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71. 发明申请

US20100029772A1 Dicarboxylic Acid Derivatives and their Use 失效
标题翻译：二羧酸衍生物及其用途
公开(公告)号：US20100029772A1
公开(公告)日：2010-02-04
申请号：US12083814
申请日：2006-10-17
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr , Dieter Lang
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr , Dieter Lang
IPC分类号： A61K31/194 , C07C63/331
CPC分类号： C07C65/28
摘要： The present application relates to novel dicarboxylic acid derivatives, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译：本申请涉及新型二羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病，特别是用于治疗和/或预防疾病的药物的用途。预防心血管疾病。

72. 发明申请

US20090181996A1 SUBSTITUTED QUINOLONES III 有权
标题翻译：取代喹诺酮III
公开(公告)号：US20090181996A1
公开(公告)日：2009-07-16
申请号：US12188940
申请日：2008-08-08
申请人： Chantal Fuerstner , Kai Thede , Holger Zimmermann , David Brueckner , Kerstin Henninger , Dieter Lang , Rudolf Schohe-Loop
发明人： Chantal Fuerstner , Kai Thede , Holger Zimmermann , David Brueckner , Kerstin Henninger , Dieter Lang , Rudolf Schohe-Loop
IPC分类号： A61K31/4709 , C07D401/10 , C07D471/10 , C07D498/10 , C07D401/14 , A61P31/12
CPC分类号： C07D401/04 , C07D401/14 , C07D471/10
摘要： The invention relates to substituted quinolones and to methods for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译：本发明涉及取代的喹诺酮类及其制备方法，以及它们用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。

73. 发明申请

US20090023717A1 MORPHINE-BRIDGED INDAZOLE DERIVATIVES 审中-公开
标题翻译：吗啡桥联吲哚衍生物
公开(公告)号：US20090023717A1
公开(公告)日：2009-01-22
申请号：US12233138
申请日：2008-09-18
申请人： Achim Feurer , Joachim Luithle , Stephan-Nicholas Wirtz , Gerhard Konig , Johannes-Peter Stasch , Frank Wunder , Dieter Lang , Elke Stahl , Thomas Schenke , Rudy Schreiber
发明人： Achim Feurer , Joachim Luithle , Stephan-Nicholas Wirtz , Gerhard Konig , Johannes-Peter Stasch , Frank Wunder , Dieter Lang , Elke Stahl , Thomas Schenke , Rudy Schreiber
IPC分类号： A61K31/5386 , A61P25/00
CPC分类号： C07D471/04
摘要： The present invention relates to novel morpholine-bridged indazole derivatives which stimulate soluble guanylate cyclase, to process for the preparation thereof, and to the use thereof for producing medicaments, in particular medicaments for the treatment of disorders of the central nervous system.
摘要翻译：本发明涉及刺激可溶性鸟苷酸环化酶的新型吗啉桥连吲唑衍生物，其制备方法及其用于制备药物，特别是用于治疗中枢神经系统疾病的药物的用途。

74. 发明申请

US20080269268A1 Substituted Phenylamino-Pyrimidines 有权
标题翻译：取代苯基氨基 - 嘧啶
公开(公告)号：US20080269268A1
公开(公告)日：2008-10-30
申请号：US11587630
申请日：2005-04-14
申请人： Hartmut Schirok , Johannes-Peter Stasch , Raimund Kast , Klaus Munter , Mark Jean Gnoth , Santiago Figureoa Perez , Michael Thutewohl , Samir Bennabi , Dieter Lang , Joachim Mittendorf , Martin Radtke , Heimo Ehmke
发明人： Hartmut Schirok , Johannes-Peter Stasch , Raimund Kast , Klaus Munter , Mark Jean Gnoth , Santiago Figureoa Perez , Michael Thutewohl , Samir Bennabi , Dieter Lang , Joachim Mittendorf , Martin Radtke , Heimo Ehmke
IPC分类号： A61K31/506 , C07D401/14 , A61P9/00 , A61P15/00
CPC分类号： C07D471/04
摘要： The invention relates to substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译：本发明涉及取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。

75. 发明申请

US20080249105A1 Pyrrolopyridine-Substituted Benzol Derivatives for Treating Cardiovascular Diseases 审中-公开
标题翻译：用于治疗心血管疾病的吡咯并吡啶取代的苯衍生物
公开(公告)号：US20080249105A1
公开(公告)日：2008-10-09
申请号：US10582184
申请日：2004-11-26
申请人： Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Minter , Dieter Lang , Santiago Figueroa Perez , Marcus Bauser , Achim Feurer , Heimo Ehmke
发明人： Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Minter , Dieter Lang , Santiago Figueroa Perez , Marcus Bauser , Achim Feurer , Heimo Ehmke
IPC分类号： A61K31/496 , C07D471/02 , A61K31/437 , A61P15/10 , A61P9/00 , C07D401/14
CPC分类号： C07D471/04
摘要： The invention relates to heteroaryl-substituted benzenes, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译：本发明涉及杂芳基取代的苯，涉及其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。

76. 发明申请

US20080132515A1 Substituted Azaquinazolines Having an Antiviral Action 有权
标题翻译：具有抗病毒作用的取代的氮杂喹啉
公开(公告)号：US20080132515A1
公开(公告)日：2008-06-05
申请号：US11579919
申请日：2005-04-23
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Frank Sussmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Frank Sussmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/04
摘要： This invention relates to substituted azaquinazolines, to a process for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.
摘要翻译：本发明涉及取代的氮杂喹唑啉，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的疾病。

77. 发明授权

US06955579B2 Monolithic seal for a sapphire metal halide lamp 有权
标题翻译：蓝宝石金属卤化物灯的单片密封
公开(公告)号：US06955579B2
公开(公告)日：2005-10-18
申请号：US10805372
申请日：2004-03-19
申请人： Arlene Hecker , George C. Wei , Helmar G. Adler , Dieter Lang
发明人： Arlene Hecker , George C. Wei , Helmar G. Adler , Dieter Lang
IPC分类号： H01J61/18 , C04B35/10 , H01J9/24 , H01J9/26 , H01J61/30 , H01J61/36 , H01J9/00
CPC分类号： H01J9/266 , H01J9/247 , H01J61/302 , H01J61/363
摘要： A method of producing a ceramic metal halide discharge lamp having a monolithic seal between a sapphire (single crystal alumina) arc tube and a polycrystalline alumina (PCA) end cap. The method includes the steps of providing an arc tube of fully dense sapphire and providing an end cap made of unsintered compressed polycrystalline alumina powder doped with magnesium oxide and yttrium oxide. The end cap is heated until it is presintered to remove organic binder material at a low temperature relative to the sintering temperature. The presintered end cap is placed on an end portion of the arc tube to form a close interface between the two. The presintered end cap and adjacent arc tube are then heated to until the end cap is fully sintered onto the arc tube and the sapphire tube grows into the end cap. A monolithic seal is formed along the interface between the end cap and the arc tube as the sapphire tube grows into the polycrystalline alumina end cap. The yttrium oxide promotes increased growth between sapphire tube and the PCA end cap and is not detrimental to the metal halide chemistry, nor subject to erosion by the metal halide chemistry.
摘要翻译：一种在蓝宝石（单晶氧化铝）电弧管和多晶氧化铝（PCA）端盖之间具有整体式密封的陶瓷金属卤化物放电灯的制造方法。该方法包括提供完全致密的蓝宝石的电弧管并提供由掺杂有氧化镁和氧化钇的未烧结压缩多晶氧化铝粉末制成的端盖的步骤。将端盖加热至预烧结，以相对于烧结温度在低温下除去有机粘合剂材料。预烧结端盖放置在电弧管的端部上，以在两者之间形成紧密的界面。然后将预烧结端盖和相邻的电弧管加热直到端盖完全烧结到电弧管上，并且蓝宝石管生长到端盖中。当蓝宝石管生长成多晶氧化铝端盖时，沿着端盖和电弧管之间的界面形成整体密封。氧化钇促进蓝宝石管和PCA端盖之间的增长，并且不会对金属卤化物化学产生不利影响，也不会被金属卤化物化学物质侵蚀。

78. 发明授权

US06919345B2 Sulfonate substituted pyrazol pyridine derivatives 失效
标题翻译：磺酸取代的吡唑吡啶衍生物
公开(公告)号：US06919345B2
公开(公告)日：2005-07-19
申请号：US10477446
申请日：2002-04-30
申请人： Johannes-Peter Stasch , Achim Feurer , Stefan Weigand , Elke Stahl , Dietmar Flubacher , Cristina Alonso-Alija , Frank Wunder , Dieter Lang , Klaus Dembowsky , Alexander Straub , Elisabeth Perzborn
发明人： Johannes-Peter Stasch , Achim Feurer , Stefan Weigand , Elke Stahl , Dietmar Flubacher , Cristina Alonso-Alija , Frank Wunder , Dieter Lang , Klaus Dembowsky , Alexander Straub , Elisabeth Perzborn
IPC分类号： A61K31/506 , A61K45/00 , A61P9/00 , A61P9/10 , A61P9/12 , A61P15/10 , A61P25/00 , A61P29/00 , C07D471/04 , A71K31/4162
CPC分类号： C07D471/04
摘要： This invention relates to pyrazol pyridine derivatives of formula (I) wherein R1 is a radical of the formula −O—SO2—R3 in which R3 is optionally substituted C1—6—alkyl, optionally substituted C3—8—cycloalkyl, or optionally substituted phenyl; R2 is H, optionally substituted C1—6—alkyl —CO—or optionally substituted C1—6—alkyl—SO2— ; as well as salts, stereoisomers, tautomers, and hydrates thereof. Pharmaceutical compositions containing these materials and methods of using them in medical treatment are also described and claimed.
摘要翻译：本发明涉及式（I）的吡唑吡啶衍生物，其中R 1是式-O-SO 2 -R 3的基团，其中R 3是任选取代的C 1-6 - 烷基，任选取代的C 3-8 - 环烷基或任选取代的苯基; R 2是H，任选取代的C 1-6 - 烷基-CO-或任选取代的C 1-6 - 烷基-SSO > 2 - ; 以及其盐，立体异构体，互变异构体及其水合物。还描述和要求保护含有这些材料的药物组合物及其在医疗中的使用方法。

79. 发明授权

US09040691B2 Hydroxymethylaryl-substituted pyrrolotriazines as ALK1 inhibitors 有权
标题翻译：羟甲基芳基取代的吡咯并三嗪作为ALK1抑制剂
公开(公告)号：US09040691B2
公开(公告)日：2015-05-26
申请号：US14130586
申请日：2012-06-26
申请人： Jürgen Klar , Verena Vöhringer , Joachim Telser , Mario Lobell , Frank Süβmeier , Volkhart Min-Jian Li , Michael Böttger , Stefan Golz , Dieter Lang , Karl-Heinz Schlemmer , Thomas Schlange , Andreas Schall , Wenlang Fu
发明人： Jürgen Klar , Verena Vöhringer , Joachim Telser , Mario Lobell , Frank Süβmeier , Volkhart Min-Jian Li , Michael Böttger , Stefan Golz , Dieter Lang , Karl-Heinz Schlemmer , Thomas Schlange , Andreas Schall , Wenlang Fu
IPC分类号： C07D487/04 , C07D401/04 , A61K31/53 , A61K31/4427 , A61P25/02 , A61P27/02 , A61K31/5377
CPC分类号： A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
摘要： This invention relates to novel 5-[(hydroxymethyl)aryl]-substituted pyrrolo[2,1-f][1,2,4]triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.
摘要翻译：本发明涉及式（I）的新的5 - [（羟甲基）芳基] - 取代的吡咯并[2,1-f] [1,2,4]三嗪-4-胺，用于制备这些化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用于治疗血管生成相关病症，特别是血管发生相关性眼部疾病的用途。

80. 发明申请

US20140228366A1 HETEROARYL-SUBSTITUTED PYRAZOLOPYRIDINES AND USE THEREOF AS SOLUBLE GUANYLATE CYCLASE STIMULATORS 审中-公开
标题翻译：异氟醚取代的吡唑啉酮及其作为可溶性葡萄糖循环刺激物的用途
公开(公告)号：US20140228366A1
公开(公告)日：2014-08-14
申请号：US14131017
申请日：2012-07-05
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder
IPC分类号： C07D471/04 , A61K31/519 , A61K31/53
CPC分类号： C07D471/04 , A61K31/519 , A61K31/53 , C07D519/00
摘要： The present application relates to novel heteroaryl-substituted pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译：本申请涉及新的杂芳基取代的吡唑并吡啶，其制备方法，单独使用或组合用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。

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