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71. 发明授权

US09668972B2 Nonsteroidal immunomodulating kit and composition and uses thereof 有权
公开(公告)号：US09668972B2
公开(公告)日：2017-06-06
申请号：US11078902
申请日：2005-03-11
申请人： Dov Tamarkin , Meir Eini , Doron Friedman
发明人： Dov Tamarkin , Meir Eini , Doron Friedman
IPC分类号： A61K9/12 , A61K8/04 , A61K8/67 , A61K31/07 , A61K31/203 , A61Q19/00 , A61K9/00 , A61K9/10
CPC分类号： A61K9/122 , A61K8/046 , A61K8/671 , A61K9/0014 , A61K9/10 , A61K31/07 , A61K31/203 , A61Q19/00
摘要： Compositions and therapeutic kits including an aerosol container containing a foamable composition that includes a nonsteroidal immunomodulating agent are described. The foamable composition includes a liquid hydrophobic carrier; a surface-active agent; polymeric additive; water; and a propellant.

72. 发明授权

US09211259B2 Antibiotic kit and composition and uses thereof 有权
标题翻译：抗生素试剂盒及其组合物及其用途
公开(公告)号：US09211259B2
公开(公告)日：2015-12-15
申请号：US11448490
申请日：2006-06-07
申请人： Doron Friedman , Alex Besonov , Dov Tamarkin , Meir Eini
发明人： Doron Friedman , Alex Besonov , Dov Tamarkin , Meir Eini
IPC分类号： A61K9/12 , A61K9/107 , A61K47/06 , A61K47/10 , A61K47/14
CPC分类号： A61K9/107 , A61K47/06 , A61K47/10 , A61K47/14 , Y02A50/473
摘要： The present invention relates to a therapeutic kit to provide a safe and effective dosage of an antibiotic agent, including an aerosol packaging assembly including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam, wherein the pressurized product comprises a foamable composition including: an antibiotic agent; at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, an organic polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight, a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent, water; and liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明涉及提供安全有效剂量的抗生素的治疗试剂盒，其包括气溶胶包装组件，其包括：容纳加压产品的容器; 以及能够释放作为泡沫的加压产品的出口，其中所述加压产品包括可发泡组合物，其包含：抗生素; 选自浓度为约2％至约50％重量的至少一种选自疏水性有机载体，有机极性溶剂，软化剂及其混合物的有机载体，表面活性剂，约0.01％至约5重量％的至少一种选自生物粘附剂，胶凝剂，成膜剂和相变剂的聚合物添加剂，水; 和液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

73. 发明申请

US20120148503A1 NON-FLAMMABLE INSECTICIDE COMPOSITION AND USES THEREOF 有权
标题翻译：不易燃的杀虫剂组合物及其用途
公开(公告)号：US20120148503A1
公开(公告)日：2012-06-14
申请号：US13400330
申请日：2012-02-20
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A01N25/06 , A01N25/16 , A61K8/04 , A01P1/00 , A01P7/04 , A01P3/00 , A61Q19/08 , A61Q19/02 , A61P37/08 , A61P37/02 , A61P29/00 , A61P31/12 , A61P31/10 , A61P33/00 , A61K9/12
CPC分类号： A01N25/06 , A01N25/16 , A01N43/30 , A01N53/00 , A01N57/12 , A01N65/08 , A01N65/12 , A61K8/046 , A61K8/31 , A61K8/37 , A61K8/375 , A61K8/4973 , A61K8/73 , A61K8/731 , A61K8/86 , A61K9/12 , A61K45/06 , A61Q17/00 , A61Q17/02 , A61Q19/02 , A61Q19/08 , Y02A50/336 , A01N25/02 , A01N25/30 , A01N65/00 , A01N25/04 , A01N2300/00
摘要： The present invention provides a safe and effective insecticide composition suitable for treating a subject infested with a parasitic anthropode or to prevent infestation by an arthropod. The insecticide composition is a foamable composition, including a first insecticide; at least one organic carrier selected from a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 5%, or about 5% to about 10%; or about 10% to about 20%; or about 20% to about 50% by weight; about 0.1% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent selected from a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; and (5) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明提供了一种安全有效的杀虫剂组合物，适用于治疗受寄生人体受体侵染的受试者或防止节肢动物侵染。杀虫剂组合物是可发泡组合物，包括第一种杀虫剂; 浓度为约2％至约5％，或约5％至约10％的至少一种选自疏水性有机载体，极性溶剂，软化剂及其混合物的有机载体; 或约10％至约20％; 或约20％至约50％; 约0.1重量％至约5重量％的表面活性剂; 约0.01重量％至约5重量％的至少一种选自生物粘附剂，胶凝剂，成膜剂和相变剂的聚合物; 和（5）浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂。

74. 发明授权

US08119106B2 Foamable iodine compositions 有权
标题翻译：可发泡碘成分
公开(公告)号：US08119106B2
公开(公告)日：2012-02-21
申请号：US12499609
申请日：2009-07-08
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K9/00 , A61K9/12 , A61K33/18
CPC分类号： A61K33/18 , A61K9/122 , Y10S514/828 , Y10S514/887 , Y10S514/928 , Y10S514/945
摘要： The present invention is related to a foamable composition of matter comprising iodine, water, a foam adjuvant, a surface-active agent and a gelling agent. This foamable composition, which may be provided in a propellant free foaming device, or alternatively may further comprise a propellant, evolves into foam, which is effective in the topical treatment and prevention of various skin disorders.
摘要翻译：本发明涉及包含碘，水，泡沫助剂，表面活性剂和胶凝剂的可发泡组合物。该可发泡组合物可以以不含推进剂的发泡装置提供，或者可以进一步包含推进剂，演变成泡沫，其在局部治疗和预防各种皮肤病中是有效的。

75. 发明申请

US20110002857A1 OLEAGINOUS PHARMACEUTICAL AND COSMETIC FOAM 有权
标题翻译： OLEAGOOUS PHARMACEUTICAL和COSMETIC FOAM
公开(公告)号：US20110002857A1
公开(公告)日：2011-01-06
申请号：US12881856
申请日：2010-09-14
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K9/12 , A61P17/00 , A61P31/00
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K9/0034 , A61K9/107 , A61K9/12 , A61K31/351 , A61K31/436 , A61K31/496 , A61K31/522 , A61K31/573 , A61K38/13 , A61K47/10 , A61K47/14 , A61Q19/00
摘要： The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明涉及含有某些活性剂的稳定的含油化妆品或治疗性泡沫组合物，其具有独特的治疗性质和使用这种组合物的治疗方法。可发泡组合物包括至少一种选自疏水性溶剂，硅油，软化剂，助溶剂及其混合物的溶剂，其中溶剂的浓度为约70重量％至约96.5重量％总组合物，至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％; 浓度为总组合物重量的约0.1％至约5％的至少一种胶凝剂; 治疗有效量的至少一种活性剂; 和至少一种液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

76. 发明授权

US07704518B2 Foamable vehicle and pharmaceutical compositions thereof 有权
标题翻译：可发泡车辆及其药物组合物
公开(公告)号：US07704518B2
公开(公告)日：2010-04-27
申请号：US11430599
申请日：2006-05-09
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A01N25/16 , A61K47/00 , A61K47/30 , A61K47/32
CPC分类号： A61K47/10 , A01N25/16 , A61K8/046 , A61K9/0014 , A61K9/0034 , A61K9/12 , A61K9/122 , A61K47/14 , A61K47/38 , A61Q19/00 , Y10S514/945 , A01N53/00
摘要： A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：吸湿性药物组合物包括至少一种浓度足以提供至少0.9的Aw值的吸湿物质和抗感染剂。起泡药物载体包括约50％至约98％的选自多元醇和PEG的极性溶剂; 0％至约48％的第二极性溶剂; 约0.2重量％至约5重量％的表面活性剂; 约0.01重量％至约5重量％的至少一种聚合物; 和以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。

77. 发明授权

US07575739B2 Foamable iodine composition 有权
标题翻译：可发泡碘组成
公开(公告)号：US07575739B2
公开(公告)日：2009-08-18
申请号：US10835359
申请日：2004-04-28
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A01N25/02
CPC分类号： A61K33/18 , A61K9/122 , Y10S514/828 , Y10S514/887 , Y10S514/928 , Y10S514/945
摘要： The present invention is related to a foamable composition of matter comprising iodine, water, a foam adjuvant, a surface-active agent and a gelling agent. This foamable composition, which may be provided in a propellant free foaming device, or alternatively may further comprise a propellant, evolves into foam, which is effective in the topical treatment and prevention of various skin disorders.
摘要翻译：本发明涉及包含碘，水，泡沫助剂，表面活性剂和胶凝剂的可发泡组合物。该可发泡组合物可以以不含推进剂的发泡装置提供，或者可以进一步包含推进剂，演变成泡沫，其在局部治疗和预防各种皮肤病中是有效的。

78. 发明申请

US20090053146A1 Metronidazole-based dermatological foams and emulsions for the preparation thereof 审中-公开
公开(公告)号：US20090053146A1
公开(公告)日：2009-02-26
申请号：US12076114
申请日：2008-03-13
申请人： Dov Tamarkin , Doron Friedman
发明人： Dov Tamarkin , Doron Friedman
IPC分类号： A61K9/12 , A61K31/4164 , A61P17/00
CPC分类号： A61K9/0014 , A61K9/107 , A61K9/122
摘要： Oil-in-water emulsions expandable into stable foams having diminished inhibitor of skin breathing and useful for the treatment of dermatological conditions/afflictions, e.g., rosacea, advantageously contain: (a) 72% to 76% of water; (b) 0.1 % to 5% of a gelling agent for the aqueous phase of the emulsion; (c) 0.75% to 2% of metronidazole; (d) 5% to 10% of mineral oil; (e) 0.5% to 10% of a surfactant; (f) 0.5% to 5% of a fatty acid; (g) 0% to 4% of a metronidazole absorption promoter (c); and (h) 0.1% to 5% of a preservative selected from the group consisting of methylparaben, propylparaben, phenoxyethanol and mixtures thereof.

79. 发明申请

US20080166303A1 Colored or colorable foamable composition and foam 审中-公开
标题翻译：有色或可着色的可发泡组合物和泡沫
公开(公告)号：US20080166303A1
公开(公告)日：2008-07-10
申请号：US11900328
申请日：2007-09-10
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K9/12 , A61P17/00
CPC分类号： A61K8/046 , A61K31/47 , A61K2800/42 , A61K2800/45 , A61Q19/00
摘要： There is described a colored or colorable topical composition, comprising: a) a foamable base composition comprising, 1) a flowable carrier composition; 2) a color agent; wherein the color agent is effective to impart, increase, decrease or otherwise affect color of a foam produced from the foamable composition and wherein the color agent is one or more agents selected from the group consisting of a colored active agent, a colored indicator, a colored excipient, a pigment, a dye, a colorant and a coloring agent; b) a propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the base composition has a first color; and wherein the foam comprising the colored or colorable topical composition has a second color upon dispensing from an aerosol container, and wherein the first color and the second color are visually different. There is also described a method of changing color, a method of administration, a use as a diagnostic and a kit.
摘要翻译：描述了一种有色或可着色的局部组合物，其包含：a）可发泡基质组合物，其包含：1）可流动的载体组合物; 2）着色剂; 其中所述着色剂有效地赋予，增加，减少或以其他方式影响由所述可发泡组合物产生的泡沫的颜色，并且其中所述着色剂是选自以下的一种或多种试剂：有色活性剂，着色指示剂，彩色赋形剂，颜料，染料，着色剂和着色剂; b）以总组合物重量计约3％至约25％的浓度的推进剂; 其中所述基础组合物具有第一颜色; 并且其中包含着色或可着色的局部组合物的泡沫在从气溶胶容器分配时具有第二颜色，并且其中第一颜色和第二颜色在视觉上不同。还描述了改变颜色，给药方法，用作诊断和试剂盒的方法。

80. 发明申请

US20080138293A1 Cosmetic and pharmaceutical foam 审中-公开
标题翻译：化妆品和药物泡沫
公开(公告)号：US20080138293A1
公开(公告)日：2008-06-12
申请号：US11894715
申请日：2007-08-20
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K9/12
CPC分类号： A61K47/46 , A01N25/16 , A61K8/046 , A61K8/60 , A61K9/0007 , A61K9/0014 , A61K9/0034 , A61K9/107 , A61K9/12 , A61K9/122 , A61K31/137 , A61K31/351 , A61K31/4164 , A61K31/4174 , A61K31/522 , A61K31/535 , A61K31/567 , A61K31/573 , A61K31/7036 , A61K31/7048 , A61K38/12 , A61K38/212 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/34 , A61K47/38 , A61K2800/75 , A61Q7/00 , A61Q7/02 , A61Q17/02 , A61Q17/04 , A61Q19/02 , A61Q19/04
摘要： The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a hydrophobic solvent, a foam adjuvant agent, a surface-active agent and a water gelling agent. The cosmetic or pharmaceutical foam carrier does not contain aliphatic alcohols, making it non-irritating and non-drying. The alcohol-free foam carrier is suitable for inclusion of both water-soluble and oil soluble pharmaceutical and cosmetic agents.
摘要翻译：本发明涉及包含水，疏水性溶剂，泡沫助剂，表面活性剂和水胶凝剂的无醇化妆品或药物泡沫载体。化妆品或药物泡沫载体不含脂肪醇，使其不刺激和不干燥。无醇泡沫载体适合包含水溶性和油溶性药物和化妆品。

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