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71. 发明授权

US07125678B2 Protein biopolymer markers predictive of type II diabetes 失效
标题翻译：预测II型糖尿病的蛋白质生物聚合物标记物
公开(公告)号：US07125678B2
公开(公告)日：2006-10-24
申请号：US09993393
申请日：2001-11-23
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： C07K14/47 , Y10T436/24 , Y10T436/255
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of at least one disease state relative to recognition of the presence and/or the absence of the biopolymer, predict disease risk assessment, and develop therapeutic avenues against the disease.
摘要翻译：本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征与识别生物聚合物的存在和/或不存在相关的至少一种疾病状态的存在或不存在的能力，预测疾病风险评估以及开发针对该疾病的治疗途径。

72. 发明授权

US07118911B1 DNA molecules stabilized for propagation in bacterial cells that encode cystic fibrosis transmembrane conductance regulator 失效
标题翻译：稳定用于在编码囊性纤维化跨膜传导调节剂的细菌细胞中繁殖的DNA分子
公开(公告)号：US07118911B1
公开(公告)日：2006-10-10
申请号：US08087132
申请日：1993-07-02
申请人： Richard Gregory , Seng H. Cheng , Alan Smith , Sucharita Paul , Kathleen M. Hehir , John Marshall
发明人： Richard Gregory , Seng H. Cheng , Alan Smith , Sucharita Paul , Kathleen M. Hehir , John Marshall
IPC分类号： C12N15/00 , C07H21/00
CPC分类号： B82Y5/00 , A61K48/00 , C07K14/4712 , C07K16/18
摘要： Disclosed are full length isolated DNAs encoding cystic fibrosis transmembrane conductance regulator (CFTR) protein and a variety of mutants thereof. Also disclosed are antibodies specific for various CFTR domains and methods for their production. Expression of CFTR from cells transformed with these CFTR genes or cDNAs demonstrate surprising CFTR intracellular distributions and results thereby providing for new diagnostic and therapeutic procedures.
摘要翻译：公开了编码囊性纤维化跨膜传导调节蛋白（CFTR）蛋白的全长分离DNA和其多种突变体。还公开了针对各种CFTR结构域的特异性抗体及其生产方法。来自用这些CFTR基因或cDNA转化的细胞的CFTR的表达表现出惊人的CFTR胞内分布和结果，从而提供新的诊断和治疗过程。

73. 发明申请

US20060211149A1 Fibronectin and fibrinogen biopolymer markers indicative of insulin resistance 审中-公开
公开(公告)号：US20060211149A1
公开(公告)日：2006-09-21
申请号：US11439813
申请日：2006-05-23
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/543 , G01N33/00 , C07K16/26
CPC分类号： C07K14/78 , Y10T436/24 , Y10T436/255
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.

74. 发明申请

US20060211140A1 Protein biopolymer markers predictive of insulin resistance 审中-公开
公开(公告)号：US20060211140A1
公开(公告)日：2006-09-21
申请号：US11437924
申请日：2006-05-19
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/543 , G01N33/00 , C07K16/26
CPC分类号： C07K14/775 , G01N33/6893 , Y10T436/24
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.

75. 发明申请

US20060211139A1 Protein biopolymer markers predictive of insulin resistance 审中-公开
公开(公告)号：US20060211139A1
公开(公告)日：2006-09-21
申请号：US11437919
申请日：2006-05-19
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/543 , G01N33/00 , C07K16/26
CPC分类号： C07K14/775 , G01N33/6893 , Y10T436/24
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.

76. 发明申请

US20060211138A1 Protein biopolymer markers predictive of insulin resistance 审中-公开
公开(公告)号：US20060211138A1
公开(公告)日：2006-09-21
申请号：US11437883
申请日：2006-05-19
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/543 , G01N33/00 , C07K16/26
CPC分类号： C07K14/775 , G01N33/6893 , Y10T436/24
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.

77. 发明申请

US20060194340A1 PROTEIN BIOPOLYMER MARKERS PREDICTIVE OF TYPE II DIABETES 失效
标题翻译：蛋白质生物标记物预测的II型糖尿病
公开(公告)号：US20060194340A1
公开(公告)日：2006-08-31
申请号：US09993393
申请日：2001-11-23
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/00 , G01N33/543 , C07K14/47
CPC分类号： C07K14/47 , Y10T436/24 , Y10T436/255
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability-to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.
摘要翻译：本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在的能力，以相对于所述生物聚合物的存在和/或不存在的识别，预测疾病风险评估以及开发针对所述疾病的治疗途径。

78. 发明申请

US20060194337A1 FIBRONECTIN PRECURSOR BIOPOLYMER MARKERS INDICATIVE OF ALZHEIMER'S DISEASE 失效
标题翻译：阿奇霉素疾病表现的FIBRONECTIN PRECURSOR BIOPOLYMER MARKERS
公开(公告)号：US20060194337A1
公开(公告)日：2006-08-31
申请号：US09993289
申请日：2001-11-23
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/543 , C07K14/47
CPC分类号： C07K14/78 , G01N33/6896 , G01N2500/00 , G01N2800/2821 , Y10S435/81
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.
摘要翻译：本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在的能力，以相对于识别所述生物聚合物的存在和/或不存在，预测疾病风险评估以及开发针对所述疾病的治疗途径。

79. 发明申请

US20060160233A1 IG HEAVY CHAIN, IG KAPPA, IG LAMBDA BIOPOLYMER MARKERS PREDICTIVE OF ALZHEIMERS DISEASE 失效
标题翻译： IG HEAVY CHAIN，IG KAPPA，IG LAMBDA BIOPOLYMER MARKERS PREDICTIVE OF ALZHEIMERS DISEASE
公开(公告)号：US20060160233A1
公开(公告)日：2006-07-20
申请号：US09993304
申请日：2001-11-23
申请人： George Jackowski , John Marshall
发明人： George Jackowski , John Marshall
IPC分类号： G01N33/00 , C07K14/47
CPC分类号： C07K16/00 , C07K2317/50 , G01N33/6857 , G01N33/6896 , G01N2500/00 , G01N2800/2821 , Y10T436/24 , Y10T436/255
摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.
摘要翻译：本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在的能力，以相对于识别所述生物聚合物的存在和/或不存在，预测疾病风险评估以及开发针对所述疾病的治疗途径。

80. 发明申请

US20060147095A1 Method and system for automatically capturing an image of a retina 审中-公开
标题翻译：自动捕获视网膜图像的方法和系统
公开(公告)号：US20060147095A1
公开(公告)日：2006-07-06
申请号：US11028726
申请日：2005-01-03
申请人： David Usher , Gregory Heacock , John Marshall , David Mueller
发明人： David Usher , Gregory Heacock , John Marshall , David Mueller
IPC分类号： G06K9/00
CPC分类号： G06K9/00604
摘要： A method and system capture an image of the interior of the eye, for example the retina and determine whether the captured image is sufficient to provide data for identifying an individual or animal before attempting to generate the identification data. If the captured image is not sufficient, the method and system automatically capture another image of the interior of the eye.
摘要翻译：一种方法和系统捕获眼睛内部的图像，例如视网膜，并且在尝试产生识别数据之前，确定捕获的图像是否足以提供用于识别个体或动物的数据。如果拍摄的图像不足，则该方法和系统自动捕获眼睛内部的另一图像。

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