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61. 发明授权

US09339634B2 Local delivery with a balloon covered by a cage 有权
公开(公告)号：US09339634B2
公开(公告)日：2016-05-17
申请号：US13762011
申请日：2013-02-07
申请人： Daniel L. Cox
发明人： Daniel L. Cox
IPC分类号： A61M25/10 , A61M25/00 , A61M25/01 , A61M25/06
CPC分类号： A61M25/1002 , A61M25/0069 , A61M25/104 , A61M2025/0081 , A61M2025/0183 , A61M2025/0681 , A61M2025/105 , A61M2025/1052 , A61M2025/1075
摘要： A catheter configured for delivering an agent to a patient's vessel wall is described. The catheter includes an inflatable balloon substantially covered by a expandable cage such that when the inflatable balloon is inflated the expandable cage substantially surrounds an outer surface of the inflated balloon. The inflatable balloon is configured to be deployed within a lumen against a lumen wall and separated from the lumen wall by the expandable cage in an expanded state, and is adapted to provide an agent delivery to a treatment site, and the expandable cage is further collapsible and is removable from said lumen.

62. 发明授权

US09332978B2 Vein closure and injection kits and methods 有权
标题翻译：静脉闭合和注射试剂盒和方法
公开(公告)号：US09332978B2
公开(公告)日：2016-05-10
申请号：US14104121
申请日：2013-12-12
申请人： Mayo Foundation for Medical Education and Research
发明人： Clark C. Otley
IPC分类号： A61B17/12 , A61M25/01 , A61B17/00 , A61B17/04 , A61B17/128 , A61B17/08 , A61B18/00 , A61M31/00 , A61M25/00 , A61M25/10
CPC分类号： A61B17/0057 , A61B17/04 , A61B17/08 , A61B17/12 , A61B17/12009 , A61B17/1285 , A61B18/00 , A61B2017/00778 , A61M25/0084 , A61M2025/0092 , A61M2025/1052
摘要： Kits, apparatus, devices and methods for treating varicose veins caused by an incompetent venous junction (e.g., the saphenofemoral and/or saphenopopliteal junctions) are disclosed. The kits may include a sheath, a vein closure device, and an injection device. Alternatively, a vein closure device may include an integral injection channel and injection device. Methods may include injecting a vein with a sclerosing agent through a needle that extends in a direction that is not aligned with a longitudinal axis of a sheath or shaft.
摘要翻译：公开了用于治疗由无力静脉结（例如，隐窝股和/或隐窝结）引起的静脉曲张的套件，装置，装置和方法。套件可以包括护套，静脉闭合装置和注射装置。或者，静脉闭合装置可以包括整体注射通道和注射装置。方法可以包括通过在不与鞘或轴的纵向轴线对齐的方向上延伸的针头注射具有硬化剂的静脉。

63. 发明授权

US09308361B2 Implantable devices and methods for treating sinusitis and other disorders 有权
标题翻译：用于治疗鼻窦炎和其他疾病的植入式装置和方法
公开(公告)号：US09308361B2
公开(公告)日：2016-04-12
申请号：US13784293
申请日：2013-03-04
申请人： Acclarent, Inc.
发明人： Ketan P. Muni , Hung V. Ha , John H. Morriss , William E. Bolger , Joshua Makower , John Y. Chang , Randy S. Chan , Nga K. Van , Anton G. Clifford , William M. Facteau
IPC分类号： A61M29/02 , A61B17/24 , A61B17/34 , A61F11/00 , A61M25/10 , A61M25/00 , A61M25/04 , A61B17/12
CPC分类号： A61M29/02 , A61B17/1204 , A61B17/12104 , A61B17/12136 , A61B17/24 , A61B17/3417 , A61B17/3421 , A61B17/3478 , A61F11/004 , A61M25/0075 , A61M25/0084 , A61M25/04 , A61M25/10 , A61M2025/105 , A61M2025/1052 , A61M2025/1086 , A61M2210/0618
摘要： A method for treating ethmoid disease in human or non-human animal subjects includes inserting a sheath containing an implantable device having an expandable member. The sheath is removed from the implantable device causing the expandable member to expand, allowing for stability of the implantable device in the subject. Stenting, spacing, draining, ventilating and/or delivering drugs and other therapeutic or diagnostic substances to desired locations within the bodies of human or non-human animal subjects may also be involved.
摘要翻译：用于在人或非人类动物受试者中治疗筛骨病的方法包括插入含有具有可扩张构件的可植入装置的护套。护套从可植入装置移除，导致可扩张构件膨胀，从而允许可植入装置在受试者中的稳定性。还可能涉及支架，间隔，排水，通气和/或递送药物和其他治疗或诊断物质到人类或非人类动物受试者体内所需位置。

64. 发明授权

US09308310B2 Localized therapy delivery and local organ protection 有权
公开(公告)号：US09308310B2
公开(公告)日：2016-04-12
申请号：US14216625
申请日：2014-03-17
申请人： Nirva Medical, LLC
发明人： Pramote Hochareon
IPC分类号： A61M1/36 , A61M25/00 , A61M25/10
CPC分类号： A61M1/3613 , A61M1/34 , A61M1/3403 , A61M1/3607 , A61M1/3615 , A61M1/3659 , A61M25/0026 , A61M25/10 , A61M39/22 , A61M2025/0031 , A61M2025/0037 , A61M2025/1052 , A61M2202/0413 , A61M2205/3368 , A61M2205/36 , A61M2230/005 , A61M2230/04
摘要： A system for perfusing a localized site within a body includes a catheter assembly having a venous access line that is adapted to deliver perfusate to the localized site, a venous or arterial drainage line adapted to drain perfusate from the localized site, and an occlusion device adapted to prevent some or substantially all physiological blood flow between the localized site and the systemic circulation of the body during and in the course of perfusing and draining perfusate to and from the localized site. The system may include a blood circuit associated with the catheter assembly to facilitate blood conditioning for use as the perfusate, in the course of a controlled perfusion and/or drainage of untreated, treated, or inactivated treated blood to and from the localized site. A delivery machine may control the blood circuit and catheter assembly in order to both deliver perfusate to, and drain some or all perfusate from, the localized site in a manner that provides perfusate to substantially only the localized site.

65. 发明申请

US20160082178A1 ANGIOGRAPHIC METHODS FOR IDENTIFICATION OF FEEDER VESSELS 审中-公开
标题翻译：用于识别进料器的血管图像方法
公开(公告)号：US20160082178A1
公开(公告)日：2016-03-24
申请号：US14958415
申请日：2015-12-03
申请人： RenovoRx, Inc.
发明人： Ramtin AGAH , Kamran NAJMABADI , Shaun R. BAGAI
IPC分类号： A61M5/00 , A61M25/00 , A61B6/00
CPC分类号： A61M5/007 , A61B6/504 , A61B17/1204 , A61B17/12136 , A61M5/142 , A61M25/007 , A61M25/0097 , A61M25/1002 , A61M25/1011 , A61M2025/0004 , A61M2025/0037 , A61M2025/0175 , A61M2025/1015 , A61M2025/1052 , A61M2210/00 , A61M2210/10 , A61M2230/30
摘要： In some embodiments, a method includes introducing a catheter device into a target artery within a patient where the target artery is near a tumor. The catheter device includes a distal occlusion member and a proximal occlusion member spaced apart from the distal occlusion member. The distal occlusion member is positioned relative to the proximal occlusion member such that an isolated region of the target artery is defined between the distal occlusion member and the proximal occlusion member causing cessation of blood flow in the isolated region. A contrast agent is injected into the target artery and travels to at least one feeder vessel leading to the tumor. A target region in the patient, including the target artery and the tumor, is imaged and a tumor feeder vessel is identified within an image based on the contrast agent visible within the tumor feeder vessel within the image.
摘要翻译：在一些实施例中，一种方法包括将导管装置引入目标动脉靠近肿瘤的患者内的目标动脉。导管装置包括远端闭塞构件和与远侧阻塞构件间隔开的近端闭塞构件。远侧阻塞构件相对于近端阻塞构件定位，使得目标动脉的隔离区域被限定在远端阻塞构件和近端阻塞构件之间，导致隔离区域中的血流停止。将造影剂注射到目标动脉中，并行进到通向肿瘤的至少一个饲养器皿。成像患者中包括靶动脉和肿瘤的靶区域，并且基于在图像内的肿瘤供体容器内可见的造影剂，在图像内识别肿瘤供体血管。

66. 发明授权

US09283066B2 Vascular device for emboli, thrombus and foreign body removal and methods of use 有权
公开(公告)号：US09283066B2
公开(公告)日：2016-03-15
申请号：US14108005
申请日：2013-12-16
申请人： Incept LLC
发明人： Leo N. Hopkins , Farhad Khosravi , Amr Salahieh , Jackson F. Demond , Jonah Lepak , Stephen Ramee , Jeff A. Krolik , Richard Renati
IPC分类号： A61M29/00 , A61F2/01 , A61B17/00 , A61B17/221 , A61M25/00 , A61M25/09 , A61M25/10
CPC分类号： A61F2/01 , A61B2017/00287 , A61B2017/2212 , A61F2/013 , A61F2002/011 , A61F2002/018 , A61F2230/0008 , A61F2230/008 , A61M25/0069 , A61M2025/09183 , A61M2025/1052 , A61M2025/109
摘要： Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops connected near a distal end of a guide wire, each support hoop having an articulation region, and a blood permeable sac affixed to the support hoop or hoops to form a mouth of the blood permeable sac. The mouth of the sac closes when the apparatus is collapsed for removal to prevent material from escaping from the sac.

67. 发明申请

US20150359540A1 Selectively Delivering Particles into the Distal Portion of the Left Gastric Artery 审中-公开
标题翻译：选择性地将颗粒递送到左胃动脉的远端部分
公开(公告)号：US20150359540A1
公开(公告)日：2015-12-17
申请号：US14740658
申请日：2015-06-16
申请人： Endobar Solutions, LLC
发明人： Nickolas Kipshidze , Ronald Jay Solar
IPC分类号： A61B17/12 , A61M5/00 , A61M39/22
CPC分类号： A61B17/12181 , A61B17/12031 , A61B17/12036 , A61B17/1204 , A61B17/12109 , A61B17/12136 , A61B17/12186 , A61B2017/00818 , A61B2017/22067 , A61B2090/3966 , A61M5/007 , A61M25/0097 , A61M25/04 , A61M39/22 , A61M2025/1052
摘要： Methods and apparatuses for embolizing an artery in a living subject using a catheter are disclosed. The catheter has a lumen and also has a balloon located near the distal end of the catheter. The distal end of the catheter is introduced into the artery, and the balloon is inflated to form a seal that prevents blood in the artery from flowing past the balloon. A mixture that includes embolic particles and contrast agent is injected through the lumen into the portion of the artery that is distally beyond the balloon. The subject's own blood or another fluid that contains platelets is injected through the lumen into the portion of the artery that is distally beyond the balloon. Subsequently, the balloon is deflated and the distal end of the catheter is withdrawn.
摘要翻译：公开了使用导管栓塞活体的动脉的方法和装置。导管具有内腔并且还具有位于导管远端附近的气囊。将导管的远端引入动脉，并且气囊膨胀以形成防止动脉血液流过气囊的密封。包括栓塞颗粒和造影剂的混合物通过内腔注射到远端超过气囊的动脉部分。受试者自己的血液或含有血小板的另一种液体通过内腔进入远端超过气囊的动脉部分。随后，气囊被放气并且导管的远端被抽出。

68. 发明申请

US20150343183A1 BALLOON CATHETER 审中-公开
标题翻译：气球导管
公开(公告)号：US20150343183A1
公开(公告)日：2015-12-03
申请号：US14820283
申请日：2015-08-06
申请人： TERUMO CLINICAL SUPPLY CO., LTD.
发明人： Tatsuya KAWASE
IPC分类号： A61M25/10 , A61M25/00
CPC分类号： A61M25/003 , A61M25/104 , A61M2025/0039 , A61M2025/0059 , A61M2025/1052
摘要： A balloon catheter has an inner tube having a first lumen, an outer tube part coaxial with the inner tube and forming a second lumen between the outer tube part and an outer surface of the inner tube, and a balloon part having a front end portion fixed to a front end portion of the inner tube and an inside communicating with the second lumen. The balloon part has a bulged portion, having an expansion forming mode formed in advance, which is elastically deformable beyond the expansion forming mode by an expansion liquid injected thereinto. The outer tube part has a front side sleeve portion extending from a rear end portion of the bulged portion of the balloon part to a proximal end of the outer tube part, integrally formed with the balloon part using the same material as that of the balloon part, and substantially non-expandable.
摘要翻译：球囊导管具有内管，其具有第一内腔，与内管同轴的外管部，并且在外管部和内管的外表面之间形成第二内腔，以及气囊部，其具有固定的前端部到内管的前端部分和与第二管腔连通的内部。气囊部具有膨胀部，其具有预先形成的膨胀成形模，该膨胀成形模可以通过注入到其中的膨胀液而弹性变形为膨胀形成模式。外筒部具有前侧套筒部，该前侧套筒部从球囊部的鼓出部的后端部到外管部的基端部，与气囊部一体形成，使用与气囊部相同的材料，并且基本上不可膨胀。

69. 发明授权

US09186131B2 Multi-lumen-catheter retractor system for a minimally-invasive, operative gastrointestinal treatment 有权
标题翻译：用于微创手术胃肠道治疗的多腔导管牵开器系统
公开(公告)号：US09186131B2
公开(公告)日：2015-11-17
申请号：US13913466
申请日：2013-06-09
申请人： Macroplata, Inc.
发明人： Gregory Piskun , John To , Mariel Fabro , Brian Tang , Sergey Kantsevoy
IPC分类号： A61B1/32 , A61B17/02 , A61B1/00 , A61B1/005 , A61B1/31 , A61B1/018 , A61B17/00 , A61B17/128 , A61B1/01 , A61M25/10 , A61B17/34
CPC分类号： A61B17/0206 , A61B1/00066 , A61B1/00078 , A61B1/00082 , A61B1/00085 , A61B1/00087 , A61B1/00135 , A61B1/00154 , A61B1/005 , A61B1/0058 , A61B1/01 , A61B1/018 , A61B1/31 , A61B1/3132 , A61B1/32 , A61B17/00234 , A61B17/0218 , A61B17/1285 , A61B17/3205 , A61B2017/00269 , A61B2017/00287 , A61B2017/00292 , A61B2017/00331 , A61B2017/0034 , A61B2017/00353 , A61B2017/00557 , A61B2017/00818 , A61B2017/0225 , A61B2017/320064 , A61B2017/345 , A61M25/1011 , A61M2025/1052
摘要： Improved methods and devices for performing an endoscopic surgery are provided. Systems are taught for operatively treating gastrointestinal disorders endoscopically in a stable, yet dynamic operative environment, and in a minimally-invasive manner. Such systems include, for example, an endoscopic surgical suite. The surgical suite can have a reversibly-expandable retractor that expands to provide a stable, operative environment within a subject. The expansion can be asymmetric around a stabilizer subsystem to maximize space for a tool and an endoscope to each be maneuvered independently to visualize a target tissue and treat the target tissue from outside the patient in a minimally invasive manner.
摘要翻译：提供了用于进行内窥镜手术的改进的方法和装置。所述系统被教导用于在稳定而又动态的手术环境中以微创方式内窥镜治疗胃肠道疾病。这样的系统包括例如内窥镜手术套件。外科手术套件可以具有可逆扩张的收缩器，其扩张以在受试者内提供稳定的手术环境。扩张可以在稳定器子系统周围是不对称的，以最大化工具和内窥镜的空间，每个人都可以独立地操纵以使目标组织可视化并且以微创方式从患者外部治疗目标组织。

70. 发明授权

US09180281B2 Adjustable balloon catheter for extravasated drug delivery 有权
标题翻译：用于外渗药物输送的可调节气囊导管
公开(公告)号：US09180281B2
公开(公告)日：2015-11-10
申请号：US13436358
申请日：2012-03-30
申请人： Lawrence J. Gerrans , Erhan H. Gunday
发明人： Lawrence J. Gerrans , Erhan H. Gunday
IPC分类号： A61M31/00 , A61M25/10 , A61M25/00
CPC分类号： A61M25/1011 , A61M25/007 , A61M25/10181 , A61M25/10184 , A61M2025/1015 , A61M2025/105 , A61M2025/1052 , A61M2025/109
摘要： An adjustable balloon catheter for extravasated drug delivery is disclosed generally including an outer catheter with a first balloon and an inner catheter with a second balloon. The inner catheter is moveably disposed in a lumen of the outer catheter such that the inner catheter moves relative to the outer catheter, changing the distance between the balloons. A fluid source supplies air to the catheters via lumens therein to inflate the balloons to create a chamber between them, and at least one of the catheters has a lumen for delivering a therapeutic and/or diagnostic agent to the chamber. The inner catheter is then moved relative to the outer catheter to decrease the size of the chamber between the balloons and decrease the fluid pressure therein such that the therapeutic and/or diagnostic agent is extravasated into the surrounding tissue.
摘要翻译：公开了一种用于外渗药物递送的可调节气囊导管，其通常包括具有第一气囊的外导管和具有第二气囊的内导管。内导管可移动地设置在外导管的内腔中，使得内导管相对于外导管移动，改变气囊之间的距离。流体源通过其中的内腔向导管提供空气，以使气囊膨胀以在它们之间形成室，并且至少一个导管具有用于将治疗剂和/或诊断剂递送至腔室的内腔。然后使内导管相对于外导管移动以减小气囊之间的腔室的尺寸并降低其中的流体压力，使得治疗剂和/或诊断剂外渗到周围组织中。

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