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    • 71. 发明授权
      US07204350B2 Master cylinder lever for a hydraulic disc brake having favorable handle pivot geometry 有权
    • Master cylinder lever for a hydraulic disc brake having favorable handle pivot geometry
    • 用于具有良好的手柄​​枢轴几何形状的液压盘式制动器的主缸操纵杆
    • US07204350B2
    • 2007-04-17
    • US10316444
    • 2002-12-10
    • Wayne R. Lumpkin
    • Wayne R. Lumpkin
    • B62L1/06 , B62L5/20
    • B60T11/22 , B62L3/023
    • A bicycle hydraulic disc brake master cylinder includes a housing having a bar clamp at one end configured for fastening the housing to a bicycle handle bar, the bar clamp receiving the handle bar along a clamp axis. A handle is pivotably connected to the housing to pivot about a pivot axis in operative association with a piston train to impart a drive force on the piston train. The handle defines a finger receptacle receiving at least one finger of a user defining an effective force point at a select distance from a distal end of the handle. A select ideal finger actuation path for the at least one finger of a user begins at a start point at the effective finger force point with the handle at an engagement point where the handle begins to drive the piston train against operative fluid resistance and extends along a line from the start point at a select angle relative to the clamp axis. A pivotable connection is provided between the handle and the housing and is located on the housing relative to the clamp axis so that with the handle actuated by a force applied to the effective finger force point along this select ideal actuation path, a mechanical advantage to the user resulting from the handle actuation does not diminish more than three percent as the handle is pivoted between the engagement point and a fully actuated position.
    • 自行车液压盘式制动器主缸包括壳体，该壳体在一端被配置成用于将壳体紧固到自行车手柄上的杆夹，该杆夹具沿夹具轴线接收把手。 手柄可枢转地连接到壳体，以围绕枢转轴线枢转，与活塞系统可操作地相关联，以在活塞列上施加驱动力。 手柄限定了一个手指插座，其容纳用户的至少一个手指，其在距离手柄的远端的选择距离处限定有效的力点。 用户的至少一个手指的选择理想的手指致动路径从有效的手指力点的起点开始，其中手柄处于接合点处，其中手柄开始驱动活塞训练器抵抗操作的流体阻力并沿着 从起始点以相对于夹具轴的选择角度的线。 在手柄和壳体之间提供可枢转连接并且相对于夹具轴线位于壳体上，使得通过由沿着该选择的理想致动路径施加到有效手指力点的力而致动手柄的手柄， 由于手柄在接合点和完全致动位置之间枢转，所以由手柄致动产生的使用者不会减少超过3％。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
    • 72. 发明授权
      US07192781B2 Methods for stabilizing 5-azacytidine in plasma 有权
    • Methods for stabilizing 5-azacytidine in plasma
    • 稳定血浆中5-氮杂胞苷的方法
    • US07192781B2
    • 2007-03-20
    • US10823394
    • 2004-04-13
    • Marsha Luna , Larry Eden , Steven Burmaster
    • Marsha Luna , Larry Eden , Steven Burmaster
    • G01N33/00 , G01N1/18
    • G01N33/491 , Y10T436/147777 , Y10T436/17 , Y10T436/24 , Y10T436/25 , Y10T436/25375 , Y10T436/255
    • The invention provides methods for stabilizing 5-azacytidine against hydrolysis in plasma. By extracting the 5-azacytidine into acetonitrile and zinc sulfate, the 5-azacytidine can be stored for at least about 3 hours at about room temperature, and for at least about 4 days at about −70° C. If the acetonitrile is removed and evaporated to dryness, the 5-azacytidine in the resulting residue is stable for at least about 14 months at about −70° C. The invention also provides methods for determining the 5-azacytidine in acetonitrile, or in the acetonitrile residue, using, for example, high-performance liquid chromatography. The methods of the invention permit a significant time interval between the initial processing of the whole blood sample and the time of 5-azacytidine determination.
    • 本发明提供了稳定5-氮杂胞苷抗血浆中水解的方法。 通过将5-氮杂胞苷提取到乙腈和硫酸锌中，5-氮杂胞苷可以在约室温下储存至少约3小时，并在约-70℃下储存至少约4天。如果除去乙腈， 蒸发至干，所得残留物中的5-氮杂胞苷在约-70℃下稳定至少约14个月。本发明还提供了在乙腈或乙腈残留物中测定5-氮杂胞苷的方法，使用 例如，高效液相色谱。 本发明的方法允许全血样品的初始处理和5-氮杂胞苷测定时间之间的显着时间间隔。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
    • 73. 发明授权
      US07182414B2 Undercarriage equipped with non-steel type rubber crawler using chain action 有权
    • Undercarriage equipped with non-steel type rubber crawler using chain action
    • 底盘配备非钢型橡胶履带采用链条作用
    • US07182414B2
    • 2007-02-27
    • US11192841
    • 2005-07-29
    • Dong-hwa Park , Joon-il Cho
    • Dong-hwa Park , Joon-il Cho
    • B62D55/18
    • B62D55/125 , B62D55/0963 , B62D55/24
    • The present invention relates to an undercarriage equipped with a coreless rubber crawler in a chain drive configuration, and more particularly, to a track system undercarriage for a skid loader in which an auxiliary axle and an auxiliary sprocket are provided to solve the problem of load concentration at the contact points of a coreless rubber crawler, which is adopted to reduce the total load of a vehicle. A gear chain is provided surrounding a main axle and the auxiliary axle, so that the load is dispersed over a large contact area of the coreless rubber crawler, thereby relieving internal stress concentrations at the sprocket and the coreless rubber crawler, and significantly improving the life span of the coreless rubber crawler.
    • 本发明涉及一种配备有链式驱动结构的无芯橡胶履带的起落架，更具体地涉及一种用于滑动装载机的轨道系统底盘系统，其中提供辅助轴和辅助链轮以解决负载集中问题 在无芯橡胶履带的接触点处，用于减少车​​辆的总负载。 围绕主轴和辅助轴设置齿轮链，使得负载分散在无芯橡胶履带的较大接触面积上，从而减轻链轮和无芯橡胶履带处的内部应力集中，显着提高寿命 无芯橡胶履带的跨度。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
    • 74. 发明授权
      US07164219B2 Electromechanical converter 有权
    • Electromechanical converter
    • 机电转换器
    • US07164219B2
    • 2007-01-16
    • US10506393
    • 2003-02-28
    • Martin Jacobus Hoeijmakers
    • Martin Jacobus Hoeijmakers
    • H02K1/22
    • B60K6/26 , B60K6/448 , B60L11/123 , B60L11/14 , H02K16/025 , H02K51/00 , H02P2207/03 , Y02T10/6217 , Y02T10/6243 , Y02T10/641 , Y02T10/642 , Y02T10/7077
    • An electromechanical converter, in particular an electric variable transmission, is provided with a primary shaft (5) having a rotor (8) mounted thereon, a secondary shaft (7) having an interrotor (15) mounted thereon, and a stator (10), fixedly mounted to the housing (3) of the electromechanical converter. Viewed from the primary shaft (5) in radial direction, the rotor (8), the interrotor (15) and the stator (10) are arranged concentrically relative to each other. The rotor (8) and the stator (10) are designed with one or more mono- or polyphase, electrically accessible windings. The interrotor (15) forms one whole both mechanically and electromagnetically, and is arranged as a conductor for the magnetic flux in an at least tangential direction.
    • 一种机电转换器，特别是电动变速器，具有安装在其上的转子（8）的主轴（5），安装有转台（15）的次级轴（7）和定子（10） ，固定地安装到机电转换器的壳体（3）上。 从主轴（5）沿径向观察，转子（8），中间转子（15）和定子（10）相对于彼此同心设置。 转子（8）和定子（10）设计有一个或多个单相或多相电可接触的绕组。 中间转子（15）机械地和电磁地形成一个整体，并且被设置为用于至少切向方向上的磁通的导体。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
    • 79. 发明授权
      US07070937B1 Marker useful for detection and measurement of free radical damage and method 失效
    • Marker useful for detection and measurement of free radical damage and method
    • 标记用于检测和测量自由基损伤和方法
    • US07070937B1
    • 2006-07-04
    • US09820416
    • 2001-03-29
    • David Bar-Or , Edward Lau
    • David Bar-Or , Edward Lau
    • G01N33/53 , G01N33/537 , G01N33/543 , C12Q1/50
    • G01N33/6893 , G01N2800/52
    • The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presence of free radicals. These alterations effect the ability of the N-terminus of the albumin molecule to bind metals. Methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of an albumin-containing sample, analysis and measurement of the ability of albumin to bind exogenous cobalt, detection and measurement of the presence of copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following free radical damage. Also taught by the present invention is the use of the peptide Asp Ala His Lys and the compound Asp-Ala-His-Lys-R, wherein R is any chemical group capable of producing a detectable signal when a metal ion capable of binding to the N-terminus of naturally-occurring albumin is bound to the compound, for detection and quantitation of the marker. Methods of the present invention also include use of the marker as a “biochemical tag,” thereby allowing for sensitive detection and measurement of the efficacy of clinical drugs and therapeutics which result in the generation of free radicals or which act to limit free radical damage. The marker also acts as a “biological tag” of a process implicated in a wide array of diseases and conditions and, accordingly, may be used to monitor and assess such diseases and conditions. Finally, the invention provides antibodies, immunoassays, and kits for use in detecting or quantitating the marker.
    • 本发明教导了一种可用于检测和测量自由基损伤的标记物。 具体地说，本发明利用在存在自由基的情况下白蛋白分子的N末端，人血液中的循环蛋白发生的改变。 这些改变影响白蛋白分子的N-末端结合金属的能力。 用于检测和定量这种改变的方法包括评估和定量含白蛋白的样品的钴结合能力，分析和测量白蛋白结合外源钴的能力，检测和测量纯化白蛋白样品中铜的存在和使用 对自由基损伤发生的血清白蛋白改变形式特异的免疫学检测。 本发明还教导了肽Asp Ala His Lys和化合物Asp-Ala-His-Lys-R的用途，其中R是能够产生可检测信号的任何化学基团，当金属离子能够结合到 天然存在的白蛋白的N末端与化合物结合，用于检测和定量标记物。 本发明的方法还包括使用标记物作为“生物化学标签”，从而允许灵敏检测和测量导致产生自由基或用于限制自由基损伤的临床药物和治疗剂的功效。 该标记还充当涉及广泛疾病和病症的过程的“生物标签”，因此可用于监测和评估这些疾病和病症。 最后，本发明提供用于检测或定量标记物的抗体，免疫测定和试剂盒。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
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