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61. 发明公开

US20240209110A1 ANTI-CD20 ANTIBODY COMPOSITIONS 审中-公开
公开(公告)号：US20240209110A1
公开(公告)日：2024-06-27
申请号：US18597711
申请日：2024-03-06
申请人： TG Therapeutics, Inc. , Laboratoire Francais Du Fractionnement Et Des Biotechnologies
发明人： George Costas Avgerinos , Patrick Michael Hossler , Jill A. Myers , Yune Z. Kunes
IPC分类号： C07K16/28 , A61K39/00
CPC分类号： C07K16/2887 , A61K2039/505 , C07K2317/41 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： Provided herein are populations of anti-CD20 antibody proteins with specified ranges of post-translational modifications. Also provided are methods of using and methods of making such populations of anti-CD20 antibody proteins.

62. 发明授权

US11884740B1 Anti-CD20 antibody compositions 有权
公开(公告)号：US11884740B1
公开(公告)日：2024-01-30
申请号：US17892407
申请日：2022-08-22
申请人： TG Therapeutics, Inc. , Laboratoire Francais Du Fractionnement Et Des Biotechnologies
发明人： George Costas Avgerinos , Patrick Michael Hossler , Jill A. Myers , Yune Z. Kunes
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2887 , A61K39/3955 , C07K2317/732 , C07K2317/734
摘要： Provided herein are populations of anti-CD20 antibody proteins with specified ranges of post-translational modifications. Also provided are methods of using and methods of making such populations of anti-CD20 antibody proteins.

63. 发明申请

US20200277385A1 Anti-CD303 Monoclonal Antibodies 审中-公开
公开(公告)号：US20200277385A1
公开(公告)日：2020-09-03
申请号：US16799703
申请日：2020-02-24
申请人： Laboratoire Francais du Fractionnement et des Biotechnologies
发明人： Nathalie FOURNIER , Alexandre FONTAYNE , Christophe de ROMEUF
IPC分类号： C07K16/28 , C12N15/79
摘要： The invention relates to chimeric or humanised anti-CD303 antibodies to nucleic acids coding for the heavy and light chains of these antibodies, expression vectors, host cells, transgenic non-human animals or transgenic plants expressing said antibodies, as well as to the uses thereof in the treatment or prevention of blastic plasmacytoid dendritic cell neoplasms (BPDCN) or inflammatory diseases, in particular autoimmune diseases, involving plasmacytoid dendritic cells.

64. 发明授权

US10683492B2 Transgenic factor VII having a specific N-glycosylation and substantially homogenous isoelectric point 有权
公开(公告)号：US10683492B2
公开(公告)日：2020-06-16
申请号：US14896763
申请日：2014-06-10
申请人： LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES
发明人： Guillaume Chevreux
IPC分类号： A61K35/14 , A61K38/48 , C07K1/00 , C07K16/00 , C07K17/00 , A61K38/43 , A61K38/57 , C07K14/745 , A61K38/36 , A61P7/02 , A61K38/00 , A61P7/00 , C12N9/64 , A01K67/027
摘要： The present invention relates to a factor VII composition having a substantially homogeneous isoelectric point and to a method for formulating such a composition. The present invention also relates to the therapeutic use of a factor VII composition having a substantially homogeneous isoelectric point.

65. 发明申请

US20200032163A1 Method for the Virus Inactivation of a Preparation of Monoclonal Antibodies 审中-公开
公开(公告)号：US20200032163A1
公开(公告)日：2020-01-30
申请号：US16337004
申请日：2017-10-02
申请人： Laboratoire Francais du Fractionnement et des Biotechnologies
发明人： Ludovic BOUCHEZ , Eve DEPAUW
IPC分类号： C11D1/72 , A61J1/10 , A61L2/00 , C07K16/08
摘要： The present invention relates to a method for the virus inactivation of a preparation of monoclonal antibodies, characterised in that it comprises a step of bringing the monoclonal antibody preparation into contact with a non-ionic detergent, said step being carried out while stirring in a disposable flexible pouch which can receive and contain the monoclonal antibody preparation.

66. 发明申请

US20190316133A1 Anti-Fibrinogen Aptamers and Uses Thereof 审中-公开
公开(公告)号：US20190316133A1
公开(公告)日：2019-10-17
申请号：US16312457
申请日：2017-07-06
申请人： Laboratoire Francais du Fractionnement et des Biotechnologies
发明人： Alexander SEIFERT
IPC分类号： C12N15/115 , C12Q1/68 , G01N33/50 , C07H21/04
摘要： The invention relates to aptamers which specifically bind to fibrinogen and their use in the purification of said protein.

67. 发明授权

US10364424B2 Factor X mutants 有权
公开(公告)号：US10364424B2
公开(公告)日：2019-07-30
申请号：US14765073
申请日：2014-02-03
申请人： LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES
发明人： Jean-Luc Plantier
IPC分类号： C12N9/64 , A61K38/48
摘要： The present invention concerns a protein comprising a mutated sequence of SEQ ID No. 1, said mutated sequence of SEQ ID No. 1 comprising at least one mutation A, A′, B, C or C′, in which: mutation A consists of substituting amino acids 43 to 52 of sequence SEQ ID No. 1 with a sequence chosen from DFLAEGLTPR (SEQ ID NO: 159), KATN*ATLSPR (SEQ ID NO: 160) and KATXATLSPR (SEQ ID NO: 161), mutation A′ consists of substituting amino acids 47 to 52 of sequence SEQ ID No. 1 with a sequence chosen from TSKLTR (SEQ ID NO: 162), FNDFTR (SEQ ID NO: 163), LSSMTR (SEQ ID NO: 164), PPSLTR (SEQ ID NO: 165) and LSCGQR (SEQ ID NO: 166), mutation B consists of inserting a sequence chosen from DFLAEGLTPR (SEQ ID NO: 159), KATN*ATLSPR (SEQ ID NO: 160), KATXATLSPR (SEQ ID NO: 161), TSKLTR (SEQ ID NO: 162), FNDFTR (SEQ ID NO: 163), LSSMTR (SEQ ID NO: 164), PPSLTR (SEQ ID NO: 165) and LSCGQR (SEQ ID NO: 166), between amino acids 52 and 53 of sequence SEQ ID No. 1, mutation C consists of inserting a sequence chosen from DFLAEGLTPR (SEQ ID NO: 159), KATN*ATLSPR (SEQ ID NO: 160) and KATXATLSPR (SEQ ID NO: 161), between amino acids 52 and 53 of sequence SEQ ID No. 1, and of deleting amino acids 4 to 13 from sequence SEQ ID No. 1, mutation C′ consists of inserting a sequence chosen from TSKLTR (SEQ ID NO: 162), FNDFTR (SEQ ID NO: 163), LSSMTR (SEQ ID NO: 164), PPSLTR (SEQ ID NO: 165) and LSCGQR (SEQ ID NO: 166), between amino acids 52 and 53 of sequence SEQ ID No. 1, and of deleting amino acids 4 to 9 from sequence SEQ ID No. 1.

68. 发明申请

US20190209659A1 STABLE LIQUID FIBRINOGEN 审中-公开
公开(公告)号：US20190209659A1
公开(公告)日：2019-07-11
申请号：US16315388
申请日：2017-07-06
申请人： LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES
发明人： Damien BATAILLE , Michel TELLIER
IPC分类号： A61K38/36 , A61K9/00 , A61K47/18 , A61K47/12
CPC分类号： A61K38/363 , A61K9/0019 , A61K47/12 , A61K47/183 , C12N15/115 , C12N2310/16 , C12N2320/50
摘要： Disclosed is a composition including stable fibrinogen in liquid form.

69. 发明申请

US20180361374A1 DEVICE SUITABLE FOR CENTRIFUGING AND METHOD USING SAME 审中-公开
公开(公告)号：US20180361374A1
公开(公告)日：2018-12-20
申请号：US16061166
申请日：2016-12-16
申请人： Laboratoire Francais du Fractionnement et des Biotechnologies
发明人： Alexandra ALARZA , Julien BILLON
IPC分类号： B01L3/00 , G01N1/40
摘要： The present invention relates to a device for processing a biological fluid comprising cells suspended in a liquid, the processing device being intended for use in a centrifugation step to separate the cells from the liquid, the processing device comprising: a pouch suitable for receiving the biological fluid, the pouch having top and bottom edges that are distanced from one another along a longitudinal axis, the pouch being composed of two flexible layers that are placed one atop the other and integrally interconnected along an interconnection area, the interconnection area being provided so as to form, between the two layers, an inner space for receiving the biological fluid and at least one opening suitable for placing the inner space in communication with an outer environment, at least one sealing member placed in the opening, for selectively opening and closing the opening, the processing device being characterized in that the inner space has: a top portion formed near the top edge and intended for receiving the supernatant liquid from the biological fluid after the centrifugation step, and a neck formed near the bottom edge and intended for receiving a cell pellet from the biological fluid after the centrifugation step, the top portion and the neck each having widths measured transversely to the longitudinal axis, the width of the neck being less than the width of the top portion.

70. 发明申请

US20180066060A1 Cell Line Overexpressing Human CD303 Antigen 审中-公开
公开(公告)号：US20180066060A1
公开(公告)日：2018-03-08
申请号：US15563046
申请日：2016-03-31
申请人： Laboratoire Francais du Fractionnement et des Biotechnologies
发明人： Nathalie FOURNIER , Christophe DE ROMEUF
IPC分类号： C07K16/28 , C12N15/79
CPC分类号： C07K16/2851 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/79 , C12N2510/00
摘要： The invention relates to a cell line expressing the gamma chain of the FcεRI receptor and human CD303 antigen, characterised in that said cell line is transfected in a stable manner by an expression vector comprising a nucleic acid molecule coding for human CD303 antigen and having strong expression of human CD303 on the surface thereof, e.g. at least 10000 molecules of human CD303 per cell, as well as a vector or vector kit that can be used to co-express the gamma chain of the FcεRI receptor and human CD303 antigen, and different uses of the cell line of the invention.

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