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61. 发明授权

US06361713B1 Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application 失效
标题翻译： ω-氢氟烷基醚，前体羧酸及其衍生物及其制备和应用
公开(公告)号：US06361713B1
公开(公告)日：2002-03-26
申请号：US09641192
申请日：2000-08-17
申请人： George G. I. Moore , Richard M. Flynn , Miguel A. Guerra , John G. Owens
发明人： George G. I. Moore , Richard M. Flynn , Miguel A. Guerra , John G. Owens
IPC分类号： C09K300
CPC分类号： A61K9/0026 , A61K49/0461 , A61K49/1806 , A61K49/226 , A62D1/00 , A62D1/0028 , A62D1/0035 , A62D1/0085 , B01D12/00 , B23K35/386 , C07C41/16 , C07C41/18 , C07C41/22 , C07C41/24 , C07C43/123 , C07C43/126 , C07C43/192 , C07C43/313 , C07C59/135 , C07C69/708 , C07C2601/14 , C07C2602/28 , C07D319/06 , C08J9/143 , C08J2203/146 , C11D1/004 , C11D7/28 , C07C43/13 , C07C43/12
摘要： Normally liquid, omega-hydrofluoroalkyl ether compounds (and selected mixtures thereof) have a saturated perfluoroaliphatic chain of carbon atoms interrupted by one or more ether oxygen atoms. The compounds can be prepared, e.g., by decarboxylation of the corresponding fluoroalkyl ether carboxylic acids and are useful, e.g., in cleaning and drying applications.
摘要翻译：通常液体的ω-氢氟烷基醚化合物（及其选择的混合物）具有被一个或多个醚氧原子间隔的碳原子的饱和全氟脂肪族链。化合物可以例如通过相应的氟烷基醚羧酸的脱羧来制备，并且可用于例如清洁和干燥应用。

62. 发明授权

US06214253B1 Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application 有权
公开(公告)号：US06214253B1
公开(公告)日：2001-04-10
申请号：US09452711
申请日：1999-12-02
申请人： George G. I. Moore , Richard M. Flynn , Miguel A. Guerra , John G. Owens
发明人： George G. I. Moore , Richard M. Flynn , Miguel A. Guerra , John G. Owens
IPC分类号： C09K500
CPC分类号： A61K9/0026 , A61K49/0461 , A61K49/1806 , A61K49/226 , A62D1/00 , A62D1/0028 , A62D1/0035 , A62D1/0085 , B01D12/00 , B23K35/386 , C07C41/16 , C07C41/18 , C07C41/22 , C07C41/24 , C07C43/123 , C07C43/126 , C07C43/192 , C07C43/313 , C07C59/135 , C07C69/708 , C07C2601/14 , C07C2602/28 , C07D319/06 , C08J9/143 , C08J2203/146 , C11D1/004 , C11D7/28 , C07C43/13 , C07C43/12
摘要： Normally liquid, omega-hydrofluoroalkyl ether compounds (and selected mixtures thereof) have a saturated perfluoroaliphatic chain of carbon atoms interrupted by one or more ether oxygen atoms. The compounds can be prepared, e.g., by decarboxylation of the corresponding fluoroalkyl ether carboxylic acids and are useful, e.g., in cleaning and drying applications.

63. 发明授权

US06204299B1 Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application 失效
公开(公告)号：US06204299B1
公开(公告)日：2001-03-20
申请号：US08881347
申请日：1997-06-24
申请人： George G. I. Moore , Richard M. Flynn , Miguel A. Guerra , John G. Owens
发明人： George G. I. Moore , Richard M. Flynn , Miguel A. Guerra , John G. Owens
IPC分类号： C08G1800
CPC分类号： A61K9/0026 , A61K49/0461 , A61K49/1806 , A61K49/226 , A62D1/00 , A62D1/0028 , A62D1/0035 , A62D1/0085 , B01D12/00 , B23K35/386 , C07C41/16 , C07C41/18 , C07C41/22 , C07C41/24 , C07C43/123 , C07C43/126 , C07C43/192 , C07C43/313 , C07C59/135 , C07C69/708 , C07C2601/14 , C07C2602/28 , C07D319/06 , C08J9/143 , C08J2203/146 , C11D1/004 , C11D7/28 , C07C43/13 , C07C43/12
摘要： Normally liquid, omega-hydrofluoroalkyl ether compounds (and selected mixtures thereof) have a saturated perfluoroaliphatic chain of carbon atoms interrupted by one or more ether oxygen atoms. The compounds can be prepared, e.g., by decarboxylation of the corresponding fluoroalkyl ether carboxylic acids and are useful, e.g., in cleaning and drying applications.

64. 发明授权

US5776496A Ultrasmall porous particles for enhancing ultrasound back scatter 失效
标题翻译：用于增强超声背散射的超细多孔颗粒
公开(公告)号：US5776496A
公开(公告)日：1998-07-07
申请号：US384193
申请日：1995-02-06
申请人： Michael R. Violante , Kevin J. Parker
发明人： Michael R. Violante , Kevin J. Parker
IPC分类号： A61K49/00 , A61K49/04 , A61K49/22 , A61K9/14
CPC分类号： A61K49/0461 , A61K49/223 , Y10S514/951 , Y10S514/965
摘要： This invention relates to the preparation, composition and applications of suspensions of ultra-small, substantially non-aggregated, non-crystalline particles of predetermined uniform size which, when suspended in a liquid, contain entrapped gaseous bubbles. These gaseous bubble particles are prepared by simultaneous co-precipitation of two compounds. In accordance with the present invention, the two compounds chosen for co-precipitation are such that one is substantially more soluble than the other in a given vehicle. When this vehicle is used for washing the co-precipitated particles, part of the soluble material is dissolved leaving a porous matrix. The porous particles then are dried and stored. The porous particles, which can be resuspended immediately prior to use, contain entrapped gas in the evacuated crevices or pores which is not displaced for a period of time because of surface tension of the suspending vehicle. These ultrasmall, substantially non-aggregated porous particles therefore can be used to advantage as ultrasound contrast agents as well as other applications.
摘要翻译：本发明涉及预定均匀尺寸的超小型，基本上非聚集的非结晶颗粒的悬浮液的制备，组成和应用，当悬浮在液体中时，其含有截留的气泡。这些气泡颗粒通过两种化合物的同时共沉淀制备。根据本发明，选择用于共沉淀的两种化合物使得在给定的载体中一种化合物比其它化合物更可溶。当该载体用于洗涤共沉淀颗粒时，溶解的部分溶解物留下多孔基体。然后将多孔颗粒干燥并储存。可以在使用前立即重新悬浮的多孔颗粒在被抽空的缝隙中包含夹带气体，由于悬浮车辆的表面张力而不被移位一段时间。因此，这些超小型，基本上非聚集的多孔颗粒可以用作超声造影剂以及其它应用。

65. 发明授权

US5658962A Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application 失效
标题翻译： ω-氢氟烷基醚，前体羧酸及其衍生物及其制备和应用
公开(公告)号：US5658962A
公开(公告)日：1997-08-19
申请号：US440450
申请日：1995-05-12
申请人： George G. I. Moore , Richard M. Flynn , Miguel A. Guerra , John G. Owens
发明人： George G. I. Moore , Richard M. Flynn , Miguel A. Guerra , John G. Owens
IPC分类号： C07D319/04 , A61K9/00 , A61K49/04 , A61K49/18 , A61K49/22 , A62D1/00 , A62D1/02 , A62D3/00 , B01D12/00 , B23K35/38 , C07B61/00 , C07C41/18 , C07C41/24 , C07C43/12 , C07C43/192 , C07C43/313 , C07C59/135 , C07C69/708 , C07C217/08 , C07C235/04 , C07C255/13 , C07C265/04 , C07C309/65 , C07D319/06 , C07F7/18 , C08G18/00 , C08G18/08 , C08J3/20 , C08J9/14 , C09K3/00 , C09K21/08 , C10M105/54 , C11D1/04 , C11D7/28 , H05K3/26
CPC分类号： A61K9/0026 , A61K49/0461 , A61K49/1806 , A61K49/226 , A62D1/00 , A62D1/0028 , A62D1/0035 , A62D1/0085 , B01D12/00 , B23K35/386 , C07C41/16 , C07C41/18 , C07C41/22 , C07C41/24 , C07C43/123 , C07C43/126 , C07C43/192 , C07C43/313 , C07C59/135 , C07C69/708 , C07D319/06 , C08J9/143 , C11D1/004 , C11D7/28 , C07C2101/14 , C07C2102/28 , C08J2203/146
摘要： Normally liquid, omega-hydrofluoroalkyl ether compounds (and selected mixtures thereof) have a saturated perfluoroaliphatic chain of carbon atoms interrupted by one or more ether oxygen atoms. The compounds can be prepared, e.g., by decarboxylation of the corresponding fluoroalkyl ether carboxylic acids and are useful, e.g., in cleaning and drying applications.
摘要翻译：通常液体的ω-氢氟烷基醚化合物（及其选择的混合物）具有被一个或多个醚氧原子间隔的碳原子的饱和全氟脂肪族链。化合物可以例如通过相应的氟烷基醚羧酸的脱羧来制备，并且可用于例如清洁和干燥应用。

66. 发明授权

US5582813A Iodine-containing fluorocarbon contrast agents 失效
标题翻译：含碘碳氟造影剂
公开(公告)号：US5582813A
公开(公告)日：1996-12-10
申请号：US188396
申请日：1994-01-27
申请人： Jean G. Riess , Leila Zarif , Veronique Sanches , Jacques Greiner
发明人： Jean G. Riess , Leila Zarif , Veronique Sanches , Jacques Greiner
IPC分类号： A61K49/04 , A61K51/12 , B01J13/00
CPC分类号： A61K49/0461 , A61K2123/00 , Y10S514/938
摘要： The present invention relates to nonterminally iodinated fluorinated compositions. The compositions, including, dispersions, emulsions, microemulsions, and gels are useful for biomedical applications, particularly radiography and scintigraphy. The compounds used in the invention preferably have the following general formula:R.sub.F CH.dbd.CIR.sup.1wherein,R.sub.F is a linear, branched, or cyclic first fluorocarbon radical, having 2 to 12 carbon atoms in which 50 to 100% of the hydrogen atoms have been replaced by fluorine atoms; andR.sup.1 is selected from the group consisting of a second fluorocarbon radical and a hydrocarbon radical, wherein,the second fluorocarbon radical is linear, branched, or cyclic, having 2 to 12 carbon atoms in which 50 to 100% of the hydrogen atoms have been replaced by fluorine atoms; andthe hydrocarbon radical is linear, branched, or cyclic, having 2 to 14 carbon atoms.
摘要翻译：本发明涉及非最终碘化的氟化组合物。组合物，包括分散体，乳液，微乳液和凝胶可用于生物医学应用，特别是放射摄影和闪烁扫描。本发明中使用的化合物优选具有以下通式：RFCH = CIR1其中，RF是具有2至12个碳原子的直链，支链或环状的第一碳氟基，其中50至100％的氢原子已被氟原子; 并且R 1选自第二氟烃基和烃基，其中，第二氟烃基为直链，支链或环状，具有2至12个碳原子，其中50至100％的氢原子已经被被氟原子取代; 烃基是直链，支链或环状的，具有2至14个碳原子。

67. 发明授权

US5502094A Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use 失效
标题翻译：包含全氟化碳醚氢化物的生理上可接受的乳液及其使用方法
公开(公告)号：US5502094A
公开(公告)日：1996-03-26
申请号：US437299
申请日：1995-05-17
申请人： George G. I. Moore , Richard M. Flynn , Miguel A. Guerra
发明人： George G. I. Moore , Richard M. Flynn , Miguel A. Guerra
IPC分类号： C07D317/72 , A61K9/00 , A61K9/107 , A61K31/00 , A61K31/075 , A61K31/08 , A61K31/335 , A61K31/34 , A61K31/357 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61P9/00 , A61P9/08 , A61P9/10 , A61P35/00 , A62D1/00 , A62D1/02 , A62D3/00 , B01D12/00 , B23K35/38 , C07C41/24 , C07C43/12 , C07C43/192 , C07C43/313 , C07C59/135 , C07C69/708 , C07D319/06 , C08K5/52
CPC分类号： A61K9/0026 , A61K49/0461 , A61K49/1806 , A61K49/226 , A62D1/0035 , B01D12/00 , B23K35/386 , C07C41/18 , C07C41/24 , C07C41/48 , C07C43/123 , C07C43/126 , C07C43/192 , C07C43/313 , C07C59/135 , C07C69/708 , C07D319/06 , C07C2101/14 , C08J2203/146 , Y10S514/822 , Y10S514/832 , Y10S514/833 , Y10S514/937 , Y10S514/941
摘要： This invention relates to physiologically acceptable emulsions of perfluorocarbon ether hydrides having 8 to 12 carbon atoms. These novel emulsions have various medical applications. They are especially useful medically as contrast media for various biological imaging modalities such as nuclear magnetic resonance, .sup.19 F-magnetic resonance imaging, ultrasound, x-ray, and computed tomography, as oxygen transport agents or "artificial bloods" in the treatment of heart attack, stroke, and other vascular obstructions, as adjuvants to coronary angioplasty and in cancer radiation treatment and chemotherapy.
摘要翻译：本发明涉及具有8至12个碳原子的全氟化碳醚氢化物的生理上可接受的乳液。这些新型乳液具有各种医疗应用。它们在医学上特别有用，作为各种生物成像模式的对比介质，例如核磁共振，19F-磁共振成像，超声，X射线和计算机断层扫描，作为氧运输剂或“人造血”治疗心脏病发作，中风和其他血管阻塞物，作为冠状动脉血管成形术和癌症放射治疗和化学疗法的佐剂。

68. 发明授权

US5492687A Compositions of iodophenoxy alkylene ethers and pharmaceutically acceptable clays for visualization of the gastrointestinal tract 失效
标题翻译：碘苯氧基亚烷基醚的组合物和用于胃肠道可视化的药学上可接受的粘土
公开(公告)号：US5492687A
公开(公告)日：1996-02-20
申请号：US237502
申请日：1994-05-03
申请人： Stephen B. Ruddy , Gregory L. McIntire , Mary E. Roberts , Edward R. Bacon
发明人： Stephen B. Ruddy , Gregory L. McIntire , Mary E. Roberts , Edward R. Bacon
IPC分类号： A61K49/04 , C07C43/225
CPC分类号： A61K49/0404 , A61K49/04 , A61K49/0409 , A61K49/0461 , C07C43/225
摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkylene ethers and pharmaceutically acceptable clays in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
摘要翻译：公开了用于口服或逆行检查胃肠道的x射线造影剂组合物，其包含药学上可接受的载体中的碘苯氧基亚烷基醚和药学上可接受的粘土; 以及它们用于胃肠道诊断放射学的方法。

69. 发明授权

US5476974A Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application 失效
公开(公告)号：US5476974A
公开(公告)日：1995-12-19
申请号：US246962
申请日：1994-05-20
申请人： George G. I. Moore , Miguel A. Guerra
发明人： George G. I. Moore , Miguel A. Guerra
IPC分类号： A61K9/00 , A61K49/04 , A61K49/18 , A61K49/22 , A62D1/00 , A62D1/02 , A62D3/00 , B01D12/00 , B23K35/38 , C07C41/24 , C07C43/12 , C07C43/192 , C07C43/313 , C07C59/135 , C07C69/708 , C07D319/06 , C07C43/02
CPC分类号： A61K9/0026 , A61K49/0461 , A61K49/1806 , A61K49/226 , A62D1/0035 , B01D12/00 , B23K35/386 , C07C41/18 , C07C41/24 , C07C41/48 , C07C43/123 , C07C43/126 , C07C43/192 , C07C43/313 , C07C59/135 , C07C69/708 , C07D319/06 , C07C2101/14 , C08J2203/146
摘要： Normally liquid, omega-hydrofluoroalkyl ether compounds (and selected mixtures thereof) have a saturated perfluoroaliphatic chain of carbon atoms interrupted by one or more ether oxygen atoms. The compounds can be prepared, e.g., by decarboxylation of the corresponding fluoroalkyl ether carboxylic acids and are useful, e.g., in cleaning and drying applications.

70. 发明授权

US5422114A Compositions of iodoaniline derivatives and cellulose derivatives for visualization of the gastrointestinal tract 失效
标题翻译：用于可视化胃肠道的碘苯胺衍生物和纤维素衍生物的组合物
公开(公告)号：US5422114A
公开(公告)日：1995-06-06
申请号：US201731
申请日：1994-02-25
申请人： Carl R. Illig , Thomas J. Caulfield , Robert W. Lee , Edward J. Baker
发明人： Carl R. Illig , Thomas J. Caulfield , Robert W. Lee , Edward J. Baker
IPC分类号： A61K9/107 , A61K49/04 , C08K5/315 , C08L101/00 , C08L101/06 , G01N21/00
CPC分类号： A61K49/0404 , A61K49/0409 , A61K49/0461
摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an x-ray producing agent of the formula or a pharmaceutically acceptable salt thereof ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract, whereinZ is H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R.sub.1 and R.sub.2 are independently H, C.sub.1 -C.sub.25 alkyl, cycloalkyl, acetyl or halo-lower-alkyl, wherein said C.sub.1 -C.sub.25 alkyl, cycloalkyl and halo lower-alkyl are optionally substituted with fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy and said acetyl is optionally substituted with fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy;n is 1-4;y is 1-4; andx is 1 or 2in a pharmaceutically acceptable carrier comprising a cellulose derivative.
摘要翻译：公开了用于胃肠道口服或逆行检查的x射线造影剂组合物，其包含下式的x射线产生剂或其药学上可接受的盐及其用于胃肠道诊断放射学的方法，其中Z 是H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代; R 1和R 2独立地为H，C 1 -C 25烷基，环烷基，乙酰基或卤代低级烷基，其中所述C 1 -C 25烷基，环烷基和卤代低级烷基任选被氟 - 低级 - 烷基，芳基，低级 - 烷氧基，羟基，羧基，低级烷氧基羰基或低级烷氧基 - 羰氧基，所述乙酰基任选被氟 - 低级 - 烷基，芳基，低级 - 烷氧基，羟基，低级 - 烷氧基羰基或低级 - 烷氧基 - 羰氧基取代; n为1-4; y为1-4; 并且在包含纤维素衍生物的药学上可接受的载体中x为1或2。

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