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    • 73. 发明授权
    • Gastrointestinal stimulation device
    • 胃肠道刺激装置
    • US07054690B2
    • 2006-05-30
    • US10691735
    • 2003-10-22
    • Mir A. Imran
    • Mir A. Imran
    • A61N1/18
    • A61N1/36007
    • A fixation device for holding stimulating electrodes in electrical contact with the wall of a portion of the gastrointestinal tract is provided. In one embodiment, the fixation device includes an expandable member that fixes the electrodes in electrical contact with the gastrointestinal tract wall. Also provided is an implantable device and method for controlling the opening and/or closing of the pylorus. In particular a device and method is provided for stimulating the duodenum to control the closing/and or opening of the pylorus.Finally, a method is provided for treating obesity by controlling the pylorus to retain food in the stomach for a desired period of time, among other things to provide a feeling of satiety and/or to reduce hunger. One aspect includes controlling the pylorus's contraction by electrical stimulation of the duodenum.
    • 提供了用于保持与胃肠道的一部分的壁电接触的刺激电极的固定装置。 在一个实施例中,固定装置包括固定电极与胃肠道壁电接触的可扩张构件。 还提供了一种用于控制幽门的打开和/或关闭的可植入装置和方法。 特别地,提供了一种用于刺激十二指肠以控制幽门的关闭和/或打开的装置和方法。 最后,提供了一种通过控制幽门以将食物保留在胃中一段期望的时间来提供饱腹感和/或减少饥饿的方法来治疗肥胖症的方法。 一方面包括通过十二指肠的电刺激来控制幽门的收缩。
    • 76. 发明授权
    • Recanalization apparatus and devices for use therein and method
    • 再生设备及其使用的装置及方法
    • US5938671A
    • 1999-08-17
    • US970952
    • 1997-11-14
    • Osamu KatohMir A. Imran
    • Osamu KatohMir A. Imran
    • A61B17/00A61B17/22A61B19/00A61F2/00
    • A61B17/3207A61B2017/003A61B2017/00867A61B2017/22077A61B2090/3782A61F2002/30098A61F2210/0033
    • Recanalization apparatus for use in crossing a stenosis forming a total occlusion in a vessel formed by a vessel wall, the stenosis having a distal end cap which is convex facing in a proximal direction. The apparatus is comprised of an outer sheath formed of an elongate flexible tubular member having proximal and distal extremities and having a lumen extending from the proximal extremity to the distal extremity. An inner sheath is slidably mounted in the lumen of the outer sheath and is formed of a flexible elongate tubular member having proximal and distal extremities. The distal extremity has a sharpened tip. The inner sheath has a length so that when the sharpened tip is disposed distally of the distal extremity of the outer sheath, the proximal extremity extends proximally of the proximal extremity of the outer sheath. An imaging guide wire is slidably mounted in the lumen of the inner sheath and has proximal and distal extremities. A transducer is mounted on the distal extremity of the imaging guide wire. The he imaging guide wire has a length so that the transducer can extend beyond the distal extremity of the inner sheath with the proximal extremity extending proximally of the proximal extremity of the inner sheath.
    • 用于跨越在容器壁形成的容器中形成完全闭塞的狭窄的再通设备,所述狭窄具有在近端方向上呈凸形的远端帽。 该装置包括由具有近端和远端的细长柔性管状构件形成的外护套,并且具有从近端延伸到远端的内腔。 内护套可滑动地安装在外护套的内腔中并且由具有近端和远端的柔性细长管状构件形成。 远端具有尖锐的尖端。 内护套具有长度,使得当锋利的尖端远离外护套的远端设置时,近端延伸到外鞘近端处的近侧。 成像引导线可滑动地安装在内护套的内腔中并且具有近端和远端。 传感器安装在成像导丝的远端上。 成像引导线具有长度,使得换能器可以延伸超出内护套的远端,近端延伸到内鞘的近端的近端处。
    • 77. 发明授权
    • Catheter apparatus and method for treating occluded vessels
    • 用于治疗闭塞血管的导管装置和方法
    • US5833650A
    • 1998-11-10
    • US464579
    • 1995-06-05
    • Mir A. Imran
    • Mir A. Imran
    • A61F2/958A61M29/00
    • A61M25/1011A61B2017/320716A61M2025/1045
    • A catheter assembly for treatment of a stenosis in a lumen in a blood-carrying vessel comprising a first flexible elongate tubular member having proximal and distal extremities. A first inflatable balloon is coaxially mounted on the distal extremity of the first flexible elongate tubular member and has a main lumen and an aspiration lumen exiting through the distal extremity. A second flexible elongate tubular member has proximal and distal extremities and has a second inflatable balloon coaxially mounted on the distal extremity and has a blood perfusion lumen extending therethrough. The second flexible elongate tubular member is slidably mounted in the main lumen of the first flexible elongate tubular member. The first balloon is positioned so that it is adjacent to but proximal of the stenosis and is thereafter inflated to create a first occlusion in the lumen in the vessel. A negative pressure is created in the lumen in the vessel distal of the first balloon through the aspiration lumen. The second balloon is positioned distal of the stenosis and is inflated to create a second occlusion in the lumen of the vessel to form a working space between the first and second balloons which brackets the stenosis. Blood is perfused through the blood perfusion lumen distal of the second occlusion. A therapeutic procedure is performed in the working space.
    • 一种用于治疗血液携带血管内腔的狭窄的导管组件,包括具有近端和远端的第一柔性细长管状构件。 第一可膨胀气囊同轴地安装在第一柔性细长管状构件的远端上,并且具有通过远端远离的主腔和抽吸腔。 第二柔性细长管状构件具有近端和远端,并且具有同轴地安装在远端上的第二可膨胀气囊,并且具有延伸穿过其中的血液灌注腔。 第二柔性细长管状构件可滑动地安装在第一柔性细长管状构件的主腔内。 将第一气囊定位成使得其与狭窄相邻但邻近,然后充气以在容器的内腔中产生第一闭塞。 通过抽吸腔在第一球囊远端的血管腔中产生负压。 第二球囊位于狭窄的远端并且被充气以在血管的内腔中产生第二闭塞,以形成第一和第二气囊之间的工作空间,其支撑狭窄。 血液通过第二次闭塞远端的血液灌注腔灌注。 在工作空间中执行治疗程序。
    • 79. 发明授权
    • Low profile balloon-on-a-wire catheter with shapeable and/or deflectable
tip and method
    • 薄型气球在线导管,具有可塑和/或可偏转的尖端和方法
    • US5779688A
    • 1998-07-14
    • US504927
    • 1995-07-20
    • Mir A. ImranCecily M. HillsmanDeepak R. GandhiDennis L. Brooks
    • Mir A. ImranCecily M. HillsmanDeepak R. GandhiDennis L. Brooks
    • A61M25/00A61M25/01A61M29/02
    • A61M25/0158A61M25/0097A61M25/104A61M2025/0186A61M2025/1079A61M2025/1093
    • A low profile, balloon-on-a-wire catheter comprising a flexible elongate tubular member having proximal and distal extremities. A balloon inflation-deflation lumen extends from the proximal extremity to the distal extremity. An inflatable balloon is carried by the distal extremity of the flexible elongate tubular member. The flexible elongate tubular member carries means which establishes communication between the lumen and the interior of the inflatable balloon. A removable inflation device is removably secured to the proximal extremity of the flexible elongate tubular member for supplying an inflation fluid to the lumen for inflating and deflating the balloon. The removable inflation device forms a high pressure seal with the proximal extremity of the flexible elongate tubular member. The removable inflation device is free of obstructions so that another balloon catheter can be advanced over the proximal extremity of the flexible elongate tubular member which serves as a stand-alone guide wire. The distal extremity of the catheter is formed so that it is mechanically shapeable or can be electrically deflectable to facilitate steering of the distal extremity.
    • 一种薄型气球在线导管,其包括具有近端和远端的柔性细长管状构件。 气球充气 - 通气腔从近端延伸到远端。 可膨胀气囊由柔性细长管状构件的远端承载。 柔性细长管状构件承载建立管腔和可充气气囊内部之间的连通的装置。 可移除的充气装置可移除地固定到柔性细长管状构件的近端,用于向腔内供应充气流体以使气囊膨胀和放气。 可移除的充气装置与柔性细长管状构件的近端形成高压密封。 可移除的充气装置没有障碍物,使得另一个气囊导管可以在用作独立导丝的柔性细长管状构件的近端上前进。 导管的远端被形成为使得其可机械地成形或可以电可偏转以便于远端的转向。