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61. 发明申请

US20140142093A1 TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS 有权
标题翻译：三氧化二氮唑酮类抗生素化合物
公开(公告)号：US20140142093A1
公开(公告)日：2014-05-22
申请号：US14096419
申请日：2013-12-04
申请人： Christian HUBSCHWERLEN , Daniel RITZ , Georg RUEEDI , Jean-Philippe SURIVET , Cornelia ZUMBRUNN-ACKLIN
发明人： Christian HUBSCHWERLEN , Daniel RITZ , Georg RUEEDI , Jean-Philippe SURIVET , Cornelia ZUMBRUNN-ACKLIN
IPC分类号： C07D471/06 , C07D487/06 , C07D519/00 , C07D471/16
CPC分类号： C07D471/06 , C07D471/16 , C07D487/06 , C07D519/00
摘要： The present invention relates to antibacterial compounds of formula (I) wherein “----” is a bond or is absent, V is CH, CR6 or N; R0 is H or, if “----” is a bond, may also be alkoxy; R1 is cyano, alkyl, or ethynyl; U is CH or N when “----” is a bond, or, if “----” is absent, U is CH2, NH or NH9; R2 is H, alkylcarbonyl or CH2—R3; R3 is H, alkyl or hydroxyalkyl; R4 is H or, if n is not 0 and R5 is H, may also be OH; R5 is H, alkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, carboxy or alkoxycarbonyl; R6 is hydroxyalkyl, carboxy, alkoxycarbonyl or —(CH2)q—NR7R8, q being 1, 2 or 3 and each of R7 and R8 independently being H or alkyl or R7 and R8 forming with the N atom bearing them a ring; R9 is alkyl or hydroxyalkyl; A is —(CH2)p—, —CH2CH2CH(OH)— or —COCH2CH(OH)—; G is substituted phenyl or G1 or G2, wherein Q is O or S and X is CH or N; and Y1, Y2 and Y3 may each be CH or N; and n is 0 when A is —CH2CH2CH(OH)— or —COCH2CH(OH)—, and n is 0, 1 or 2 when A is —(CH2)p—, p being 1, 2, 3 or 4, with the proviso that the sum of n and p is then 2, 3 or 4; and to salts of such compounds.
摘要翻译：本发明涉及式（I）的抗菌化合物，其中“----”是键或不存在，V是CH，CR 6或N; R 0是H，或者如果“----”是键，也可以是烷氧基; R1是氰基，烷基或乙炔基; 当“----”是键时，U是CH或N，或者如果不存在“----”，则U是CH 2，NH或NH 9; R2是H，烷基羰基或CH2-R3; R3是H，烷基或羟烷基; R4是H或如果n不为0且R5是H，也可以是OH; R5是H，烷基，羟基烷基，氨基烷基，烷氧基烷基，羧基或烷氧基羰基; R6是羟基烷基，羧基，烷氧基羰基或 - （CH2）q-NR7R8，q是1,2或3，R7和R8各自独立地是H或烷基或R7和R8与带有它们的N原子形成环; R9是烷基或羟烷基; A是 - （CH 2）p - ， - CH 2 CH 2 CH（OH） - 或-COCH 2 CH（OH） - ; G是取代的苯基或G1或G2，其中Q是O或S，X是CH或N; Y1，Y2和Y3各自为CH或N; 当A为-CH 2 CH 2 CH（OH） - 或-COCH 2 CH（OH） - 时，n为0，当A为 - （CH 2）p - ，p为1,2,3或4时，n为0,1或2，条件是n和p之和为2,3或4; 和这些化合物的盐。

62. 发明授权

US08729096B2 Imidazolidine-2,4-dione derivatives as N-formyl peptide receptor 2 modulators 有权
标题翻译：咪唑烷-2,4-二酮衍生物作为N-甲酰基肽受体2调节剂
公开(公告)号：US08729096B2
公开(公告)日：2014-05-20
申请号：US13765527
申请日：2013-02-12
申请人： Allergan, Inc.
发明人： Richard L. Beard , Vidyasagar Vuligonda , John E. Donello , Veena Viswanath , Michael E. Garst
IPC分类号： A61K31/4353 , A61K31/4178 , A61K31/4164 , C07D471/06 , C07D487/10 , C07D233/02
CPC分类号： A61K31/4353 , A61K31/4164 , A61K31/4178 , C07D233/02 , C07D233/72 , C07D233/78 , C07D471/04 , C07D471/06 , C07D487/04 , C07D487/10
摘要： The present invention relates to novel imidazolidine-2,4-dione derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor 2 (FPR2).
摘要翻译：本发明涉及新的咪唑烷-2,4-二酮衍生物，其制备方法，含有它们的药物组合物及其作为N-甲酰基肽受体2（FPR2）调节剂的药物的用途。

63. 发明授权

US08722888B2 Materials and methods for the preparation of anisotropically-ordered solids 失效
标题翻译：用于制备各向异性有序固体的材料和方法
公开(公告)号：US08722888B2
公开(公告)日：2014-05-13
申请号：US13677149
申请日：2012-11-14
申请人： Travis D. Carson , Suk-Wah Tam-Chang
发明人： Travis D. Carson , Suk-Wah Tam-Chang
IPC分类号： C07D221/18
CPC分类号： C07D221/18 , B82Y20/00 , C07D471/06 , C09K19/02 , C09K19/3488 , G02F1/0054 , G02F1/0063 , G02F2001/133726 , G02F2202/36 , Y10T428/10 , Y10T428/1041 , Y10T428/2982
摘要： The invention provides materials and methods for making anisotropic solids which may be in the form of films, layers, shaped elements, and other shaped articles. The methods provide anisotropic solids without the need for rolling, rubbing, or stretching to impart orientational alignment of the molecules of the solid. The methods employ organic or organometallic compounds which are soluble orienting molecules. The solvent or solvent system must be sufficiently volatile to be removed without disruption of the molecular orientation. The soluble orienting molecules include those containing one or more hydrophilic and/or ionic groups and the solvent or solvent system can be a polar organic solvent or solvent system or an aqueous solvent or solvent system. The invention also provides novel compounds having quaterrylene, perylene and naphthalene ring systems carrying one or more hydrophilic and/or ionic groups. These novel compounds can exhibit useful absorption and fluorescence properties in solution and in the solid phase and can exhibit useful liquid crystalline properties.
摘要翻译：本发明提供用于制备各向异性固体的材料和方法，其可以是膜，层，成形元件和其它成形制品的形式。该方法提供各向异性固体，而不需要滚动，摩擦或拉伸以赋予固体分子的取向取向。该方法采用有机或有机金属化合物，它们是可溶取向分子。溶剂或溶剂体系必须具有足够的挥发性以便在不破坏分子取向的情况下除去。可溶取向分子包括含有一个或多个亲水基团和/或离子基团的分子，溶剂或溶剂系统可以是极性有机溶剂或溶剂体系或水溶剂或溶剂体系。本发明还提供具有季铵基，二萘嵌苯和萘环体系携带一个或多个亲水和/或离子基团的新型化合物。这些新型化合物可以在溶液和固相中表现出有用的吸收和荧光特性，并且可以显示出有用的液晶性质。

64. 发明申请

US20140080853A1 Compounds and Formulations Suitable for Radical Scavenging 有权
标题翻译：适用于自由基清除的化合物和配方
公开(公告)号：US20140080853A1
公开(公告)日：2014-03-20
申请号：US14076612
申请日：2013-11-11
申请人： Solenne BV
发明人： David F. Kronholm , Alexander B. Sieval , Jan C. Hummelen
IPC分类号： C07D471/06 , A61K8/49
CPC分类号： C07D221/18 , A61K8/4926 , A61K2800/522 , A61Q19/00 , A61Q19/004 , C07D471/06
摘要： The present invention relates to compositions and methods of using free radical scavengers with reduced 1O2 generation. In certain embodiments, these compositions and methods of use relate to fullerene-derived ketolactams and fullerene-derived ketolactam derivatives, fullerene derivatives, and/or fullerenes. In yet other embodiments, the invention relates to cosmetic or dermatological compositions comprising said free radical scavengers with reduced 1O2 generation.
摘要翻译：本发明涉及使用还原的一氧化二氮的自由基清除剂的组合物和方法。在某些实施方案中，这些组合物和使用方法涉及富勒烯衍生的酮内酰胺和富勒烯衍生的酮内酰胺衍生物，富勒烯衍生物和/或富勒烯。在其它实施方案中，本发明涉及化妆品或皮肤病学组合物，其包含具有降低的1O 2代的所述自由基清除剂。

65. 发明申请

US20140080813A1 TRICYCLIC QUINOLINE AND QUINOXALINE DERIVATIVES 审中-公开
公开(公告)号：US20140080813A1
公开(公告)日：2014-03-20
申请号：US13829568
申请日：2013-03-14
申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人： Wilfried Braje
IPC分类号： C07D471/06
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.

66. 发明申请

US20140080220A1 Azide Substituted Naphthylene or Rylene Imide Derivatives and their Use as Reagents in Click-Reactions 有权
标题翻译：叠氮取代的亚萘基或亚芳基衍生物及其作为点滴反应的试剂
公开(公告)号：US20140080220A1
公开(公告)日：2014-03-20
申请号：US14085058
申请日：2013-11-20
申请人： Thomas Gessner , Helmut Reichelt , Ingo Münster , Martin Könemann , Neil Gregory Pschirer , Jianqiang Qu , Rüdiger Sens , Anja Schwögler , Antonio Manetto
发明人： Thomas Gessner , Helmut Reichelt , Ingo Münster , Martin Könemann , Neil Gregory Pschirer , Jianqiang Qu , Rüdiger Sens , Anja Schwögler , Antonio Manetto
IPC分类号： C07D221/18 , C12Q1/68 , C07D221/14
CPC分类号： C07D221/18 , C07D221/14 , C07D471/06 , C09B5/62 , C09B57/007 , C12Q1/68 , Y10T436/143333
摘要： Novel mono-azide substituted rylene-imide derivatives, their use in methods for the detection of analytes and reagents kits for the detection of analytes comprising said novel mono-azide substituted rylene-imide derivatives.
摘要翻译：新型单叠氮取代的亚芳基 - 亚胺衍生物，其用于检测分析物的方法和用于检测包含所述新型单叠氮取代的亚芳基 - 亚胺衍生物的分析物的试剂盒。

67. 发明申请

US20140045879A1 Pharmaceutical Compositions for the Treatment of Capillary Arteriopathy 有权
标题翻译：用于治疗毛细血管病变的药物组合物
公开(公告)号：US20140045879A1
公开(公告)日：2014-02-13
申请号：US13354832
申请日：2012-01-20
申请人： Rudolf Reiter , Johannes Tack , Reinhard Horowski
发明人： Rudolf Reiter , Johannes Tack , Reinhard Horowski
IPC分类号： C07D471/06
CPC分类号： C07D471/06 , A61K31/00 , A61K31/48
摘要： The present invention relates to the use of ergot derivatives or ergolines, and in particular of lisuride and terguride for the prophylaxis and treatment of constrictive capillary arteriopathy. Constrictive capillary arteriopathy refers to the diseases pulmonary arterial hypertension, endogenously induced or exogenously induced glomeruloscleroses as well as secondary Raynaud's syndrome.
摘要翻译：本发明涉及麦角衍生物或麦角蛋白，特别是利鲁司特和替麦格德用于预防和治疗缩窄性毛细血管病变的用途。狭窄性毛细血管动脉病是指肺动脉高压，内源诱导或外源性诱导的肾小球硬化以及继发性雷诺综合征的疾病。

68. 发明授权

US08624029B2 Lipidated imidazoquinoline derivatives 有权
标题翻译：脂质咪唑并喹啉衍生物
公开(公告)号：US08624029B2
公开(公告)日：2014-01-07
申请号：US13125342
申请日：2009-10-23
申请人： David A. Johnson
发明人： David A. Johnson
IPC分类号： C07F9/06
CPC分类号： C07D471/06 , A61K2039/55511 , C07D471/04 , C07F9/6561
摘要： The compounds of the subject invention are adjuvant molecules that comprise a imidazoquinoline molecule covalently linked to a phospho- or phosphonolipid group. The compounds of the invention have been shown to be inducers of interferon-a, IL-12 and other immunostimulatory cytokines and possess an improved activity profile in comparison to known cytokine inducers when used as adjuvants for vaccine antigens.
摘要翻译：本发明的化合物是包含与磷酸或磷脂酰脂基共价连接的咪唑并喹啉分子的佐剂分子。已经显示本发明的化合物是干扰素-α，IL-12和其他免疫刺激性细胞因子的诱导剂，并且当用作疫苗抗原的佐剂时，与已知的细胞因子诱导剂相比具有改善的活性。

69. 发明授权

US08609846B2 Naphthalene monoimide derivatives and use thereof as photosensitizers in solar cells and photodetectors 有权
标题翻译：萘单酰亚胺衍生物及其在太阳能电池和光电探测器中作为光敏剂的用途
公开(公告)号：US08609846B2
公开(公告)日：2013-12-17
申请号：US13331647
申请日：2011-12-20
申请人： Neil Gregory Pschirer , Jan Schoeneboom , Felix Eickemeyer , Helmut Reichelt , Ruediger Sens , Ingmar Bruder
发明人： Neil Gregory Pschirer , Jan Schoeneboom , Felix Eickemeyer , Helmut Reichelt , Ruediger Sens , Ingmar Bruder
IPC分类号： C07D221/06 , C07D471/06 , H01L31/042
CPC分类号： C07D471/06 , C07D409/14
摘要： The present invention relates to compounds of the formulae Ia and Ib in which the variables R, n, A, B, R1 and R2 are each as defined in the description. The present invention further relates to the use of compounds of the formula Ia or Ib or mixtures of compounds of the formulae Ia and Ib and/or isomers or mixtures of the isomers of the compounds of the formulae Ia and Ib as photosensitizers in solar cells and photodetectors, and to solar cells and photodetectors which comprise such compounds of the formula Ia or Ib or mixtures of compounds of the formulae Ia and Ib and/or isomers or mixtures of the isomers of the compounds of the formulae Ia and Ib as photosensitizers.
摘要翻译：本发明涉及式Ia和Ib的化合物，其中变量R，n，A，B，R 1和R 2各自如说明书中所定义。本发明还涉及式Ia或Ib化合物或式Ia和Ib化合物的混合物和/或式Ia和Ib化合物的异构体或异构体的混合物在太阳能电池中作为光敏剂的用途，以及光电检测器，以及包含式Ia或Ib的化合物或式Ia和Ib化合物的混合物和/或式Ia和Ib化合物的异构体的异构体或者混合物的太阳能电池和光电检测器作为光敏剂。

70. 发明申请

US20130317207A1 CARBOXY X RHODAMINE ANALOGS 有权
公开(公告)号：US20130317207A1
公开(公告)日：2013-11-28
申请号：US13682589
申请日：2012-11-20
申请人： Promega Corporation
发明人： Thomas A. KIRKLAND , Mark G. MCDOUGALL , Stephen DWIGHT
IPC分类号： C07H19/10 , C07H19/073 , C07D491/22 , C07D471/06 , C07D491/147 , C07D491/16
CPC分类号： G01N33/542 , C07D223/16 , C07D471/06 , C07D491/147 , C07D491/16 , C07D491/22 , C07F9/65586 , C07H19/073 , C07H19/10 , C09B11/24 , C12Q1/686 , G01N33/582 , G01N33/6845 , G01N2333/90241
摘要： The present invention provides novel fluorescent dyes and kits containing the same, which are useful for labeling a wide variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis and/or treatment of disease conditions.

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