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61. 发明申请

US20110123978A1 HUMAN PAPILLOMA VIRUS (HPV) DETECTION USING NUCLEIC ACID PROBES, MICROBEADS AND FLUORESCENT-ACTIVATED CELL SORTER (FACS) 有权
标题翻译：人乳头瘤病毒（HPV）检测使用核酸探针，微生物和荧光激活细胞分离器（FACS）
公开(公告)号：US20110123978A1
公开(公告)日：2011-05-26
申请号：US12911660
申请日：2010-10-25
申请人： Karl Poetter , Toby Gould
发明人： Karl Poetter , Toby Gould
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708
摘要： The present invention relates generally to the field of diagnostic and detection assays. More particularly, the present invention provides methods, and reagents including biochips for detecting the presence of, or distinguishing between, one or more analytes in a sample.
摘要翻译：本发明一般涉及诊断和检测测定领域。更具体地，本发明提供方法和试剂，包括用于检测样品中一种或多种分析物的存在或区分的生物芯片。

62. 发明授权

US07935484B2 Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assay 有权
标题翻译：使用核酸扩增测定法检测血浆或血清中细胞外肿瘤相关核酸
公开(公告)号：US07935484B2
公开(公告)日：2011-05-03
申请号：US11695421
申请日：2007-04-02
申请人： Christopher D. Gocke , Michael S. Kopreski
发明人： Christopher D. Gocke , Michael S. Kopreski
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C07K14/82 , C07K14/47 , C07K14/4746 , C07K2319/00 , C12Q1/683 , C12Q1/686 , C12Q1/6865 , C12Q1/6886 , C12Q1/708 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16 , C12Q2535/125
摘要： This invention relates to detection of specific extracellular nucleic acid in human or animal blood plasma or serum associated with disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor-associated DNA including non-mutated hypermethylated DNA, and to methods of detecting and monitoring extracellular mutant oncogenes or tumor-associated DNA including non-mutated hypermethylated DNA found in blood plasma or serum. In particular, the invention relates to the detection, identification, or monitoring of the existence, progression or clinical status of neoplasia in humans or other animals that contain a mutation that is associated with the neoplasm through detection of the non-mutated hypermethylated nucleic acid of the neoplasm in plasma or serum fractions.
摘要翻译：本发明涉及在人或动物血浆或与疾病相关的血清中特异性细胞外核酸的检测。具体地说，本发明涉及从突变型致癌基因或其他肿瘤相关DNA（包括非突变型高甲基化DNA）衍生的核酸的检测，以及检测和监测细胞外突变致癌基因或肿瘤相关DNA的方法，包括非突变高甲基化DNA 血浆或血清。特别地，本发明涉及通过检测非突变的高甲基化核酸的检测，鉴定或监测包含与肿瘤相关的突变的人或其他动物中的瘤形成的存在，进展或临床状态血浆或血清中的肿瘤。

63. 发明申请

US20110065906A1 COMPOSITIONS AND METHODS FOR RECOVERY OF NUCLEIC ACIDS OR PROTEINS FROM TISSUE SAMPLES FIXED IN CYTOLOGY MEDIA 有权
标题翻译：用于从细胞培养基中固定的组织样品中恢复核酸或蛋白质的组合物和方法
公开(公告)号：US20110065906A1
公开(公告)日：2011-03-17
申请号：US12881531
申请日：2010-09-14
申请人： Shubing LIU , Suganthi Ramachandran
发明人： Shubing LIU , Suganthi Ramachandran
IPC分类号： C07H21/04 , C12N5/07
CPC分类号： C12N15/1003 , C12N1/06 , C12N15/1013 , C12Q1/6806 , C12Q1/708 , C12Q2565/519 , C12Q2565/531
摘要： The present invention provides compositions and methods for improving nucleic acid or protein recovery from fixed biological samples.
摘要翻译：本发明提供了用于从固定生物样品中提高核酸或蛋白回收率的组合物和方法。

64. 发明申请

US20110039265A1 Method of detecting tumor-associated DNA in plasma or serum 有权
标题翻译：检测血浆或血清中肿瘤相关DNA的方法
公开(公告)号：US20110039265A1
公开(公告)日：2011-02-17
申请号：US12854039
申请日：2010-08-10
申请人： Christopher D. Gocke , Michael S. Kopreski
发明人： Christopher D. Gocke , Michael S. Kopreski
IPC分类号： C12Q1/68
CPC分类号： C07K14/82 , C07K14/47 , C07K14/4746 , C07K2319/00 , C12Q1/683 , C12Q1/686 , C12Q1/6865 , C12Q1/6886 , C12Q1/708 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16 , C12Q2535/125
摘要： This invention relates to detection of specific extracellular nucleic acid in plasma or serum fractions of human or animal blood associated with neoplastic or proliferative disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor-associated DNA, and to those methods of detecting and monitoring extracellular mutant oncogenes or tumor-associated DNA found in the plasma or serum fraction of blood by using rapid DNA extraction followed by nucleic acid amplification with or without enrichment for mutant DNA. In particular, the invention relates to the detection, identification, or monitoring of the existence, progression or clinical status of benign, premalignant, or malignant neoplasms in human or other animals that contain a mutation that is associated with the neoplasm through detection of the mutated nucleic acid of the neoplasm in plasma or serum fractions. The invention permits the detection of extracellular, tumor-associated nucleic acid in the serum or plasma of humans or other animals recognized as having a neoplastic or proliferative disease or in individuals without any prior history or diagnosis of neoplastic or proliferative disease. The invention provides the ability to detect extracellular nucleic acid derived from genetic sequences known to be associated with neoplasia, such a oncogenes, as well as genetic sequences previously unrecognized as being associated with neoplastic or proliferative disease. The invention thereby provides methods for early identification of colorectal, pancreatic, lung, breast, bladder, ovarian, lymphoma and all other malignancies carrying tumor-related mutations of DNA and methods for monitoring cancer and other neoplastic disorders in humane and other animals.
摘要翻译：本发明涉及在与肿瘤或增生性疾病相关的人或动物血液的血浆或血清部分中检测特异性细胞外核酸。具体地，本发明涉及来自突变致癌基因或其他肿瘤相关DNA的核酸的检测，以及通过使用快速DNA检测和监测在血浆或血清部分中发现的细胞外突变致癌基因或肿瘤相关DNA的方法提取后进行核酸扩增，扩增或不扩增突变DNA。特别地，本发明涉及检测，鉴定或监测人或其他动物中的良性，恶化前或恶性肿瘤的存在，进展或临床状态，其含有通过检测突变的肿瘤与赘生物相关的突变血浆或血清级分中的肿瘤核酸。本发明允许检测被认为具有肿瘤或增殖性疾病的人或其他动物的血清或血浆中的细胞外，肿瘤相关核酸，或者在没有任何先前的肿瘤或增殖性疾病的历史或诊断的个体中。本发明提供了检测源自已知与肿瘤相关的遗传序列的细胞外核酸的能力，例如癌基因，以及先前未被认识为与肿瘤或增殖性疾病相关的遗传序列。因此，本发明提供了用于早期鉴定结直肠，胰腺，肺，乳腺，膀胱，卵巢，淋巴瘤和携带DNA的肿瘤相关突变的所有其他恶性肿瘤的方法以及用于监测人类和其他动物中的癌症和其他肿瘤性疾病的方法。

65. 发明申请

US20110027778A1 COMPOSITION COMPRISING AN OLIGONUCLEOTIDE MIXTURE FOR IMPROVED DETECTION OF HUMAN PAPILLOMAVIRUS GENOTYPES 有权
标题翻译：包含用于改善人类斑马鱼基因组检测的寡核苷酸混合物的组合物
公开(公告)号：US20110027778A1
公开(公告)日：2011-02-03
申请号：US12675355
申请日：2008-08-26
申请人： Markus Schmitt , Tim Waterboer , Michael Pawlita
发明人： Markus Schmitt , Tim Waterboer , Michael Pawlita
IPC分类号： C12Q1/68
CPC分类号： C12Q1/708 , C12Q2537/143 , C12Q2549/119
摘要： The present invention relates to a composition comprising an oligonucleotide mixture. Moreover, the present invention relates to the use of said oligonucleotide mixture for diagnosing different HPV genotypes in a sample of a subject. Further encompassed is a method for diagnosing different HPV genotypes in a sample of a subject and a kit carrying out said method.
摘要翻译：本发明涉及包含寡核苷酸混合物的组合物。此外，本发明涉及用于诊断受试者样品中不同HPV基因型的所述寡核苷酸混合物的用途。进一步包括用于诊断受试者样品中不同HPV基因型的方法和进行所述方法的试剂盒。

66. 发明授权

US07790375B2 Primer for detection of human papillomavirus 失效
标题翻译：用于检测人乳头状瘤病毒的底物
公开(公告)号：US07790375B2
公开(公告)日：2010-09-07
申请号：US10581649
申请日：2006-03-14
申请人： Joo-Sung Yang , Hyeran Cha
发明人： Joo-Sung Yang , Hyeran Cha
IPC分类号： C12Q1/68
CPC分类号： C12Q1/708
摘要： Disclosed are primers specific to the genome of HPV genotypes 11, 16, 18 and 31. Also disclosed are a kit for detecting the HPV genome comprising the primers and a method of detecting the HPV genome using the primers.
摘要翻译：公开了对HPV基因型11,16,18和31的基因组特异的引物。还公开了用于检测包含引物的HPV基因组的试剂盒和使用引物检测HPV基因组的方法。

67. 发明授权

US07682792B2 Detection of nucleic acids from multiple types of human papillomaviruses 有权
标题翻译：检测来自多种类型人乳头状瘤病毒的核酸
公开(公告)号：US07682792B2
公开(公告)日：2010-03-23
申请号：US11926984
申请日：2007-10-29
申请人： Sylvia A. Norman , Jennifer J. Bungo , William L. Hanna , Neeraj P. Rao
发明人： Sylvia A. Norman , Jennifer J. Bungo , William L. Hanna , Neeraj P. Rao
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： C12Q1/708 , C07K14/005 , C12N2710/20022 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products are disclosed.
摘要翻译：公开了核酸寡核苷酸序列，其包括可用于检测与宫颈癌相关的多种类型的人乳头状瘤病毒（HPV）的扩增寡聚体和探针寡聚体。公开了通过体外扩增HPV核酸序列并检测扩增产物来检测生物标本中多种HPV类型的方法。

68. 发明申请

US20090233269A1 Detection of a Target in a Preservative Solution 有权
标题翻译：在防腐剂溶液中检测靶
公开(公告)号：US20090233269A1
公开(公告)日：2009-09-17
申请号：US12408179
申请日：2009-03-20
申请人： James Linder , Menashi Cohenford , Erin Coffman , Brian B. Lentrichia , Henrik Stender , Kenneth Oliveira
发明人： James Linder , Menashi Cohenford , Erin Coffman , Brian B. Lentrichia , Henrik Stender , Kenneth Oliveira
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6841 , C12Q1/6888 , C12Q1/708 , C12Q2525/107
摘要： This invention relates to methods, articles and compositions useful in detecting target substances in an alcoholic preservative solution, and for identifying sensors useful for binding to such targets. The methods allow for the simultaneous performance of sufficient fixation of a sample and binding of a detectable sensor to a target of interest in the sample. In one aspect, a method is provided that comprises contacting a sample suspected of containing a target with a detectable sensor molecule known to bind to such target in an alcoholic preservative solution. The method maybe performed in multiplex form to permit simultaneous analysis of a plurality of targets. Methods for identifying a sensor capable of binding to a desired target in an alcoholic preservative solution are also provided. An alcoholic preservative solution comprising one or more such detectable sensors is also provided. Also provided is a sample comprising a bound sensor provided by such a process. Also provided are kits useful for such methods.
摘要翻译：本发明涉及可用于检测酒精防腐溶液中的目标物质的方法，制品和组合物，以及用于识别用于结合这些靶标的传感器。所述方法允许同时执行样品的充分固定并将可检测传感器与样品中感兴趣的靶标结合。在一个方面，提供了一种方法，其包括将怀疑含有靶标的样品与已知结合到该酒精防腐溶液中的该靶标的可检测传感器分子接触。该方法可以以多路复用形式执行以允许多个目标的同时分析。还提供了用于鉴定能够结合到酒精防腐剂溶液中所需目标物的传感器的方法。还提供了包含一种或多种这种可检测传感器的酒精防腐剂溶液。还提供了包括由这种方法提供的绑定传感器的样本。还提供了可用于这种方法的试剂盒。

69. 发明申请

US20090220945A1 HPV E6, E7 mRNA ASSAY AND METHODS OF USE THEREOF 有权
标题翻译： HPV E6，E7 mRNA测定及其使用方法
公开(公告)号：US20090220945A1
公开(公告)日：2009-09-03
申请号：US12391634
申请日：2009-02-24
申请人： Bruce K. Patterson
发明人： Bruce K. Patterson
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708 , C12Q1/6841 , C12Q2600/158 , G06F19/00
摘要： Provided is an HPV E6, E7 mRNA assay, referenced herein as the “In Cell HPV Assay,” that is capable of sensitive and specific detection of normal cervical cells undergoing malignant transformation as well as abnormal cervical cells with pre-malignant or malignant lesions. The In Cell HPV Assay identifies HPV E6, E7 mRNA via in situ hybridization with oligonucleotides specific for HPV E6, E7 mRNA and quantitates the HPV E6, E7 mRNA via flow cytometry. The In Cell HPV Assay can be carried out in less than three hours directly from liquid-based cervical (“LBC”) cytology specimens. The In Cell HPV Assay provides an efficient and highly sensitive alternative to the Pap smear for determining abnormal cervical cytology.
摘要翻译：提供了HPV E6，E7mRNA测定法，其在本文中被称为“In Cell HPV Assay”，其能够敏感和特异性检测经历恶性转化的正常宫颈细胞以及具有恶性前或恶性病变的异常宫颈细胞。 In Cell HPV Assay通过与HPV E6，E7 mRNA特异性寡核苷酸的原位杂交鉴定HPV E6，E7 mRNA，并通过流式细胞术定量HPV E6，E7 mRNA。 In Cell HPV Assay可以在不到三个小时的时间内直接从液体宫颈（“LBC”）细胞学标本中进行。 In Cell HPV Assay提供了一种有效和高度敏感的替代方法，用于确定宫颈细胞学异常的Pap涂片。

70. 发明授权

US07569349B2 Methods for selecting monoclonal antibody therapies using extracellular DNA 失效
标题翻译：使用细胞外DNA选择单克隆抗体疗法的方法
公开(公告)号：US07569349B2
公开(公告)日：2009-08-04
申请号：US11739477
申请日：2007-04-24
申请人： Christopher D. Gocke , Michael S. Kopreski , Floyd A. Benko
发明人： Christopher D. Gocke , Michael S. Kopreski , Floyd A. Benko
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C07K14/82 , C07K14/47 , C07K14/4746 , C07K2319/00 , C12Q1/683 , C12Q1/686 , C12Q1/6865 , C12Q1/6886 , C12Q1/708 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16 , C12Q2535/125
摘要： This invention relates to detection of specific extracellular nucleic acid in plasma or serum fractions of human or animal blood associated with neoplastic or proliferative disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor-associated DNA, and to those methods of detecting and monitoring extracellular mutant oncogenes or tumor-associated DNA found in the plasma or serum fraction of blood by using rapid DNA extraction followed by nucleic acid amplification with or without enrichment for mutant DNA. In particular, the invention relates to the detection, identification, or monitoring of the existence, progression or clinical status of benign, premalignant, or malignant neoplasms in humans or other animals that contain a mutation that is associated with the neoplasm through detection of the mutated nucleic acid of the neoplasm in plasma or serum fractions. The invention permits the detection of extracellular, tumor-associated nucleic acid in the serum or plasma of humans or other animals recognized as having a neoplastic or proliferative disease or in individuals without any prior history or diagnosis of neoplastic or proliferative disease. The invention provides the ability to detect extracellular nucleic acid derived from genetic sequences known to be associated with neoplasia, such as oncogenes, as well as genetic sequences previously unrecognized as being associated with neoplastic or proliferative disease. The invention thereby provides methods for early identification of colorectal, pancreatic, lung, breast, bladder, ovarian, lymphoma and all other malignancies carrying tumor-related mutations of DNA and methods for monitoring cancer and other neoplastic disorders in humans and other animals.
摘要翻译：本发明涉及在与肿瘤或增生性疾病相关的人或动物血液的血浆或血清部分中检测特异性细胞外核酸。具体地，本发明涉及来自突变致癌基因或其他肿瘤相关DNA的核酸的检测，以及通过使用快速DNA检测和监测在血浆或血清部分中发现的细胞外突变致癌基因或肿瘤相关DNA的方法提取后进行核酸扩增，扩增或不扩增突变DNA。特别地，本发明涉及通过检测突变体的检测，鉴定或监测包含与赘生物相关的突变的人或其他动物中的良性，恶化前或恶性肿瘤的存在，进展或临床状态血浆或血清级分中的肿瘤核酸。本发明允许检测被认为具有肿瘤或增殖性疾病的人或其他动物的血清或血浆中的细胞外，肿瘤相关核酸，或者在没有任何先前的肿瘤或增殖性疾病的历史或诊断的个体中。本发明提供了检测源自已知与肿瘤形成相关的遗传序列的细胞外核酸的能力，例如癌基因，以及先前未被认识为与肿瘤或增殖性疾病相关的遗传序列。因此，本发明提供了用于早期鉴定结直肠，胰腺，肺，乳腺，膀胱，卵巢，淋巴瘤和携带DNA的肿瘤相关突变的所有其他恶性肿瘤的方法以及用于监测人和其他动物中的癌症和其他肿瘤性疾病的方法。

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