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71. 发明授权

US08672144B2 Adsorbent filter media for removal of biological contaminants in process liquids 有权
标题翻译：用于去除工艺液体中生物污染物的吸附剂过滤介质
公开(公告)号：US08672144B2
公开(公告)日：2014-03-18
申请号：US13669494
申请日：2012-11-06
申请人： EMD Millipore Corporation
发明人： David P. Yavorsky
IPC分类号： B01D39/20 , B01J20/14
CPC分类号： B01D39/2079 , B01D2239/0407 , B01D2239/08 , B01J20/10 , B01J20/103 , B01J20/14 , B01J20/165 , B01J20/18 , B01J20/20 , B01J20/28026 , B01J20/2803
摘要： Adsorbent filter media particularly suited for removal of biological contaminants in process liquids. A porous fixed bed of adsorbent material is formed, using only a granular adsorbent and a water-insoluble thermoplastic binder. The resulting composite filter allows for a higher amount of adsorbent with smaller adsorbent particles than conventional depth filters. Elimination of cellulose fiber, as well as the elimination of the thermoset binder, results in reduced contamination of the process liquid.
摘要翻译：吸附剂过滤介质特别适用于去除工艺液体中的生物污染物。仅使用粒状吸附剂和水不溶性热塑性粘合剂形成吸附剂材料的多孔固定床。所得到的复合过滤器允许比常规深度过滤器更大量的具有较小吸附剂颗粒的吸附剂。消除纤维素纤维以及消除热固性粘合剂导致工艺液体的污染减少。

72. 发明授权

US08668673B2 Holding needle comprising gripping cheeks 有权
标题翻译：保持针包括抓握的脸颊
公开(公告)号：US08668673B2
公开(公告)日：2014-03-11
申请号：US11258478
申请日：2005-10-25
申请人： Stephane Olivier , Jerome Geyer , Gerard Muller
发明人： Stephane Olivier , Jerome Geyer , Gerard Muller
IPC分类号： A61M5/178
CPC分类号： B23P19/04 , A61B17/3417 , A61B17/3421 , A61M5/158 , A61M5/162 , A61M25/06 , A61M25/065 , A61M2005/1623 , Y10T29/49826 , Y10T29/49892 , Y10T29/49895 , Y10T29/49897 , Y10T29/49899 , Y10T29/49947
摘要： A take-off needle comprises a hollow lance having a distal end adapted to perform a insertion operation, said hollow lance being connected to at least one pipe provided with a spigot for it to be connected to a tube, and comprising a body for holding the hollow lance and pipe relative to each other such that the spigot projects from the holding body, said needle further comprising two flanges held on respective sides of and spaced from the holding body by virtue of a spacer disposed between each flange and the holding body, said flanges extending in a longitudinal direction from the spigot to the vicinity of the proximal end of the hollow lance, the width of each flange being greater than the width of the portion of the holding body facing the flanges.
摘要翻译：起飞针包括具有适于执行插入操作的远端的中空喷枪，所述中空喷枪连接到至少一个设置有插口的管子，以将其连接到管，并且包括用于保持相对于彼此的中空喷枪和管道，使得插口从保持体突出，所述针还包括两个凸缘，该两个凸缘由于设置在每个凸缘和保持体之间的间隔件而保持在保持体的相应侧并与其间隔开，所述凸缘从纵向方向延伸到中空喷枪的近端附近，每个凸缘的宽度大于保持体面对凸缘的部分的宽度。

73. 发明授权

US08552177B2 Room temperature stable agarose solutions 有权
标题翻译：室温稳定的琼脂糖溶液
公开(公告)号：US08552177B2
公开(公告)日：2013-10-08
申请号：US13221439
申请日：2011-08-30
申请人： Wilson Moya , Neil P. Soice
发明人： Wilson Moya , Neil P. Soice
IPC分类号： C08B37/02 , C08B37/00 , C07H1/00 , C07H3/00
CPC分类号： C08J3/09 , C08J2305/00 , C08L5/02 , C08L5/12 , D06M11/13 , D06M11/155 , D06M11/38 , D06M15/03 , D06M23/10 , Y10T428/24149 , Y10T428/249953 , Y10T442/20
摘要： A method for making functionalized porous crosslinked polysaccharide gel coated structures used as liquid chromatography media is provided. The method includes impregnating a porous substrate with a room temperature stable aqueous polysaccharide solution containing water, 0.1% to 20% of a polysaccharide, 18% to 54% of a gel-inhibiting agent to prevent the gel from re-gelling, and 0.001% to 10% of an anionic fluorosurfactant for optimum solution coatability onto the substrate, each concentration is by total weight of the aqueous solution. Next water is evaporated from the coating, followed by exposing the dehydrated coating to a gelling agent thereby forming a porous polysaccharide gel coated substrate. Next the gel coated substrate is exposed to a crosslinking agent forming a porous crosslinked polysaccharide gel coated substrate. Next, the gel coated substrate is functionalized by contacting the porous polysaccharide gel coated substrate with sodium 3-bromopropanesulfonate, thereby attaching sulfopropyl ligands to the gel coated substrate, resulting in a functionalized porous absorptive polysaccharide gel coated chromatography structure. When the functionalized gel coated chromatography structure is used as liquid chromatography media, and a protein (e.g. lysozyme) containing solution contacts the media, the sulfopropyl ligands attached to the gel coated chromatography structure will bond to the protein, thereby removing the protein from the protein containg solution.
摘要翻译：提供了用作液相色谱介质的功能化多孔交联多糖凝胶涂层结构的方法。该方法包括用含有水，0.1％至20％的多糖，18％至54％的凝胶抑制剂的室温稳定的水性多糖溶液浸渍多孔基材以防止凝胶重新凝胶化，并且0.001％至10％的阴离子含氟表面活性剂，用于在基材上获得最佳的溶液涂布性，每种浓度均为水溶液的总重量。接下来的水从涂层中蒸发，然后将脱水涂层暴露于胶凝剂，从而形成多孔多糖凝胶涂覆的基质。接下来，将凝胶涂覆的基底暴露于形成多孔交联多糖凝胶涂覆的基底的交联剂。接下来，通过使多孔多糖凝胶涂覆的基质与3-溴丙磺酸钠接触使凝胶涂覆的底物功能化，从而将磺丙基配体连接到凝胶涂覆的基质上，得到官能化的多孔吸收多糖凝胶涂层色谱结构。当将功能化凝胶涂层色谱结构用作液相色谱介质，并且含有蛋白质（例如溶菌酶）的溶液与培养基接触时，附着在凝胶涂层色谱结构上的磺丙基配体将与蛋白质结合，从而从蛋白质中除去蛋白质包含解决方案

74. 发明授权

US08551261B2 Module for purifying a fluid containing a cleaning agent, and methods of fabricating and using this kind of module 有权
标题翻译：用于净化含有清洁剂的流体的模块，以及制造和使用这种模块的方法
公开(公告)号：US08551261B2
公开(公告)日：2013-10-08
申请号：US13249713
申请日：2011-09-30
申请人： Yves Gaignet , Ichiro Kano
发明人： Yves Gaignet , Ichiro Kano
IPC分类号： B08B9/00
CPC分类号： B01D65/06 , A61L2/186 , A61L2202/16 , B01D29/62 , B01D61/025 , B01D61/027 , B01D61/04 , B01D61/10 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/20 , B01D65/00 , B01D65/02 , B01D65/022 , B01D2311/04 , B01D2311/16 , B01D2321/168 , B01F1/0027 , C02F1/281 , C02F1/283 , C02F1/44 , C02F1/50 , C02F5/145 , C02F2201/006 , B01D2311/12 , B01D2311/2626
摘要： Described herein is a disposable module for purifying a fluid, in particular water, adapted to form part of a fluid purification system and method of cleaning at least a portion of a fluid purification system using such a disposable module, where the method includes the steps of: (a) providing a disposable module which includes a housing containing a cleaning agent from the outset: (b) connecting the module to a purification system which is downstream of the module and starting a system cleaning procedure, thereby to clean at least a portion of the purification system.
摘要翻译：本文描述了一种用于净化适于形成流体净化系统的一部分的流体特别是水的一次性模块和使用这种一次性模块清洁至少一部分流体净化系统的方法，其中该方法包括以下步骤：（a）提供一次性模块，其包括从一开始就含有清洁剂的壳体：（b）将模块连接到在模块下游的净化系统，并开始系统清洁程序，从而清洁至少一部分的净化系统。

75. 发明授权

US08536316B2 Methods for purifying a target protein from one or more impurities in a sample 有权
标题翻译：从样品中的一种或多种杂质纯化靶蛋白的方法
公开(公告)号：US08536316B2
公开(公告)日：2013-09-17
申请号：US12851082
申请日：2010-08-05
申请人： Neil Soice , John Dana Hubbard , Yu Zhang , James Hamzik
发明人： Neil Soice , John Dana Hubbard , Yu Zhang , James Hamzik
IPC分类号： A23J1/00 , C07K1/00
CPC分类号： C07K1/36 , C07K16/00
摘要： The present invention relates, at least in part, to improved methods of protein purification. In particular, the present invention relates, at least in part, to methods for purifying an Fc region containing protein from a composition comprising the Fc region containing protein and one or more impurities, where the methods eliminate the need for a holding tank and/or a buffer exchange step.
摘要翻译：本发明至少部分地涉及改进的蛋白质纯化方法。特别地，本发明至少部分涉及从含有Fc区蛋白质和一种或多种杂质的组合物中纯化含有Fc区的蛋白质的方法，其中该方法不需要储存罐和/或缓冲交换步骤。

76. 发明授权

US08500322B2 Disposable vortex breaker for plastic bag 有权
标题翻译：一次性塑料袋防涡流破碎机
公开(公告)号：US08500322B2
公开(公告)日：2013-08-06
申请号：US13178097
申请日：2011-07-07
申请人： Martin Morrissey , David DeCoste
发明人： Martin Morrissey , David DeCoste
IPC分类号： B01F13/08
CPC分类号： B01F7/162 , B01F13/08 , B01F15/00831 , B01F15/0085 , B01F15/00915 , C12M23/14 , C12M23/28 , C12M23/34 , C12M27/02
摘要： The present invention consists of a closed presterilized bag having a disposable mixing element within it, a drive mechanism outside of the bag for rotating the mixing element without voiding sterility and a vortex breaker in the form of one or more plastic sheet materials that are attached to various inner surfaces of the bag and disrupt the formation of vortices within the bag. Preferably the sheet(s) are formed of the same material as the bag and are sealed to the bag surfaces. More preferably, the sheet(s) extend across a diameter of the bag. Most preferably, the sheet(s) are perforated with one or more slits or openings to allow for good flow and mixing without a vortex being formed.
摘要翻译：本发明包括在其内具有一次性混合元件的封闭的预灭菌袋，在袋外面用于旋转混合元件而不产生空隙不育的驱动机构，以及一种或多种塑料片材的形式的涡流破碎机，袋子的各种内表面并破坏袋子内的涡流的形成。优选地，片材由与袋相同的材料形成并且密封到袋表面。更优选地，片材延伸穿过袋的直径。最优选地，片材穿过一个或多个狭缝或开口，以允许良好的流动和混合而不形成涡流。

77. 发明授权

US12050159B2 Embossed film bioprocessing containers and integrity testing of bioprocessing containers 有权
公开(公告)号：US12050159B2
公开(公告)日：2024-07-30
申请号：US16644109
申请日：2018-09-27
申请人： EMD Millipore Corporation
发明人： Brian Pereira , Stephen Proulx
IPC分类号： G01M3/32 , B01L3/00
CPC分类号： G01M3/3218 , B01L3/505 , B01L2300/0861
摘要： A testing method that includes the steps of evacuating air from a container to a negative atmospheric pressure, the container being a collapsible, flexible container, and comprising at least two opposing flexible walls, wherein a surface of at least one of the walls internal to the container comprises a plurality of channels or recessed features on said at least one wall and monitoring a mass flow or a state of vacuum so as to determine the integrity of the container. The container can be of any size or conformation, with or without attached fittings.

78. 外观设计

USD1025288S1 Filter assembly bracket 有权
公开(公告)号：USD1025288S1
公开(公告)日：2024-04-30
申请号：US29799417
申请日：2021-07-14
申请人： EMD Millipore Corporation
设计人： James Ormond , Gregory Straeffer , Bailey Vaillancourt , Joseph Michael Almasian
摘要： FIG. 1 is a first perspective view of the filter assembly bracket of the present invention.
FIG. 2 is a second perspective view of the filter assembly bracket of the present invention.
FIG. 3 is a front view of the filter assembly bracket of the present invention.
FIG. 4 is a rear view of the filter assembly bracket of the present invention.
FIG. 5 is a left-side view of the filter assembly bracket of the present invention.
FIG. 6 is a right-side view of the filter assembly bracket of the present invention.
FIG. 7 is a top view of the filter assembly bracket of the present invention.
FIG. 8 is a bottom view of the filter assembly bracket of the present invention; and,
FIG. 9 is a view of the filter assembly bracket of the present invention illustrating environmental context holding two filter unit assemblies together.
The view labels used herein to denote, front, rear, left-side, right-side, top and bottom views are for convenience only and should not be interpreted as limiting her orientation of the bracket.
The broken lines in the Figures are for illustrative purposes only and form no part of the claimed design.

79. 外观设计

USD1024269S1 Filter assembly holder 有权
公开(公告)号：USD1024269S1
公开(公告)日：2024-04-23
申请号：US29799414
申请日：2021-07-14
申请人： EMD Millipore Corporation
设计人： James Ormond , Gregory Straeffer , Bailey Vaillancourt , Joseph Michael Almasian
摘要： FIG. 1 is a first perspective view of the filter assembly holder of the present invention.
FIG. 2 is a second perspective view of the filter assembly holder of the present invention.
FIG. 3 is a front view of the filter assembly holder of the present invention.
FIG. 4 is a rear view of the filter assembly holder of the present invention.
FIG. 5 is a left-side view of the filter assembly holder of the present invention.
FIG. 6 is a right-side view of the filter assembly holder of the present invention.
FIG. 7 is a top view of the filter assembly holder of the present invention.
FIG. 8 is a bottom view of the filter assembly holder of the present invention.
FIG. 9 is a first view of the filter assembly holder of the present invention in an environmental context holding two filter unit assemblies together; and,
FIG. 10 is a second view of the filter assembly holder of the present invention illustrating environmental context holding two filter unit assemblies together.
The view labels used herein to denote, front, rear, left-side, right-side, top and bottom views are for convenience only and should not be interpreted as limiting her orientation of the Bracket.
The broken lines in the Figures are for illustrative purposes only and form no part of the claimed design.

80. 发明授权

US11772020B2 High capacity composite depth filter media with low extractables 有权
公开(公告)号：US11772020B2
公开(公告)日：2023-10-03
申请号：US17819969
申请日：2022-08-16
申请人： EMD Millipore Corporation
发明人： Maybelle Woo , David Yavorsky , John Amara , Nripen Singh , Kwok-Shun Cheng
IPC分类号： B01D39/16 , B01D29/66
CPC分类号： B01D39/1623 , B01D29/66 , B01D39/163 , B01D2239/0407 , B01D2239/0654 , B01D2239/086
摘要： A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyacrylonitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased binding capacity for soluble impurities such as DNA and host cell proteins from biological/cell culture feedstreams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.

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