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71. 发明申请

US20190321174A1 PERCUTANEOUS VALVE PROSTHESIS AND SYSTEM AND METHOD FOR IMPLANTING THE SAME 审中-公开
公开(公告)号：US20190321174A1
公开(公告)日：2019-10-24
申请号：US16503179
申请日：2019-07-03
申请人： Edwards Lifesciences CardiAQ LLC
发明人： Arshad Quadri
IPC分类号： A61F2/24
摘要： A method for delivering a heart valve prosthesis to a native valve annulus comprises expanding an expandable frame at the native valve annulus and positioning a replacement heart valve within the expandable frame. The expandable frame preferably includes a first anchoring portion that is positioned on a first side of the native valve annulus and a second anchoring portion that is positioned on a second side of the native valve annulus. The first anchoring portion engages tissue on the first side of the native valve annulus and the second anchoring portion engages tissue on the second side of the native valve annulus for securing the expandable frame to the native valve annulus. The replacement heart valve comprises a plurality of leaflets for replacing the function of the native valve.

72. 发明授权

US10441412B2 Vascular implant and delivery system 有权
公开(公告)号：US10441412B2
公开(公告)日：2019-10-15
申请号：US15288693
申请日：2016-10-07
申请人： Edwards Lifesciences CardiAQ LLC
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24 , A61F2/95
摘要： A vascular implant for replacing a native heart valve comprises a self expanding stent supporting a valve body having leaflets. The stent preferably comprises an anchoring structure configured to prevent the implant from passing through the valve annulus. For delivery, the implant is compacted within a delivery device and secured at one end. During delivery the implant is partially released from the delivery device, and positioning of the implant can be verified prior to full release. The implant can be at least partially resheathed and repositioned if desired.

73. 发明申请

US20190298520A1 STEERABLE DELIVERY SYSTEM FOR REPLACEMENT MITRAL VALVE AND METHODS OF USE 审中-公开
公开(公告)号：US20190298520A1
公开(公告)日：2019-10-03
申请号：US16447196
申请日：2019-06-20
申请人： Edwards Lifesciences CardiAQ LLC
发明人： Alexander H. Cooper , David Robert Landon , Julio Cesar Sanchez , Glen T. Rabito , J. Brent Ratz , Arshad Quadri , Kevin M. Stewart , Patrick Chow
IPC分类号： A61F2/24
摘要： Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. A delivery component can have a plurality of slots that provide for desired bending of the delivery component, particularly compound bending of the delivery component that can facilitate steering of the delivery component in three dimensions.

74. 发明授权

US10350066B2 Steerable delivery system for replacement mitral valve and methods of use 有权
公开(公告)号：US10350066B2
公开(公告)日：2019-07-16
申请号：US15245669
申请日：2016-08-24
申请人： Edwards Lifesciences CardiAQ LLC
发明人： Alexander H. Cooper , David Robert Landon , Julio Cesar Sanchez , Glen T. Rabito , J. Brent Ratz , Arshad Quadri , Kevin M. Stewart , Patrick Chow
IPC分类号： A61F2/95 , A61F2/24 , A61M25/00 , A61F2/97
摘要： Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. A delivery component can have a plurality of slots that provide for desired bending of the delivery component, particularly compound bending of the delivery component that can facilitate steering of the delivery component in three dimensions.

75. 发明授权

US10166097B2 Replacement heart valve and method 有权
公开(公告)号：US10166097B2
公开(公告)日：2019-01-01
申请号：US15011247
申请日：2016-01-29
申请人： Edwards Lifesciences CardiAQ LLC
发明人： Arshad Quadri , J. Brent Ratz , Robrecht Michiels
IPC分类号： A61F2/24
摘要： A replacement heart valve has an expandable frame configured to engage a native valve annulus and a valve body mounted to the expandable frame. The valve body can have a plurality of valve leaflets configured to open to allow flow in a first direction and engage one another so as to close and prevent flow in a second direction, the second direction being opposite the first direction.

76. 发明申请

US20180263795A1 PERCUTANEOUS HEART VALVE 审中-公开
公开(公告)号：US20180263795A1
公开(公告)日：2018-09-20
申请号：US15984027
申请日：2018-05-18
申请人： Edwards Lifesciences CardiAQ LLC
发明人： Arshad Quadri
IPC分类号： A61F2/82 , A61F2/915 , A61F2/24 , A61F2/848
摘要： A method of delivering a percutaneous heart valve is disclosed. The percutaneous heart valve includes an expandable frame having a plurality of cells and a valve seated inside the expandable frame. The heart valve also includes a proximal anchoring portion and a distal anchoring portion having a plurality of distal anchors. After expansion, the proximal anchoring portion extends distally and a portion of each distal anchor extends proximally. A portion of each distal anchor is positioned radially outwardly from the frame and extends in a direction that is substantially parallel with the longitudinal axis. Proximal portions of the distal anchors are preferably spaced apart by less than two cell lengths from a distal portion of the proximal anchoring portion. During deployment, radial expansion of the frame draws the proximal anchoring portion and the distal anchors into closer proximity with body tissue positioned therebetween.

77. 发明授权

US09968449B2 Heart valve 有权
公开(公告)号：US09968449B2
公开(公告)日：2018-05-15
申请号：US15219122
申请日：2016-07-25
申请人： Edwards Lifesciences CardiAQ LLC
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/848 , A61F2/24
摘要： A heart valve includes a valve body made of a flexible material such as pericardium. The valve body is made of two layers of material, an outer layer, and an inner layer that defines a plurality of leaflets. The leaflets of the inner layer are attached to the outer layer. In some embodiments the valve body is made by cutting a single piece of flat source tissue, folding the cut tissue and forming it into a tubular pattern having the inner and outer layers. The multi-layer valve body can be mounted on a stent for delivery within a patient's heart.

78. 发明申请

US20170056171A1 STEERABLE DELIVERY SYSTEM FOR REPLACEMENT MITRAL VALVE AND METHODS OF USE 审中-公开
标题翻译：用于替代麻药阀的可转换输送系统及其使用方法
公开(公告)号：US20170056171A1
公开(公告)日：2017-03-02
申请号：US15245669
申请日：2016-08-24
申请人： Edwards Lifesciences CardiAQ LLC
发明人： Alexander H. Cooper , David Robert Landon , Julio Cesar Sanchez , Glen T. Rabito , J. Brent Ratz , Arshad Quadri , Kevin M. Stewart , Patrick Chow
IPC分类号： A61F2/24 , A61B17/00
CPC分类号： A61F2/2436 , A61F2/97 , A61F2002/9517 , A61F2220/0041
摘要： Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. A delivery component can have a plurality of slots that provide for desired bending of the delivery component, particularly compound bending of the delivery component that can facilitate steering of the delivery component in three dimensions.
摘要翻译：本文描述了装置，系统和方法，以提供用于将假体递送到身体位置的改进的可操作性，例如用于将替换的二尖瓣递送到天然二尖瓣位置。输送部件可以具有多个槽，其提供输送部件的期望的弯曲，特别是可以便于三维地输送部件的转向的输送部件的复合弯曲。

79. 发明申请

US20170035562A1 VASCULAR IMPLANT AND DELIVERY SYSTEM 审中-公开
标题翻译：血管植入和输送系统
公开(公告)号：US20170035562A1
公开(公告)日：2017-02-09
申请号：US15288693
申请日：2016-10-07
申请人： Edwards Lifesciences CardiAQ LLC
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/24 , A61F2/2418 , A61F2/243 , A61F2/2436 , A61F2/2439 , A61F2/95 , A61F2002/9522 , A61F2002/9534 , A61F2220/0016 , A61F2220/0033 , A61F2220/0075 , A61F2230/0013 , A61F2250/001
摘要： A vascular implant for replacing a native heart valve comprises a self expanding stent supporting a valve body having leaflets. The stent preferably comprises an anchoring structure configured to prevent the implant from passing through the valve annulus. For delivery, the implant is compacted within a delivery device and secured at one end. During delivery the implant is partially released from the delivery device, and positioning of the implant can be verified prior to full release. The implant can be at least partially resheathed and repositioned if desired.
摘要翻译：用于替换天然心脏瓣膜的血管植入物包括支撑具有传单的阀体的自扩张支架。支架优选地包括构造成防止植入物通过瓣膜环的锚定结构。为了交付，植入物在输送装置内压实并固定在一端。在输送期间，植入物部分地从输送装置释放，并且可以在完全释放之前验证植入物的定位。如果需要，植入物可以至少部分地重新固定并重新定位。

80. 发明申请

US20160331532A1 PERCUTANEOUS VALVE PROSTHESIS AND SYSTEM AND METHOD FOR IMPLANTING THE SAME 审中-公开
标题翻译： PERCUTANEOUSO VALVE PROSTHISIS AND SYSTEM AND METHOD FOR IMPLANTING THE SAME
公开(公告)号：US20160331532A1
公开(公告)日：2016-11-17
申请号：US15221435
申请日：2016-07-27
申请人： Edwards Lifesciences CardiAQ LLC
发明人： Arshad Quadri
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2230/0054 , A61F2250/006
摘要： A method for delivering a heart valve prosthesis to a native valve annulus comprises expanding an expandable frame at the native valve annulus and positioning a replacement heart valve within the expandable frame. The expandable frame preferably includes a first anchoring portion that is positioned on a first side of the native valve annulus and a second anchoring portion that is positioned on a second side of the native valve annulus. The first anchoring portion engages tissue on the first side of the native valve annulus and the second anchoring portion engages tissue on the second side of the native valve annulus for securing the expandable frame to the native valve annulus. The replacement heart valve comprises a plurality of leaflets for replacing the function of the native valve.
摘要翻译：用于将心脏瓣膜假体递送到自然瓣膜环的方法包括在天然瓣膜环处扩展可扩张框架并将置换心脏瓣膜定位在可扩张框架内。可膨胀框架优选地包括定位在天然瓣膜环的第一侧上的第一锚定部分和位于天然瓣膜环的第二侧上的第二锚固部分。第一锚定部分接合在天然瓣膜环的第一侧上的组织，并且第二锚定部分接合在天然瓣膜环的第二侧上的组织，用于将可扩张框架固定到天然瓣膜环。替换心脏瓣膜包括用于替代天然瓣膜功能的多个传单。

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