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61. 发明授权

US08486383B2 Method of treating pulmonary disease with interferons 有权
标题翻译：用干扰素治疗肺部疾病的方法
公开(公告)号：US08486383B2
公开(公告)日：2013-07-16
申请号：US13374308
申请日：2011-12-21
申请人： Gerald Smaldone , Rany Condos
发明人： Gerald Smaldone , Rany Condos
IPC分类号： A61K38/00 , A61K38/21 , C07K14/00
CPC分类号： A61K38/217 , A61K9/0073
摘要： A method of treating a pulmonary disease such as, for instance idiopathic pulmonary fibrosis (IPF), mixed connective tissue disease and asthma, comprising administering an aerosolized interferon such as interferon γ in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) alone or in combination with other therapeutic agents are provided.
摘要翻译：本文提供治疗肺部疾病例如特发性肺纤维化（IPF），混合结缔组织病和哮喘的方法，其包括以治疗有效量施用雾化干扰素如干扰素γ。此外，提供了一种或多种雾化干扰素单独或与其它治疗剂组合的药物组合物。

62. 发明授权

US08317975B2 Product and processes from an integrated forest biorefinery 有权
标题翻译：综合森林生物精炼的产品和流程
公开(公告)号：US08317975B2
公开(公告)日：2012-11-27
申请号：US11412593
申请日：2006-04-27
申请人： Thomas E. Amidon , Raymond Francis , Gary M. Scott , Jeremy Bartholomew , Bandaru V. Ramarao , Christopher D. Wood
发明人： Thomas E. Amidon , Raymond Francis , Gary M. Scott , Jeremy Bartholomew , Bandaru V. Ramarao , Christopher D. Wood
IPC分类号： D21C3/26 , D21C3/02 , D21C9/10 , D21C9/14 , D21C9/147 , D21C9/153
CPC分类号： D21C3/04 , D21C1/02 , D21C3/00 , D21C3/02 , D21C3/222 , D21C5/005 , D21C9/1057 , D21C9/1063 , D21C9/123 , D21C9/147 , D21C9/163 , D21C11/0007 , D21H11/02 , D21H11/08 , D21H11/10 , D21H17/005 , D21H21/32
摘要： An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes. The aqueous extract in embodiments including a water extract step is separated into acetic acid and hemicellulose sugar aqueous solutions.
摘要翻译：制浆和漂白木质纤维素材料的综合方法，其中木质纤维素材料的装料在制浆和漂白之前被生物泵送和/或水提取。木素纤维素材料可以在破坏木质素 - 碳水化合物复合物的酶存在下机械制浆和漂白。在包括水提取步骤的实施方案中的水提取物被分离成乙酸和半纤维素糖水溶液。

63. 发明授权

US07709766B2 System and method for manufacturing embedded conformal electronics 有权
标题翻译：用于制造嵌入式保形电子的系统和方法
公开(公告)号：US07709766B2
公开(公告)日：2010-05-04
申请号：US10491609
申请日：2003-08-05
申请人： Richard Gambino , Jon Longtin , Sanjay Sampath
发明人： Richard Gambino , Jon Longtin , Sanjay Sampath
IPC分类号： B23K26/38
CPC分类号： H01L21/76894 , B23K26/0093 , B23K26/361 , B23K2101/36 , C23C4/18 , C23C4/185 , G03F7/70383 , H01L21/76838 , H01L35/32 , H01L35/34 , H05K3/027 , H05K3/04 , H05K3/043 , H05K3/14 , H05K2203/1344
摘要： A method for fabricating an electronic device comprises providing a substrate (501), direct writing a functional material by a thermal spray on the substrate (502) and removing a portion of the function material to form the electronic or sensory device (503).
摘要翻译：一种用于制造电子器件的方法，包括提供衬底（501），通过热喷涂将功能材料直接写在衬底（502）上，并去除功能材料的一部分以形成电子或感觉器件（503）。

64. 发明授权

US07687428B1 Method of synthesizing and processing carbon-supported, gold and gold-based multimetallic nanoparticles for use as catalysts 失效
标题翻译：用作催化剂的碳载金，金和金基多金属纳米粒子的合成和加工方法
公开(公告)号：US07687428B1
公开(公告)日：2010-03-30
申请号：US11391830
申请日：2006-03-29
申请人： Chuan-Jian Zhong , Jin Luo , Nancy N. Kariuki , Linyang Wang , Peter Njoki , Derrick Mott
发明人： Chuan-Jian Zhong , Jin Luo , Nancy N. Kariuki , Linyang Wang , Peter Njoki , Derrick Mott
IPC分类号： B01J23/42 , H01M4/38
CPC分类号： H01M4/921 , B01J21/18 , B01J23/002 , B01J23/8906 , B01J35/0033 , B01J35/006 , B01J35/008 , B01J2523/00 , H01M4/925 , H01M4/926 , H01M8/1011 , Y02E60/523 , B01J2523/19 , B01J2523/828 , B01J2523/842
摘要： A method of preparing carbon-loaded, gold-based nanoparticle catalysts useful as anode catalysts for the electrocatalytic methanol oxidation reaction (MOR) as well as the oxygen reduction reaction (ORR). AumPtnM100-m-n catalysts may be prepared by either a two-phase protocol or by a thermal decomposition/reduction protocol. The prepared nanoparticles having different bimetallic ratios are assembled on carbon black support materials and activated by thermal treatment. This approach provides good control of nanoparticle size, composition and/or surface properties. Electrocatalytic MOR activities of the prepared and activated AuPt nanoparticle provided in accordance with the methods of the invention are present in both acidic and alkaline electrolytes.
摘要翻译：制备用作电催化甲醇氧化反应（MOR）的阳极催化剂以及氧还原反应（ORR）的负载碳的纳米金属催化剂的方法。 AumPtnM100-m-n催化剂可以通过两相方案或通过热分解/还原方案来制备。将具有不同双金属比率的制备的纳米颗粒组装在炭黑载体材料上并通过热处理活化。该方法提供对纳米颗粒尺寸，组成和/或表面性质的良好控制。根据本发明方法提供的制备和活化的AuPt纳米颗粒的电催化MOR活性存在于酸性和碱性电解质中。

65. 发明申请

US20090326200A1 Altered ospa of borrelia burgdorferi 有权
标题翻译：改变勃氏疏螺旋体的ospa
公开(公告)号：US20090326200A1
公开(公告)日：2009-12-31
申请号：US12313443
申请日：2008-11-19
申请人： Benjamin J. Luft , John J. Dunn , Shohei Koide , Catherine L. Lawson
发明人： Benjamin J. Luft , John J. Dunn , Shohei Koide , Catherine L. Lawson
IPC分类号： C07K14/195
CPC分类号： C07K14/20 , A61K39/00 , C07K2319/00 , Y02A50/401
摘要： Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.
摘要翻译：本文提供了具有某些改变的来自莱姆病引起的疏螺旋体的OspA多肽。在一个实施方案中，所述改变增加含有所述改变的OspA多肽的构象稳定性，同时保持相应未改变的OspA多肽的至少一些抗原性。在另一个实施方案中，与相应的未改变的OspA多肽相比，改变的OspA多肽具有降低的与hLFA-1的交叉反应性。

66. 发明授权

US07408346B2 Simultaneous phase cycling for nuclear magnetic resonance spectroscopy 失效
标题翻译：用于核磁共振光谱的同步相循环
公开(公告)号：US07408346B2
公开(公告)日：2008-08-05
申请号：US11474249
申请日：2006-06-23
申请人： Thomas A. Szyperski , David M. Parish
发明人： Thomas A. Szyperski , David M. Parish
IPC分类号： G01V3/00
CPC分类号： G01R33/4616
摘要： The present invention discloses a method of simultaneously conducting more than one step of a radiofrequency phase cycle in a nuclear magnetic resonance (NMR) experiment. The method first involves providing a sample. Next, one or more radiofrequency pulses are applied to a plurality of spatially discrete slices of the sample under conditions effective to simultaneously conduct more than one step of a radiofrequency phase cycle in a single transient. Then, NMR signals generated from the step of applying the radiofrequency pulses are acquired. Finally, the NMR signals are processed to obtain an NMR spectrum.
摘要翻译：本发明公开了一种在核磁共振（NMR）实验中同时进行射频相循环的一个以上步骤的方法。该方法首先涉及提供样品。接下来，在有效同时在单个瞬态中同时进行射频相位循环的多个步骤的条件下，将一个或多个射频脉冲施加到样本的多个空间上离散的片段。然后，获取从施加射频脉冲的步骤产生的NMR信号。最后，对NMR信号进行处理以获得NMR光谱。

67. 发明申请

US20070224184A1 Method for treating cellulite 审中-公开
标题翻译：脂肪团治疗方法
公开(公告)号：US20070224184A1
公开(公告)日：2007-09-27
申请号：US11703269
申请日：2007-02-07
申请人： Marie Badalemente , Alexander Dagum
发明人： Marie Badalemente , Alexander Dagum
IPC分类号： A61K38/48
CPC分类号： A61K8/66 , A61K38/4886 , A61K2800/30 , A61K2800/91 , A61Q19/06
摘要： The invention relates to the discovery that collagenase injections are effective in dissolving and lysing the collagenase septa network in the skin that comprises cellulite. As such, the invention relates to methods of treating cellulite in a patient in need of such treatment comprising injecting or otherwise delivering the effective amount of purified collagenase to the collagenase septa network of cellulite in the skin. The invention also relates to the use of collagenase in the manufacture of a medicament to treat cellulite of the skin.
摘要翻译：本发明涉及胶原酶注射在包含脂肪团的皮肤中溶解和裂解胶原酶隔膜网络的发现。因此，本发明涉及在需要这种治疗的患者中治疗脂肪团的方法，包括将有效量的纯化胶原酶注射或以其他方式递送到皮肤中脂肪团的胶原酶隔膜网络。本发明还涉及胶原酶在制备治疗皮肤脂肪团的药物中的用途。

68. 发明申请

US20070206008A1 Apparatus and Method for Real-Time Volume Processing and Universal Three-Dimensional Rendering 失效
标题翻译：用于实时卷处理和通用三维渲染的装置和方法
公开(公告)号：US20070206008A1
公开(公告)日：2007-09-06
申请号：US11556993
申请日：2006-11-06
申请人： Arie Kaufman , Ingmar Bitter , Frank Dachille , Kevin Kreeger , Baoquan Chen
发明人： Arie Kaufman , Ingmar Bitter , Frank Dachille , Kevin Kreeger , Baoquan Chen
IPC分类号： G06T15/20
CPC分类号： G06T15/08 , G06T15/06 , G06T15/40
摘要： An apparatus and method for real-time volume processing and universal three-dimensional rendering. The apparatus includes a plurality of three-dimensional (3D) memory units; at least one pixel bus for providing global horizontal communication; a plurality of rendering pipelines; at least one geometry bus; and a control unit. The apparatus includes a block processor having a circular ray integration pipeline for processing voxel data and ray data. Rays are generally processed in image order thus permitting great flexibility (e.g., perspective projection, global illumination). The block processor includes a splatting unit and a scattering unit. A method for casting shadows and performing global illumination in relation to light sources includes sweeping a two dimensional array of rays through the volume can also be implemented with the apparatus. A method for approximating a perspective projection includes using parallel projection.
摘要翻译：用于实时卷处理和通用三维渲染的装置和方法。该装置包括多个三维（3D）存储器单元; 用于提供全局水平通信的至少一个像素总线; 多个渲染管线; 至少一个几何总线; 和控制单元。该装置包括具有用于处理体素数据和射线数据的圆形射线集成管线的块处理器。通常以图像顺序处理光线，从而允许很大的灵活性（例如，透视投影，全局照明）。块处理器包括分散单元和散射单元。用于投射阴影和执行与光源相关的全局照明的方法包括扫描通过该体积的二维阵列的射线也可以用该装置来实现。用于近似透视投影的方法包括使用平行投影。

69. 发明申请

US20070079944A1 Product and processes from an integrated forest biorefinery 有权
标题翻译：综合森林生物精炼的产品和流程
公开(公告)号：US20070079944A1
公开(公告)日：2007-04-12
申请号：US11412593
申请日：2006-04-27
申请人： Thomas Amidon , Raymond Francis , Gary Scott , Jeremy Bartholomew , Bandaru Ramarao , Christopher Wood
发明人： Thomas Amidon , Raymond Francis , Gary Scott , Jeremy Bartholomew , Bandaru Ramarao , Christopher Wood
IPC分类号： D21C3/26 , D21C9/10 , D21C9/14 , D21C9/147 , D21C9/153
CPC分类号： D21C3/04 , D21C1/02 , D21C3/00 , D21C3/02 , D21C3/222 , D21C5/005 , D21C9/1057 , D21C9/1063 , D21C9/123 , D21C9/147 , D21C9/163 , D21C11/0007 , D21H11/02 , D21H11/08 , D21H11/10 , D21H17/005 , D21H21/32
摘要： An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes. The aqueous extract in embodiments including a water extract step is separated into acetic acid and hemicellulose sugar aqueous solutions.
摘要翻译：制浆和漂白木质纤维素材料的综合方法，其中木质纤维素材料的装料在制浆和漂白之前被生物泵送和/或水提取。木素纤维素材料可以在破坏木质素 - 碳水化合物复合物的酶存在下机械制浆和漂白。在包括水提取步骤的实施方案中的水提取物被分离成乙酸和半纤维素糖水溶液。

70. 发明授权

US07060281B1 Groups of barrelia burgdorferi and borrelia afzelii that cause lyme disease in humans 有权
标题翻译：在人类中引起淋巴细胞病的组织的胆囊炎和勃氏疏螺旋体
公开(公告)号：US07060281B1
公开(公告)日：2006-06-13
申请号：US09596746
申请日：2000-06-19
申请人： Raymond J. Dattwyler , Gerald Seinost , Daniel Dykhuizen , Benjamin J. Luft , Maria J. C. Gomes-Solecki
发明人： Raymond J. Dattwyler , Gerald Seinost , Daniel Dykhuizen , Benjamin J. Luft , Maria J. C. Gomes-Solecki
IPC分类号： A61K39/116 , A61K39/00 , A61K39/02
CPC分类号： A61K39/0225 , A61K39/00 , C07K14/20 , C07K2319/00 , G01N33/56911 , Y02A50/401 , Y02A50/57
摘要： The present invention is drawn to an immunogenic composition comprising OspC polypeptides from Lyme Disease causing Borrelia. In one embodiment, the immunogenic composition of the present invention comprises at least one OspC polypeptide or immunogenic fragment thereof from each of Borrelia burgdorferi OspC families A, B, I and K. In another embodiment, the immunogenic composition of the present invention comprises at least one OspC polypeptide or immunogenic fragment thereof from each of Borrelia afzelii OspC families A and B.
摘要翻译：本发明涉及一种免疫原性组合物，其包含来自莱姆病引起的疏螺旋体的OspC多肽。在一个实施方案中，本发明的免疫原性组合物包含来自勃氏疏螺旋体OspC家族A，B，I和K中的每一种的至少一种OspC多肽或其免疫原性片段。在另一个实施方案中，本发明的免疫原性组合物至少包含来自Borrelia afzelii OspC家族A和B的每一个的一个OspC多肽或其免疫原性片段。

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