其中R1，R2，X，Y和Z与上述定义相同，与乙硼烷在惰性溶剂中反应。

74. 发明授权

US4009173A Butyrophenone derivatives 失效
标题翻译：丁酰苯衍生物
公开(公告)号：US4009173A
公开(公告)日：1977-02-22
申请号：US617730
申请日：1975-09-29
申请人： Kikuo Sasajima , Masaru Nakao , Isamu Maruyama , Keiichi Ono , Shigenari Katayama , Shigeho Inaba , Hisao Yamamoto
发明人： Kikuo Sasajima , Masaru Nakao , Isamu Maruyama , Keiichi Ono , Shigenari Katayama , Shigeho Inaba , Hisao Yamamoto
IPC分类号： C07D211/64 , C07D403/04
CPC分类号： C07D211/64
摘要： Novel butyrophenone derivatives of the formula: ##STR1## wherein R.sub.1 represents a hydroxyl group or ##STR2## (wherein R.sub.6 and R.sub.7 are each a hydrogen atom or a lower alkyl group or, when taken together with the adjacent nitrogen atom, may form a heterocyclic group), R.sub.2 represents an optionally substituted phenyl group or ##STR3## (wherein R.sub.8 and R.sub.9 are each a hydrogen atom or a lower alkyl group or, when taken together with the adjacent nitrogen atom, may form a heterocyclic group), R.sub.4 represents a hydrogen atom, a lower alkyl group or an optionally substituted phenyl group, R.sub.5 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a trifluoromethyl group, R.sub.10 represents a hydrogen atom or an acyl group represented by R.sub.3 CO- (wherein R.sub.3 is a hydrogen atom, a lower alkyl group or an optionally substituted phenyl group) and Z represents two hydrogen atoms or an oxygen atom, provided that when Z is an oxygen atom and R.sub.1 is ##STR4## R.sub.10 can not be a hydrogen atom, and their acid addition salts, which are useful as central and autonomic nervous system depressants.
摘要翻译：下式的新型丁基苯酚衍生物：其中R 1表示羟基或（其中R 6和R 7各自为氢原子或低级烷基，或者当与相邻的氮原子一起形成杂环时基团），R 2表示任选取代的苯基或者其中R 8和R 9各自为氢原子或低级烷基，或者当与相邻的氮原子一起形成杂环基时，R 4表示氢原子，低级烷基或任选取代的苯基，R 5表示氢原子，卤素原子，低级烷基，低级烷氧基或三氟甲基，R 10表示氢原子或R 3 CO 3表示的酰基 - （其中R 3是氢原子，低级烷基或任选取代的苯基），Z代表两个氢原子或氧原子，条件是当Z是氧原子且R 1不能是氢原子，和它们的酸加成盐，其可用作中枢神经系统抑制剂和自主神经系统抑制剂。

75. 发明授权

US4002611A Preparation of benzodiazepines 失效
标题翻译：苯二氮卓类的制备
公开(公告)号：US4002611A
公开(公告)日：1977-01-11
申请号：US797663
申请日：1969-02-07
申请人： Hisao Yamamoto , Shigeho Inaba , Tadashi Okamoto , Toshiyuki Hirohashi , Kikuo Ishizumi , Michihiro Yamamoto , Isamu Maruyama , Kazuo Mori , Tsuyoshi Kobayashi
发明人： Hisao Yamamoto , Shigeho Inaba , Tadashi Okamoto , Toshiyuki Hirohashi , Kikuo Ishizumi , Michihiro Yamamoto , Isamu Maruyama , Kazuo Mori , Tsuyoshi Kobayashi
IPC分类号： C07D209/04 , C07D209/08 , C07D243/16
CPC分类号： C07D209/04 , C07D209/08
摘要： A 1-alkyl-1,2,4,5-tetrahydro-3H-1,4-benzodiazepine derivative is produced by contacting a 1-aminoethyl-indole derivative with a suitable oxidizing agent and then reducing the resulting 1-acyl-2,3-dihydro-1H-1,4-benzodiazepine derivative. The starting 1-aminoethyl-indole derivative is prepared by subjecting a 3-phenyl-indole derivative to cyanomethylation (or carbamoylemethylation) and then reducing the resulting 1-cyanomethyl- (or 1-carbamoylmethyl)-indole derivative. The 1-acyl-1,2,4,5-tetrahydro-3H-1,4-benzodiazepine derivative is useful as a tranquillizer, muscle-relaxant, etc.
摘要翻译： 1-烷基-1,2,4,5-四氢-3H-1,4-苯并二氮杂衍生物是通过使1-氨基乙基 - 吲哚衍生物与合适的氧化剂接触，然后将所得1-酰基-2 3-二氢-1H-1,4-苯并二氮杂衍生物。起始的1-氨基乙基 - 吲哚衍生物通过使3-苯基 - 吲哚衍生物进行氰甲基化（或氨甲酰甲基化）然后还原所得的1-氰基甲基 - （或1-氨基甲酰基甲基） - 吲哚衍生物来制备。 1-酰基-1,2,4,5-四氢-3H-1,4-苯并二氮杂衍生物可用作镇静剂，肌肉松弛剂等

76. 发明授权

US3976420A Method and apparatus for burning fuels 失效
标题翻译：燃烧燃料的方法和装置
公开(公告)号：US3976420A
公开(公告)日：1976-08-24
申请号：US554703
申请日：1975-03-03
申请人： Yasuro Takahashi , Hisao Yamamoto
发明人： Yasuro Takahashi , Hisao Yamamoto
IPC分类号： F23D14/22 , F23C6/00 , F23C6/04 , F23C99/00 , F23D14/00 , F23D14/70 , F23D23/00 , F23C5/00
CPC分类号： F23C6/047 , F23D14/00 , F23D23/00
摘要： Method and burner apparatus for burning fuels wherein an air-fuel premixture of a low fuel concentration formed by premixing a fuel with combustion air in an amount larger than the theoretical air amount necessary for combustion of said fuel is fed and burnt in a combustion zone, and simultaneously, a fuel and combustion air in an amount smaller than the theoretical air amount necessary for combustion of said fuel are fed separately and burnt in the vicinity of said combustion zone or an air-fuel premixture formed by premixing a fuel with a part of combustion air supplied in said amount and the remainder of said combustion air are fed separately in the vicinity of said combustion zone.
摘要翻译：用于燃烧燃料的方法和燃烧器装置，其中通过将燃料与燃烧空气预混合形成的低燃料浓度的空气燃料预混合物的量大于燃烧所需燃料所需的理论空气量，在燃烧区域中进行燃烧，同时，燃料和燃烧空气的量小于所述燃料燃烧所需的理论空气量，分别在所述燃烧区附近被供给燃烧，或者通过将燃料与一部分燃料预混合形成的空气燃料预混合物以所述量供应的燃烧空气和剩余的所述燃烧空气在所述燃烧区附近单独供给。

77. 发明授权

US3965106A 3-Phenoxypropylamine derivatives 失效
标题翻译： 3-苯氧基丙胺衍生物
公开(公告)号：US3965106A
公开(公告)日：1976-06-22
申请号：US423981
申请日：1973-12-12
申请人： Isamu Maruyama , Masaru Nakao , Kikuo Sasajima , Shigeho Inaba , Hisao Yamamoto
发明人： Isamu Maruyama , Masaru Nakao , Kikuo Sasajima , Shigeho Inaba , Hisao Yamamoto
IPC分类号： C07D295/08 , C07D211/52 , C07D295/092
CPC分类号： C07D295/088 , C07D211/52
摘要： A 3-phenoxypropylamine derivative of the formula: ##SPC1##Wherein Y is ##SPC2##(wherein R.sub.1 is a halogen atom or a trifluoromethyl group) or ##SPC3##(wherein R.sub.2 is a lower alkyl group) and its pharmaceutically acceptable salts which are useful as central nervous system depressing agents.
摘要翻译：下式的3-苯氧基丙胺衍生物：

78. 发明授权

US3962446A Analgesic compositions containing 2-cyanoalkylbenzomorphan derivatives and salts thereof 失效
标题翻译：含有2-氰基烷基苯并喃衍生物及其盐的止痛组合物
公开(公告)号：US3962446A
公开(公告)日：1976-06-08
申请号：US523412
申请日：1974-11-13
申请人： Toshio Atsumi , Kenji Kobayashi , Yoshiaki Takebayashi , Hisao Yamamoto
发明人： Toshio Atsumi , Kenji Kobayashi , Yoshiaki Takebayashi , Hisao Yamamoto
IPC分类号： A61K31/395 , A61K31/485
CPC分类号： A61K31/395
摘要： An analgesic composition comprising an analgesically effective amount of at least one 6,7-benzomorphan derivative of the formula: ##SPC1##Wherein R is a hydrogen atom, a hydroxyl group, a C.sup.1 - C.sup.3 alkoxy group or a C.sup.1 - C.sup.8 alkanoyloxy group; R.sub.1 is a hydrogen atom, a C.sup.1 - C.sup.5 alkyl group, a phenyl group, a halophenyl group, an alkylphenyl group wherein the alkyl moiety has 1 to 3 carbon atoms, an alkoxyphenyl group wherein the alkoxy moiety has 1 to 3 carbon atoms, a trifluoromethylphenyl group, an alkylthiophenyl group wherein the alkylthio moiety has 1 to 3 carbon atoms or a group of the formula (C.sub.m H.sub.2m.sub.-p.sub.+1) - (R.sub.9).sub.p wherein m is an integer of 1 - 6, p is an integer of 1 - 2 and R.sub.9 is a C.sup.1 - C.sup.3 alkoxy group; R.sub. 2 is a hydrogen atom or a C.sup.1 - C.sup.3 alkyl group; R.sub.3 is a hydrogen atom, a C.sup.1 - C.sup.3 alkyl group, a phenyl group or an alkoxyphenyl group wherein the alkoxy moiety has 1 to 3 carbon atoms; R.sub.4 is a hydrogen atom or a hydroxyl group, or R.sub.3 and R.sub.4 may form a C.sup.1 - C.sup.3 alkylidene group or a carbonyl group together with a carbon atom to which these substituents are bonded; R.sub.5 is a hydrogen atom or C.sup.1 - C.sup.3 alkyl group; R.sub.6 is a hydrogen atom or a methyl group; R.sub.7 and R.sub.8 are independently a hydrogen atom or a C.sup.1 - C.sup.2 alkyl group; and n is an integer of 0 - 2; or an acid addition salt thereof, and a pharmaceutically acceptable carrier or diluent, is disclosed.
摘要翻译：一种止痛组合物，其包含镇痛有效量的至少一种下式的6,7-苯并吗啉衍生物：WHEREIN R是氢原子，羟基，C1-C3烷氧基或C1-C8烷酰氧基; R1为氢原子，C1-C5烷基，苯基，卤代苯基，烷基部分为碳原子数1〜3的烷基苯基，烷氧基部分为碳原子数1〜3的烷氧基苯基，三氟甲基苯基，其中烷硫基部分具有1至3个碳原子的烷硫基苯基或式（CmH2m-p + 1） - （R9）p的基团，其中m是1-6的整数，p是整数1 - 2和R9是C1-C3烷氧基; R 2是氢原子或C 1 -C 3烷基; R3是氢原子，C1-C3烷基，苯基或烷氧基苯基，其中烷氧基部分具有1至3个碳原子; R4是氢原子或羟基，或者R3和R4可以与这些取代基结合的碳原子一起形成C1-C3亚烷基或羰基; R5是氢原子或C1-C3烷基; R6是氢原子或甲基; R 7和R 8独立地为氢原子或C 1 -C 2烷基; n为0-2的整数; 或其酸加成盐，以及药学上可接受的载体或稀释剂。

79. 发明授权

US3950346A Novel process for producing 2-ketoethylbenzomorphan derivatives and salts thereof 失效
标题翻译：生产2-乙基苯并吡喃衍生物的新方法及其制备方法
公开(公告)号：US3950346A
公开(公告)日：1976-04-13
申请号：US356807
申请日：1973-05-03
申请人： Toshio Atsumi , Kenji Kobayashi , Yoshiaki Takebayashi , Hisao Yamamoto
发明人： Toshio Atsumi , Kenji Kobayashi , Yoshiaki Takebayashi , Hisao Yamamoto
IPC分类号： C07D221/26
CPC分类号： C07D221/26
摘要： 2-Ketoethyl-6,7-benzomorphan derivatives of the formula: ##SPC1##And their pharmaceutically acceptable non-toxic salts, which are useful as non-addictive analgesics and pain-relieving agents and can be prepared by reacting the corresponding 6,7-benzomorphan derivative of the formula: ##SPC2##With a vinyl carbonyl compound of the formula: ##EQU1## [wherein R' is a hydrogen atom or a group of the formula: --OR" (wherein R" is a hydrogen atom, an alkanoyl group, an alkyl group, an aralkyl group, an alkoxycarbonylmethyl group or a tetrahydropyranyl group), R.sub.1 is a hydrogen atom, an alkyl group or a substituted or unsubstituted aryl group, R.sub.2 is a hydrogen atom or an alkyl group and A is an alkyl group, an alkoxy group, a substituted or unsubstituted aryl group or a substituted or unsubstituted amino group].

80. 发明授权

US07968271B2 Photosensitive recording material, planographic printing plate precursor, and stacks of the same 失效
标题翻译：感光记录材料，平版印刷版前体和它们的叠层
公开(公告)号：US07968271B2
公开(公告)日：2011-06-28
申请号：US11715995
申请日：2007-03-09
申请人： Hisao Yamamoto , Hiromitsu Yanaka , Takahiro Goto , Shigeo Koizumi
发明人： Hisao Yamamoto , Hiromitsu Yanaka , Takahiro Goto , Shigeo Koizumi
IPC分类号： G03F7/00 , G03F7/26
CPC分类号： G03F7/092 , B41C1/1016 , B41C2201/02 , B41C2201/04 , B41C2201/10 , B41C2201/12 , B41C2201/14 , B41C2210/04 , B41C2210/06 , B41C2210/22 , B41C2210/24 , B41M5/368 , G03F7/11
摘要： The present invention provides a photosensitive recording material having a support, and a photosensitive layer and a protective layer formed in this order on or above the support. The photosensitive layer contains a polymerization initiator, a sensitizing agent, and a polymerizable compound. Further, the protective layer contains a water-insoluble and alkali-soluble dye that has an absorption wavelength region different from the absorption wavelength region of the sensitizing agent, and the dye is dispersed in a solid state in the protective layer. The present invention also provides a planographic printing plate precursor including the photosensitive recording material, a stack of the photosensitive recording materials, and a stack of the planographic printing plate precursors.
摘要翻译：本发明提供一种具有支持体的光敏记录材料，以及在该载体上或上方依次形成的感光层和保护层。感光层含有聚合引发剂，增感剂和聚合性化合物。此外，保护层含有具有与敏化剂的吸收波长区域不同的吸收波长区域的水不溶性碱溶性染料，染料在保护层中以固体状态分散。本发明还提供了包括感光记录材料的平版印刷版原版，感光记录材料的叠层和平版印刷版前体的叠层。

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