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    • 71. 发明申请
    • METHOD AND APPARATUS FOR SOAKING AND DRAINING WOOD CHIPS OR CHUNKS
    • 用于排水和排水的木制品或杂物的方法和装置
    • US20080223224A1
    • 2008-09-18
    • US12111737
    • 2008-04-29
    • John C. Martin
    • John C. Martin
    • A23L1/01
    • A23B4/048A23B4/052A23B4/0523A47J37/0704C10L5/44Y02A40/949Y02E50/10Y02E50/30
    • An apparatus for soaking wood chips or chunks in a liquid and draining the liquid from the wood chips or chunks includes at least a container and a lid. The container includes a sidewall and a bottom surface. The bottom surface and at least a portion of the sidewall are contiguous for containing a liquid therein and for holding the wood chips or chunks within the liquid. The lid has at least one aperture and may be removably coupled to the container. The method places the wood chips or chunks into the apparatus, places all or part of the apparatus into a soaking medium or otherwise fills the apparatus with a soaking medium, soaks the wood chips or chunks, drains the soaking medium from the apparatus, and then positions the wood chips or chunks in a useful position for cooking either with further manipulation or by placement of the entire apparatus in the cooking area.
    • 用于将木屑或块块浸泡在液体中并从木屑或块排出液体的装置至少包括容器和盖子。 容器包括侧壁和底面。 底表面和侧壁的至少一部分是连续的,用于在其中容纳液体并将木片或块保持在液体内。 盖子具有至少一个孔口,并且可拆卸地联接到容器。 该方法将木片或块放入设备中,将全部或部分设备放入浸泡介质中,或以其他方式用浸渍介质填充设备,浸泡木屑或块,将浸泡介质从设备中排出,然后 将木片或块放置在有用的位置,以便进一步操作或通过将整个设备放置在烹饪区域中进行烹饪。
    • 73. 发明授权
    • Optical selection and collection of DNA fragments
    • DNA片段的光学选择和收集
    • US5879625A
    • 1999-03-09
    • US951955
    • 1997-10-17
    • Mary C. RoslaniecJohn C. MartinJames H. JettL. Scott Cram
    • Mary C. RoslaniecJohn C. MartinJames H. JettL. Scott Cram
    • C12N15/10C12N15/12C12Q1/68G01N15/14G01N1/14
    • G01N15/1459C12N15/1006C12Q1/68G01N2015/0038G01N2015/149Y10T436/143333
    • Optical selection and collection of DNA fragments. The present invention includes the optical selection and collection of large (>.mu.g) quantities of clonable, chromosome-specific DNA from a sample of chromosomes. Chromosome selection is based on selective, irreversible photoinactivation of unwanted chromosomal DNA. Although more general procedures may be envisioned, the invention is demonstrated by processing chromosomes in a conventional flow cytometry apparatus, but where no droplets are generated. All chromosomes in the sample are first stained with at least one fluorescent analytic dye and bonded to a photochemically active species which can render chromosomal DNA unclonable if activated. After passing through analyzing light beam(s), unwanted chromosomes are irradiated using light which is absorbed by the photochemically active species, thereby causing photoinactivation. As desired chromosomes pass this photoinactivation point, the inactivating light source is deflected by an optical modulator; hence, desired chromosomes are not photoinactivated and remain clonable. The selection and photoinactivation processes take place on a microsecond timescale. By eliminating droplet formation, chromosome selection rates 50 times greater than those possible with conventional chromosome sorters may be obtained. Thus, usable quantities of clonable DNA from any source thereof may be collected.
    • DNA片段的光学选择和收集。 本发明包括从染色体样品中大量(>μg)量的可克隆,染色体特异性DNA的光学选择和收集。 染色体选择基于不需要的染色体DNA的选择性不可逆光激活。 尽管可以设想更一般的程序,但是通过在常规流式细胞术装置中处理染色体但是不产生液滴来证明本发明。 样品中的所有染色体首先用至少一种荧光分析染料染色,并与光化学活性物质结合,如果激活可使染色体DNA不可克隆。 在通过分析光束之后,使用被光化学活性物质吸收的光照射不想要的染色体,从而引起光激活。 根据需要,染色体通过该光激活点,灭活光源被光学调制器偏转; 因此,期望的染色体不是光激活的并且保持克隆。 选择和光激活过程在微秒的时间尺度上进行。 通过消除液滴形成,可以获得比常规染色体分选机可能的染色体选择率高50倍的染色体选择率。 因此,可以收集来自其任何来源的可克隆DNA的可用量。
    • 76. 发明授权
    • Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl)
purines as antiviral agent
    • 取代9-(1或3-单酰氧基或1,3-二酰氧基-2-丙氧基甲基)嘌呤作为抗病毒剂
    • US5250535A
    • 1993-10-05
    • US451262
    • 1982-12-22
    • Julien P. H. VerheydenJohn C. Martin
    • Julien P. H. VerheydenJohn C. Martin
    • C07D473/02C07C43/178C07D473/00C07D473/18A61K31/52
    • C07D473/00C07C43/1785C07C43/1786
    • Compounds useful as antiviral agents are defined by the following formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is hydrogen or --C(O)R.sup.7 wherein R.sup.7 is hydrogen, alkyl of one to nineteen carbon atoms, hydroxyalkyl of one to eight carbon atoms, alkoxyalkyl of two to nine carbon atoms, alkenyl of two to nineteen carbon atoms, phenyl, 1-adamantyl or 2-carboxyethyl and the pharmaceutically acceptable alkali metal salts thereof;R.sup.2 is --C(O)R.sup.7 wherein R.sup.7 is as defined above;R.sup.3 is hydrogen, halo, thio, lower alkylthio of one to six carbon atoms, azido, NR.sup.9 R.sup.10 wherein R.sup.9 and R.sup.10 are independently hydrogen or lower alkyl of one to six carbon atoms or --NHC(O)R.sup.8 wherein R.sup.8 is hydrogen, alkyl of one to nineteen carbon atoms or 1-adamantyl; and(a) R.sup.6 is hydrogen, halo, lower alkoxy of one to six carbon atoms, azido, thio, lower alkylthio of one to six carbon atoms, --NR.sup.9 R.sup.10 wherein R.sup.9 and R.sup.10 are as defined above or --NHC(O)R.sup.8 wherein R.sup.8 is as defined above and R.sup.4 together with R.sup.5 is a bond; or(b) R.sup.5 together with R.sup.6 is a keto group and R.sup.4 is hydrogen.
    • 可用作抗病毒剂的化合物由下式定义:其中R 1是氢或-C(O)R 7,其中R 7是氢,一个至十九个碳原子的烷基,或其药学上可接受的酸加成盐, 1至8个碳原子的羟烷基,2至9个碳原子的烷氧基烷基,2至19个碳原子的烯基,苯基,1-金刚烷基或2-羧乙基及其药学上可接受的碱金属盐; R 2是-C(O)R 7,其中R 7如上所定义; R3是氢,卤素,硫代,1-6个碳原子的低级烷硫基,叠氮基,NR9R10,其中R9和R10独立地是氢或1-6个碳原子的低级烷基或-NHC(O)R8,其中R8是氢, 一至十九个碳原子或1-金刚烷基; 和(a)R6是1-6个碳原子的氢,卤素,低级烷氧基,1-6个碳原子的叠氮基,硫代,低级烷硫基,-NR9R10,其中R9和R10如上所定义,或-NHC(O)R 8,其中 R8如上所定义,R4与R5一起是键; 或(b)R 5与R 6一起为酮基,且R 4为氢。
    • 79. 发明授权
    • Laser particle sorter
    • 激光粒子分选机
    • US4887721A
    • 1989-12-19
    • US126156
    • 1987-11-30
    • John C. MartinTudor N. Buican
    • John C. MartinTudor N. Buican
    • B07C5/342B07C5/36G01N15/14
    • B07C5/362B07C5/342G01N15/1459G01N2015/149
    • Method and apparatus for sorting particles, such as biological particles. A first laser defines an optical path having an intensity gradient which is effective to propel the particles along the path but which is sufficiently weak that the particles are not trapped in an axial direction. A probe laser beam interrogates the particles to identify predetermined phenotypical characteristics of the particles. A second laser beam intersects the driving first laser beam, wherein the second laser beam is activated by an output signal indicative of a predetermined characteristic. The second laser beam is switchable between a first intensity and a second intensity, where the first intensity is effective to displace selected particles from the driving laser beam and the second intensity is effective to propel selected particles along the deflection laser beam. The selected particles may then be propelled by the deflection beam to a location effective for further analysis.
    • 用于分选颗粒的方法和装置,例如生物颗粒。 第一激光器限定具有强度梯度的光路,该强度梯度有效地沿着路径推进颗粒,但是足够弱使得颗粒不被沿轴向捕获。 探针激光束询问颗粒以识别颗粒的预定表型特征。 第二激光束与驱动的第一激光束相交,其中第二激光束由表示预定特性的输出信号激活。 第二激光束可以在第一强度和第二强度之间切换,其中第一强度有效地从驱动激光束移位所选择的粒子,并且第二强度有效地沿着偏转激光束推进所选择的粒子。 所选择的颗粒然后可以被偏转束推进到有效进一步分析的位置。