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71. 发明申请

US20090018100A1 MATERIALS AND METHODS FOR TREATING OCULAR-RELATED DISORDERS 审中-公开
标题翻译：用于治疗与眼睛有关的疾病的材料和方法
公开(公告)号：US20090018100A1
公开(公告)日：2009-01-15
申请号：US12237036
申请日：2008-09-24
申请人： Imre Kovesdi , Douglas E. Brough , Lisa Wei , Duncan L. McVey
发明人： Imre Kovesdi , Douglas E. Brough , Lisa Wei , Duncan L. McVey
IPC分类号： A61K31/711 , A61P27/02
CPC分类号： C07K14/811 , A61K48/005 , A61K48/0075 , C07K14/71 , C12N2799/022 , H04L45/02 , H04L49/355 , H04L49/358
摘要： The present invention is directed to a method of prophylactically or therapeutically treating an animal for at least one ocular-related disorder, e.g., ocular neovascularization or age-related macular degeneration. The method comprises contacting an ocular cell with an expression vector comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and the same or different nucleic acid sequence encoding a neurotrophic agent. The method also can comprise contacting an ocular cell with different expression vectors, each comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and/or a nucleic acid sequence encoding a neurotrophic agent. In addition, the present invention provides a viral vector comprising a nucleic acid sequence encoding pigment epithelium-derived factor (PEDF) or a therapeutic fragment thereof.
摘要翻译：本发明涉及一种预防性或治疗性地治疗动物至少一种与眼部相关的疾病，例如眼睛新生血管形成或年龄相关性黄斑变性的方法。该方法包括使眼细胞与包含编码血管生成抑制剂的核酸序列和编码神经营养剂的相同或不同核酸序列的表达载体接触。该方法还可以包括使眼细胞与不同的表达载体接触，每种表达载体包含编码血管生成抑制剂的核酸序列和/或编码神经营养剂的核酸序列。此外，本发明提供了包含编码色素上皮衍生因子（PEDF）的核酸序列或其治疗片段的病毒载体。

72. 发明申请

US20080248060A1 ADENOVIRAL VECTOR-BASED MALARIA VACCINES 审中-公开
标题翻译：腺病毒基因疟原虫疫苗
公开(公告)号：US20080248060A1
公开(公告)日：2008-10-09
申请号：US11971433
申请日：2008-01-09
申请人： Joseph T. Bruder , C. Richter King , Thomas Richie , Keith Limbach , Denise Louis Doolan
发明人： Joseph T. Bruder , C. Richter King , Thomas Richie , Keith Limbach , Denise Louis Doolan
IPC分类号： A61K39/00 , A61P37/00
CPC分类号： A61K39/015 , A01K2227/105 , A01K2267/0337 , A61K2039/5256 , A61K2039/53 , C07K14/445 , Y02A50/412
摘要： The invention provides a method of inducing an immune response against malaria in a mammal. The method comprises intramuscularly administering to a mammal a composition comprising a pharmaceutically acceptable carrier and either or both of (a) a first adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum circumsporozoite protein (CSP) operably linked to a human CMV promoter, and/or (b) a second adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum apical membrane antigen 1 (AMA-1) antigen operably linked to a human CMV promoter.
摘要翻译：本发明提供在哺乳动物中诱导针对疟疾的免疫应答的方法。该方法包括向哺乳动物施用包含药学上可接受的载体的组合物和（a）第一种腺病毒载体，其包含与人CMV启动子可操作地连接的编码恶性疟原虫环子孢子蛋白（CSP）的核酸序列，和/或（b）包含编码与人CMV启动子可操作地连接的恶性疟原虫顶端膜抗原1（AMA-1）抗原的核酸序列的第二腺病毒载体。

73. 发明申请

US20070098692A1 MATERIALS AND METHODS FOR TREATING OCULAR-RELATED DISORDERS 审中-公开
标题翻译：用于治疗与眼睛有关的疾病的材料和方法
公开(公告)号：US20070098692A1
公开(公告)日：2007-05-03
申请号：US11610364
申请日：2006-12-13
申请人： Imre Kovesdi , Douglas Brough , Lisa Wei , Duncan McVey
发明人： Imre Kovesdi , Douglas Brough , Lisa Wei , Duncan McVey
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/005 , A61K48/0075 , C07K14/71 , C07K14/811 , C12N2710/10343 , C12N2799/022
摘要： The present invention is directed to a method of prophylactically or therapeutically treating an animal for at least one ocular-related disorder, e.g., ocular neovascularization or age-related macular degeneration. The method comprises contacting an ocular cell with an expression vector comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and the same or different nucleic acid sequence encoding a neurotrophic agent. The method also can comprise contacting an ocular cell with different expression vectors, each comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and/or a nucleic acid sequence encoding a neurotrophic agent. In addition, the present invention provides a viral vector comprising a nucleic acid sequence encoding pigment epithelium-derived factor (PEDF) or a therapeutic fragment thereof.
摘要翻译：本发明涉及一种预防性或治疗性地治疗动物至少一种与眼部相关的疾病，例如眼睛新生血管形成或年龄相关性黄斑变性的方法。该方法包括使眼细胞与包含编码血管生成抑制剂的核酸序列和编码神经营养剂的相同或不同核酸序列的表达载体接触。该方法还可以包括使眼细胞与不同的表达载体接触，每种表达载体包含编码血管生成抑制剂的核酸序列和/或编码神经营养剂的核酸序列。此外，本发明提供了包含编码色素上皮衍生因子（PEDF）的核酸序列或其治疗片段的病毒载体。

74. 发明授权

US07195896B2 Complementary adenoviral vector systems and cell lines 有权
标题翻译：互补腺病毒载体系统和细胞系
公开(公告)号：US07195896B2
公开(公告)日：2007-03-27
申请号：US09964065
申请日：2001-09-26
申请人： Imre Kovesdi , Douglas E Brough , Duncan L McVey , Joseph T Bruder , Alena Lizonova
发明人： Imre Kovesdi , Douglas E Brough , Duncan L McVey , Joseph T Bruder , Alena Lizonova
IPC分类号： C12N5/10 , C12N15/64 , C12N15/861 , C12N15/86
CPC分类号： C12N7/00 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/4712 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10352 , C12N2810/60 , C12N2810/6081 , C12N2830/002 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44 , Y10S977/799
摘要： The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.
摘要翻译：本发明提供多重缺陷型腺病毒载体和补体细胞系。还提供了多重缺陷型腺病毒载体的重组体和涉及使用这种重组体的基因治疗，疫苗接种等的治疗方法。

75. 发明授权

US06998263B2 Methods of preparing and using a viral vector library 有权
标题翻译：制备和使用病毒载体文库的方法
公开(公告)号：US06998263B2
公开(公告)日：2006-02-14
申请号：US09780526
申请日：2001-02-09
申请人： Imre Kovesdi , Duncan L. McVey , Thomas J. Wickham , Joseph T. Bruder , Douglas E. Brough
发明人： Imre Kovesdi , Duncan L. McVey , Thomas J. Wickham , Joseph T. Bruder , Douglas E. Brough
IPC分类号： C12N15/63 , C12N7/01
CPC分类号： C12N15/1093 , A61K48/00 , C12N15/86 , C12N2710/10343 , C12N2710/10345 , C12N2810/40
摘要： The present invention provides a library of viral vectors, wherein each member comprises a first heterologous DNA encoding a first gene product and a second heterologous DNA encoding a second gene product. The first heterologous DNA is common to each member of the library, while the second heterologous DNA varies between members of the library. The present invention additionally provides a method of constructing a library of viral vectors. The method comprises carrying out homologous recombination between a first DNA molecule and a second DNA molecule to form a pool of intermediate viral vector genomes. One or more linear third DNA molecules are ligated into the pool of intermediate viral genomes to produce a library of viral vector genomes. Alternatively, homologous recombination between linear DNA molecules and recipient DNA molecules produces a library of viral vector genomes. The library of viral vector genomes is converted into a library of viral vectors.
摘要翻译：本发明提供病毒载体文库，其中每个成员包含编码第一基因产物的第一异源DNA和编码第二基因产物的第二异源DNA。第一个异源DNA对于文库的每个成员是共同的，而第二异源DNA在文库的成员之间是不同的。本发明另外提供构建病毒载体文库的方法。该方法包括在第一DNA分子和第二DNA分子之间进行同源重组以形成中间病毒载体基因组池。将一个或多个线性第三DNA分子连接到中间病毒基因组池中以产生病毒载体基因组文库。或者，线性DNA分子和受体DNA分子之间的同源重组产生病毒载体基因组文库。将病毒载体基因组文库转化为病毒载体文库。

76. 发明申请

US20050277193A1 Vectors and methods for gene transfer 审中-公开
公开(公告)号：US20050277193A1
公开(公告)日：2005-12-15
申请号：US11155845
申请日：2005-06-17
申请人： Thomas Wickham , Imre Kovesdi , Douglas Brough
发明人： Thomas Wickham , Imre Kovesdi , Douglas Brough
IPC分类号： A61K38/00 , A61K48/00 , C07K14/075 , C07K14/705 , C12N1/21 , C12N7/00 , C12N15/861 , C12N15/866 , C12N15/87
CPC分类号： C12N15/87 , A61K38/00 , A61K48/00 , C07K14/005 , C07K14/70546 , C07K2319/00 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , C12N2710/10345 , C12N2710/10351 , C12N2710/14143 , C12N2810/40 , C12N2810/405 , C12N2810/60 , C12N2810/6018 , C12N2810/855 , C12N2810/856 , C12N2810/859
摘要： The present invention provides a recombinant adenovirus comprising coat proteins that lack native binding. In particular, the present invention provides a recombinant adenovirus comprising a penton base protein and a fiber protein, wherein the penton base protein and the fiber protein lack native binding. The present invention further provides a recombinant adenovirus comprising (a) a penton base protein that lacks native binding and (b) a nonnative amino acid sequence that binds a cell-surface binding site.

77. 发明授权

US06913927B2 Non-adenoviral gene product-based complementing cells for adenoviral vectors 失效
标题翻译：用于腺病毒载体的非腺病毒基因产物互补细胞
公开(公告)号：US06913927B2
公开(公告)日：2005-07-05
申请号：US10695605
申请日：2003-10-28
申请人： Douglas E. Brough , Jason G. D. Gall , Imre Kovesdi
发明人： Douglas E. Brough , Jason G. D. Gall , Imre Kovesdi
IPC分类号： C12N5/08 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/02 , C12N15/63 , C12N15/64 , C12N15/861
CPC分类号： C12N7/00 , C12N2710/10051 , C12N2710/10052 , C12N2710/10351 , C12N2710/10352
摘要： The invention provides cells and methods of using the cells for the propagation of replication-deficient adenoviral vectors. The cells comprise at least one heterologous nucleic acid sequence which upon expression produces at least one non-adenoviral gene product that complements in trans for a deficiency in at least one essential gene function of one or more regions of an adenoviral genome so as to propagate a replication-deficient adenoviral vector comprising an adenoviral genome deficient in the at least one essential gene function of the one or more regions when present in the cell.
摘要翻译：本发明提供了细胞和使用细胞促进复制缺陷型腺病毒载体的方法。所述细胞包含至少一种异源核酸序列，其在表达时产生至少一种非腺病毒基因产物，所述非腺病毒基因产物在腺病毒基因组的一个或多个区域的至少一个必需基因功能缺陷中互补互补，从而传播复制缺陷型腺病毒载体，其包含存在于细胞中时所述一个或多个区域的至少一个必需基因功能缺陷的腺病毒基因组。

78. 发明授权

US06861229B2 Method of identifying a gene product 有权
标题翻译：识别基因产物的方法
公开(公告)号：US06861229B2
公开(公告)日：2005-03-01
申请号：US10336702
申请日：2003-01-03
申请人： Miguel E. Carrión , Imre Kovesdi
发明人： Miguel E. Carrión , Imre Kovesdi
IPC分类号： C12N15/10 , C12N15/861 , C12Q1/68 , G01N33/53 , C12N15/63 , C12N15/70 , C11N15/861
CPC分类号： C12N15/86 , C12N15/1055 , C12N2710/10343 , C12Q1/6816 , C12Q1/6897 , C12Q2563/167
摘要： The present invention provides a method of identifying a gene product. The method comprises providing a multiplicity of cells comprising a first gene product. Preferably, the first gene product is produced in the multiplicity of cells by expressing a first exogenous nucleic acid sequence encoding the first gene product. A library of second nucleic acid sequences encoding second gene products is then introduced into the multiplicity of cells. The second nucleic acid sequences are expressed in the multiplicity of cells to produce the second gene products such that the first gene product and at least one of the second gene products contact. The method further comprises causing a complex to form between the first gene product, an affinity molecule that binds the first gene product, and at least one of the second gene products, and subsequently retrieving the complex. At least one second gene product of the complex then is identified.
摘要翻译：本发明提供鉴定基因产物的方法。该方法包括提供包含第一基因产物的多个细胞。优选地，通过表达编码第一基因产物的第一外源核酸序列，在多种细胞中产生第一基因产物。然后将编码第二基因产物的第二核酸序列的文库导入多个细胞。第二核酸序列在多重细胞中表达以产生第二基因产物，使得第一基因产物和第二基因产物中的至少一个接触。所述方法还包括使第一基因产物，结合第一基因产物的亲和分子与至少一种第二基因产物形成复合物，随后检索该复合物。然后鉴定该复合物的至少一个第二基因产物。

79. 发明申请

US20030170899A1 Chimeric vectors comprising a phage packaging site and a portion derived from the genome of a eukaryotic virus 有权
公开(公告)号：US20030170899A1
公开(公告)日：2003-09-11
申请号：US10162043
申请日：2002-06-03
申请人： GenVec, Inc.
发明人： Duncan L. McVey , Douglas E. Brough , Mohammed Zuber , Imre Kovesdi
IPC分类号： C12N007/00 , C12N015/74 , C12N001/21
CPC分类号： C12N15/86 , C12N2710/10343 , C12N2710/10344 , C12N2795/10344 , C12N2810/405 , C12N2830/002 , C12N2830/005 , C12N2830/15 , C12N2830/55
摘要： The present invention provides an improved method of making eukaryotic gene transfer vectors comprising homologous recombining lambdid vectors with a second DNA in a bacterium to generate novel recombinant eukaryotic viral gene transfer vectors as well as a novel lambdid vector used in the inventive method and an inventive system comprising the novel lambdid vector.

80. 发明申请

US20030158132A1 Method for enhancing bone density or formation 审中-公开
标题翻译：增强骨密度或形成的方法
公开(公告)号：US20030158132A1
公开(公告)日：2003-08-21
申请号：US10053637
申请日：2002-01-22
申请人： GenVec, Inc.
发明人： Imre Kovesdi
IPC分类号： A61K048/00 , C12N005/08
CPC分类号： C07K14/52 , A61K48/00 , C07K14/47 , C07K14/475 , C07K2319/00 , C07K2319/02 , C12N9/16 , C12N2799/022
摘要： The invention pertains to a method for enhancing bone density or formation. In accordance with the method, a nucleic acid encoding a secreted alkaline phosphatase (SEAP) is administered to a cell in a region of a bone such that the nucleic acid is expressed to produce the SEAP, whereby bone density or formation is enhanced within the region. The method can be employed to produce a bone graft having a cell harboring an exogenous nucleic acid encoding a SEAP. To facilitate the inventive method, the invention provides a recombinant viral vector having a nucleic acid encoding a SEAP. Optionally, a nucleic acid encoding an angiogenic protein and/or a nucleic acid encoding an osteogenic protein is employed in conjunction with the nucleic acid encoding a SEAP.
摘要翻译：本发明涉及一种增强骨密度或形成的方法。根据该方法，将编码分泌的碱性磷酸酶（SEAP）的核酸施用于骨的区域中的细胞，使得所述核酸被表达以产生SEAP，从而在该区域内增强骨密度或形成。该方法可用于产生具有含有编码SEAP的外源核酸的细胞的骨移植物。为了促进本发明的方法，本发明提供了具有编码SEAP的核酸的重组病毒载体。任选地，编码血管生成蛋白和/或编码成骨蛋白的核酸的核酸与编码SEAP的核酸结合使用。

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