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    • 65. 发明授权
    • Method for producing nanocapsules in the absence of an organic solvent, and nanocapsules produced thereby
    • 在不存在有机溶剂的情况下制备纳米胶囊的方法和由此制备的纳米胶囊
    • US09233079B2
    • 2016-01-12
    • US13757342
    • 2013-02-01
    • UNIVERSITE CLAUDE BERNARD LYON I
    • Fabrice PirotFrancoise Falson
    • B01J13/10A61K9/51
    • A61K9/5192B01J13/10
    • A method for preparing an aqueous suspension of nanocapsules comprising an oily core surrounded by a polymeric shell, comprises mixing first and second phases, wherein the first oily phase comprises a hydrophobic polymer, an oil or a mixture of oils, at least one active ingredient, and a surfactant TA1. The oily phase is brought to a temperature T1 higher than the melting point of the hydrophobic polymer, the hydrophobic polymer being miscible, at this temperature T1, with the mixture of the surfactant TA1 and the oil or mixture of oils, and the active ingredient being miscible, soluble or solubilized in the mixture of the surfactant TA1 and the oil or mixture of oils. The second polar phase comprises a hydrophilic polymer in the form of a hydrogel in an aqueous solution containing a surfactant TA2, to form the nanocapsules in an aqueous suspension.
    • 一种制备纳米胶囊的水性悬浮液的方法,其包含由聚合物壳包围的油性芯,包括混合第一和第二相,其中所述第一油相包含疏水性聚合物,油或油的混合物,至少一种活性成分, 和表面活性剂TA1。 使油相达到高于疏水性聚合物的熔点的温度T1,在该温度T1下,疏水性聚合物与表面活性剂TA1和油或油混合物的混合物是可混溶的,活性成分为 可混溶,溶解或溶解在表面活性剂TA1和油或油混合物的混合物中。 第二极性相包含在含有表面活性剂TA2的水溶液中的水凝胶形式的亲水性聚合物,以在水性悬浮液中形成纳米胶囊。
    • 69. 发明申请
    • Microencapsulation of oxygen or water sensitive materials
    • 氧气或水敏感材料的微胶囊化
    • US20050249952A1
    • 2005-11-10
    • US10654422
    • 2003-09-04
    • Niraj VasishthaHerman SchlameusDarren Barlow
    • Niraj VasishthaHerman SchlameusDarren Barlow
    • A23L1/00B01J13/02B01J13/04B01J13/08B01J13/10B32B5/16
    • B01J13/08A23P10/30A23P20/20B01J13/02B01J13/04B01J13/10Y10T428/2985Y10T428/2989Y10T428/2991
    • A barrier coating composition includes a polymer material and a structuring agent dispersed in said polymer material, wherein the structuring agent decreases oxygen or water permeability through the polymer material. The barrier coating composition can be used to coat a core component, which can be oxygen or water sensitive, to form a microencapsulated material. The microencapsulated material can be formed by microencapsulation methods, which include atomization or coacervation methods, including forming an oil emulsion of an oil phase and an aqueous phase, the oil phase including the core component and the aqueous phase including the polymer material, adding the structuring agent to one of the oil phase and the aqueous phase, mixing the oil emulsion to form desired particle sizes of the core component, forming the shell component around the core component to form the microencapsulated material, and extracting the formed microencapsulated material from the oil emulsion.
    • 阻隔涂层组合物包括分散在所述聚合物材料中的聚合物材料和结构化剂,其中所述结构剂通过所述聚合物材料降低氧气或水的渗透性。 阻挡涂层组合物可用于涂覆可以是氧或水敏感的核心组分以形成微胶囊化材料。 微胶囊化材料可以通过包括雾化或凝聚方法在内的微囊化方法形成,包括形成油相和水相的油乳液,所述油相包括核心组分和包含聚合物材料的水相,添加结构化 将其与油相和水相之一混合,将油乳液混合以形成所需粒径的核心组分,在芯组分周围形成壳组分以形成微囊化材料,并从油乳液中提取形成的微胶囊化材料 。