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    • 66. 发明申请
    • SUPRAMOLECULAR BIOCONJUGATES
    • US20030118595A1
    • 2003-06-26
    • US08967269
    • 1997-11-07
    • CHRISTOF M. NIEMEYERCHARLES R. CANTORTAKESHI SANOCASSANDRA L. SMITH
    • A61K039/00C07K017/00
    • B82Y5/00A61K47/54A61K47/55A61K47/557A61K47/6949A61K51/1268C03C17/30C03C17/3405C12Q1/6804C12Q1/682
    • The invention relates to supramolecular bioconjugates and to methods for assembling and utilizing supramolecular bioconjuigates. Supramolecalar bioconjugates comprise a plurality of first nucleic acids and a plurality of mediators wherein each mediator comprises a second nucleic acid complementary to a sequence within said plurality of first nucleic acids. To assemble a supramolecalar bioconjugate, one or more sets of bioreactive agents are coupled to the plurality of mediators, forming a plurality of bioreactive complexes The plurality of bioreactive complexes are hybridized to the plurality of first nucleic acids to form the supramolecular bioconjugate. Bioconjugates can be used to detect and isolate targets, to screen samples for targets such as antigens, to treat patients with multiple agents or to diagnose disorders in the form of a kit.
    • 本发明涉及超分子生物缀合物和组分和利用超分子生物复合物的方法。 超分子生物缀合物包含多个第一核酸和多个介质,其中每个介体包含与所述多个第一核酸内的序列互补的第二核酸。 为了组装超分子生物缀合物,将一组或多组生物反应剂偶联到多个介体上,形成多个生物反应性复合物。多个生物反应性复合物与多个第一核酸杂交以形成超分子生物缀合物。 生物共轭物可用于检测和分离靶标,筛选靶标如抗原的样品,以治疗患有多种药物的患者或以试剂盒的形式诊断疾病。