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71. 发明授权

US07337005B2 Methods for stimulating a nerve root ganglion 有权
标题翻译：刺激神经根神经节的方法
公开(公告)号：US07337005B2
公开(公告)日：2008-02-26
申请号：US11221570
申请日：2005-09-07
申请人： Daniel H. Kim , Mir A. Imran
发明人： Daniel H. Kim , Mir A. Imran
IPC分类号： A61N1/05
CPC分类号： A61N1/36071 , A61M5/142 , A61M25/06 , A61M2210/1003 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36067 , A61N1/36139 , A61N1/36171
摘要： Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more nerve root ganglia through implantation of an electrode on, in or around a nerve root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more nerve root ganglia through implantation of an electrode on, in or around a nerve root ganglia in combination with a pharmacological agent.
摘要翻译：本发明的一些实施方案通过在神经根神经节内或周围植入电极来提供用于选择性刺激和/或神经根神经节神经调节的刺激系统和组件。本发明的一些其他实施方案提供了一种或多种背根神经节的选择性神经刺激的方法以及将神经刺激应用于脊髓的技术。本发明的其它实施方案通过在神经根神经节内部或周围植入一种电极来选择性刺激和/或神经调节神经根神经节的刺激系统和组件，其与药理学组合。

72. 发明授权

US07160258B2 Capsule and method for treating or diagnosing the intestinal tract 有权
标题翻译：胶囊和治疗或诊断肠道的方法
公开(公告)号：US07160258B2
公开(公告)日：2007-01-09
申请号：US09892404
申请日：2001-06-26
申请人： Mir A. Imran , Olivier K. Colliou , Ted W. Layman , Sharon L. Lake , Harm TenHoff , Timothy J. Hughes
发明人： Mir A. Imran , Olivier K. Colliou , Ted W. Layman , Sharon L. Lake , Harm TenHoff , Timothy J. Hughes
IPC分类号： A61B5/117 , A61B5/103 , A61B5/05
CPC分类号： A61M31/002 , A61B1/00016 , A61B1/00082 , A61B1/041 , A61B5/002 , A61B5/0084 , A61B5/01 , A61B5/036 , A61B5/0538 , A61B5/06 , A61B5/061 , A61B5/065 , A61B5/073 , A61B5/11 , A61B5/14503 , A61B5/14539 , A61B5/1459 , A61B5/42 , A61B5/4233 , A61B5/4255 , A61B5/4839 , A61B5/6801 , A61B5/6873 , A61B18/14 , A61B2018/00482 , A61B2018/00577 , A61B2018/00642 , A61B2018/00702 , A61B2018/00821 , A61B2562/162 , A61M5/172 , A61M5/1723 , A61N1/36007 , A61N1/37205
摘要： A device and method for mapping, diagnosing and treating the intestinal tract is provided using a capsule passing through the intestinal tract. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of sensed information may be derived from the pass of a capsule. Capsules may be subsequently passed through to treat the intestinal tract at a determined location along its length. One variation uses an electrical stimulation capsule to treat and/or diagnose a condition in the intestinal tract.
摘要翻译：使用通过肠道的胶囊提供用于映射，诊断和治疗肠道的装置和方法。此外，提供了胶囊跟踪系统，用于沿着肠道长度跟踪胶囊的位置，因为采用各种治疗和/或感测方式。在一个变型中，使用声信号来确定胶囊的位置。感测信息的图可以从胶囊的通过导出。随后可以将胶囊通过以沿着其长度在确定的位置治疗肠道。一个变体使用电刺激胶囊来治疗和/或诊断肠道中的病症。

73. 发明授权

US07054690B2 Gastrointestinal stimulation device 有权
标题翻译：胃肠道刺激装置
公开(公告)号：US07054690B2
公开(公告)日：2006-05-30
申请号：US10691735
申请日：2003-10-22
申请人： Mir A. Imran
发明人： Mir A. Imran
IPC分类号： A61N1/18
CPC分类号： A61N1/36007
摘要： A fixation device for holding stimulating electrodes in electrical contact with the wall of a portion of the gastrointestinal tract is provided. In one embodiment, the fixation device includes an expandable member that fixes the electrodes in electrical contact with the gastrointestinal tract wall. Also provided is an implantable device and method for controlling the opening and/or closing of the pylorus. In particular a device and method is provided for stimulating the duodenum to control the closing/and or opening of the pylorus.Finally, a method is provided for treating obesity by controlling the pylorus to retain food in the stomach for a desired period of time, among other things to provide a feeling of satiety and/or to reduce hunger. One aspect includes controlling the pylorus's contraction by electrical stimulation of the duodenum.
摘要翻译：提供了用于保持与胃肠道的一部分的壁电接触的刺激电极的固定装置。在一个实施例中，固定装置包括固定电极与胃肠道壁电接触的可扩张构件。还提供了一种用于控制幽门的打开和/或关闭的可植入装置和方法。特别地，提供了一种用于刺激十二指肠以控制幽门的关闭和/或打开的装置和方法。最后，提供了一种通过控制幽门以将食物保留在胃中一段期望的时间来提供饱腹感和/或减少饥饿的方法来治疗肥胖症的方法。一方面包括通过十二指肠的电刺激来控制幽门的收缩。

74. 发明授权

US06251073B1 Miniaturized ultrasound apparatus and method 有权
标题翻译：小型化超声仪器及方法
公开(公告)号：US06251073B1
公开(公告)日：2001-06-26
申请号：US09378175
申请日：1999-08-20
申请人： Mir A. Imran , Glen W. McLaughlin , William D. Lipps , James M. Brennan
发明人： Mir A. Imran , Glen W. McLaughlin , William D. Lipps , James M. Brennan
IPC分类号： A61B800
CPC分类号： G01S7/52079 , A61B8/06 , A61B8/08 , A61B8/0833 , A61B8/0866 , A61B8/13 , A61B8/4209 , A61B8/4427 , A61B8/4438 , A61B8/4455 , A61B8/462 , A61B8/465 , A61B8/467 , A61B8/469 , A61B8/488 , A61B8/56 , G01S7/52034 , G01S7/5208 , G01S7/52082 , G01S7/52084 , G01S7/52096 , G01S15/8979 , G01S15/8981
摘要： Ultrasound apparatus for examining tissue in a region of interest in a body comprising a housing having a viewing aperture. An ultrasonic transducer is provided comprised of an array of ultrasonic elements disposed in the viewing aperture. Electrical pulses are supplied to the transducer for transducer excitation to introduce ultrasonic signals into the body for reflection from the tissue in the region of interest. The transducer is capable of converting ultrasonic signals reflected from the tissue within the body to the transducer to provide electrical signals. The electrical signals are gain corrected in accordance with time. In-phase and out-of-phase components of the electrical signals are provided and then digitized. The digitized electrical signals are collected to form one image for a single frame of the tissue in the region of interest in the body from transducer excitations less than thirty-three in number which is then displayed.
摘要翻译：用于检查身体中感兴趣区域中的组织的超声仪器，其包括具有观察孔的壳体。提供超声换能器，其包括设置在观察孔中的超声波元件的阵列。将电脉冲提供给用于换能器激发的换能器，以将超声波信号引入体内，用于来自感兴趣区域中的组织的反射。换能器能够将从身体内的组织反射的超声信号转换成换能器以提供电信号。电信号根据时间进行增益校正。提供电信号的同相和异相分量然后数字化。数字化的电信号被收集，以便在小于三十三个数字的传感器激发下，在体内感兴趣的区域中的组织的单个帧形成一个图像，然后显示该图像。

75. 发明授权

US6039743A Guide wire having distal extremity with adjustable support characteristic and method 失效
标题翻译：导丝具有远端，具有可调支撑特性和方法
公开(公告)号：US6039743A
公开(公告)日：2000-03-21
申请号：US902772
申请日：1997-07-30
申请人： Dignah B. Quiachon , Deepak R. Gandhi , Dennis L. Brooks , Mir A. Imran , Roger J. Guidi
发明人： Dignah B. Quiachon , Deepak R. Gandhi , Dennis L. Brooks , Mir A. Imran , Roger J. Guidi
IPC分类号： A61F11/00 , A61M25/00 , A61M25/09 , A61M29/00
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/0915 , A61M2025/09158 , A61M2025/09175
摘要： A guide wire having a distal extremity with an adjustable support characteristic including a core wire having proximal and distal extremities. The distal extremity has a reduced cross sectional area which is more flexible than the proximal extremity. A tip is secured to the distal extremity of the core wire. A sleeve of superelastic material is disposed coaxially on the distal extremity of the core wire. The sleeve is annealed so that it is relatively flexible at a temperature ranging from 20.degree. to 40.degree. C. and becomes progressively stiffer as temperature increases. The core wire conducts electrical energy to the superelastic sleeve to supply heat to the sleeve and extends from the proximal extremity of the core wire to the sleeve to cause the sleeve to become stiffer to thereby increase the stiffness of the distal extremity of the guide wire. A guide wire is provided having a distal extremity with an adjustable support characteristic which varies from a floppy characteristic to a stiff characteristic.
摘要翻译：一种具有远端的引导线，其具有可调节的支撑特征，包括具有近端和远端的芯线。远端具有减小的横截面积，其比近端更灵活。尖端被固定到芯线的远端。超弹性材料的套筒同轴地设置在芯线的远端上。套管退火，使其在20°至40°C的温度范围内具有相对的柔韧性，随着温度升高而逐渐变硬。芯线将电能传导到超弹性套管以向套管供热并且从芯线的近端延伸到套筒以使套筒变得更硬，从而增加导丝的远端的刚度。提供导丝，其具有远端，具有可调整的支撑特性，其从软盘特性变为刚性特征。

76. 发明授权

US5938671A Recanalization apparatus and devices for use therein and method 失效
标题翻译：再生设备及其使用的装置及方法
公开(公告)号：US5938671A
公开(公告)日：1999-08-17
申请号：US970952
申请日：1997-11-14
申请人： Osamu Katoh , Mir A. Imran
发明人： Osamu Katoh , Mir A. Imran
IPC分类号： A61B17/00 , A61B17/22 , A61B19/00 , A61F2/00
CPC分类号： A61B17/3207 , A61B2017/003 , A61B2017/00867 , A61B2017/22077 , A61B2090/3782 , A61F2002/30098 , A61F2210/0033
摘要： Recanalization apparatus for use in crossing a stenosis forming a total occlusion in a vessel formed by a vessel wall, the stenosis having a distal end cap which is convex facing in a proximal direction. The apparatus is comprised of an outer sheath formed of an elongate flexible tubular member having proximal and distal extremities and having a lumen extending from the proximal extremity to the distal extremity. An inner sheath is slidably mounted in the lumen of the outer sheath and is formed of a flexible elongate tubular member having proximal and distal extremities. The distal extremity has a sharpened tip. The inner sheath has a length so that when the sharpened tip is disposed distally of the distal extremity of the outer sheath, the proximal extremity extends proximally of the proximal extremity of the outer sheath. An imaging guide wire is slidably mounted in the lumen of the inner sheath and has proximal and distal extremities. A transducer is mounted on the distal extremity of the imaging guide wire. The he imaging guide wire has a length so that the transducer can extend beyond the distal extremity of the inner sheath with the proximal extremity extending proximally of the proximal extremity of the inner sheath.
摘要翻译：用于跨越在容器壁形成的容器中形成完全闭塞的狭窄的再通设备，所述狭窄具有在近端方向上呈凸形的远端帽。该装置包括由具有近端和远端的细长柔性管状构件形成的外护套，并且具有从近端延伸到远端的内腔。内护套可滑动地安装在外护套的内腔中并且由具有近端和远端的柔性细长管状构件形成。远端具有尖锐的尖端。内护套具有长度，使得当锋利的尖端远离外护套的远端设置时，近端延伸到外鞘近端处的近侧。成像引导线可滑动地安装在内护套的内腔中并且具有近端和远端。传感器安装在成像导丝的远端上。成像引导线具有长度，使得换能器可以延伸超出内护套的远端，近端延伸到内鞘的近端的近端处。

77. 发明授权

US5833650A Catheter apparatus and method for treating occluded vessels 失效
标题翻译：用于治疗闭塞血管的导管装置和方法
公开(公告)号：US5833650A
公开(公告)日：1998-11-10
申请号：US464579
申请日：1995-06-05
申请人： Mir A. Imran
发明人： Mir A. Imran
IPC分类号： A61F2/958 , A61M29/00
CPC分类号： A61M25/1011 , A61B2017/320716 , A61M2025/1045
摘要： A catheter assembly for treatment of a stenosis in a lumen in a blood-carrying vessel comprising a first flexible elongate tubular member having proximal and distal extremities. A first inflatable balloon is coaxially mounted on the distal extremity of the first flexible elongate tubular member and has a main lumen and an aspiration lumen exiting through the distal extremity. A second flexible elongate tubular member has proximal and distal extremities and has a second inflatable balloon coaxially mounted on the distal extremity and has a blood perfusion lumen extending therethrough. The second flexible elongate tubular member is slidably mounted in the main lumen of the first flexible elongate tubular member. The first balloon is positioned so that it is adjacent to but proximal of the stenosis and is thereafter inflated to create a first occlusion in the lumen in the vessel. A negative pressure is created in the lumen in the vessel distal of the first balloon through the aspiration lumen. The second balloon is positioned distal of the stenosis and is inflated to create a second occlusion in the lumen of the vessel to form a working space between the first and second balloons which brackets the stenosis. Blood is perfused through the blood perfusion lumen distal of the second occlusion. A therapeutic procedure is performed in the working space.
摘要翻译：一种用于治疗血液携带血管内腔的狭窄的导管组件，包括具有近端和远端的第一柔性细长管状构件。第一可膨胀气囊同轴地安装在第一柔性细长管状构件的远端上，并且具有通过远端远离的主腔和抽吸腔。第二柔性细长管状构件具有近端和远端，并且具有同轴地安装在远端上的第二可膨胀气囊，并且具有延伸穿过其中的血液灌注腔。第二柔性细长管状构件可滑动地安装在第一柔性细长管状构件的主腔内。将第一气囊定位成使得其与狭窄相邻但邻近，然后充气以在容器的内腔中产生第一闭塞。通过抽吸腔在第一球囊远端的血管腔中产生负压。第二球囊位于狭窄的远端并且被充气以在血管的内腔中产生第二闭塞，以形成第一和第二气囊之间的工作空间，其支撑狭窄。血液通过第二次闭塞远端的血液灌注腔灌注。在工作空间中执行治疗程序。

78. 发明授权

US5813997A Guide wire with deflectable tip and method 失效
公开(公告)号：US5813997A
公开(公告)日：1998-09-29
申请号：US690749
申请日：1996-08-01
申请人： Mir A. Imran , Deepak R. Gandhi , Henry Bourang , Dignah B. Quiachon , Andrew Y. Chow
发明人： Mir A. Imran , Deepak R. Gandhi , Henry Bourang , Dignah B. Quiachon , Andrew Y. Chow
IPC分类号： A61M25/00 , A61M25/01 , A61M25/09 , H04L7/00 , A61B5/00
CPC分类号： A61M25/0144 , A61M25/0158 , A61M25/09 , H04L7/0008 , A61M2025/0063 , A61M2025/0915 , A61M25/0054
摘要： Guide wire for use in a medical procedure and for use with the power supply comprising a flexible elongate tubular member having proximal and distal extremities and having a bore extending from the proximal extremity to the distal extremity. A core wire extends through the bore of the flexible elongate tubular member. A coil assembly is mounted on the distal extremity of the flexible elongate member and has a distal extremity. A rounded tip is formed on the distal extremity. An actuator member has at least a portion thereof disposed in the coil assembly and has proximal and distal extremities. The proximal extremity of the actuator member is secured to the distal extremity of the flexible elongate tubular member. The distal extremity of the actuator member is secured to the rounded tip. The actuator member has a portion thereof formed of a shape memory material and incorporating a shape member therein. A heater is disposed in the vicinity of said portion of the actuator member for heating said portion to cause it to assume the predetermined shape memory. Electrical conductors are connected to the heater and extending to the proximal extremity of the flexible elongate tubular member and are adapted to be connected to the power supply to supply energy to the heater.

79. 发明授权

US5779688A Low profile balloon-on-a-wire catheter with shapeable and/or deflectable tip and method 失效
标题翻译：薄型气球在线导管，具有可塑和/或可偏转的尖端和方法
公开(公告)号：US5779688A
公开(公告)日：1998-07-14
申请号：US504927
申请日：1995-07-20
申请人： Mir A. Imran , Cecily M. Hillsman , Deepak R. Gandhi , Dennis L. Brooks
发明人： Mir A. Imran , Cecily M. Hillsman , Deepak R. Gandhi , Dennis L. Brooks
IPC分类号： A61M25/00 , A61M25/01 , A61M29/02
CPC分类号： A61M25/0158 , A61M25/0097 , A61M25/104 , A61M2025/0186 , A61M2025/1079 , A61M2025/1093
摘要： A low profile, balloon-on-a-wire catheter comprising a flexible elongate tubular member having proximal and distal extremities. A balloon inflation-deflation lumen extends from the proximal extremity to the distal extremity. An inflatable balloon is carried by the distal extremity of the flexible elongate tubular member. The flexible elongate tubular member carries means which establishes communication between the lumen and the interior of the inflatable balloon. A removable inflation device is removably secured to the proximal extremity of the flexible elongate tubular member for supplying an inflation fluid to the lumen for inflating and deflating the balloon. The removable inflation device forms a high pressure seal with the proximal extremity of the flexible elongate tubular member. The removable inflation device is free of obstructions so that another balloon catheter can be advanced over the proximal extremity of the flexible elongate tubular member which serves as a stand-alone guide wire. The distal extremity of the catheter is formed so that it is mechanically shapeable or can be electrically deflectable to facilitate steering of the distal extremity.
摘要翻译：一种薄型气球在线导管，其包括具有近端和远端的柔性细长管状构件。气球充气 - 通气腔从近端延伸到远端。可膨胀气囊由柔性细长管状构件的远端承载。柔性细长管状构件承载建立管腔和可充气气囊内部之间的连通的装置。可移除的充气装置可移除地固定到柔性细长管状构件的近端，用于向腔内供应充气流体以使气囊膨胀和放气。可移除的充气装置与柔性细长管状构件的近端形成高压密封。可移除的充气装置没有障碍物，使得另一个气囊导管可以在用作独立导丝的柔性细长管状构件的近端上前进。导管的远端被形成为使得其可机械地成形或可以电可偏转以便于远端的转向。

80. 发明授权

US5766203A Sheath with expandable distal extremity and balloon catheters and stents for use therewith and method 失效
标题翻译：具有可扩展的远端末端和气囊导管和与其一起使用的支架的护套和方法
公开(公告)号：US5766203A
公开(公告)日：1998-06-16
申请号：US728769
申请日：1996-10-10
申请人： Mir A. Imran , Deepak R. Gandhi , Anant V. Hegde , Gholam-Reza Zadno-Azizi
发明人： Mir A. Imran , Deepak R. Gandhi , Anant V. Hegde , Gholam-Reza Zadno-Azizi
IPC分类号： A61F2/06 , A61F2/84 , A61M25/00 , A61M25/06 , A61M29/00
CPC分类号： A61F2/958 , A61M2025/0063 , A61M2025/1086 , A61M25/005 , A61M25/0053 , A61M25/0668
摘要： A sheath for advancement into a vessel of a patient having a stenosis therein which at least partially occludes the flow of blood in the vessel. A flexible elongate tubular member has proximal and distal extremities with a lumen extending from the proximal extremity to the distal extremity. A portion of the distal extremity of the flexible elongate tubular member is radially expandable. The expandable portion carries stiffening elements that impart pushability and column strength to the expandable portion.
摘要翻译：用于进入其中具有狭窄的患者的血管的护套，其至少部分地封闭血管中的血液流。柔性细长管状构件具有近端和远端，其末端具有从近端延伸到远端的内腔。柔性细长管状构件的远端的一部分是可径向扩张的。可膨胀部分承载加强元件，其赋予可膨胀部分的推压性和柱强度。

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