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61. 发明授权

US09808649B2 Immobilization system to support an in vivo medical device 有权
公开(公告)号：US09808649B2
公开(公告)日：2017-11-07
申请号：US15399805
申请日：2017-01-06
申请人： Medical Tool & Technology, LLC
发明人： Richard David Helmig , John Scott Wheeler
IPC分类号： A61N5/10 , A61F5/37
CPC分类号： A61N5/10 , A61F5/3776 , A61N5/1016 , A61N2005/1012 , A61N2005/1097
摘要： The problem of securing the position of an internally placed medical device that extends out of the body during targeted high-dose-rate (HDR) brachytherapy is solved by a uniquely configured immobilization system that can be utilized to stabilize medical devices placed, for example, within the uterus or cervix. During the process of transporting a patient from the location where the HDR applicator is emplaced, for example, where the tandem and ring is placed within the cervix of a patient, to the location where the treatment is actually applied to the tissue, the medical device can move out of place and in so doing cause discomfort, pain, or an ineffective treatment for the patient. The embodiments of this immobilization system can include a strap apparatus, a straddling girdle, and bracket that can be attached to a patient. This immobilization system ensures the position of an internally placed medical device during targeted HDR brachytherapy.

62. 发明授权

US09320915B2 Brachytherapy tandem and ovoid implantation devices and methods 有权
标题翻译：近距离放射治疗串联和卵形植入装置及方法
公开(公告)号：US09320915B2
公开(公告)日：2016-04-26
申请号：US14613038
申请日：2015-02-03
申请人： Mark A. D'Andrea
发明人： Mark A. D'Andrea
IPC分类号： A61N5/10 , A61B18/04 , A61B18/00
CPC分类号： A61N5/1016 , A61B18/04 , A61B2017/22051 , A61B2017/22054 , A61B2017/22055 , A61B2017/22061 , A61B2017/22062 , A61B2017/22068 , A61B2017/22069 , A61B2018/00273 , A61B2018/00285 , A61B2018/00559 , A61B2018/046 , A61B2090/033 , A61B2090/0445 , A61B2090/0481 , A61N5/1067 , A61N5/1071 , A61N2005/1003 , A61N2005/1012 , A61N2005/1094
摘要： Intracavitary brachytherapy tandem and ovoid oncology treatment systems and methods are provided. One such system and method employs a multi-part tandem having a detachable distal section suitable for retaining within a body cavity such as the uterus, both during radiation treatment and during recovery time between radiation treatments. This distal portion can be intended for single-patient use and be disposed of after completion of a radiation treatment session having multiple radiation dose treatment times. One or both of real time in vivo detection and monitoring and hypertherapy features can be included. One or more of the system tandem or ovoid colpostats feature bendability to tailor the system to the specific body and patient being treated. The method includes having a tandem distal section inserted into a body cavity such as a uterus and remaining within the body cavity in between treatment times. Other systems and methods incorporate balloon devices that assist in spacing radiation doses away from body sites at which radiation treatment is not intended. Balloon devices also can be provided for adjusting and maintaining separation spacing between two ovoid colpostats while intracavitary.
摘要翻译：提供腔内近距离放射治疗系统和卵巢肿瘤治疗系统和方法。一种这样的系统和方法采用多部分串联，其具有适于在放射治疗期间和在放射治疗之间的恢复时间期间保持在诸如子宫的体腔内的可分离远端部分。该远端部分可以用于单次患者使用，并且在完成具有多个辐射剂量治疗时间的放射治疗会话之后进行处置。可以包括实时体内检测和监测和超治疗特征中的一个或两个。一个或多个系统串联或卵巢粘滞剂具有弯曲性，可以将系统定制到被治疗的特定身体和患者。该方法包括将串联远端部分插入到诸如子宫的体腔中并在治疗时间之间保留在体腔内。其他系统和方法包括气球装置，其有助于将辐射剂量与远离身体部位的辐射处理隔开。还可以提供气球装置用于在腔内调节和保持两个卵状粘液瓶之间的间隔。

63. 发明申请

US20150157878A1 BRACHYTHERAPY TANDEM AND OVOID IMPLANTATION DEVICES AND METHODS 审中-公开
公开(公告)号：US20150157878A1
公开(公告)日：2015-06-11
申请号：US14613038
申请日：2015-02-03
申请人： Mark A. D'Andrea
发明人： Mark A. D'Andrea
IPC分类号： A61N5/10
CPC分类号： A61N5/1016 , A61B18/04 , A61B2017/22051 , A61B2017/22054 , A61B2017/22055 , A61B2017/22061 , A61B2017/22062 , A61B2017/22068 , A61B2017/22069 , A61B2018/00273 , A61B2018/00285 , A61B2018/00559 , A61B2018/046 , A61B2090/033 , A61B2090/0445 , A61B2090/0481 , A61N5/1067 , A61N5/1071 , A61N2005/1003 , A61N2005/1012 , A61N2005/1094
摘要： Intracavitary brachytherapy tandem and ovoid oncology treatment systems and methods are provided. One such system and method employs a multi-part tandem having a detachable distal section suitable for retaining within a body cavity such as the uterus, both during radiation treatment and during recovery time between radiation treatments. This distal portion can be intended for single-patient use and be disposed of after completion of a radiation treatment session having multiple radiation dose treatment times. One or both of real time in vivo detection and monitoring and hypertherapy features can be included. One or more of the system tandem or ovoid colpostats feature bendability to tailor the system to the specific body and patient being treated. The method includes having a tandem distal section inserted into a body cavity such as a uterus and remaining within the body cavity in between treatment times. Other systems and methods incorporate balloon devices that assist in spacing radiation doses away from body sites at which radiation treatment is not intended. Balloon devices also can be provided for adjusting and maintaining separation spacing between two ovoid colpostats while intracavitary.
摘要翻译：提供腔内近距离放射治疗系统和卵巢肿瘤治疗系统和方法。一种这样的系统和方法采用多部分串联，其具有适于在放射治疗期间和在放射治疗之间的恢复时间期间保持在诸如子宫的体腔内的可分离远端部分。该远端部分可以用于单次患者使用，并且在完成具有多个辐射剂量治疗时间的放射治疗会话之后进行处置。可以包括实时体内检测和监测和超治疗特征中的一个或两个。一个或多个系统串联或卵巢粘滞剂具有弯曲性，可以将系统定制到被治疗的特定身体和患者。该方法包括将串联远端部分插入到诸如子宫的体腔中并在治疗时间之间保留在体腔内。其他系统和方法包括气球装置，其有助于将辐射剂量与远离身体部位的辐射处理隔开。还可以提供气球装置用于在腔内调节和保持两个卵状粘液瓶之间的间隔。

64. 发明授权

US08979725B2 Brachytherapy tandem and ovoid implantation devices and methods 有权
标题翻译：近距离放射治疗串联和卵形植入装置及方法
公开(公告)号：US08979725B2
公开(公告)日：2015-03-17
申请号：US13478794
申请日：2012-05-23
申请人： Mark A. D'Andrea
发明人： Mark A. D'Andrea
IPC分类号： A61N5/00 , A61M36/00 , A61M36/04 , A61M36/10 , A61M36/12 , A61N5/10
CPC分类号： A61N5/1016 , A61B18/04 , A61B2017/22051 , A61B2017/22054 , A61B2017/22055 , A61B2017/22061 , A61B2017/22062 , A61B2017/22068 , A61B2017/22069 , A61B2018/00273 , A61B2018/00285 , A61B2018/00559 , A61B2018/046 , A61B2090/033 , A61B2090/0445 , A61B2090/0481 , A61N5/1067 , A61N5/1071 , A61N2005/1003 , A61N2005/1012 , A61N2005/1094
摘要： Intracavitary brachytherapy tandem and ovoid oncology treatment systems and methods are provided. One such system and method employs a multi-part tandem having a detachable distal section retained within a body cavity during and between radiation treatments. This can be for single-patient use and disposed of after completion of a multiple-dose radiation treatment session. Real time in vivo detection and monitoring and hytpertherapy features can be included. Tandem or ovoid colpostats can feature bendability to tailor the system to the specific body and patient being treated. Other systems and methods incorporate balloon devices that assist in spacing radiation doses away from chosen body sites. Balloon devices also can be provided for adjusting and maintaining separation spacing between two ovoid colpostats.
摘要翻译：提供腔内近距离放射治疗系统和卵巢肿瘤治疗系统和方法。一种这样的系统和方法采用多部分串联，其中在放射治疗期间和之间具有保持在体腔内的可分离远端部分。这可以用于单次患者使用，并在多剂量放射治疗会话完成后进行处置。可以包括实时的体内检测和监测和疗法特征。串联或卵球蛋白凝块可以具有弯曲性，可以将系统定制到特定身体和被治疗的患者。其他系统和方法包括有助于将辐射剂量与所选择的身体部位隔开的球囊装置。还可以提供气球装置用于调节和保持两个卵巢凝块体之间的间隔。

65. 发明申请

US20150051861A1 QUALITY ASSURANCE SYSTEM AND METHOD FOR NAVIGATION-ASSISTED PROCEDURES 审中-公开
标题翻译：质量保证系统和导航辅助程序的方法
公开(公告)号：US20150051861A1
公开(公告)日：2015-02-19
申请号：US14388325
申请日：2013-03-26
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Jochen Kruecker , Shyam Bharat , Cynthia Ming-Fu Kung
IPC分类号： G01D18/00 , G01N29/04 , G01B7/00 , G01H17/00 , A61B5/06 , A61N5/10
CPC分类号： G01D18/00 , A61B5/061 , A61B17/3403 , A61B34/20 , A61B2017/00725 , A61B2017/3411 , A61N5/1007 , A61N2005/1012 , G01B7/003 , G01H17/00 , G01N29/04
摘要： A calibration system includes a channel block (102) having a plurality of channels (104) formed therein. The channels are configured to correspond to locations where treatment devices are inserted for treatment of a patient. The channels are dimensioned to restrict motion of the treatment devices. A tracking system (128) is configured to monitor a position of a treatment device (108) inserted in one or more of the channels. The tracking system is configured to generate tracking data for the at least one treatment device for comparison with an expected position for the treatment device.
摘要翻译：校准系统包括其中形成有多个通道（104）的通道块（102）。通道被配置为对应于处理装置被插入以治疗患者的位置。通道的尺寸被限制以限制治疗装置的运动。跟踪系统（128）被配置为监视插入在一个或多个通道中的治疗装置（108）的位置。跟踪系统被配置为产生用于至少一个治疗装置的跟踪数据，用于与治疗装置的预期位置进行比较。

66. 发明申请

US20140275971A1 Automatic Needle Insertion Location Identification 有权
标题翻译：自动针插入位置识别
公开(公告)号：US20140275971A1
公开(公告)日：2014-09-18
申请号：US13833593
申请日：2013-03-15
申请人： NEOCOIL, LLC
发明人： Brian Brown , Emad Abdelsalam , Paul Ropella , Steven Wolff
IPC分类号： A61B19/00 , G01R33/28
CPC分类号： A61B90/17 , A61B10/0275 , A61B17/3403 , A61B34/20 , A61B2017/00221 , A61B2017/3411 , A61B2090/0811 , A61M5/427 , A61N2005/1012 , G01R33/28 , G01R33/3692
摘要： A system for automatically identifying a needle insertion location from a medical diagnostic image, such as an MRI image, and providing a visual indication of the needle insertion location is disclosed. A grid plate is located proximate to an anatomical region and is preferably incorporated in an MRI support structure utilized to immobilize the anatomical region. An MRI scanner obtains an MRI image of the anatomical region, and an MRI technician places a marker on the MRI image, identifying the needle insertion location. The MRI image and the marker are transferred from the MRI scanner to another device, such as a tablet computer, which is configured to convert the MRI image and the marker to coordinates and an insertion depth. A visual indicator is located proximate to or integrated with the grid plate that provides the needle insertion coordinates and insertion depth to the MRI technician.
摘要翻译：公开了一种用于从医学诊断图像（例如MRI图像）自动识别针插入位置并提供针插入位置的视觉指示的系统。格栅板位于解剖区域附近，并且优选地并入用于固定解剖区域的MRI支撑结构中。 MRI扫描器获得解剖区域的MRI图像，并且MRI技术人员将标记放置在MRI图像上，识别针插入位置。 MRI图像和标记从MRI扫描器传送到另一个设备，例如平板计算机，其被配置为将MRI图像和标记转换为坐标和插入深度。视觉指示器位于栅格板附近或与栅板一体化，其向MRI技术人员提供针插入坐标和插入深度。

67. 发明授权

US08834339B2 Assembly for performing brachytherapy treatment of a tumour tissue in an animal body 有权
标题翻译：用于对动物体内的肿瘤组织进行近距离放射治疗的装置
公开(公告)号：US08834339B2
公开(公告)日：2014-09-16
申请号：US13120282
申请日：2009-09-23
申请人： Jean-Michel Hannoun-Levi , Cor Van De Wardt , Arie Luite Visscher , Dirk Binnekamp
发明人： Jean-Michel Hannoun-Levi , Cor Van De Wardt , Arie Luite Visscher , Dirk Binnekamp
IPC分类号： A61N5/00 , A61N5/10
CPC分类号： A61N5/1016 , A61N2005/1012
摘要： This invention relates to an assembly for performing brachytherapy treatment of tumour tissue in an animal body comprising at least a longitudinally extending intracavitary component and at least a guiding unit which extends at least partly parallel to said intracavitary component. Said guiding unit comprises at least one interstitial needle for guiding a radiation source into the tumour tissue. Said guiding unit is tubular over at least a longitudinal distance sufficient that in use a proximal end of said guiding unit is situated outside said body to be treated, while a distal end of said guiding unit is situated in situ close to or adjacent the tumour tissue.
摘要翻译：本发明涉及一种用于对动物体内的肿瘤组织进行近距离放射治疗处理的组件，其包括至少纵向延伸的腔内部件和至少部分平行于所述腔内部件延伸的引导单元。所述引导单元包括用于将辐射源引导到肿瘤组织中的至少一个间质针。所述引导单元在至少一个纵向距离上是管状的，足以使用中所述引导单元的近端位于待治疗的身体外部，而所述引导单元的远端位于原位附近或邻近肿瘤组织。

68. 发明授权

US08764619B2 Brachytherapy fiducial needle fixation system and method 有权
标题翻译：近距离放射治疗基准针固定系统及方法
公开(公告)号：US08764619B2
公开(公告)日：2014-07-01
申请号：US12427667
申请日：2009-04-21
申请人： Charlie Pitman
发明人： Charlie Pitman
IPC分类号： A61M36/00 , A61N5/10 , A61B17/34
CPC分类号： A61N5/1007 , A61B5/061 , A61B8/0841 , A61B17/3403 , A61B90/39 , A61B2017/3411 , A61B2090/3908 , A61B2090/3925 , A61B2090/3991 , A61N5/1015 , A61N5/1027 , A61N5/1049 , A61N2005/1012
摘要： A mechanism to facilitate the insertion of radioactive sources/source strands into soft tissue, such as breast tissue, and a method that utilizes this mechanism with the goal of improving the reproducibility of the procedure and ensuring that the sources are reliably and consistently inserted in an exact position per a patient prescription treatment plan from patient to patient as well as improve the ease-of-use of the device and procedure are provided.
摘要翻译：促进将放射源/源股插入软组织（例如乳腺组织）中的机制，以及利用该机制的方法，目的是提高手术的再现性，并确保将来源可靠且一致地插入到提供了从患者到患者的每个患者处方计划的精确位置以及提高装置和程序的易用性。

69. 发明授权

US08301228B2 Real time radiation treatment planning system 有权
标题翻译：实时辐射治疗计划系统
公开(公告)号：US08301228B2
公开(公告)日：2012-10-30
申请号：US13013051
申请日：2011-01-25
申请人： Johann Kindlein , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
发明人： Johann Kindlein , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
IPC分类号： A61B6/00
CPC分类号： A61N5/1031 , A61N5/1001 , A61N5/1007 , A61N5/1039 , A61N2005/1012 , A61N2005/1032 , A61N2005/1074 , G06F19/00 , G06F19/3481
摘要： The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm. For pre-planning or virtual simulation purposes, the processing means is arranged to determine in real time the optimal number and position of at least one of the needles, positions of energy emitting sources within the needles, and the dwell times of the energy emitting sources at the positions. For post-planning purposes, the processing means is arranged to determine, based on three-dimensional image information, in real time the real needle positions and the dwell times of the energy emitting sources for the positions.
摘要翻译：本发明涉及一种实时放射治疗计划系统，用于使用空心针对动物体的预先选择的解剖部分进行放射治疗。根据本发明的实施例，系统可以包括处理装置处理装置，其被配置为相对于预先选择的解剖部分内的一个或多个特定器官执行三维成像算法和三维图像分割算法并且相对于针，用于使用至少一个单目标或多目标基于解剖的遗传优化算法将用成像装置获得的图像数据转换成解剖部分的三维图像。对于预先规划或虚拟模拟目的，处理装置被布置成实时确定针中的至少一个针的最佳数量和位置，针内的能量发射源的位置以及能量发射源的停留时间在职位。为了规划后的目的，处理装置被布置成基于三维图像信息实时确定位置的能量发射源的实际针位置和停留时间。

70. 发明授权

US08162884B2 Apparatus for introducing catheters or needles into a body part 有权
标题翻译：将导管或针引入体部的装置
公开(公告)号：US08162884B2
公开(公告)日：2012-04-24
申请号：US11564733
申请日：2006-11-29
申请人： Eric van't Hooft
发明人： Eric van't Hooft
IPC分类号： A61M5/00 , A61M5/32
CPC分类号： A61N5/1027 , A61B2017/3411 , A61B2017/3484 , A61N2005/1011 , A61N2005/1012
摘要： A template, to be provided at some distance from the skin, provided with multiple guide holes for needles or catheters of which one or more can anchor in the prostate. The template is provided with a locking mechanism so that, after placement, the anchored needles keep all needles in their original places. The above-described method of fixedly positioning a treatment template prevents the needles from moving due to swelling of the tissue in the prostate, which causes the irradiation source, which is later provided in the needles, to improperly irradiate the area.
摘要翻译：在距离皮肤一定距离处设置的模板设置有用于针或导管的多个引导孔，其中一个或多个可锚定在前列腺中。该模板设置有锁定机构，使得在放置之后，锚定针将所有针保持在其原始位置。上述固定定位处理模板的方法防止针头由于前列腺中的组织的溶胀而移动，这导致后面提供在针中的照射源不适当地照射该区域。

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