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61. 发明申请

US20030119054A1 Polypeptide immobilization 有权
标题翻译：多肽固定
公开(公告)号：US20030119054A1
公开(公告)日：2003-06-26
申请号：US09923760
申请日：2001-08-07
发明人： Milan Mrksich , Christian Hodneland
IPC分类号： C12Q001/68 , G01N033/53 , C07C321/20 , C07D213/28 , C07D207/46
CPC分类号： G01N33/6845 , B82Y30/00 , C07C323/58 , C07F9/4006 , C07F9/4084 , C07F9/65515 , C40B30/04 , G01N33/54353 , G01N33/551 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： A substrate comprises a surface, and a plurality of moieties, on at least a portion of the surface. The moieties are moieties of formula:Surf-LnullQnullT,where nullT comprises a reactant ligand, and Surf- designates where the moiety attaches to the surface. The substrate can be made into a protein chip by the reaction of a reactant ligand and a fusion polypeptide, where the fusion polypeptide includes a capture polypeptide moiety which corresponds to the reactant ligand.
摘要翻译：衬底包括在表面的至少一部分上的表面和多个部分。这些部分是式：Surf-L-Q-T的部分，其中-T包含反应物配体，并且Surf-表示部分连接到表面。底物可以通过反应物配体和融合多肽的反应制成蛋白质芯片，其中融合多肽包括对应于反应物配体的捕获多肽部分。

62. 发明授权

US5109043A Process for the preparation of organophosphorus derivatives of 2,4-di-tert-butylphenol, of 4,4'-dihalomagnesium compounds of biphenyl and the use of the organophosphorus derivatives for the stabilization of polyolefin molding 失效
标题翻译：制备2,4-二 - 叔丁基苯酚的4,4'-二氢马来酸化合物的联苯衍生物的有机衍生物的方法和用于稳定聚烯烃成型的有机磷衍生物的用途
公开(公告)号：US5109043A
公开(公告)日：1992-04-28
申请号：US452751
申请日：1989-12-19
申请人： Manfred Bohshar , Hans-Jerg Kleiner , Karl Waldmann , Gerhard Pfahler
发明人： Manfred Bohshar , Hans-Jerg Kleiner , Karl Waldmann , Gerhard Pfahler
IPC分类号： C09K15/32 , C07F3/02 , C07F9/40 , C07F9/48 , C08K5/53 , C08K5/5393 , C08L23/00
CPC分类号： C07F9/4875 , C07F3/02 , C07F9/4084 , C08K5/5393
摘要： A process for the preparation of organophosphorus derivatives of 2,4-di-tert-butylphenol with a high proportion of organophosphorus derivatives of biphenyl, which comprises reacting, in a first step, a 4,4'-dihalobiphenyl whose halogen has an atomic weight of at least 35, under Grignard conditions with magnesium to form the corresponding Grignard compound and this is further reacted in a second step with bis(2,4-di-tert-butylphenyl) chlorophosphite with the formation of a mixture in which at least 50% by weight of the phosphorus is combined in the form of tetrakis(2,4-di-tert-butylphenyl) 4,4'-biphenylenediphosphonite. The invention further relates to a polyolefin molding composition containing tetrakis(2,4-di-tert-butylphenyl) 4,4'-biphenylenediphosphonite which was prepared by reaction of a 4,4'-dihalobiphenyl whose halogen has an atomic weight of at least 35 with magnesium to form the Grignard compound and by subsequent reaction with bis(2,4-di-tert-butylphenyl) chlorophosphite. The invention furthermore relates to a process for the preparation of 4,4'-dihalomagnesium compounds of biphenyl by reacting a 4,4'-dihalobiphenyl whose halogen has an atomic weight of at least 35 in the absence of an entrainer, with fine-particle magnesium which is held in suspension.
摘要翻译：一种制备2,4-二叔丁基苯酚有机磷衍生物与高比例联苯有机磷衍生物的方法，其包括在第一步中使卤素原子量为4,4'-二卤联苯至少35，在Grignard条件下用镁形成相应的格氏化合物，并且在第二步中进一步与双（2,4-二叔丁基苯基）氯亚磷酸酯反应形成混合物，其中至少50 按重量计的磷重量合并为四（2,4-二叔丁基苯基）4,4'-联苯二亚磷酸盐的形式。本发明还涉及一种含有四（2,4-二叔丁基苯基）4,4'-联苯二亚磷酸盐的聚烯烃模塑组合物，其通过使卤素原子量至少为原子量的4,4'-二卤代联苯 35与镁形成格氏化合物，随后与双（2,4-二叔丁基苯基）氯亚磷酸酯反应。本发明还涉及通过在不存在夹带剂的情况下使卤素原子量至少为35的4,4'-二卤联苯与细颗粒反应来制备联苯的4,4'-二卤代镁化合物的方法保持悬浮的镁。

63. 发明授权

US4659567A Molecules with antibody combining sites that bind to hydrolytic transition states 失效
标题翻译：具有结合水解转变状态的抗体结合位点的分子
公开(公告)号：US4659567A
公开(公告)日：1987-04-21
申请号：US648406
申请日：1984-09-07
申请人： Alfonso Tramontano , Richard A. Lerner
发明人： Alfonso Tramontano , Richard A. Lerner
IPC分类号： C07D311/16 , C07D405/12 , C07F9/40 , C07F9/553 , C07F9/6558 , C07K16/44 , G01N33/53 , A61K39/00 , C07D209/48 , C07F9/65
CPC分类号： C07D405/12 , C07D311/16 , C07F9/4056 , C07F9/4084 , C07F9/5537 , C07F9/65586 , C07K16/44 , G01N33/53 , Y10S435/814
摘要： A phosphonamidate or phosphonate analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester ligand is used to produce antibodies of predetermined specificity. The antibodies include an epitope that binds to and thereby stabilizes the tetrahedral carbon atom of the amide or ester hydrolysis transition state of the ligand to hydrolyze the ligand at a predetermined site.
摘要翻译：使用具有基本上对应于酰胺或酯配体的水解转变状态的构象的构象的膦酰胺酸酯或膦酸酯类似物 - 配体来产生预定特异性的抗体。抗体包括结合并由此稳定配体的酰胺或酯水解过渡态的四面体碳原子以在预定位点水解配体的表位。

64. 发明授权

US4634788A Herbicidal glyphosate oxime derivatives 失效
标题翻译：除草草甘膦肟衍生物
公开(公告)号：US4634788A
公开(公告)日：1987-01-06
申请号：US741930
申请日：1985-06-06
申请人： Om P. Dhingra , John E. Franz , Harrison R. Hakes
发明人： Om P. Dhingra , John E. Franz , Harrison R. Hakes
IPC分类号： A01N57/22 , C07F9/40
CPC分类号： C07F9/4084 , A01N57/22 , C07F9/4006
摘要： Novel herbicidal oxime derivatives of aryl glyphosate esters are described and claimed along with a process for producing such oxime derivatives.
摘要翻译：芳基草甘膦酯的新型除草肟衍生物与生产这种肟衍生物的方法一起被描述和要求。

65. 发明授权

US4456566A Process for preparing amides of methylphosphonates 失效
标题翻译：制备甲基膦酸酯酰胺的方法
公开(公告)号：US4456566A
公开(公告)日：1984-06-26
申请号：US157713
申请日：1980-06-09
申请人： Milton L. Honig , Edward D. Weil
发明人： Milton L. Honig , Edward D. Weil
IPC分类号： C07F9/40 , C07F9/44 , C07F9/6571 , C07F9/6587 , C08G79/02 , C08G79/04
CPC分类号： C07F9/44 , C07F9/4084 , C07F9/657181 , C07F9/6587 , C08G79/02 , C08G79/04
摘要： A process is provided for the preparation of diaryl methylphosphonates through the reaction of triaryl phosphites with methanol in the pressure of a catalytic quantity of methyl iodide. The reaction is conducted at a temperature of from about 170.degree. C. to about 250.degree. C. New and useful derivatives are produced by reaction of the diaryl methylphosphonates with polyols or amines.
摘要翻译：提供了通过在催化量的甲基碘的压力下通过亚磷酸三芳基酯与甲醇的反应制备二芳基甲基膦酸酯的方法。反应在约170℃至约250℃的温度下进行。通过二芳基甲基膦酸酯与多元醇或胺的反应制备新的和有用的衍生物。

66. 发明授权

US4381390A Thermoplastic polyphosphonatophenyl ester carbonate from aryloxycarbonyloxy-benzoic acid aryl ester and preparation thereof 失效
标题翻译：来自芳氧基羰基氧基 - 苯甲酸芳基酯的热塑性聚膦酰基苯基碳酸酯及其制备
公开(公告)号：US4381390A
公开(公告)日：1983-04-26
申请号：US311360
申请日：1981-10-15
申请人： Manfred Schmidt , Ludwig Bottenbruch
发明人： Manfred Schmidt , Ludwig Bottenbruch
IPC分类号： C08G79/00 , C07F9/40 , C08G63/692 , C08G79/02 , C08G79/04 , C08G63/32
CPC分类号： C08G79/04 , C07F9/4084 , C08G63/692
摘要： A two step catalyzed process for the preparation of thermoplastic polyphosphonatophenyl ester carbonates comprising first, the preparation of an aryloxy carbonyloxy-benzoic acid aryl ester and second, its transesterification with a phosphonic acid diphenyl ester and a diphenol is disclosed.
摘要翻译：公开了一种用于制备热塑性聚膦酸苯酯的碳酸酯的两步催化方法，其首先包括制备芳氧基羰基氧基 - 苯甲酸芳酯，其次是其与膦酸二苯酯和二酚的酯交换。

67. 发明授权

US4362723A S-Aryl S-(tertiary alkyl) alkylphosphonodithioate insecticides and nematocides 失效
标题翻译： S-（叔烷基）烷基二硫代磷酸酯杀虫剂和杀线虫剂
公开(公告)号：US4362723A
公开(公告)日：1982-12-07
申请号：US221643
申请日：1980-12-31
申请人： Mohamed A. Fahmy
发明人： Mohamed A. Fahmy
IPC分类号： A01N57/22 , C07F9/40 , C07F9/42
CPC分类号： A01N57/22 , C07F9/4084 , C07F9/425
摘要： Compounds having the formula ##STR1## in which R is alkyl of 1 to 8 carbon atoms, haloalkyl of 1 to 8 carbon atoms, alkenyl of 2 to 8 carbon atoms, haloalkenyl of 2 to 8 carbon atoms, alkynyl of 2 to 8 carbon atoms or haloalkynyl of 2 to 8 carbon atoms;R.sub.1 is aryl;R.sub.2 is tertiary alkyl of 4 to 8 carbon atoms; are disclosed as well as their use as insecticides and nematocides, e.g., in controlling Corn rootworm and Southern Armyworm.
摘要翻译：具有式“IMAGE”的化合物，其中R是1至8个碳原子的烷基，1至8个碳原子的卤代烷基，2至8个碳原子的烯基，2至8个碳原子的卤代链烯基，2至8个碳原子的炔基或2-8个碳原子的卤代炔基; R1是芳基; R2是4〜8个碳原子的叔烷基; 被公开以及它们作为杀虫剂和杀线虫剂的用途，例如控制玉米根虫和南方蛔虫。

68. 发明授权

US4305891A Method for preparing O-4-(hydroxyalkyl)-thiophenyl phosphates 失效
标题翻译：制备O-4-（羟基烷基） - 硫代苯基磷酸酯的方法
公开(公告)号：US4305891A
公开(公告)日：1981-12-15
申请号：US140115
申请日：1980-04-14
申请人： Francis W. Jones
发明人： Francis W. Jones
IPC分类号： B01J31/00 , C07B61/00 , C07F9/09 , C07F9/12 , C07F9/165 , C07F9/18 , C07F9/24 , C07F9/38 , C07F9/40
CPC分类号： C07F9/242 , C07C323/00 , C07F9/12 , C07F9/18 , C07F9/4084
摘要： Organophosphorus esters, useful as intermediates in the synthesis of fibre-reactive insect proofing agents for keratinous materials, are prepared as follows: ##STR1## wherein: R.sub.1 is an alkyl, alkoxy, alkylamino or alkylmercapto radical with 1-6 carbon atoms a dialkylamino radical of 2 to 6 carbon atoms or a phenyl or amino radical;R.sub.2 is an alkyl radical of 1-6 carbon atoms;R.sub.3 is a divalent alkylene radical of 1-12 carbon atoms;X is either a sulphur or oxygen atom; andhal is either a chlorine or bromine atom.
摘要翻译：有机磷酯可用作合成角质材料的纤维反应性防虫剂的中间体，如下制备： + TR + TR + TR 其中 R 1是具有1-6个碳原子的烷基，烷氧基，烷基氨基或烷基巯基，具有2至6个碳原子的二烷基氨基或苯基或氨基; R2是1-6个碳原子的烷基; R3是1-12个碳原子的二价亚烷基; X是硫或氧原子; 并且hal是氯或溴原子。

69. 发明授权

US4284626A O-aryl S-branched alkyl alkylphosphonodithioate insecticides and nematocides 失效
标题翻译： O-芳基S-支链烷基二硫代磷酸酯杀虫剂和杀线虫剂
公开(公告)号：US4284626A
公开(公告)日：1981-08-18
申请号：US108329
申请日：1979-12-31
申请人： Mohamed A. Fahmy
发明人： Mohamed A. Fahmy
IPC分类号： A01N57/22 , C07F9/38 , C07F9/40 , C07F9/42
CPC分类号： A01N57/22 , C07F9/4084 , C07F9/425
摘要： Compounds having the formula ##STR1## in which R is alkyl of 1 to 8 carbon atoms;R.sub.1 is aryl;R.sub.2 is branched alkyl of 3 to 8 carbon atoms; andtheir use as insecticides and nematocides, e.g., in controlling corn rootworm and southern armyworm.
摘要翻译：具有式“IMAGE”的化合物，其中R是1至8个碳原子的烷基; R1是芳基; R2是3〜8个碳原子的支链烷基; 以及它们作为杀虫剂和杀线虫剂的用途，例如控制玉米根虫和南方粘虫。

70. 发明授权

US4194029A Novel 4-chromanone-7-phosphates and phosphonates and the insecticidal use thereof 失效
标题翻译：新型4-苯并二氢吡喃酮-7-磷酸酯和膦酸酯及其杀虫用途
公开(公告)号：US4194029A
公开(公告)日：1980-03-18
申请号：US934436
申请日：1978-08-17
申请人： Hsiao-Ling Lam
发明人： Hsiao-Ling Lam
IPC分类号： C07D311/22 , C07F9/40 , C07F9/655 , A61K31/35
CPC分类号： C07F9/65522 , C07D311/22 , C07F9/4084
摘要： Novel insecticidal and/or miticidal compounds have the formula ##STR1## in which R is C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy; R.sub.1 is C.sub.1 -C.sub.3 alkoxy; R.sub.2 and R.sub.3 are C.sub.1 -C.sub.3 alkyl; R.sub.4 is hydrogen or C.sub.1 -C.sub.3 alkyl and R.sub.5 is hydrogen, chloro or C.sub.1 -C.sub.3 alkoxy.
摘要翻译：新型杀虫和/或杀螨化合物具有其中R为C 1 -C 3烷基或C 1 -C 3烷氧基的式“IMAGE” R1是C1-C3烷氧基; R2和R3是C1-C3烷基; R4是氢或C1-C3烷基，R5是氢，氯或C1-C3烷氧基。

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