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    • 76. 发明申请
    • Nanoporous stents with improved radiolucency
    • 具有改善放射性的纳米多支架
    • US20060276885A1
    • 2006-12-07
    • US11431941
    • 2006-05-10
    • Whye-Kei LyeGary OwensMichael ReedBrian WamhoffKareen LooiJoshua Spradlin
    • Whye-Kei LyeGary OwensMichael ReedBrian WamhoffKareen LooiJoshua Spradlin
    • A61F2/02A61F2/82
    • A61L31/022A61F2/07A61F2/91A61F2/915A61F2002/91541A61F2210/0076A61F2250/0067A61L31/10A61L31/146A61L31/16A61L31/18A61L2300/606A61L2400/12A61N1/05
    • The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
    • 本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。 更具体地,本发明涉及具有至少一个多孔层的可植入医疗装置,以及用于制造这种装置的方法,以及用治疗剂加载这些装置。 将混合物或合金放置在医疗装置的表面上,然后通常除去混合物或合金的一种组分,而不会通常除去混合物或合金的其它组分。 在一些实施例中,多孔层适于粘合非金属涂层,包括药物洗脱的聚合物涂层。 多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。 本发明的一个实施方案涉及包括血管支架的医疗装置,其具有适于抵抗狭窄或细胞增殖的至少一个多孔层,而不需要洗脱治疗剂。 本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法,装置和规格。
    • 77. 发明申请
    • Nanoporous stents with magnesium leaching
    • 纳米多孔支架与镁浸出
    • US20060276884A1
    • 2006-12-07
    • US11431424
    • 2006-05-10
    • Whye-Kei LyeGary OwensBrian WamhoffMichael ReedKareen LooiJoshua Spradlin
    • Whye-Kei LyeGary OwensBrian WamhoffMichael ReedKareen LooiJoshua Spradlin
    • A61F2/82
    • A61L31/022A61F2/07A61F2/91A61F2/915A61F2002/91541A61F2210/0076A61F2250/0067A61L31/10A61L31/146A61L31/16A61L31/18A61L2300/606A61L2400/12A61N1/05
    • The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
    • 本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。 更具体地,本发明涉及具有至少一个多孔层的可植入医疗装置,以及用于制造这种装置的方法,以及用治疗剂加载这些装置。 将混合物或合金放置在医疗装置的表面上,然后通常除去混合物或合金的一种组分,而不会通常除去混合物或合金的其它组分。 在一些实施例中,多孔层适于粘合非金属涂层,包括药物洗脱的聚合物涂层。 多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。 本发明的一个实施方案涉及包括血管支架的医疗装置,其具有适于抵抗狭窄或细胞增殖的至少一个多孔层,而不需要洗脱治疗剂。 本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法,装置和规格。
    • 79. 发明申请
    • Dealloyed nanoporous stents
    • 脱合纳米多孔支架
    • US20060276877A1
    • 2006-12-07
    • US11430510
    • 2006-05-09
    • Gary OwensWhye-Kei LyeMichael ReedJoshua SpradlinBrian WamhoffMatthew HudsonKareen Looi
    • Gary OwensWhye-Kei LyeMichael ReedJoshua SpradlinBrian WamhoffMatthew HudsonKareen Looi
    • A61F2/82B01J19/00
    • A61L31/022A61F2/07A61F2/91A61F2/915A61F2002/91541A61F2210/0076A61F2250/0067A61L31/10A61L31/146A61L31/16A61L31/18A61L2300/606A61L2400/12A61N1/05
    • The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
    • 本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。 更具体地,本发明涉及具有至少一个多孔层的可植入医疗装置,以及用于制造这种装置的方法,以及用治疗剂加载这些装置。 将混合物或合金放置在医疗装置的表面上,然后通常除去混合物或合金的一种组分,而不会通常除去混合物或合金的其它组分。 在一些实施例中,多孔层适于粘合非金属涂层,包括药物洗脱的聚合物涂层。 多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。 本发明的一个实施方案涉及包括血管支架的医疗装置,其具有适于抵抗狭窄或细胞增殖的至少一个多孔层,而不需要洗脱治疗剂。 本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法,装置和规格。