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71. 发明授权

US07103416B2 Visual prosthesis including enhanced receiving and stimulating portion 有权
标题翻译：视觉假体包括增强的接收和刺激部分
公开(公告)号：US07103416B2
公开(公告)日：2006-09-05
申请号：US09761270
申请日：2001-01-16
申请人： Jerry Ok , Robert J. Greenberg , Mark Humayun
发明人： Jerry Ok , Robert J. Greenberg , Mark Humayun
IPC分类号： A61N1/08
CPC分类号： A61F2/14 , A61N1/0543 , A61N1/36046
摘要： A visual prosthesis including an enhanced receiving and stimulating portion for electrically stimulating retinal tissue to present an apparent image to a user. The prosthesis includes an extracellular camera which responds to a real image to generate a real image signal. The real image signal is coupled, e.g., RF coupling, from an extracellular primary coil to a secondary coil. The secondary coil is preferably affixed within the vitreous body of the user's eye positioned for good signal coupling to the primary coil and arranged to be in good thermal contact with the vitreous body which acts as a heat sink. A hermetically sealed housing containing signal processing circuitry is also preferably placed in the vitreous body to assure efficient heat transfer away from the housing. The circuitry is electrically connected to the secondary coil and responds to an output signal therefrom to produce an apparent image signal for driving an electrode array. The electrode array is configured to electrically stimulate the eye's retinal tissue to enable a user to perceive an apparent image.
摘要翻译：一种视觉假体，包括用于电刺激视网膜组织以向用户呈现明显图像的增强的接收和刺激部分。假体包括对真实图像进行响应以生成实像信号的细胞外相机。真实图像信号从细胞外初级线圈耦合到例如RF耦合到次级线圈。次级线圈优选地固定在用户眼睛的玻璃体内，用于良好的信号耦合到初级线圈并被布置成与用作散热器的玻璃体良好的热接触。包含信号处理电路的气密密封的壳体也优选放置在玻璃体中，以确保远离壳体的有效热传递。电路电连接到次级线圈并响应于其输出信号以产生用于驱动电极阵列的视在信号。电极阵列被配置为电刺激眼睛的视网膜组织以使得使用者能够感知视觉图像。

72. 发明申请

US20060111605A1 Methods and apparatus for intraocular brachytherapy 失效
公开(公告)号：US20060111605A1
公开(公告)日：2006-05-25
申请号：US11228030
申请日：2005-09-15
申请人： Charles Larsen , Richard Hillstead , Roelof Trip , Eugene deJuan , Mark Humayun , Eberhard Fritz , Rainer Pintaske
发明人： Charles Larsen , Richard Hillstead , Roelof Trip , Eugene deJuan , Mark Humayun , Eberhard Fritz , Rainer Pintaske
IPC分类号： A61N5/00
CPC分类号： A61N5/1017 , A61N5/1049 , A61N2005/1058
摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end.

73. 发明申请

US20050208457A1 Digital object recognition audio-assistant for the visually impaired 审中-公开
标题翻译：视觉障碍者的数字对象识别音频助理
公开(公告)号：US20050208457A1
公开(公告)日：2005-09-22
申请号：US11030678
申请日：2005-01-05
申请人： Wolfgang Fink , Mark Humayun
发明人： Wolfgang Fink , Mark Humayun
IPC分类号： G09B21/00
CPC分类号： G09B21/00
摘要： A camera-based object detection system for a severely visually impaired or blind person consisting a digital camera mounted on the person's eyeglass or head that takes images on demand. Near-real time image processing algorithms decipher certain attributes of the captured image by processing it for edge pattern detection within a central region of the image. The results are classified by artificial neural networks trained on a list of known objects, in a look up table, or by a threshold. Once the pattern is classified a descriptive sentence is constructed of the object and its certain attributes and a computer-based voice synthesizer is used to verbally announce the descriptive sentence. The invention is used to determine the size of an object, or its distance from another object, and can be used in conjunction with an IR-sensitive camera to provide “sight” in poor visibility conditions, or at night.
摘要翻译：一种用于严重视觉障碍或盲人的摄像机物体检测系统，包括安装在人眼镜或头上的数字照相机，其根据需要拍摄图像。近实时图像处理算法通过对图像的中心区域中的边缘图案检测进行处理来解码捕获图像的某些属性。结果通过在已知对象的列表，查找表中或通过阈值训练的人造神经网络进行分类。一旦模式被分类，描述性句子由对象及其某些属性构成，并且使用基于计算机的语音合成器来口头公布描述性句子。本发明用于确定物体的尺寸或其与另一物体的距离，并且可以与IR敏感相机结合使用，以在较差的可视性条件或夜间提供“视线”。

74. 发明授权

US09308124B2 Apparatus and methods for delivering therapeutic agents 有权
公开(公告)号：US09308124B2
公开(公告)日：2016-04-12
申请号：US12340095
申请日：2008-12-19
申请人： Mark Humayun , Sean Caffey
发明人： Mark Humayun , Sean Caffey
IPC分类号： A61F9/00 , A61M31/00
CPC分类号： A61F9/0017 , A61F9/0026 , A61F2250/0068 , A61M31/002
摘要： In various embodiments, a drug-delivery device includes one or more reservoirs that may each contain a therapeutic agent for delivery to a patient.

75. 发明授权

US08914098B2 Medical and veterinary imaging and diagnostic procedures utilizing optical probe systems 有权
标题翻译：使用光学探针系统的医学和兽医成像和诊断程序
公开(公告)号：US08914098B2
公开(公告)日：2014-12-16
申请号：US12718266
申请日：2010-03-05
申请人： Jeffrey Brennan , Mark Humayun , Sean Caffey
发明人： Jeffrey Brennan , Mark Humayun , Sean Caffey
IPC分类号： A61B6/00 , A61B5/00 , A61M25/01 , A61B8/08 , A61B17/00 , A61B19/00 , A61B8/12 , A61B18/20 , A61N5/00
CPC分类号： A61B5/0066 , A61B3/10 , A61B3/102 , A61B3/14 , A61B5/0073 , A61B5/415 , A61B5/418 , A61B5/6852 , A61B8/12 , A61B8/4245 , A61B8/5276 , A61B18/20 , A61B34/20 , A61B2017/00207 , A61B2017/00694 , A61B2034/2048 , A61B2034/2051 , A61B2090/061 , A61B2090/3735 , A61B2090/3954 , A61M25/01 , A61M2025/0166 , A61N5/00 , Y10T29/49826
摘要： An imaging method includes providing a handpiece having a probe tip insertable into human or animal tissue disposed at an end thereof, and, an optical coherence tomography (OCT) probe connected to the handpiece such that a functionality of the OCT probe is provided at the probe tip. The probe tip is disposed adjacent to or into human or animal tissue. Imaging of the tissue, measuring at least one of a feature size or a quantifiable characteristic of a structure in the tissue for biometry analysis, and/or performing a diagnostic procedure on the tissue or a device implanted in the tissue is performed with the OCT probe.
摘要翻译：成像方法包括提供具有可插入设置在其末端的人或动物组织的探针尖端的手持件，以及连接到手持件的光学相干断层摄影（OCT）探针，使得在探针处提供OCT探针的功能性小费。探针尖端设置在人体或动物组织附近或之内。测量组织的成像，测量用于生物分析分析的组织中的结构的特征尺寸或可量化特征中的至少一个，和/或对组织或植入组织中的装置执行诊断程序，使用OCT探针。

76. 发明申请

US20140243712A1 THROMBOLYSIS IN RETINAL VESSELS WITH ULTRASOUND 审中-公开
标题翻译：超声波血管内血栓形成
公开(公告)号：US20140243712A1
公开(公告)日：2014-08-28
申请号：US13780535
申请日：2013-02-28
申请人： Mark Humayun , Xiaochen Xu , Qifa Zhou , K. Kirk Shung , Hossein Ameri , Gerald Chader
发明人： Mark Humayun , Xiaochen Xu , Qifa Zhou , K. Kirk Shung , Hossein Ameri , Gerald Chader
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B17/22012 , A61F9/00745 , A61N2007/0047
摘要： Systems and methods are described providing for the use of ultrasound energy to effect the dislodging of one or more blood clots inside blood vessels. Such clots can include those inside retinal vessels, especially in patients with central retinal vein occlusion. Embodiments of the present disclosure may be used for any retinal arterial or venous occlusion. In exemplary embodiments, a small probe can be inserted into the eye of a patient and placed over the retinal vessels. Acoustic streaming created by the probe can be directed to an area or region including targeted blood vessels, resulting in increased flow in one or more retinal veins and facilitating or effecting mechanical dislodging of one or more blood clots in the targets blood vessels. Exemplary embodiments can utilize ultrasonic energy produced at a frequency of approximately 44 MHz to 46 MHz with pulse repetition frequencies of approximately 100 Hz to 100 kHz.
摘要翻译：描述了使用超声能量来实现血管内的一个或多个血块的移动的系统和方法。视网膜血管，包括视网膜中央静脉阻塞的患者尤其如此。本公开的实施方案可用于任何视网膜动脉或静脉闭塞。在示例性实施例中，可以将小探针插入患者的眼睛并放置在视网膜血管上。由探针产生的声流可以被引导到包括目标血管的区域或区域，导致一个或多个视网膜静脉中的流量增加并且促进或实现靶血管中的一个或多个血块的机械移除。示例性实施例可以利用大约44MHz至46MHz的频率产生的超声能量，脉冲重复频率约为100Hz至100kHz。

77. 发明授权

US08755896B2 Treatment of consumption disorders with biostimulation 有权
标题翻译：用生物刺激治疗消费障碍
公开(公告)号：US08755896B2
公开(公告)日：2014-06-17
申请号：US12025454
申请日：2008-02-04
申请人： Mark Humayun , Sean Caffey , Jeff Brennan
发明人： Mark Humayun , Sean Caffey , Jeff Brennan
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0548 , A61N1/36025
摘要： Nerves that carry taste sensations to the brain are stimulated in order to diminish (or, depending on the application, augment) the pleasure ordinarily associated with consumption behavior to be modified.
摘要翻译：刺激携带大脑感觉的神经被刺激，以减少（或根据应用，增加）通常与要修饰的消费行为相关的乐趣。

78. 发明授权

US08080593B2 Reversible thermoresponsive adhesives for implants 有权
标题翻译：用于植入物的可逆热敏粘合剂
公开(公告)号：US08080593B2
公开(公告)日：2011-12-20
申请号：US11947770
申请日：2007-11-29
申请人： Mark Humayun , Buddy R. Ratner , James Weiland , Murat Tunc , Xuanhong Cheng
发明人： Mark Humayun , Buddy R. Ratner , James Weiland , Murat Tunc , Xuanhong Cheng
IPC分类号： C08G61/02 , A61B19/00 , A61B17/08 , A61B17/04 , A61L17/00 , A61F2/16 , A61F2/18
CPC分类号： A61L24/001 , A61B17/00491 , A61F9/007 , A61L24/06 , C08L33/26
摘要： The present invention relates to thermoresponsive adhesives. The invention further relates to methods for the reversible attachment of retinal implants, other implants, and drug delivery devices.
摘要翻译：本发明涉及热敏粘合剂。本发明还涉及视网膜植入物，其它植入物和药物递送装置的可逆附着的方法。

79. 发明申请

US20110282191A1 OPTICAL COHERENCE TOMOGRAPHY FOR NEURAL-SIGNAL APPLICATIONS 审中-公开
标题翻译：用于神经信号应用的光学相干图像
公开(公告)号：US20110282191A1
公开(公告)日：2011-11-17
申请号：US13106393
申请日：2011-05-12
申请人： Jeffrey Brennan , Mark Humayun , Sean Caffey
发明人： Jeffrey Brennan , Mark Humayun , Sean Caffey
IPC分类号： A61B6/03
CPC分类号： G01B9/02028 , A61B3/102 , A61B5/0066 , A61B5/0073 , A61B5/04001 , A61B2562/0233 , A61B2562/043 , A61B2562/063 , A61F2009/00851 , A61N1/0529 , A61N1/0551 , A61N1/3605 , G01B9/02007 , G01B9/02016 , G01B9/02027 , G01B9/02091 , G01N21/4795 , H04J14/02
摘要： An electrode carrier includes multiple electrodes, each electrode having a contact located at a different position along a distal end of the carrier, and multiple optical fibers, each associated with one of the electrodes and having an end face proximate to the contact of the associated electrode. Each optical fiber end face may capture optical information from tissue adjacent to the associated contact. The electrode carrier may be used for interfacing with an OCT system and a neural signal system.
摘要翻译：电极载体包括多个电极，每个电极具有位于沿着载体的远端的不同位置处的触点，以及多个光纤，每个光纤与电极中的一个相关联并且具有靠近相关电极的接触的端面。每个光纤端面可以从与相关联的接触相邻的组织捕获光学信息。电极载体可用于与OCT系统和神经信号系统的接口。

80. 发明授权

US08014878B2 Flexible circuit electrode array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US08014878B2
公开(公告)日：2011-09-06
申请号：US11207644
申请日：2005-08-19
申请人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
发明人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
IPC分类号： A61N1/36
CPC分类号： H05K3/0011 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , Y10T29/49124
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
摘要翻译：聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。通过将适量的热应用于完整的阵列，可以引起曲线。对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。此外，沿着边缘添加材料是有利的。在柔性电路阵列中提供折叠或扭曲是更有利的。可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

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