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71. 发明授权

US6086556A Medical device balloons containing thermoplastic elastomers 有权
标题翻译：包含热塑性弹性体的医疗装置气球
公开(公告)号：US6086556A
公开(公告)日：2000-07-11
申请号：US129029
申请日：1998-08-04
申请人： Bruce Hamilton , Ronald A. Sahatjian
发明人： Bruce Hamilton , Ronald A. Sahatjian
IPC分类号： A61F2/958 , A61L29/00 , A61L29/04 , A61M25/00 , A61M29/00
CPC分类号： A61M25/1029 , A61L29/049 , A61M25/0045 , A61M25/1002 , A61M2025/1075 , A61M25/1038
摘要： A dilatation balloon and catheter for insertion into a bodily conduit. The catheter (10) includes shaft (12) and a dilatation balloon (24) at the distal end of the shaft. The balloon is inflated via a central lumen (14) in the shaft for delivery of a fluid inflation media. The balloon is fabricated from a combination of a thermoplastic elastomer (TPE), preferably an engineering thermoplastic elastomer (ETE), with a non-compliant structural polymeric material. The combination may be a blend of the non-compliant structural polymer and the TPE. Alternatively, the combination may be a layered balloon having, for example, a non-compliant structural polymer inner layer and a soft, abrasion resistant, elastomeric outer layer. Methods for fabricating the balloon from the combination of a TPE and a non-compliant structural polymer are also disclosed.
摘要翻译：用于插入身体导管的扩张球囊和导管。导管（10）在轴的远端包括轴（12）和膨胀气球（24）。气球通过轴中的中心腔（14）膨胀，用于输送流体充气介质。气球由热塑性弹性体（TPE），优选工程热塑性弹性体（ETE）与非柔顺结构聚合材料的组合制成。该组合可以是不顺应结构聚合物和TPE的混合物。或者，组合可以是具有例如不顺应结构聚合物内层和柔软，耐磨损的弹性体外层的分层气囊。还公开了从TPE和不顺应结构聚合物的组合制造球囊的方法。

72. 发明授权

US5674192A Drug delivery 失效
标题翻译：药物递送
公开(公告)号：US5674192A
公开(公告)日：1997-10-07
申请号：US97248
申请日：1993-07-23
申请人： Ronald A. Sahatjian , James J. Barry
发明人： Ronald A. Sahatjian , James J. Barry
IPC分类号： A61M25/00 , A61B17/03 , A61F2/00 , A61F2/90 , A61K9/00 , A61K38/49 , A61K48/00 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61M16/04 , A61M29/02 , A61M31/00 , A61M1/00
CPC分类号： A61M25/104 , A61F2/90 , A61K38/49 , A61K48/00 , A61K9/0024 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A61L33/0023 , A61L33/0029 , A61M16/0481 , A61M25/0045 , A61F2230/0013 , A61F2250/0067 , A61L2300/256 , A61L2300/258 , A61L2300/416 , A61L2300/42 , A61L2300/45 , A61L2300/602 , A61L2300/606 , A61L2300/622 , A61M2025/0046 , A61M2025/0057 , A61M2025/09183 , A61M2025/105 , A61M2025/1086 , A61M2205/0266
摘要： The invention features a catheter and methods for delivering drug to tissue at a desired location of the wall of a body lumen. The catheter is constructed for insertion in a body lumen and has a catheter shaft and an expandable portion mounted on the catheter shaft. The expandable portion is expandable to a controlled pressure to fill the cross-section of the body lumen and press against the wall of the body lumen. In one embodiment, at least a portion of the exterior surface of the expandable portion is defined by a coating of a tenaciously adhered swellable hydrogel polymer. Incorporated in the hydrogel polymer is an aqueous solution of a preselected drug to be delivered to the tissue or plaque. The hydrogel polymer and drug are selected to allow rapid release of a desired dosage of the drug from the hydrogel polymer coating during compression of the hydrogel polymer coating against the wall of the lumen when the expandable portion is expanded. In other embodiments the polymer is released from the expandable portion in response to pressure, to coat the wall of the body lumen.
摘要翻译：本发明的特征在于导管和用于将药物递送到体腔壁的所需位置处的组织的方法。导管被构造成用于插入体腔，并且具有导管轴和安装在导管轴上的可扩张部分。可膨胀部分可膨胀至受控的压力以填充体腔的横截面并压靠身体腔的壁。在一个实施例中，可膨胀部分的外表面的至少一部分由强力粘附的可溶胀水凝胶聚合物的涂层限定。掺入水凝胶聚合物中的是待递送至组织或斑块的预选药物的水溶液。选择水凝胶聚合物和药物，以便当可膨胀部分膨胀时，水凝胶聚合物涂层在水凝胶聚合物涂层压靠内腔壁时，从水凝胶聚合物涂层快速释放所需剂量的药物。在其它实施方案中，聚合物响应于压力从可膨胀部分释放，以涂覆体腔的壁。

73. 发明授权

US5059205A Percutaneous anti-migration vena cava filter 失效
标题翻译：经皮反流式静脉滤器
公开(公告)号：US5059205A
公开(公告)日：1991-10-22
申请号：US404166
申请日：1989-09-07
申请人： Fozan O. El-Nounou , Michael A. Savin , Ronald A. Sahatjian , Michael Weinreich , Thomas F. Kordis
发明人： Fozan O. El-Nounou , Michael A. Savin , Ronald A. Sahatjian , Michael Weinreich , Thomas F. Kordis
IPC分类号： A61F2/01 , A61F2/06
CPC分类号： A61F2/01 , A61F2002/016 , A61F2002/8486 , A61F2230/005 , A61F2230/0067
摘要： A filter device positionable within a blood vessel for trapping blood clots in that vessel, the filter device comprising a head with a plurality of divergent legs each secured at its proximal end, to the head, each leg having a hook arranged at its distal end. The distal end includes a reversely bent portion of the leg which itself is bent radially outwardly, ending in the shape of a sharp point. The reversely bent portion of the leg comprises a pad to minimize the depth of penetration of the hook.A further embodiment of the leg shows a radially outwardly directed radius of curvature to create a conical configuration to the filter assembly, while distributing the stress concentration along the length of the bend, so that the elastic limit of the material, stainless steel in this embodiment, is not exceeded, and which permits compact delivery of the filter, and adequate radially directed force to permit slight hook penetration of a vessel wall.
摘要翻译：一种位于血管内的过滤器装置，用于捕获血管内的血块，该过滤装置包括头部，该头部具有多个分支腿，每个头部在其近端固定到头部，每个腿部具有设置在其远端的钩。远端包括腿的反向弯曲部分，其本身被径向向外弯曲，以尖锐的形状终止。腿的反向弯曲部分包括垫，以最小化钩的穿透深度。腿的另一实施例示出了径向向外指向的曲率半径，以在沿着弯曲部分的长度分布应力集中的同时向过滤器组件产生锥形结构，使得在该实施例中的不锈钢材料的弹性极限，并且其允许过滤器的紧密输送以及足够的径向力以允许容器壁的轻微的钩子穿透。

74. 发明授权

US4525413A Optical device including birefringent polymer 失效
标题翻译：光学装置包括双折射聚合物
公开(公告)号：US4525413A
公开(公告)日：1985-06-25
申请号：US601579
申请日：1984-04-18
申请人： Howard G. Rogers , Ruth C. Bilofsky , Russell A. Gaudiana , Ronald A. Sahatjian
发明人： Howard G. Rogers , Ruth C. Bilofsky , Russell A. Gaudiana , Ronald A. Sahatjian
IPC分类号： G02B1/08 , G02B5/30 , B32B9/04 , C08G69/32
CPC分类号： G02B1/08 , G02B5/305 , Y10S428/91 , Y10S428/913 , Y10S428/918 , Y10T428/24942 , Y10T428/31504 , Y10T428/31544 , Y10T428/31649 , Y10T428/31736 , Y10T428/31786 , Y10T428/3179 , Y10T428/31935
摘要： Optical devices including a molecularly oriented highly birefringent polymer are disclosed. The devices include molecularly oriented polymers comprising recurring units which exhibit a distribution of high electron density about the long axes of the polymer and the recurring units thereof. Transparent birefringent polymers comprising a plurality of recurring units having a substantially cylindrical distribution of electron density about the long axis of such units and the chain-extended polymers are included in optical devices and articles. The polymers exhibit high birefringence and simulate in a polymer the optical properties of a uniaxial crystal.
摘要翻译：公开了包括分子取向的高双折射聚合物的光学器件。这些装置包括分子取向聚合物，其包含围绕聚合物长轴和其重复单元显示出高电子密度分布的重复单元。包括多个重复单元的透明双折射聚合物包含在光学器件和制品中，所述重复单元具有围绕这种单元的长轴的基本上圆柱形的电子密度分布和扩链聚合物。聚合物表现出高双折射性，并且在聚合物中模拟单轴晶体的光学性质。

75. 发明授权

US4415648A Variable density photographic transparencies 失效
标题翻译：可变密度摄影透明胶片
公开(公告)号：US4415648A
公开(公告)日：1983-11-15
申请号：US234687
申请日：1981-02-17
申请人： Ruth C. Bilofsky , Ronald A. Sahatjian
发明人： Ruth C. Bilofsky , Ronald A. Sahatjian
IPC分类号： G03C8/52 , G03B27/76
CPC分类号： G03C8/52
摘要： Photographic transparency assemblies comprising a photographic image supported on a transparent sheet material associated with a light polarizer element. The transparency assembly, including the light polarizer element, can be viewed in conjunction with a second partially crossed light polarizer element in order to modify the transmission density of the transparency image.
摘要翻译：照相透明组件，其包括支撑在与偏光元件相关联的透明片材上的摄影图像。可以与第二部分交叉的偏光器元件一起观看包括光偏振器元件的透明度组件，以便改变透明度图像的透射密度。

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