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71. 发明申请

US20130010925A1 X-RAY IMAGING APPARATUS HAVING VIBRATION STABILISING MEANS, AND METHOD FOR OPERATING SUCH AN X-RAY IMAGING APPARATUS 有权
标题翻译：具有振动稳定装置的X射线成像装置以及操作这种X射线成像装置的方法
公开(公告)号：US20130010925A1
公开(公告)日：2013-01-10
申请号：US13481083
申请日：2012-05-25
申请人： Carlos MARTINEZ FERREIRA , Omar AL ASSAD
发明人： Carlos MARTINEZ FERREIRA , Omar AL ASSAD
IPC分类号： G01N23/04
CPC分类号： A61B6/4441 , A61B6/4476 , A61B6/504 , A61B6/547
摘要： An X-ray imaging apparatus is provided. The X-ray imaging apparatus comprises an imaging assembly mounted on a rotary arm, the imaging assembly comprising an X-ray source and an X-ray detector coupled to the rotary arm so that X-rays emitted by the X-ray source are incidental to the X-ray detector. The X-ray imaging apparatus further comprises a first vibration measurement device coupled to the X-ray source and a second vibration measurement device coupled to the X-ray detector, and a first actuator and a second actuator configured to move the X-ray source and the X-ray detector to suppress'at least one component of the vibrations measured by the first and second vibration measurement devices.
摘要翻译：提供了一种X射线成像装置。 X射线成像装置包括安装在旋转臂上的成像组件，成像组件包括X射线源和耦合到旋转臂的X射线检测器，使得由X射线源发射的X射线是偶然的到X射线检测器。 X射线成像装置还包括耦合到X射线源的第一振动测量装置和耦合到X射线检测器的第二振动测量装置，以及第一致动器和第二致动器，其被配置成将X射线源和X射线检测器，以抑制由第一和第二振动测量装置测量的振动的至少一个分量。

72. 发明申请

US20120057324A1 VARIABLE-SPECTRUM SOLAR SIMULATOR 有权
标题翻译：可变光谱太阳能模拟器
公开(公告)号：US20120057324A1
公开(公告)日：2012-03-08
申请号：US13257465
申请日：2010-03-26
申请人： Juan Carlos Martinez Antón
发明人： Juan Carlos Martinez Antón
IPC分类号： F21V9/02 , F21V13/00
CPC分类号： G01J1/08 , F21S8/006 , G01J1/0488 , G01J2003/1213 , G01J2003/1282
摘要： The invention relates to a variable-spectrum solar simulator for characterising photovoltaic systems. The simulator can be used to obtain a spectrum adjusted to the solar spectrum, both for a standard spectrum or a real spectrum adjusted to local irradiation conditions. The simulator also allows the spatial-angular characteristics of the sun to be reproduced. The invention comprises: a broad-spectrum light source, the flux from which is emitted through an aperture; an optical system which collimates the primary source; a system which disperses the beam chromatically; an optical system which forms an image of the dispersed primary source at a given position, at which a spatial mask is placed in order to filter the received irradiance spectrally; an optical system which captures the filtered spectrum and returns, mixes and concentrates same in a secondary source with the desired spectral, angular, and spatial characteristics; an optical system which collimates the secondary source such that it reproduces the angular characteristics of the sun; and a control system.
摘要翻译：本发明涉及用于表征光伏系统的可变光谱太阳模拟器。可以使用模拟器来获得调整到太阳光谱的光谱，无论是对于调整到局部照射条件的标准光谱或实际光谱。模拟器还允许重现太阳的空间角特性。本发明包括：广谱光源，通过孔径射出的光通量; 准直主源的光学系统; 色散分散光束的系统; 光学系统，其在给定位置处形成分散的初级源的图像，在该位置放置空间掩模以频谱地滤除接收的辐照度; 捕获滤波光谱并返回，混合并集中在具有期望光谱，角度和空间特性的次级光源中的光学系统; 准直次级光源的光学系统，使其再现太阳的角度特性; 和控制系统。

73. 发明申请

US20110081292A1 Methods Of Treating Viral Hepatitis 审中-公开
标题翻译：治疗病毒性肝炎的方法
公开(公告)号：US20110081292A1
公开(公告)日：2011-04-07
申请号：US12944432
申请日：2010-11-11
申请人： Francisco Sanchez-Madrid , Carlos-Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gómez
发明人： Francisco Sanchez-Madrid , Carlos-Martinez Alonso , David Sancho Madrid , Pablo Engel Rocamora , Enric Esplugues Artola , Javier Vega Ramos , Pilar Lauzurica Gómez
IPC分类号： A61K51/10 , A61K39/395 , A61P31/14
CPC分类号： C07K16/2851 , A61K2039/505 , C07K2317/76
摘要： Disclosed are methods of treating viral hepatitis including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antibodies specific to the early activation molecules, and methods of use, are also disclosed.
摘要翻译：公开了治疗病毒性肝炎的方法，包括向受试者施用有效量的早期活化分子激动剂，拮抗剂或deputor。还公开了对早期活化分子特异性的人单克隆抗体及其使用方法。

74. 发明申请

US20100227317A1 Method for the Molecular Diagnosis of Prostate Cancer and Kit for Implementing Same 审中-公开
标题翻译：前列腺癌分子诊断方法及其实施方法
公开(公告)号：US20100227317A1
公开(公告)日：2010-09-09
申请号：US12224061
申请日：2007-02-15
申请人： Timothy Thomson Okatsu , Raquel Bermudo Gascon , Angel Ramirez Ortiz , David Abia , Carlos Martinez Alonso , Pedro Luis Fernandez Ruiz , Berta Ferrer Fabrega , Elias Campo Guerri , Elisabet Rosell Vives
发明人： Timothy Thomson Okatsu , Raquel Bermudo Gascon , Angel Ramirez Ortiz , David Abia , Carlos Martinez Alonso , Pedro Luis Fernandez Ruiz , Berta Ferrer Fabrega , Elias Campo Guerri , Elisabet Rosell Vives
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2600/158 , Y02A90/26
摘要： The invention relates to a method for the molecular diagnosis of prostate cancer, comprising the in vitro analysis of the overexpression or underexpression of combinations of genes that can distinguish, with high statistical significance, tumorous prostate samples from non-tumorous prostate samples. The invention also relates to a kit for the molecular diagnosis of prostate cancer, which can perform the above-mentioned detection.
摘要翻译：本发明涉及用于分子诊断前列腺癌的方法，其包括能够以高统计学意义区分来自非肿瘤前列腺样品的肿瘤前列腺样品的基因组合的过表达或低表达的体外分析。本发明还涉及可以进行上述检测的用于前列腺癌分子诊断的试剂盒。

75. 发明授权

US07226191B1 Lighted handgrip assembly 失效
标题翻译：照明手柄装配
公开(公告)号：US07226191B1
公开(公告)日：2007-06-05
申请号：US11076777
申请日：2005-03-10
申请人： Carlos Martinez
发明人： Carlos Martinez
IPC分类号： F21V21/08
CPC分类号： F21V33/006 , B60N3/026 , B60Q1/2669 , B60Q1/323 , E04F2011/1872 , F21S9/02
摘要： A lighted handgrip assembly has a hand grip housing with the lighting system mounted therein, in order to indicate the location thereof. The handgrip housing includes an inner metal tube and outer plastic tube, which are supported in end caps, one end cap secured to each end of the tube.
摘要翻译：点亮的手柄组件具有安装在其中的照明系统的手柄壳体，以便指示其位置。手柄外壳包括内金属管和外塑料管，它们被支撑在端盖中，一个端盖固定在管的每一端。

76. 发明申请

US20050221287A1 Functional inactivation of cxcr4-mediated responses in growth hormone transgenic mice through socs53 upregulation 审中-公开
公开(公告)号：US20050221287A1
公开(公告)日：2005-10-06
申请号：US10500558
申请日：2002-12-31
申请人： Carlos Martinez-Alonzo , Mario Mellado , Jose Rodrigues-Frade
发明人： Carlos Martinez-Alonzo , Mario Mellado , Jose Rodrigues-Frade
IPC分类号： G01N33/50 , A01K67/027 , A61K38/00 , A61K45/00 , A61P1/04 , A61P1/16 , A61P7/00 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P31/18 , A61P37/08 , A61P43/00 , C12N15/09 , C12Q1/02 , C12Q1/70 , G01N33/15 , G01N33/569 , G01N33/68 , G01N33/74
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A61K38/00 , G01N33/56988 , G01N33/6863 , G01N33/74 , G01N2333/16 , G01N2500/10
摘要： A method is provided of identifying compounds for use in a pharmaceutical composition having an anti-viral effect against CXCR4-dependent HIV activity comprising: providing a first aliquot of CXCR-4-expressing GH-Tg cells; contacting said first aliquot with HIV particles; providing a second aliquot of CXCR4-expressing GH-Tg cells; contacting said second aliquot with a test ligand; contacting said second aliquot with HIV particles; and isolating virus from said first and said second aliquot of cells, wherein a decrease in the ability to isolate virus from said second aliquot cells indicates said test ligand possess anti-viral activity against HIV. Also provided is a method of identifying compounds for use in a pharmaceutical composition having a therapeutic effect against a disease involving CXCR4-dependent chemotaxis comprising providing a first aliquot CXCR4-expressing GH-Tg cells; contacting said first aliquot with CXCL12; measuring a first migration indes; providing a second aliquot of CXCR4-expressing GH-Tg cells; contacting said second aliquot with CXCL12; contacting said second aliquot with a test ligand; measuring a second migration index; and determing a therapeutic potential. In addition, compounds for us in a pharmaceutical composition having a therapeutic effect against a SOCS3 inhibitable disease are identified by a method comprising: providing a first cell having at least one chemokine receptor expressed thereon, said first cell having been transfected with at least one SOCS construct; contacting said first cell with at least one chemokine, measuring a first migration index; providing a second cell having at least one chemokine receptor expressed thereon, said second cell having been transfected with at least one SOCS construct; contacting said second cell with at least one chemokine; measuring a second migration index; and determining a therapeutic potential subjects having a disease associated with CXCR4-dependent HIV are treated by administering to said subject a therapeutically anti-viral effective amount of a compound that induces the expression of SOCS3 and a pharmaceutically acceptable carrier.

77. 发明申请

US20050192441A1 Methods for the preparation of stereoisomerically enriched amines 审中-公开
标题翻译：制备立体异构体富集的胺的方法
公开(公告)号：US20050192441A1
公开(公告)日：2005-09-01
申请号：US11003830
申请日：2004-12-03
申请人： Shanghui Hu , Carlos Martinez , Junhua Tao , Daniel Yazbeck
发明人： Shanghui Hu , Carlos Martinez , Junhua Tao , Daniel Yazbeck
IPC分类号： C07C269/06 , C07C269/08 , C07C271/22 , C07D207/16 , C07D207/24 , C07D277/18 , C07D417/02 , C12P13/04 , C12P13/24 , C12P17/10 , C12P17/14 , C12P41/00
CPC分类号： C07C269/06 , C07C269/08 , C07D207/16 , C12P13/04 , C12P13/24 , C12P17/10 , C12P17/14 , C12P41/005 , C07C271/22
摘要： The present invention relates to methods of preparing a stereoisomerically enriched compound of formula (I), wherein R6 is hydrogen, comprising treating a compound of formula (I), wherein R6 is chosen from C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, —(CR7R8)t(C6-C14 aryl), and —(CR7R8)t(4-10 membered heterocyclic), and wherein said C6-C14 aryl and 4-10 membered heterocyclic are optionally substituted with at least one substituent chosen from halo, C1-C10 alkyl, —OR7, and —N(R7R8), with a biocatalyst in an aqueous solution, an organic solvent, or a mixture of organic and aqueous solvents wherein at least one stereoisomer is selectively hydrolyzed.
摘要翻译：本发明涉及制备其中R 6为氢的式（I）化合物的立体异构体富集化合物的方法，其包括处理式（I）化合物，其中R 6 = >选自C 1 -C 10烷基，C 2 -C 10链烯基，C 1 -C 10烷基，C 1 -C 10烷基， C 1 -C 12烷基，（C 1 -C 10）烷基，（C 1 -C 10）烷基，（C 6 -C 14芳基），和 - （CR 7 R 8） 4-10元杂环），并且其中所述C 6 -C 14 - 芳基和4-10元杂环任选被至少一个选自卤素， C 1 -C 10烷基，-OR 7和-N（R 7 R 8） SUP>），在水溶液中的生物催化剂，有机溶剂或有机和水性溶剂的混合物，其中至少一种立体异构体被选择性水解。

78. 发明申请

US20050033481A1 Real-time performance monitoring and management system 有权
标题翻译：实时性能监控与管理系统
公开(公告)号：US20050033481A1
公开(公告)日：2005-02-10
申请号：US10914789
申请日：2004-08-09
申请人： Vikram Budhraja , James Dyer , Carlos Martinez Morales
发明人： Vikram Budhraja , James Dyer , Carlos Martinez Morales
IPC分类号： G06F20060101 , H02J3/00 , H02J13/00
CPC分类号： G01R21/133 , H02J3/008 , H02J13/001 , H02J13/0093 , H02J2003/003 , H02J2003/007 , Y02E60/74 , Y02E60/76 , Y04S10/30 , Y04S10/40 , Y04S10/54 , Y04S40/22 , Y04S50/10
摘要： A real-time performance monitoring system for monitoring an electric power grid. The electric power grid has a plurality of grid portions, each grid portion corresponding to one of a plurality of control areas. The real-time performance monitoring system includes a monitor computer for monitoring at least one of reliability metrics, generation metrics, transmission metrics, suppliers metrics, grid infrastructure security metrics, and markets metrics for the electric power grid. The data for metrics being monitored by the monitor computer are stored in a data base, and a visualization of the metrics is displayed on at least one display computer having a monitor. The at least one display computer in one said control area enables an operator to monitor the grid portion corresponding to a different said control area.
摘要翻译：一种用于监控电网的实时性能监测系统。电网具有多个格栅部分，每个格栅部分对应于多个控制区域中的一个。实时性能监测系统包括一台监控计算机，用于监测电网的可靠性度量，发电量度，传输指标，供应商指标，电网基础设施安全指标和市场指标中的至少一个。由监视器计算机监控的度量的数据被存储在数据库中，并且在具有监视器的至少一个显示计算机上显示度量的可视化。一个所述控制区域中的至少一个显示计算机使得操作者能够监视对应于不同所述控制区域的网格部分。

79. 发明授权

US06780644B1 Use of beta recombinase in eukaryotic cells, especially for transgenic work 失效
标题翻译：在真核细胞中使用β重组酶，特别是转基因作物
公开(公告)号：US06780644B1
公开(公告)日：2004-08-24
申请号：US09158272
申请日：1998-09-22
申请人： Vincente Días , Fernando Rojo , Carlos Martinez Alonso , Juan C. Alonso , Antonio Bernad
发明人： Vincente Días , Fernando Rojo , Carlos Martinez Alonso , Juan C. Alonso , Antonio Bernad
IPC分类号： C12N1563
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2217/075 , A61K48/00 , C12N15/87 , C12N15/90 , C12N15/907
摘要： The invention relates to the use of prokaryotic beta recombinase in eukaryotic cells, especially for transgenic work in eukaryotic cells. It also relates to the use of prokaryotic beta recombinase for site-specific intramolecular recombination between two six sites in eukaryotic cells. The use of the gene coding for beta recombinase for promoting the deletion of DNA sequences located between directly oriented six sites in mammalian cells and for catalysing site-specific resolution of DNA sequences in an extrachromosomal target introduced into an eukaryotic cell are also disclosed.
摘要翻译：本发明涉及在真核细胞中使用原核生物β重组酶，特别是在真核细胞中用于转基因工程。其还涉及原核生物β重组酶在真核细胞中两个六个位点之间的位点特异性分子内重组的用途。还公开了编码β重组酶的基因，用于促进位于哺乳动物细胞中直接取向的六个位点之间的DNA序列的缺失和用于催化引入真核细胞的染色体外靶中的DNA序列的位点特异性拆分。

80. 发明授权

US06298106B1 Frequency synthesiser 有权
标题翻译：频率合成器
公开(公告)号：US06298106B1
公开(公告)日：2001-10-02
申请号：US09324857
申请日：1999-06-03
申请人： José Miguel Hernandez Gamazo , Tomás Motos Lopez , Carlos Martinez Fernandez , Victor Manuel Cortijo Fernandez , Pablo Antonio Garcia Gil
发明人： José Miguel Hernandez Gamazo , Tomás Motos Lopez , Carlos Martinez Fernandez , Victor Manuel Cortijo Fernandez , Pablo Antonio Garcia Gil
IPC分类号： H03D324
CPC分类号： H03L7/18
摘要： The present invention relates to a frequency synthesizer for generating an output signal (So) the frequency of which has a non-integer, fractional relationship of value Nn/Nd, where Nn and Nd are integer numbers, with respect to a frequency (fr) of an input signal (Sr). The synthesizer is characterized in that it comprises a device for multiplying by M, where M is an integer number, the frequency of the input signal in order to produce a high frequency intermediate signal (Si), and a device for dividing the frequency of this intermediate signal by (M×Nd)/Nn in order to generate the output signal (So).
摘要翻译：频率合成器本发明涉及一种频率合成器，用于产生其频率相对于频率（fr）的频率具有值Nn / Nd的非整数分数关系（其中Nn和Nd是整数）的输出信号（So）的输入信号（Sr）。合成器的特征在于，它包括用于乘以M的装置，其中M是整数，输入信号的频率以产生高频中间信号（Si），以及用于将该频率分频的装置中间信号由（MxNd）/ Nn生成输出信号（So）。

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