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71. 发明授权

US10450923B2 Exhaust gas control apparatus for internal combustion engine and control method for exhaust gas control apparatus 有权
公开(公告)号：US10450923B2
公开(公告)日：2019-10-22
申请号：US15807808
申请日：2017-11-09
申请人： TOYOTA JIDOSHA KABUSHIKI KAISHA , THE DOSHISHA
发明人： Kazuhiro Umemoto , Toshihiro Mori , Hiromasa Nishioka , Jiro Senda , Eriko Matsumura
IPC分类号： F01N3/20 , F01N3/08 , F01N3/36 , F01N9/00 , F01N11/00 , F01N13/00
摘要： An exhaust gas control apparatus for an internal combustion engine is provided. The exhaust gas control apparatus is equipped with a NOx reduction catalyst, a reducing agent tank, a reducing agent supply device, a booster, a heater, and an electronic control unit. The electronic control unit is configured to perform control of raising a temperature of a reducing agent to a first target temperature such that the reducing agent supplied by the reducing agent supply device is brought into a gas-liquid mixed state in an exhaust passage, when energy of exhaust gas is lower than a first threshold.

72. 发明申请

US20180329238A1 LIQUID CRYSTAL MOLECULE ORIENTATION CONTROL METHOD AND LIQUID CRYSTAL DEVICE 审中-公开
公开(公告)号：US20180329238A1
公开(公告)日：2018-11-15
申请号：US15768328
申请日：2016-10-12
申请人： THE DOSHISHA
发明人： Daisuke KOYAMA , Satoki TANIGUCHI , Yuki SHIMIZU
IPC分类号： G02F1/1333 , G02F1/1337
CPC分类号： G02F1/1333 , G02F1/13 , G02F1/1337 , G02F2001/133394
摘要： Provided are a liquid crystal molecule orientation control method and a liquid crystal device which render it possible to change the orientation of liquid crystal molecules without using an electric field. In controlling the orientation of liquid crystal molecules 103a, which are contained in a liquid crystal material 103 sandwiched between alignment films 104, by the liquid crystal molecule orientation control method, an ultrasonic wave is generated in a piezoelectric material 102 so as to propagate to the liquid crystal material 103, and static pressure is generated in accordance with the ultrasonic wave, with the result that the orientation is changed in accordance with the magnitude of the static pressure.

73. 发明申请

US20180038918A1 Cell Deterioration Diagnostic Method and Cell Deterioration Diagnostic Device 审中-公开
公开(公告)号：US20180038918A1
公开(公告)日：2018-02-08
申请号：US15552842
申请日：2016-02-24
申请人： THE DOSHISHA
发明人： Naoto NAGAOKA , Naoyuki YOSHIOKA , Naoya NARITA, I
IPC分类号： G01R31/36 , H02J7/00 , H01M10/0525 , H01M10/48
CPC分类号： G01R31/392 , G01R31/367 , G01R31/374 , G01R31/378 , G01R31/388 , G01R31/389 , H01M10/0525 , H01M10/42 , H01M10/48 , H01M10/486 , H02J7/00 , H02J7/008
摘要： Relatively inexpensive and practical cell deterioration diagnostic method and cell deterioration diagnostic device are provided. A cell deterioration diagnostic method diagnoses cell deterioration of a secondary cell having a transient characteristic. The method includes: a charging step of charging the secondary cell; a calculation step of calculating an integrated value of a potential difference obtained by subtracting a cell internal voltage V0 of the secondary cell from a cell inter-terminal voltage of the secondary cell by integrating the potential difference as the cell inter-terminal voltage converges to the cell internal voltage V0 after completion of charging; and a diagnosis step of diagnosing the cell deterioration of the secondary cell based on the integrated value.

74. 发明申请

US20170362129A1 ZrO2-Al2O3-BASED CERAMIC SINTERED COMPACT AND PRODUCTION METHOD THEREOF 有权
公开(公告)号：US20170362129A1
公开(公告)日：2017-12-21
申请号：US15390088
申请日：2016-12-23
申请人： THE DOSHISHA , DAIICHI KIGENSO KAGAKU KOGYO CO., LTD.
发明人： Ken Hirota , Xiaoteng Ge , Hideo Kimura
IPC分类号： C04B35/488 , C04B35/64
CPC分类号： C04B35/4885 , C04B35/6262 , C04B35/62695 , C04B35/63416 , C04B35/64 , C04B2235/3217 , C04B2235/3225 , C04B2235/3246 , C04B2235/5454 , C04B2235/549 , C04B2235/604 , C04B2235/656 , C04B2235/6562 , C04B2235/6567 , C04B2235/667 , C04B2235/765 , C04B2235/77 , C04B2235/781 , C04B2235/785 , C04B2235/96
摘要： A ZrO2—Al2O3-based ceramic sintered compact containing tetragonal ZrO2 particles having a crystallite size of from 5 to 20 nm as a main component and having an α-Al2O3 crystallite size of not greater than 75 nm and a relative density of not less than 99% can be produced by preparing a Y2O3 partially stabilized ZrO2—Al2O3-based powder having a molar ratio (mol %) of zirconia (ZrO2) and yttria (Y2O3) of from 96.5:3.5 to 97.5:2.5 and a mass ratio (mass %) of ZrO2 containing Y2O3 and alumina (Al2O3) of from 85:15 to 75:25, molding this powder by cold isostatic pressing, and then performing sintering to a high density by microwave sintering for 45 to 90 min in an inert gas atmosphere at 1200 to 1400° C. When performing microwave sintering, a heating rate is preferably from 5 to 20° C./min up to 600° C. and from 50 to 150° C./min at 600° C. or higher.

75. 发明申请

US20170143647A1 INTESTINAL FLORA IMPROVING COMPOSITION CONTAINING ASTAXANTHIN AND ITS USE 审中-公开
公开(公告)号：US20170143647A1
公开(公告)日：2017-05-25
申请号：US15423156
申请日：2017-02-02
申请人： THE DOSHISHA , FUJI CHEMICAL INDUSTRY CO., LTD.
发明人： Yoshikazu YONEI , Kumi TOMINAGA , Eiji YAMASHITA
IPC分类号： A61K31/122
CPC分类号： A61K31/122 , A61K9/0053
摘要： An oral composition that improves intestinal flora via oral intake includes astaxanthin as an active ingredient, and excludes a component that can form skin tissue, the composition improving the intestinal flora by reducing or suppressing either or both of an increase in gram-negative bacteria and an increase in bacteria that belong to the Clostridium coccoides group.

76. 发明授权

US09658191B2 Atomic flux measurement device 有权
公开(公告)号：US09658191B2
公开(公告)日：2017-05-23
申请号：US13733594
申请日：2013-01-03
申请人： THE DOSHISHA , ARIOS INC.
发明人： Tadashi Ohachi , Motoi Wada , Osamu Ariyada , Nobuhiko Yamabe
IPC分类号： G01N27/70 , C23C14/54 , C30B23/00 , H05H1/00 , G06F17/00
CPC分类号： G01N27/70 , C23C14/543 , C30B23/005 , G06F17/00 , H05H1/0081
摘要： An atomic flux measurement device for measuring the amount of dissociated atomic flux produced by discharge and emitted from a plasma generation cell into a vacuum camber. The atomic flux measurement device includes a counter electrode body including a pair of first and second sheet-like electrodes that are arranged substantially parallel to each other with a predetermined spacing between them, a direct-current power supply configured to maintain the first sheet-like electrode at a negative potential so that atoms attached to the inner surface of the sheet-like electrode undergo self-ionization and to apply a direct-current voltage between the first and second sheet-like electrodes so that a current flows between the first and second sheet-like electrodes, and a direct-current ammeter configured to measure a current flowing due to electrons emitted by the self-ionization of the dissociated atoms attached to the inner surface of the first sheet-like electrode.

77. 发明申请

US20160317528A1 COMBINED AGENT FOR CELL THERAPY OF CORNEAL ENDOTHELIAL CELL 审中-公开
标题翻译：组合细胞治疗角膜内皮细胞的药物
公开(公告)号：US20160317528A1
公开(公告)日：2016-11-03
申请号：US15108355
申请日：2013-12-27
申请人： KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION , THE DOSHISHA , SENJU PHARMACEUTICAL CO., LTD.
发明人： Noriko KOIZUMI , Naoki OKUMURA , Shigeru KINOSHITA
IPC分类号： A61K31/4745 , A61K9/00 , A61K35/44 , A61K35/30
CPC分类号： A61K31/4745 , A61K9/0048 , A61K35/30 , A61K35/44 , A61K45/06
摘要： The present invention provides an agent for treating or preventing a disease, a disorder or a condition of a corneal endothelium, said agent comprising a corneal endothelial cell and a myosin II-specific inhibitor. More specifically, the myosin II-specific inhibitor is blebbistatin. The disease, the disorder or the condition is typically a disorder associated with Fuchs endothelial corneal dystrophy or corneal endothelial dysfunction (bullous keratopathy). Also provided is a method for treating or preventing a corneal endothelial disease, said method comprising a step of administering an effective amount of a myosin II-specific inhibitor together with a corneal endothelial cell to a subject.
摘要翻译：本发明提供了用于治疗或预防角膜内皮的疾病，病症或病症的药剂，所述药物包含角膜内皮细胞和肌球蛋白II特异性抑制剂。更具体地说，肌球蛋白II特异性抑制剂是blebbistatin。疾病，病症或病症通常是与Fuchs内皮角膜营养不良或角膜内皮功能障碍（大疱性角膜病）相关的病症。还提供了治疗或预防角膜内皮细胞疾病的方法，所述方法包括向受试者施用有效量的肌球蛋白II特异性抑制剂与角膜内皮细胞一起的步骤。

78. 发明申请

US20160266114A1 CORNEAL ENDOTHELIAL CELL MARKER 审中-公开
标题翻译：角膜内皮细胞标记
公开(公告)号：US20160266114A1
公开(公告)日：2016-09-15
申请号：US14908036
申请日：2014-07-28
申请人： KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION , THE DOSHISHA , SENJU PHARMACEUTICAL CO., LTD.
发明人： Noriko KOIZUMI , Naoki OKUMURA , Hiroatsu HIRANO , Shigeru KINOSHITA , Morio UENO
IPC分类号： G01N33/569 , A61K35/30
CPC分类号： G01N33/56966 , A61K35/30 , C12N5/0621 , G01N2333/705 , G01N2333/70596
摘要： The purpose of the present invention is to provide a method of purification and preparation of cultured corneal endothelial cells, and in particular, to provide cell surface markers for use in corneal endothelial cells not including transformed cells. Provided are cell markers for distinguishing normal cells and transformed cells, in particular normal and transformed corneal endothelium cells. These cell markers relate to specific cell surface markers, for example, to a normal corneal endothelial surface marker such as CD166, and a transformed cell surface marker such as CD73. By using the transformed cell surface marker such as CD73 to remove transformed cells by sorting, it becomes possible to improve purity of a normal cultured corneal endothelium. By using normal corneal endothelial surface marker such as CD166, or by combined use with the transformed cell surface marker, it becomes possible to provide a means for verifying the purity of a prepared corneal endothelium.
摘要翻译：本发明的目的是提供一种纯化和制备角膜内皮细胞的方法，特别是提供用于不包括转化细胞的角膜内皮细胞的细胞表面标志物。提供用于区分正常细胞和转化细胞的细胞标志物，特别是正常和转化的角膜内皮细胞。这些细胞标志物涉及特定细胞表面标志物，例如与正常角膜内皮表面标志物如CD166和转化的细胞表面标志物如CD73相关。通过使用转化的细胞表面标记如CD73通过分选来除去转化的细胞，可以提高正常培养的角膜内皮的纯度。通过使用正常的角膜内皮表面标记如CD166，或通过与转化的细胞表面标记物的组合使用，可以提供一种验证制备的角膜内皮的纯度的方法。

79. 发明授权

US09258850B2 Microwave heating device and image fixing apparatus using the same 有权
标题翻译：微波加热装置及其使用的图像定影装置
公开(公告)号：US09258850B2
公开(公告)日：2016-02-09
申请号：US13686668
申请日：2012-11-27
申请人： MURATA MACHINERY, LTD. , THE DOSHISHA
发明人： Shinzo Yoshikado , Yoshihiro Shojo , Isao Fukuda
IPC分类号： H05B6/64 , H05B6/70 , H05B6/74 , H05B6/78
CPC分类号： H05B6/6402 , H05B6/701 , H05B6/74 , H05B6/78
摘要： A heating chamber is divided into a plurality of spaces by barrier sections including a conductive material. Phase shifters having different lengths with respect to a direction and including a dielectric body having permittivity higher than air are inserted in positions of a terminal section, in the spaces except for at least one space, to differentiate positions of bottoms of standing microwaves formed in the respective spaces from each other with respect to the direction. In addition, impedance adjusters having different lengths with respect to the direction and including a dielectric body having permittivity higher than air are inserted in positions on an upstream side of a region passed by the object to be heated, in the spaces except for at least one space, to reduce differences in impedance of the spaces from an entrance of the heating chamber to the terminal section including the phase shifters.
摘要翻译：加热室由包括导电材料的阻挡部分分成多个空间。相对于方向具有不同长度的相位移器并且包括具有高于空气的介电常数的电介质的介电体被插入在除了至少一个空间之外的空间中的端子部分的位置中，以区分形成在该位置的立式微波的底部的位置相对于方向彼此相对应的空间。此外，具有相对于方向具有不同长度的阻抗调节器并且包括具有高于空气的介电常数的电介质的介电体被插入到被待加热物体通过的区域的上游侧的位置中，除了至少一个空间，以减少空间与加热室的入口到包括移相器的端子部分的阻抗差异。

80. 发明授权

US09045525B2 Amyloid β-protein-specific production-inhibiting polypeptide 有权
标题翻译：淀粉样蛋白和蛋白特异性产生抑制多肽
公开(公告)号：US09045525B2
公开(公告)日：2015-06-02
申请号：US14372597
申请日：2013-01-16
申请人： THE DOSHISHA
发明人： Yasuo Ihara , Satoru Funamoto , Toru Sasaki
IPC分类号： C07K7/08 , C07K4/00 , C07K14/00 , A61P25/28 , C07K7/06 , C07K14/81 , C07K14/47 , A61K38/00
CPC分类号： C07K7/06 , A61K38/00 , C07K14/00 , C07K14/4711 , C07K14/81 , C07K14/8142
摘要： A primary object of the present invention is to develop a compound that specifically inhibits the production of Aβ protein and serves as an active ingredient of a drug to treat and/or prevent Alzheimer's disease.This object can be achieved by a polypeptide having the amino acid sequence represented by any one of SEQ ID NOs: 1, 13, 14, and 22, that binds to the N-terminal region of βCTF; a γ-secretase activity inhibitor containing the polypeptide; β-secretase activity inhibitor; Aβ protein production inhibitor; and an agent for treating and/or preventing Alzheimer's disease.
摘要翻译：本发明的主要目的是开发特异性抑制A＆Bgr的生产的化合物。并且用作治疗和/或预防阿尔茨海默病的药物的活性成分。该目的可以通过具有与SEQ ID NO：13,14和22中任一个表示的氨基酸序列的多肽来实现，所述氨基酸序列与CTF的N末端区域结合; 含有该多肽的γ-分泌酶活性抑制剂; 分泌酶活性抑制剂; A＆bgr 蛋白质生产抑制剂; 和用于治疗和/或预防阿尔茨海默氏病的药剂。

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