专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明授权

US09533063B1 Aerosols incorporating ceragenin compounds and methods of use thereof 有权
标题翻译：包含cerornin化合物的气溶胶及其使用方法
公开(公告)号：US09533063B1
公开(公告)日：2017-01-03
申请号：US13783007
申请日：2013-03-01
申请人： Paul B. Savage
发明人： Paul B. Savage
IPC分类号： A61L2/18 , A61L2/22
CPC分类号： A01N45/00 , A01N25/06 , A01N25/12
摘要： Aerosols that include ceragenin compounds (i.e., ceragenin-containing aerosols), methods for delivering such aerosols, and devices for delivering such aerosols. Ceragenins can be used to kill a broad range of microbes (e.g., bacteria, viruses, fungi, bacterial spores, fungal spores, and the like), yet they are thought to be completely non-toxic to humans and other higher eukaryotes. Aerosols can penetrate into the nooks and crannies of a space and kill microbes that may lurk in a space. In addition, ceragenins have a extended mode of action, which allows them to continue killing microbes in a space for an extended period of time.
摘要翻译：包括cerornin化合物（即含有ceragenin的气溶胶），递送这种气溶胶的方法和用于递送这种气溶胶的装置的气溶胶。 Ceragenins可用于杀死广泛的微生物（例如细菌，病毒，真菌，细菌孢子，真菌孢子等），但是它们被认为对人类和其它高等真核生物完全无毒。气溶胶可以渗透到空间的角落和角落，并杀死可能潜伏在空间中的微生物。此外，ceragenins具有延长的作用方式，允许它们在长时间内继续杀死空间中的微生物。

72. 发明授权

US09434759B1 Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds 有权
标题翻译：阳离子甾族抗微生物化合物及其制备方法
公开(公告)号：US09434759B1
公开(公告)日：2016-09-06
申请号：US14866213
申请日：2015-09-25
申请人： Paul B. Savage
发明人： Paul B. Savage
IPC分类号： C07J41/00 , A61K31/575 , C07C225/00 , C07C211/00
CPC分类号： C07J41/0088 , A61K31/575 , C07C211/00 , C07C225/00 , C07J41/0055 , C07J41/0061
摘要： Cationic steroidal antimicrobial (CSA) compounds having amide functionality and methods of manufacturing such CSA compounds. The CSA compound can be a compound of Formula (I), Formula (II), Formula (III), or a salt thereof: where R18 has the following structure: —R20—(C═O)—N—R21R22 R20 is omitted or substituted or unsubstituted alkyl, alkenyl, alkynyl, or aryl, and R21 and R22 are independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or substituted or unsubstituted aryl, provided that at least one of R21 and R22 is not hydrogen.

73. 发明申请

US20150314342A1 METHODS AND APPARATUS FOR CLEANING OR DISINFECTING A WATER DELIVERY SYSTEM 有权
标题翻译：用于清洁或消毒水输送系统的方法和装置
公开(公告)号：US20150314342A1
公开(公告)日：2015-11-05
申请号：US14694028
申请日：2015-04-23
申请人： Chad S. Beus , Paul B. Savage
发明人： Chad S. Beus , Paul B. Savage
IPC分类号： B08B9/08 , A61K31/575 , A01N33/08 , A61L2/16 , B08B9/027 , A01K7/00 , B08B3/08 , A61L2/18 , A01N37/44
CPC分类号： A01K7/00 , A01N33/08 , A01N37/44 , A01N45/00 , A61K31/575 , B08B3/08 , B08B9/027 , B08B9/08 , B08B9/0856 , C02F1/50 , C02F1/688 , C02F2303/04 , C02F2307/14
摘要： Methods for cleaning or disinfecting water delivery systems, self-cleaning or self-disinfecting water delivery systems, and inserts for use in cleaning or disinfecting water delivery systems utilize cationic steroidal antimicrobial (CSA) molecules to kill microbes and/or break up biofilms within water delivery systems. The methods and systems involve adding CSA molecules to water to form an aqueous CSA composition and passing the aqueous CSA composition through the water delivery system, such as a water storage vessel and/or water delivery line to clean or disinfect the water delivery system. CSA molecules can be added to a water storage vessel, water delivery line, or well, such as by a solid or liquid CSA composition. A CSA-eluting composition may provide CSA molecules to water to form an aqueous CSA composition that passes through or is stored within the water delivery system. CSA molecules provided to agricultural animals in drinking water may improve animal health.
摘要翻译：用于清洁或消毒输水系统，自清洁或自消除水输送系统的方法以及用于清洁或消毒给水系统的插入物使用阳离子甾族抗微生物（CSA）分子来杀死微生物和/或分解水中的生物膜送货系统。方法和系统包括将CSA分子加入到水中以形成水性CSA组合物，并使CSA组合物通过水输送系统，例如储水容器和/或输水管线，以清洁或消毒给水系统。可以将CSA分子加入储水容器，输水管线或井中，例如通过固体或液体CSA组合物。 CSA洗脱组合物可以将CSA分子提供给水以形成通过或储存在输水系统中的水性CSA组合物。在饮用水中向农业动物提供的CSA分子可以改善动物健康。

74. 发明申请

US20150239928A1 CATIONIC STEROIDAL ANTIMICROBIAL COMPOUNDS 审中-公开
标题翻译：阳离子类固醇抗微生物化合物
公开(公告)号：US20150239928A1
公开(公告)日：2015-08-27
申请号：US14624200
申请日：2015-02-17
申请人： Paul B. Savage
发明人： Paul B. Savage
IPC分类号： C07J43/00 , C07J41/00
摘要： Disclosed herein are cationic steroidal antimicrobials (“CSAs” or “ceragenins”) and methods of making the same. Particularly advantageous methods are identified for the synthesis of CSAs. CSAs may be formulated for treating subjects with ailments responsive to CSAs, including but not limited to treating bacterial infections. Accordingly, some embodiments include formulations and methods of administering CSAs.
摘要翻译：本文公开了阳离子甾体抗微生物剂（“CSA”或“ceragenins”）及其制备方法。鉴定了用于合成CSA的特别有利的方法。可以配制CSA用于治疗对CSA有反应性疾病的受试者，包括但不限于治疗细菌感染。因此，一些实施方案包括施用CSA的制剂和方法。

75. 发明申请

US20150140063A1 HYDROPHOBIC CERAGENIN COMPOUNDS AND DEVICES INCORPORATING SAME 有权
标题翻译：疏水性钙化合物和与其同时进行的装置
公开(公告)号：US20150140063A1
公开(公告)日：2015-05-21
申请号：US14602499
申请日：2015-01-22
申请人： Paul B. Savage
发明人： Paul B. Savage
IPC分类号： C07J41/00 , A61L27/18 , A61L27/54 , A61L27/34
CPC分类号： C07J41/0055 , A61L27/14 , A61L27/18 , A61L27/34 , A61L27/52 , A61L27/54 , A61L29/04 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/208 , A61L2300/404 , A61L2300/606 , C07C211/00
摘要： A hydrophobic cationic steroidal anti-microbial (ceragenin) compound forms an amphiphilic compound having a hydrophobic sterol face and a hydrophilic cationic face. The hydrophobic CSA also includes a hydrophobic substituent that gives the ceragenin compound a C Log P value of at least 6.0, 6.25, 6.5, 7.5, 8.5, or 10.
摘要翻译：疏水性阳离子甾族抗微生物（ceragenin）化合物形成具有疏水性固醇面和亲水性阳离子面的两亲性化合物。疏水性CSA还包括疏水性取代基，其给予cerornin化合物的C Log P值至少为6.0,6.25,6.5,7.5,8.5或10。

76. 发明授权

US08975310B2 Hydrophobic ceragenin compounds and devices incorporating same 有权
标题翻译：疏水性ceragenin化合物和结合相同的装置
公开(公告)号：US08975310B2
公开(公告)日：2015-03-10
申请号：US13554957
申请日：2012-07-20
申请人： Paul B. Savage
发明人： Paul B. Savage
IPC分类号： C07J41/00 , C08G59/50 , C08K5/24 , C09D5/16 , C07C211/00 , A61L27/52 , A61L27/54 , A61L31/14 , A61L31/16 , A61L27/34 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10
CPC分类号： C07J41/0055 , A61L27/14 , A61L27/18 , A61L27/34 , A61L27/52 , A61L27/54 , A61L29/04 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/208 , A61L2300/404 , A61L2300/606 , C07C211/00
摘要： A hydrophobic cationic steroidal anti-microbial (ceragenin) compound forms an amphiphilic compound having a hydrophobic sterol face and a hydrophilic cationic face. The hydrophobic CSA also includes a hydrophobic substituent that gives the ceragenin compound a CLogP value of at least 6.5.
摘要翻译：疏水性阳离子甾族抗微生物（ceragenin）化合物形成具有疏水性固醇面和亲水性阳离子面的两亲性化合物。疏水性CSA还包括疏水取代基，其使得cerornin化合物的CLogP值至少为6.5。

77. 发明授权

US08932614B2 Incorporation of particulate ceragenins in polymers 有权
标题翻译：颗粒状铈甙元在聚合物中的结合
公开(公告)号：US08932614B2
公开(公告)日：2015-01-13
申请号：US13594608
申请日：2012-08-24
申请人： Paul B. Savage , Carl Genberg
发明人： Paul B. Savage , Carl Genberg
IPC分类号： A01N25/26 , A61K9/00 , A01N45/00 , A61K31/58 , A61K31/56 , A01N25/10 , A61F2/02 , A61L27/34 , A61L27/54
CPC分类号： A01N45/00 , A01N25/10 , A61F2/02 , A61L27/34 , A61L27/54 , A61L2300/404
摘要： A composite that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 μm, 50 nm to 10 μm, 100 nm to 5 μm, or 1 μm to 10 μm. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.
摘要翻译：一种复合材料，其包括具有空隙结构的聚合物材料和与所述空隙结构相关联的颗粒状氧烷基素材料（即，ceragenin颗粒）。复合材料中的表面活性剂颗粒的平均粒径为5nm〜20μm，50nm〜10μm，100nm〜5μm或1μm〜10μm的范围。该复合材料具有高负载量的ceragenin颗粒（例如，约10重量％至约25重量％）。该复合材料具有良好的聚合物稳定性，以特征洗脱速率在持续的时间内从配置在复合材料中的ceragenin颗粒释放ceragenins的能力，以及在持续时间内杀死大量细菌和其他易感微生物的能力时间。

78. 发明申请

US20140194401A1 METHODS FOR REDUCING CELLULAR PROLIFERATION AND TREATING CERTAIN DISEASES 有权
标题翻译：减少细胞增殖和治疗某些疾病的方法
公开(公告)号：US20140194401A1
公开(公告)日：2014-07-10
申请号：US14149675
申请日：2014-01-07
申请人： Carl Genberg , Paul B. Savage
发明人： Carl Genberg , Paul B. Savage
IPC分类号： A61K31/575
CPC分类号： A61K31/575 , A61K31/56
摘要： Disclosed herein are methods of treating cancer and/or reducing cellular proliferation in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.
摘要翻译：本文公开了治疗患者的癌症和/或减少细胞增殖的方法，包括鉴定需要治疗的患者和施用治疗有效量的至少一种阳离子类固醇抗微生物剂（CSA）或其药学上可接受的盐。本文还考虑了包含这些组合物的组合物和关于这些方法的说明书。

79. 发明授权

US08530002B1 Methods for attaching polymerizable ceragenins to water treatment membranes using silane linkages 有权
标题翻译：使用硅烷键将可聚合的ceragenins连接到水处理膜的方法
公开(公告)号：US08530002B1
公开(公告)日：2013-09-10
申请号：US12986221
申请日：2011-01-07
申请人： Michael Hibbs , Susan J. Altman , Howland D. T. Jones , Paul B. Savage
发明人： Michael Hibbs , Susan J. Altman , Howland D. T. Jones , Paul B. Savage
IPC分类号： B05D3/04 , B05D3/10
CPC分类号： C08F2/48 , C09D5/1637 , C09D5/1675
摘要： This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.
摘要翻译：本发明涉及用于化学接枝和将ceragenin分子连接到聚合物底物上的方法; 合成含有ceragenin的共聚物的方法; 制备铈基改性水处理膜和间隔物的方法; 以及使用ceragenin改性的处理膜和间隔物处理污染水的方法。 Ceragenins是合成产生的展示广谱杀菌活性的抗微生物肽模拟物。可以使用胺连接，酰胺连接，UV接枝或硅烷涂覆方法将烯酮官能化的ceragenins（例如丙烯酰胺官能化的ceragenins）连接到聚酰胺反渗透膜上。此外，硅烷官能化的ceragenins可以直接连接到具有游离羟基的聚合物表面。

80. 发明授权

US08529681B1 Biofouling-resistant ceragenin-modified materials and structures for water treatment 有权
标题翻译：生物结垢抗性ceragenin改性材料和水处理结构
公开(公告)号：US08529681B1
公开(公告)日：2013-09-10
申请号：US12986234
申请日：2011-01-07
申请人： Michael Hibbs , Susan J. Altman , Howland D. T. Jones , Paul B. Savage
发明人： Michael Hibbs , Susan J. Altman , Howland D. T. Jones , Paul B. Savage
IPC分类号： C09D5/16 , C09D5/00 , C08F2/46 , C08F2/48
CPC分类号： C08F2/48 , C09D5/1637 , C09D5/1675
摘要： This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.
摘要翻译：本发明涉及用于化学接枝和将ceragenin分子连接到聚合物底物上的方法; 合成含有ceragenin的共聚物的方法; 制备铈基改性水处理膜和间隔物的方法; 以及使用ceragenin改性的处理膜和间隔物处理污染水的方法。 Ceragenins是合成产生的展示广谱杀菌活性的抗微生物肽模拟物。可以使用胺连接，酰胺连接，UV接枝或硅烷涂覆方法将烯基官能化的ceragenins（例如丙烯酰胺官能化的ceragenins）连接到聚酰胺反渗透膜上。此外，硅烷官能化的ceragenins可以直接连接到具有游离羟基的聚合物表面。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式