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71. 发明申请

US20080189619A1 SYSTEM AND METHOD OF SCHEDULING AND RESERVING VIRTUAL MEETING LOCATIONS IN A CALENDARING APPLICATION 有权
标题翻译：在日历应用程序中调度和保留虚拟会议位置的系统和方法
公开(公告)号：US20080189619A1
公开(公告)日：2008-08-07
申请号：US11671708
申请日：2007-02-06
申请人： Michael Reed , Linda J. Scott , Robert V. Williamson
发明人： Michael Reed , Linda J. Scott , Robert V. Williamson
IPC分类号： G06F17/00
CPC分类号： G06Q10/109
摘要： A mechanism is provided for scheduling and reserving virtual meeting locations in a calendaring application. Participants use a calendaring application to schedule meetings. If the meeting takes place in a location within the virtual persistent world, then the calendaring application sends the meeting information, including virtual user IDs of the invitees, meeting location, and other virtual world requirements or parameters for the meeting, to a software agent. The software agent receives the meeting information and generates a script for creating the meeting location and a script for destroying the meeting location.
摘要翻译：提供了一种用于在日历应用程序中调度和预留虚拟会议位置的机制。参与者使用日历应用程序安排会议。如果会议发生在虚拟持久化世界中的某个位置，那么日历应用程序将会议信息（包括受邀者的虚拟用户ID，会议位置和会议的其他虚拟世界要求或参数）发送到软件代理。软件代理接收会议信息，并生成用于创建会议位置的脚本和用于销毁会议位置的脚本。

72. 发明申请

US20080038740A1 DEVICE AND METHOD FOR EXTRACTION AND ANALYSIS OF NUCLEIC ACIDS FROM BIOLOGICAL SAMPLES 有权
标题翻译：从生物样品中提取和分析核酸的装置和方法
公开(公告)号：US20080038740A1
公开(公告)日：2008-02-14
申请号：US11768076
申请日：2007-06-25
申请人： Michael Reed , Oliver Nanassy , Paul Haydock , Nigel Sharma , Ronald Bardell , Perry Hargrave
发明人： Michael Reed , Oliver Nanassy , Paul Haydock , Nigel Sharma , Ronald Bardell , Perry Hargrave
IPC分类号： C12Q1/68 , C12M1/00
CPC分类号： C12Q1/6851 , B01L3/5027 , B01L3/50273 , B01L7/525 , B01L2200/10 , B01L2300/0816 , B01L2300/0887 , B01L2400/0457 , B01L2400/0487 , C12Q1/6806 , C12Q1/686 , Y10T436/143333 , C12Q2565/629 , C12Q2565/137 , C12Q2563/173
摘要： Device and methods for extracting and analyzing nucleic acids from biological samples.
摘要翻译：从生物样品中提取和分析核酸的装置和方法。

73. 发明申请

US20070213383A1 Sulfamic acid ester compounds useful in the inhibition of steroid sulphatase activity and aromatase activity 有权
标题翻译：用于抑制类固醇硫酸酯酶活性和芳香酶活性的氨基磺酸酯化合物
公开(公告)号：US20070213383A1
公开(公告)日：2007-09-13
申请号：US11603941
申请日：2006-11-22
申请人： Barry Potter , Michael Reed , Lawrence Woo , Atul Purohit , Christian Burbert , Paul Wood , Oliver Sutcliffe
发明人： Barry Potter , Michael Reed , Lawrence Woo , Atul Purohit , Christian Burbert , Paul Wood , Oliver Sutcliffe
IPC分类号： A61K31/4196 , A61K31/426 , A61K31/421 , C07D277/68 , A61K31/425 , C07D249/12
CPC分类号： C07D249/08
摘要： There is provided a compound of Formula III or Formula IV wherein A is selected from H, OH, halogen and hydrocarbyl D, E and F are each independently of each other an optional linker group; P, Q and R are independently of each other a ring system, wherein R4 and R5 are independently selected from H, alkyl, cycloalkyl, alkenyl, acyl and aryl, or combinations thereof, or together represent alkylene, wherein the or each alkyl or cycloalkyl or alkenyl or optionally contain one or more hetero atoms or groups.
摘要翻译：提供式III或式IV的化合物，其中A选自H，OH，卤素和烃基D，E和F各自独立地为任选的连接基团; P，Q和R彼此独立地为环系，其中R 4和R 5独立地选自H，烷基，环烷基，烯基，酰基和芳基，或其组合，或一起表示亚烷基，其中所述或每个烷基或环烷基或烯基或任选地含有一个或多个杂原子或基团。

74. 发明申请

US20070179977A1 Multimedia search system 失效
标题翻译：多媒体搜索系统
公开(公告)号：US20070179977A1
公开(公告)日：2007-08-02
申请号：US11490263
申请日：2006-07-21
申请人： Michael Reed , Greg Bestick , Carol Greenhalgh , Norman Bastin , Ron Carlton , Stanley Frank , Dale Good , Neil Holman , Carl Holzman , Ann Jensen , Harold Kester , Dave Meatman , Edwardo Munevar , Derryl Rogers , Gail Maatman
发明人： Michael Reed , Greg Bestick , Carol Greenhalgh , Norman Bastin , Ron Carlton , Stanley Frank , Dale Good , Neil Holman , Carl Holzman , Ann Jensen , Harold Kester , Dave Meatman , Edwardo Munevar , Derryl Rogers , Gail Maatman
IPC分类号： G06F7/00
CPC分类号： G06F17/30637 , G06F17/30038 , G06F17/30241 , G06F17/30265 , G06F17/30274 , G06F17/30277 , G06F17/3064 , G11B27/105 , G11B27/34 , G11B2220/213 , G11B2220/2545 , Y10S707/919 , Y10S707/99933 , Y10S707/99943 , Y10S707/99945 , Y10S707/99948
摘要： A database search system that retrieves multimedia information in a flexible, user friendly system. The search system uses a multimedia database consisting of text, picture, audio and animated data. That database is searched through multiple graphical and textual entry paths. Those entry paths include an idea search, a title finder search, a topic tree search, a picture explorer search, a history timeline search, a world atlas search, a researcher's assistant search, and a feature articles search.
摘要翻译：数据库搜索系统，用于在灵活的，用户友好的系统中检索多媒体信息。搜索系统使用由文本，图片，音频和动画数据组成的多媒体数据库。通过多个图形和文本输入路径搜索该数据库。这些入口路径包括想法搜索，标题查找器搜索，主题树搜索，图片浏览器搜索，历史时间线搜索，世界地图集搜索，研究者助理搜索和特征文章搜索。

75. 发明申请

US20070026458A1 Assessing insulin resistance using biomarkers 审中-公开
标题翻译：使用生物标志物评估胰岛素抵抗
公开(公告)号：US20070026458A1
公开(公告)日：2007-02-01
申请号：US11303754
申请日：2005-12-16
申请人： David Polidori , Scott Siler , Leif Wennerberg , Seth Michelson , Michael Reed
发明人： David Polidori , Scott Siler , Leif Wennerberg , Seth Michelson , Michael Reed
IPC分类号： G01N33/53 , G06F19/00
CPC分类号： G01N33/66 , G01N33/6893 , G01N33/723 , G01N2333/62 , G01N2800/042 , G01N2800/52
摘要： The invention encompasses novel biomarkers and methods for assessing insulin resistance in a subject. The novel biomarkers of the invention include various plasma constituent (e.g., insulin, glucose, lactate and/or triglyceride) concentrations. The methods of the invention include measuring various plasma constituent concentrations and calculating a predicted euglycemic hyperinsulinemic clamp glucose infusion rate (GIR) based on the plasma constituent concentrations.
摘要翻译：本发明包括用于评估受试者中胰岛素抵抗的新型生物标志物和方法。本发明的新型生物标志物包括各种血浆成分（例如胰岛素，葡萄糖，乳酸和/或甘油三酸酯）浓度。本发明的方法包括测量各种血浆成分浓度，并基于血浆成分浓度计算预测的正血糖高胰岛素钳位葡萄糖输注速率（GIR）。

76. 发明申请

US20060276885A1 Nanoporous stents with improved radiolucency 审中-公开
标题翻译：具有改善放射性的纳米多支架
公开(公告)号：US20060276885A1
公开(公告)日：2006-12-07
申请号：US11431941
申请日：2006-05-10
申请人： Whye-Kei Lye , Gary Owens , Michael Reed , Brian Wamhoff , Kareen Looi , Joshua Spradlin
发明人： Whye-Kei Lye , Gary Owens , Michael Reed , Brian Wamhoff , Kareen Looi , Joshua Spradlin
IPC分类号： A61F2/02 , A61F2/82
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
摘要翻译：本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

77. 发明申请

US20060276884A1 Nanoporous stents with magnesium leaching 审中-公开
标题翻译：纳米多孔支架与镁浸出
公开(公告)号：US20060276884A1
公开(公告)日：2006-12-07
申请号：US11431424
申请日：2006-05-10
申请人： Whye-Kei Lye , Gary Owens , Brian Wamhoff , Michael Reed , Kareen Looi , Joshua Spradlin
发明人： Whye-Kei Lye , Gary Owens , Brian Wamhoff , Michael Reed , Kareen Looi , Joshua Spradlin
IPC分类号： A61F2/82
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
摘要翻译：本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

78. 发明申请

US20060276878A1 Dealloyed nanoporous stents 审中-公开
公开(公告)号：US20060276878A1
公开(公告)日：2006-12-07
申请号：US11431109
申请日：2006-05-09
申请人： Gary Owens , Whye-Kei Lye , Michael Reed , Joshua Spradlin , Brian Wamhoff , Matthew Hudson , Kareen Looi
发明人： Gary Owens , Whye-Kei Lye , Michael Reed , Joshua Spradlin , Brian Wamhoff , Matthew Hudson , Kareen Looi
IPC分类号： A61F2/82 , B01J19/00
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.

79. 发明申请

US20060276877A1 Dealloyed nanoporous stents 审中-公开
标题翻译：脱合纳米多孔支架
公开(公告)号：US20060276877A1
公开(公告)日：2006-12-07
申请号：US11430510
申请日：2006-05-09
申请人： Gary Owens , Whye-Kei Lye , Michael Reed , Joshua Spradlin , Brian Wamhoff , Matthew Hudson , Kareen Looi
发明人： Gary Owens , Whye-Kei Lye , Michael Reed , Joshua Spradlin , Brian Wamhoff , Matthew Hudson , Kareen Looi
IPC分类号： A61F2/82 , B01J19/00
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
摘要翻译：本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

80. 发明申请

US20060142360A1 Compound 失效
公开(公告)号：US20060142360A1
公开(公告)日：2006-06-29
申请号：US11209186
申请日：2005-08-22
申请人： Barry Lloyd Potter , Lok Wai Woo , Atul Purohit , Michael Reed , Oliver Sutcliffe , Christian Bubert
发明人： Barry Lloyd Potter , Lok Wai Woo , Atul Purohit , Michael Reed , Oliver Sutcliffe , Christian Bubert
IPC分类号： A61K31/4196 , C07D249/14 , C07D249/08
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D413/12 , C07D417/12
摘要： There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C═O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.

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