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71. 发明授权

US08623013B2 Ablation catheters and associated systems and methods 有权
公开(公告)号：US08623013B2
公开(公告)日：2014-01-07
申请号：US13560942
申请日：2012-07-27
申请人： Mark T. Stewart , James Skarda
发明人： Mark T. Stewart , James Skarda
IPC分类号： A61B18/18
摘要： An ablation catheter assembly includes an elongate catheter body having a proximal portion, a distal portion and a lumen therethrough. A helical structure associated with the catheter distal portion carries a plurality of independently operable electrodes and is transformable between a low-profile configuration wherein a straightening element is positioned in the lumen and an expanded configuration wherein the straightening element is at least partially retracted from the spiral structure. When the helical structure is in the expanded configuration, a laterally offset tip portion extends distally therefrom.

72. 发明授权

US08409219B2 Method and system for placement of electrical lead inside heart 有权
标题翻译：电线内置心脏的方法和系统
公开(公告)号：US08409219B2
公开(公告)日：2013-04-02
申请号：US12570390
申请日：2009-09-30
申请人： James F. Kelley , Zhongping C. Yang , Mark T. Stewart
发明人： James F. Kelley , Zhongping C. Yang , Mark T. Stewart
IPC分类号： A61B19/00
CPC分类号： A61N1/059 , A61B17/12 , A61B17/12009 , A61B17/128 , A61B17/3468 , A61B2017/00247 , A61B2017/12018 , A61B2018/00392
摘要： A method of placing an electrical lead of an implantable cardiac device inside a heart of a patient. The method includes securing a tool to an atrial appendage of the heart to hold onto the atrial appendage, piercing the atrial appendage, and creating an aperture in the atrial appendage while holding the atrial appendage with the tool. The method also includes moving a distal end of the electrical lead into the heart through the aperture in the atrial appendage and into a ventricle of the heart. Furthermore, the method includes coupling the distal end of the electrical lead to cardiac tissue in the ventricle and delivering an electrical signal to the cardiac tissue in the ventricle of the heart to maintain a predetermined heartbeat of the heart.
摘要翻译：将可植入心脏装置的电引线放置在患者心脏内的方法。该方法包括将工具固定到心脏的心房附着物，以固定在心房附近，刺穿心房附件，以及在用该工具持有心房附件的同时创建心房附近的孔。该方法还包括通过心耳中的孔将电引线的远端移动到心脏中并进入心脏的心室。此外，该方法包括将电导线的远端耦合到心室中的心脏组织，并将电信号传送到心脏心室的心脏组织以维持心脏的预定心跳。

73. 发明申请

US20120078076A1 HEART WALL ABLATION/MAPPING CATHETER AND METHOD 有权
标题翻译：心墙吸引/绘图导管及方法
公开(公告)号：US20120078076A1
公开(公告)日：2012-03-29
申请号：US13282997
申请日：2011-10-27
申请人： Mark T. Stewart , Johnson E. Goode
发明人： Mark T. Stewart , Johnson E. Goode
IPC分类号： A61B5/04 , A61B18/14
CPC分类号： A61M25/0147 , A61B18/1492 , A61B2017/00243 , A61B2018/00916 , A61M25/0152 , A61M2025/015 , A61M2025/0161
摘要： A catheter suitable for use in applying ablation energy to body tissue or detecting electrical signals conducted within the body tissue is disclosed. The catheter has a deflectable distal tip section. At least one electrode is adapted to be disposed against body tissue for delivery of ablation energy thereto or for conduction of body tissue electrical signals. An actuation mechanism comprising first and second pull wires is adapted to curve a proximal segment in a first direction and to independently bend an intermediate segment in a second direction.
摘要翻译：公开了一种适用于向身体组织施加消融能量或检测在身体组织内传导的电信号的导管。导管具有可偏转的远侧末端部分。至少一个电极适于设置成抵靠身体组织，用于向其传递消融能量或用于传导人体组织电信号。包括第一和第二拉线的致动机构适于在第一方向上弯曲近端段并且在第二方向独立地弯曲中间段。

74. 发明申请

US20100168740A1 Heart Wall Ablation/Mapping Catheter and Method 审中-公开
标题翻译：心墙消融/绘图导管和方法
公开(公告)号：US20100168740A1
公开(公告)日：2010-07-01
申请号：US12721895
申请日：2010-03-11
申请人： Mark T. Stewart , Johnson E. Goode , James M. Speckien , Mark A. Taube , Eduardo N. Warman
发明人： Mark T. Stewart , Johnson E. Goode , James M. Speckien , Mark A. Taube , Eduardo N. Warman
IPC分类号： A61B18/14
CPC分类号： A61M25/0147 , A61B18/1492 , A61B2017/00243 , A61B2018/00916 , A61M25/0152 , A61M2025/015 , A61M2025/0161
摘要： Steerable electrophysiology catheters for use in mapping and/or ablation of accessory pathways in myocardial tissue of the heart wall and methods of use thereof are disclosed. The catheter comprises a catheter body and handle, the catheter body having a proximal section and a distal section and manipulators that enable the deflection of a distal segment of the distal tip section with respect to the independently formed curvature of a proximal segment of the distal tip section through a bending or knuckle motion of an intermediate segment between the proximal and distal segments. A wide angular range of deflection within a very small curve or bend radius in the intermediate segment is obtained. At least one distal tip electrode is preferably confined to the distal segment which can have a straight axis extending distally from the intermediate segment. The curvature of the proximal segment and the bending angle of the intermediate segment are independently selectable. The axial alignment of the distal segment with respect to the nominal axis of the proximal shaft section of the catheter body can be varied between substantially axially aligned (0° curvature) in an abrupt knuckle bend through a range of about −90° to about +180° within a bending radius of between about 2.0 mm and 7.0 mm and preferably less than 5.0 mm. The proximal segment curve can be independently formed in a range of about −180° through about +270° with respect to the axis of the proximal shaft section to provide an optimum angular orientation of the distal electrode(s). The distal segment can comprise a highly flexible elongated distal segment body and electrode(s) that conform with the shape and curvature of the heart wall.
摘要翻译：公开了用于在心壁的心肌组织中辅助通路的测绘和/或消融的可操纵的电生理学导管及其使用方法。导管包括导管主体和手柄，导管主体具有近端部分和远端部分以及操纵器，其能够相对于远端尖端的近端段的独立形成的曲率偏转远侧末端部分的远端部分通过近端段和远端段之间的中间段的弯曲或转向关节运动。获得在中间段内的非常小的曲线或弯曲半径内的宽的角度范围的偏转。至少一个远端末端电极优选地限制在远端段，该远段可以具有从中间段向远侧延伸的直轴。近端段的曲率和中间段的弯曲角度是可独立选择的。远侧段相对于导管主体的近端轴部分的标称轴线的轴向对准可以在突变关节弯曲部中的大致轴向对准（0°曲率）之间变化约-90°至约+ 弯曲半径为约2.0mm至7.0mm，优选小于5.0mm的180°。近端段曲线可相对于近轴部分的轴线独立地形成在约-180°至约+ 270°的范围内，以提供远端电极的最佳角度取向。远端段可以包括高度柔性的细长远端段体和符合心壁的形状和曲率的电极。

75. 发明授权

US06840091B1 Geophysical method for quantification of dense non-aqueous phase liquids in the subsurface 失效
标题翻译：用于定量地下致密非水相液体的地球物理方法
公开(公告)号：US06840091B1
公开(公告)日：2005-01-11
申请号：US10604240
申请日：2003-07-03
申请人： Mark T. Stewart
发明人： Mark T. Stewart
IPC分类号： E21B47/10 , G01N9/36 , G01N27/22 , G01N33/24 , E21B49/08
CPC分类号： G01N33/24 , E21B47/10 , G01N9/36 , G01N27/221
摘要： The present invention is a method of calculating non-aqueous phase liquid saturation in a soil sample including the steps of measuring the bulk dielectric constant of the sample, measuring the bulk density of the sample, estimating the bulk porosity of the sample from the measured bulk density and calculating the non-aqueous phase liquid saturation from the measured bulk dielectric constant and the estimated bulk porosity.
摘要翻译：本发明是一种在土壤样品中计算非水相液体饱和度的方法，包括以下步骤：测量样品的体积介电常数，测量样品的体积密度，从测量体积估计样品的体积孔隙度从测量的体介电常数和估计的体积孔隙度计算非水相液体饱和度。

76. 发明授权

US06755790B2 Transseptal access tissue thickness sensing dilator devices and methods for fabricating and using same 失效
标题翻译：经血管通路组织厚度感应扩张装置及其制造和使用方法
公开(公告)号：US06755790B2
公开(公告)日：2004-06-29
申请号：US10269768
申请日：2002-10-14
申请人： Mark T. Stewart , Harry A. Puryear
发明人： Mark T. Stewart , Harry A. Puryear
IPC分类号： A61B814
CPC分类号： A61B8/0883 , A61B5/1076 , A61B8/12 , A61B8/445 , A61B8/4472 , A61B18/1492 , A61B2017/00106 , A61B2018/00375 , A61B2090/062
摘要： The present invention relates to medical devices; in particular, the present invention provides devices and methods for sensing thickness of cardiac tissue and the like so that medical procedures may be efficiently performed through and/or upon a discrete location having suitable tissue thickness. The invention includes an elongated resilient dilator apparatus having an ultrasound transceiver coupled thereto. When the ultrasound transceiver is disposed proximate a region of relatively thin tissue, such as a latent Fossa Ovalis valve, a clinician receives a signal. The clinician may then proceed with enhanced confidence to pierce the relatively thin tissue. Thus, in the case of a transseptal procedure, the clinician gains access to the left atrial chamber from the right atrial chamber.
摘要翻译：本发明涉及医疗器械; 特别地，本发明提供用于感测心脏组织等的厚度的装置和方法，使得可以通过和/或在具有适当组织厚度的离散位置上有效地执行医学程序。本发明包括具有耦合到其上的超声波收发器的细长弹性扩张器装置。当超声收发器设置在相对薄的组织的区域附近时，例如潜在的Fossa Ovalis瓣膜时，临床医生接收信号。然后，临床医生可以进一步增强信心以刺穿相对薄的组织。因此，在经心脏手术的情况下，临床医生从右心房获得进入左心房。

77. 发明授权

US06702811B2 Ablation catheter assembly with radially decreasing helix and method of use 有权
标题翻译：消融导管组件具有径向减小的螺旋和使用方法
公开(公告)号：US06702811B2
公开(公告)日：2004-03-09
申请号：US09848555
申请日：2001-05-03
申请人： Mark T. Stewart , James R. Skarda
发明人： Mark T. Stewart , James R. Skarda
IPC分类号： A61B1814
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2017/00867 , A61B2018/00065 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/00375 , A61B2018/00404 , A61B2018/00898 , A61B2018/1407 , A61B2018/1435 , A61B2018/1472
摘要： A catheter assembly for treatment of cardiac arrhythmia. The catheter assembly includes a catheter body and an ablative energy source. The catheter body includes a proximal portion, an intermediate portion, and a distal portion. The intermediate portion extends from the proximal portion and defines a longitudinal axis. The distal portion extends from the intermediate portion and includes an ablation section and a tip. The ablation section forms a loop defining a diameter greater than an outer dimension of a pulmonary vein ostium. The tip extends distally from the ablation section and is configured to locate a pulmonary vein. Finally, the ablative energy source is associated with the ablation section. With this configuration, upon activation of the energy source, the ablation section ablates a desired lesion pattern. In one preferred embodiment, the ablation section forms a distally decreasing radius helix, whereas the tip includes a relatively linear leader section. With this one preferred configuration, the tip readily locates a pulmonary vein and guides the ablation section to a seated relationship about a pulmonary vein ostium (or extra-ostial).
摘要翻译：用于治疗心律失常的导管组件。导管组件包括导管主体和消融能源。导管主体包括近端部分，中间部分和远端部分。中间部分从近端部分延伸并且限定纵向轴线。远侧部分从中间部分延伸并且包括消融部分和尖端。消融部分形成限定直径大于肺静脉口的外部尺寸的环。尖端从消融部分向远端延伸并且被配置为定位肺静脉。最后，烧蚀能源与消融部分相关联。利用这种配置，在激活能量源时，消融部分消除所需的损伤模式。在一个优选实施例中，消融部分形成远端减小的半径螺旋，而尖端包括相对线性的引导部分。利用这一优选的构造，尖端容易地定位肺静脉，并将消融部分引导到关于肺静脉口（或口外）的就座关系。

78. 发明授权

US06372283B1 Plasma process for surface modification of pyrolitic carbon 失效
标题翻译：用于表面改性热解碳的等离子体工艺
公开(公告)号：US06372283B1
公开(公告)日：2002-04-16
申请号：US09285953
申请日：1999-04-02
申请人： Hong S. Shim , Mark C. S. Shu , David L. Miller , Edward Di Domenico , Catherine E. Taylor , Kenneth Keeney , Mark T. Stewart , Eileen L. Halverson
发明人： Hong S. Shim , Mark C. S. Shu , David L. Miller , Edward Di Domenico , Catherine E. Taylor , Kenneth Keeney , Mark T. Stewart , Eileen L. Halverson
IPC分类号： B05D306
CPC分类号： A61L33/0088 , A61F2/24 , A61L27/34 , A61L33/0094 , B05D1/62
摘要： The present invention provides a method for modifying a pyrolytic carbon surface to improve adhesion between it and a subsequently added polymer and/or a bio-active compound. In particular, plasma depositing an oxygen-containing, silicon-containing film forming monomer on a pyrolytic carbon surface improves adhesion of a polymer thereto, wherein the modified pyrolytic carbon surface and silicone rubber has a wet adhesion peel force greater than the wet adhesion peel force between an unmodified pyrolytic carbon and silicone rubber as measured by ASTM D 903-49 after 28 days in an aqueous environment, typically, at least 10 times greater.
摘要翻译：本发明提供了一种改性热解碳表面以改善其与随后加入的聚合物和/或生物活性化合物之间的粘合性的方法。特别地，在热解碳表面上等离子体沉积含氧的含硅膜形成单体改善了聚合物对其的粘合性，其中改性热解碳表面和硅橡胶具有大于湿粘合剥离力的湿粘合剥离力在未经改性的热解碳和硅橡胶之间，在水性环境中28天后通过ASTM D 903-49测量，通常为至少10倍以上。

79. 发明授权

US6101973A Apparatus for reducing friction on polymeric surfaces 有权
标题翻译：减少聚合物表面摩擦的装置
公开(公告)号：US6101973A
公开(公告)日：2000-08-15
申请号：US262632
申请日：1999-03-04
申请人： Mark T. Stewart , Kenneth E. Cobian , Michael J. Ebert
发明人： Mark T. Stewart , Kenneth E. Cobian , Michael J. Ebert
IPC分类号： A61L29/14 , A61L33/00 , B05D3/14 , B05D7/24 , B29C59/10 , B29C59/14 , C23C16/02 , C23C16/04 , C23C16/30 , C23C16/505 , C23C16/00 , C23F1/02
CPC分类号： B05D1/62 , A61L29/141 , A61L33/0088 , B05D3/144 , B29C59/103 , B29C59/142 , C23C16/0245 , C23C16/045 , C23C16/30 , C23C16/505 , H01J37/32082 , B29L2023/00 , B29L2031/7542
摘要： This invention relates to an apparatus and a method for improving slip characteristics on the surface of a polymeric material, such as an outer surface, inner surface, or both of polymeric tubing.
摘要翻译：本发明涉及用于改善聚合物材料（例如聚合物管的外表面，内表面或两者）的表面上的滑动特性的装置和方法。

80. 发明授权

US5693196A Plasma process for reducing friction within the lumen of polymeric tubing 失效
标题翻译：用于减少聚合物管内腔内摩擦的等离子体方法
公开(公告)号：US5693196A
公开(公告)日：1997-12-02
申请号：US707347
申请日：1996-09-03
申请人： Mark T. Stewart , Mary M. Morris , Edward Di Domenico , Kenneth W. Keeney
发明人： Mark T. Stewart , Mary M. Morris , Edward Di Domenico , Kenneth W. Keeney
IPC分类号： H05H1/46 , B29C59/14 , B29C71/04 , B29K19/00 , B29L23/00 , C08J5/16 , C08J7/00 , H05H1/24
CPC分类号： B29C59/142 , B29K2083/00 , B29L2031/753 , B29L2031/7534
摘要： This invention relates to the preferential glow discharge at the inside diameter (ID) of plastic tubing, particularly very small tubing.
摘要翻译：本发明涉及塑料管的内径（ID）上的优先辉光放电，特别是非常小的管。

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