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71. 发明申请

US20190081341A1 REFLECTIVE LAMINATES 审中-公开
公开(公告)号：US20190081341A1
公开(公告)日：2019-03-14
申请号：US16083694
申请日：2017-03-09
申请人： W.L. Gore & Associates, Inc.
发明人： Alexander Agapov
IPC分类号： H01M8/1023 , H01M8/1039 , H01M8/1053 , H01M8/106 , H01M8/1067
摘要： A reflective laminate for use in fuel cell manufacture. The reflective laminate includes a polymer sheet and a reflective substrate having a reflectivity greater than 6% at each wavelength from 400 nm to 1000 nm removably adhered to the polymer sheet. The polymer sheet can include a polymer electrolyte membrane such as a perfluorosulfonic acid resin reinforced with expanded porous polytetrafluoroethylene. The reflective substrate can include a metal substrate (e.g., aluminum). The reflective substrate can reflect a portion of electromagnetic radiation traversing the polymer sheet. The portion of electromagnetic radiation reflected by the reflective substrate can be used to determine a characteristic or property of the polymer sheet (e.g., a size of the polymer sheet, a thickness of the polymer sheet, or a defect of the polymer sheet). A catalyst electrode can be applied to opposite sides of the polymer sheet to form a membrane electrode assembly (“MEA”).

72. 发明申请

US20180271779A1 Injectable and Biodegradable Polymer Formulations For Controlled Release of Biologic Agents 审中-公开
公开(公告)号：US20180271779A1
公开(公告)日：2018-09-27
申请号：US15935692
申请日：2018-03-26
申请人： W.L. Gore & Associates, Inc.
发明人： Paul C. Begovac , Robert L. Cleek , Mei Li
IPC分类号： A61K9/00 , A61K9/51 , A61K47/34 , C08G63/08 , C08G64/02
摘要： The present disclosure is directed to injectable formulations that include biodegradable polymers based on trimethylene carbonate (TMC) with mole fractions of polylactic acid (PLA) and/or polyglycolic acid (PGA) that are used to deliver a bioactive agent to a targeted site. Excipients such as polyethylene glycol (PEG) may be added to the formulations to reduce the injection force and/or to modulate the release of the bioactive agent. Suitable biodegradable polymers for use in the injectable formulations include D,L-PLA:TMC, D-PLA:TMC, L-PLA:TMC, TMC:PLA:PGA and variations thereof. Additionally, copolymers of TMC and PLA and terpolymers of TMC:PLA:PGA may be formed into nanoparticles and delivered to the target site with an injectable crosslinkable polyethylene glycol system. In at least one embodiment, the injectable formulations are used to treat ocular diseases.

73. 发明授权

US09463006B2 Over-the-wire interlock attachment/detachment mechanism 有权
公开(公告)号：US09463006B2
公开(公告)日：2016-10-11
申请号：US14099394
申请日：2013-12-06
申请人： W.L. Gore & Associates, Inc.
发明人： Sean T. Forde , Steven W. Opolski
IPC分类号： A61B17/00 , A61F2/01 , A61F2/95 , A61F2/962 , A61B17/12
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/12022 , A61B2017/00575 , A61B2017/00619 , A61B2017/1205 , A61F2/01 , A61F2/95 , A61F2/962 , A61F2002/011 , A61F2002/018 , A61F2002/9505 , A61F2002/9528 , A61F2230/005 , A61F2230/0067
摘要： The over-the-wire interlock attachment/detachment mechanism includes a cylindrical lock receiving section of a small diameter attached to an implantable medical device such as a blood clot filter, a stent, or a septal occluder. This cylindrical lock receiving section has a plurality of spaced, curved cutouts to receive both the guide fingers and contoured locking fingers formed on a cylindrical locking section. The locking fingers are angled outwardly from the cylindrical body of the cylindrical locking section, and are moved inwardly into engagement with the curved cutouts of the cylindrical lock receiving section by a sheath which slides over the cylindrical locking section or other suitable operator.

74. 发明申请

US20160157912A1 DEVICES AND METHODS FOR TREATING CARDIAC TISSUE 审中-公开
标题翻译：用于治疗心脏组织的装置和方法
公开(公告)号：US20160157912A1
公开(公告)日：2016-06-09
申请号：US15043397
申请日：2016-02-12
申请人： W.L. Gore & Associates, Inc.
发明人： Sean Forde
IPC分类号： A61B18/00 , A61B18/18 , A61B18/14 , A61B18/24
CPC分类号： A61B18/1492 , A61B17/12022 , A61B18/00 , A61B18/18 , A61B18/1815 , A61B18/24 , A61B2017/00575 , A61B2018/00291 , A61B2018/00351 , A61B2018/1861 , A61B2018/2238 , A61B2018/2244
摘要： The invention generally relates to devices and methods for treating cardiac tissue, including percutaneous closure of cardiac openings such as a patent foramen ovale (PFO) and obliteration of the cardiac cul-de-sacs. The invention includes a device having at least one elongated member. The elongated member has a first material and a second material interwoven with at least a portion of the first material. The second material is capable of transferring energy to tissue in need of treatment.
摘要翻译：本发明一般涉及用于治疗心脏组织的装置和方法，包括心脏开放的经皮闭合，例如卵圆孔（PFO）和闭塞心脏死囊。本发明包括具有至少一个细长构件的装置。细长构件具有与第一材料的至少一部分交织的第一材料和第二材料。第二种材料能够将能量转移到需要治疗的组织中。

75. 发明授权

US09326759B2 Tubular patent foramen ovale (PFO) closure device with catch system 有权
标题翻译：管状卵圆孔（PFO）闭合装置带捕获系统
公开(公告)号：US09326759B2
公开(公告)日：2016-05-03
申请号：US13934031
申请日：2013-07-02
申请人： W.L. Gore & Associates, Inc.
发明人： Andrzej J. Chanduszko , David J. Callaghan
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623
摘要： Occluder devices for occluding an anatomical aperture, such as an atrial septal defect (ASD) or a patent foramen ovale (PFO) comprise two sides connected by a central tube. The occluder devices are formed from a tube, which is cut to produce struts in each side. Upon the application of force, the struts deform into loops. The loops may be of various shapes, sizes, and configurations, and, in at least some embodiments, the loops have rounded peripheries. In some embodiments, at least one of the sides includes a tissue scaffold. The occluder devices include a catch system that maintains its deployed state in vivo. When an occluder device is deployed in vivo, the two sides are disposed on opposite sides of the septal tissue surrounding the aperture and the catch system is deployed so that the occluder device exerts a compressive force on the septal tissue and closes the aperture.
摘要翻译：用于闭塞解剖孔的封堵器装置，例如房间隔缺损（ASD）或卵圆孔卵孔（PFO），包括通过中心管连接的两侧。封堵器装置由管子形成，管子被切割以在每一侧产生支柱。施加力时，支柱变形成环。环可以是各种形状，尺寸和构造，并且在至少一些实施例中，环具有圆形的周边。在一些实施例中，至少一个侧面包括组织支架。闭塞器装置包括在体内保持其部署状态的捕获系统。当在体内部署闭塞器装置时，两侧设置在围绕孔的隔膜组织的相对侧上，并且止动系统被展开，使得封堵器装置对隔膜组织施加压缩力并闭合孔。

76. 发明申请

US20160031130A1 Method For Producing Porous Articles From Alternating Poly(ethylene tetrafluoroethylene) and Articles Produced Therefrom 有权
标题翻译：从交替聚（乙烯四氟乙烯）生产多孔制品及其制品的方法
公开(公告)号：US20160031130A1
公开(公告)日：2016-02-04
申请号：US14811510
申请日：2015-07-28
申请人： W.L. Gore & Associates, Inc.
发明人： Guy A. Sbriglia
IPC分类号： B29C43/24 , B29C51/26 , C08F214/26
CPC分类号： C08F214/265 , B01D71/32 , B29C43/003 , B29C43/24 , B29C47/0004 , B29C47/0011 , B29C47/92 , B29C51/266 , B29C55/005 , B29C55/02 , B29C2947/92514 , B29C2947/926 , B29C2947/92685 , B29C2947/92704 , B29D99/0078 , B29K2023/06 , B29K2027/12 , B29K2105/04 , B29K2995/0041 , B29K2995/0088 , B29L2007/007 , B32B2327/12 , C08F214/26 , H01M2/1653
摘要： Polyethylene tetrafluoroethylene) (ETFE) polymers having an average molecular weight of at least 300,000 g/mol and a melt enthalpy of at least 57 J/g are provided. The ETFE polymer may include at least one additional comonomer. The ETFE polymer is used to form a porous tape or membrane that has a node and fibril structure. A porous ETFE tape may be formed by lubricating the ETFE polymer and subjecting the lubricated polymer to pressure at a temperature below the melting point of the ETFE polymer. Optionally, the ETFE tape may be expanded at a temperature below the melting temperature of the ETFE polymer to form an expanded ETFE membrane. Alternatively, the ETFE polymer may subjected to heat and pressure without the addition of a lubricant to form a dense preform. The dense preform may be subsequently slit in a length direction and stretched to form a dense ETFE fiber.
摘要翻译：提供平均分子量至少为300,000g / mol，熔体焓至少为57J / g的聚乙烯四氟乙烯）（ETFE）聚合物。 ETFE聚合物可以包括至少一种另外的共聚单体。 ETFE聚合物用于形成具有节点和原纤维结构的多孔带或膜。可以通过润滑ETFE聚合物并使润滑的聚合物在低于ETFE聚合物的熔点的温度下进行压力来形成多孔ETFE带。任选地，ETFE胶带可以在低于ETFE聚合物的熔融温度的温度下膨胀以形成膨胀的ETFE膜。或者，ETFE聚合物可以经受加热和加压而不加入润滑剂以形成致密的预型体。紧密的预型件可以随后在长度方向上切割并拉伸以形成致密的ETFE纤维。

77. 发明申请

US20150148841A1 DELIVERY/RECOVERY SYSTEM FOR SEPTAL OCCLUDER 审中-公开
标题翻译： SEPTAL OCCLUDER的交付/恢复系统
公开(公告)号：US20150148841A1
公开(公告)日：2015-05-28
申请号：US14613303
申请日：2015-02-03
申请人： W.L. Gore & Associates, Inc.
发明人： Carol A. Devellian , David R. Widomski , Andrzej J. Chanduszko
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623
摘要： A delivery/recovery system to allow an operator to deploy and recover a medical implant, such as an occluder for closing a patent foramen ovale (PFO). In one embodiment, the system includes a delivery mandrel for preventing the occluder from moving in the proximal direction, a delivery wire for securing the occluder to the delivery mandrel and preventing unwanted movement in the distal direction, and a sheath for enveloping the delivery wire, mandrel and occluder. By moving the sheath relative to the occluder in a series of steps, the occluder opens first on a distal side and then on a proximal side, in a manner that holds the occluder in place.
摘要翻译：一种运输/恢复系统，允许操作者部署和恢复医疗植入物，例如用于闭合卵孔专利（PFO）的封堵器。在一个实施例中，系统包括用于防止封堵器沿近端方向移动的输送心轴，用于将封堵器固定到输送心轴并防止在远端方向上的不期望的运动的输送线，以及用于包封输送线的护套，心轴和闭塞器。通过以一系列步骤相对于闭塞器移动护套，封堵器首先在远端侧开放，然后在近侧开口，以将封堵器保持在适当位置的方式。

78. 发明申请

US20140222058A1 CATCH MEMBERS FOR OCCLUDER DEVICES 审中-公开
标题翻译：用于监听设备的CATCH成员
公开(公告)号：US20140222058A1
公开(公告)日：2014-08-07
申请号：US14078330
申请日：2013-11-12
申请人： W.L. Gore & Associates, Inc.
发明人： Steven W. Opolski , Sean T. Forde , Stephanie M. Kladakis , David J. Callaghan
IPC分类号： A61B17/12
CPC分类号： A61B17/1215 , A61B17/0057 , A61B2017/00004 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623
摘要： Devices and techniques for modifying and maintaining a configuration of an occlusion device for the closure of physical anomalies, such as an atrial septal defect, a patent foramen ovale (PFO), and other septal and vascular defects are described. The devices and techniques relate particularly to, but are not limited to, modifying and maintaining a configuration of a PFO occluder made from a polymer tube. The proximal portion of a catch member may be provided with one or more protrusions, or arms, or bump or other raised element for securing the occluder in a partial or fully deployed configuration, either temporarily or permanently.
摘要翻译：描述了用于修改和保持用于闭合物理异常的闭塞装置的构造的装置和技术，例如房间隔缺损，卵圆孔卵孔（PFO）以及其它间隔和血管缺陷。所述装置和技术特别涉及但不限于修改和维持由聚合物管制成的PFO封堵器的构造。捕获构件的近侧部分可以设置有一个或多个突起，或臂或凸起或其它凸起元件，用于将闭塞器临时或永久地部分地或完全展开的构造固定。

79. 发明申请

US20140102974A1 Composite Filter Media For Fuel Streams 有权
标题翻译：用于燃料流的复合过滤介质
公开(公告)号：US20140102974A1
公开(公告)日：2014-04-17
申请号：US14049544
申请日：2013-10-09
申请人： W.L. Gore & Associates, Inc.
发明人： Gary P. Harp
IPC分类号： B01D71/36
CPC分类号： B01D71/36 , B01D69/10 , B01D69/12 , B01D2325/20 , B01D2325/24 , B01D2325/38 , F02M37/221
摘要： The present invention provides a composite filter media for use in a fuel stream wherein the composite media provides significantly improved resistance to water penetration as indicated by the FWWPP normalized for fuel IFT and a reduced resistance to flow of the fuel stream as indicated by the Ratio of Resistances.
摘要翻译：本发明提供一种用于燃料流的复合过滤介质，其中复合介质提供显着提高的耐水渗透性，如对于燃料IFT标准化的FWWPP所示，并且燃料流的流动阻力降低，如抵抗力

80. 发明申请

US20140088640A1 Delivery/Recovery System for Septal Occluder 有权
标题翻译：隔膜闭塞器的交付/恢复系统
公开(公告)号：US20140088640A1
公开(公告)日：2014-03-27
申请号：US14042134
申请日：2013-09-30
申请人： W.L. Gore & Associates, Inc.
发明人： Carol A. Devellian , David R. Widomski , Andrzej J. Chanduszko
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623
摘要： A delivery/recovery system to allow an operator to deploy and recover a medical implant, such as an occluder for closing a patent foramen ovale (PFO). In one embodiment, the system includes a delivery mandrel for preventing the occluder from moving in the proximal direction, a delivery wire for securing the occluder to the delivery mandrel and preventing unwanted movement in the distal direction, and a sheath for enveloping the delivery wire, mandrel and occluder. By moving the sheath relative to the occluder in a series of steps, the occluder opens first on a distal side and then on a proximal side, in a manner that holds the occluder in place.
摘要翻译：一种运输/恢复系统，允许操作者部署和恢复医疗植入物，例如用于闭合卵孔专利（PFO）的封堵器。在一个实施例中，系统包括用于防止封堵器沿近端方向移动的输送心轴，用于将封堵器固定到输送心轴并防止在远端方向上的不期望的运动的输送线，以及用于包封输送线的护套，心轴和闭塞器。通过以一系列步骤相对于闭塞器移动护套，封堵器首先在远端侧开放，然后在近侧开口，以将封堵器保持在适当位置的方式。

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