专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明申请

US20070292907A1 Compositions and method for regulating ubiquitin-specific processing proteases 审中-公开
标题翻译：调节泛素特异性加工蛋白酶的组成和方法
公开(公告)号：US20070292907A1
公开(公告)日：2007-12-20
申请号：US11542471
申请日：2006-10-03
申请人： Yigong Shi , Min Hu
发明人： Yigong Shi , Min Hu
IPC分类号： C07K7/06 , C07K2/00 , C12Q1/34
CPC分类号： C12Q1/37 , C07K7/06 , C07K14/00 , C07K2299/00 , C12N9/6472 , G01N2500/00
摘要： The disclosure contained herein provides compounds and methods for identification of compounds that agonize or antagonize the function of USP14, a member of the ubiquitin-specific processing protease (UBP) family. Over-expression or gain-of-function of UBP's contributes to a range of diseases such as cancer, thus inhibition of USP14 by antagonists may provide a strategy for therapeutic intervention. Loss-of-function or reduced expression of UBP's, or reduced expression of the proteasome, contributes to improper synaptic activity and neurodegenerative diseases, thus activation of USP14 by agonists may provide a strategy for therapeutic intervention.
摘要翻译：本文所含的公开内容提供了用于鉴定激动或拮抗USP14（泛素特异性加工蛋白酶（UBP）家族的成员）的功能的化合物的化合物和方法。 UBP的过表达或功能增强有助于一系列疾病如癌症，因此拮抗剂对USP14的抑制可能提供治疗干预的策略。功能丧失或UBP表达下降，或蛋白酶体表达降低，导致不适当的突触活动和神经退行性疾病，因此激动剂激活USP14可提供治疗干预的策略。

62. 发明申请

US20070021408A1 Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权
标题翻译：芳基和杂芳基取代的四氢苯并氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取
公开(公告)号：US20070021408A1
公开(公告)日：2007-01-25
申请号：US11487884
申请日：2006-07-17
申请人： Bruce Molino , Shuang Liu , Aruna Sambandam , Peter Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David Manning , Matthew Isherwood , Kristen Fleming , Wenge Cui , Richard Olson
发明人： Bruce Molino , Shuang Liu , Aruna Sambandam , Peter Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David Manning , Matthew Isherwood , Kristen Fleming , Wenge Cui , Richard Olson
IPC分类号： A61K31/55 , C07D487/02 , C07D403/02
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
摘要翻译：本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。

63. 发明申请

US20060100174A1 Configuration of glycosaminoglycans 审中-公开
标题翻译：糖胺聚糖的配置
公开(公告)号：US20060100174A1
公开(公告)日：2006-05-11
申请号：US11301491
申请日：2005-12-12
申请人： Min Hu
发明人： Min Hu
IPC分类号： A61K31/737 , A61K31/728 , C08B37/00
CPC分类号： C08B37/0072 , A61K31/726
摘要： The present invention provides stable glycosaminoglycan (GSG) structures and methods of use of such GAG structures. These structures comprise a core of free GAG, a coating of crosslinked GAG surrounding the core, and a layer of a positively charged moiety surrounding the crosslinked GAG layer. These GAG structures provide improved stability, both in in vivo and external use. Furthermore, resurfacing of the structures provides improved cell adhesion and thus improved delivery of the GAG into living cells and tissues.
摘要翻译：本发明提供稳定的糖胺聚糖（GSG）结构和使用这种GAG结构的方法。这些结构包括游离GAG的芯，围绕芯的交联GAG的涂层和围绕交联的GAG层的带正电的部分的层。这些GAG结构在体内和外部使用都提供了改进的稳定性。此外，结构的表面重建提供改善的细胞粘附，并因此改善GAG向活细胞和组织的递送。

64. 发明授权

US09625475B2 Indole and indoline derivatives and methods of use thereof 有权
公开(公告)号：US09625475B2
公开(公告)日：2017-04-18
申请号：US12727723
申请日：2010-03-19
申请人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人： Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号： A61K31/55 , C07D487/00 , C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00 , G01N33/68 , C07D471/18 , C07D487/10 , G01N33/50
CPC分类号： G01N33/6896 , C07D471/18 , C07D487/10 , G01N33/5058 , G01N2800/2814 , G01N2800/30
摘要： The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

65. 发明授权

US08640832B2 Central control braking system 有权
标题翻译：中央控制制动系统
公开(公告)号：US08640832B2
公开(公告)日：2014-02-04
申请号：US13252048
申请日：2011-10-03
申请人： Xugui Chen , Min Hu , Mingzhao Zhou
发明人： Xugui Chen , Min Hu , Mingzhao Zhou
IPC分类号： B60B33/00 , B60T7/06 , B62B5/04
CPC分类号： B60B33/0092 , A61G7/018 , A61G7/0528 , A61G7/1046 , A61G13/104 , B62B5/0433 , Y10T16/18 , Y10T16/184 , Y10T16/1853 , Y10T16/195 , Y10T16/196
摘要： A central control braking system includes: a pedestal; at least one caster mounted at a bottom portion of the pedestal; a brake transmission shaft for controlling the caster; a plate girder movably connected to the pedestal; a pedal fixed to the plate girder; and a reversing rotary assembly connecting the plate girder and the brake transmission shaft, wherein the reversing rotary assembly enables the brake transmission shaft to rotate in reverse under the control of the pedal.
摘要翻译：中央控制制动系统包括：基座; 安装在基座的底部的至少一个脚轮; 用于控制脚轮的制动传动轴; 可移动地连接到基座的板梁; 固定在板梁上的踏板; 以及连接板梁和制动传动轴的可逆旋转组件，其中，反转旋转组件使得制动传动轴能够在踏板的控制下相反地旋转。

66. 发明授权

US07956050B2 Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权
标题翻译：芳基和杂芳基取代的四氢苯并氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取
公开(公告)号：US07956050B2
公开(公告)日：2011-06-07
申请号：US11487884
申请日：2006-07-17
申请人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
发明人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
IPC分类号： A61P25/00 , A61K31/55 , C07D223/16
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
摘要翻译：本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。

67. 发明授权

US09731054B2 Breast pump comprising heating cup 有权
公开(公告)号：US09731054B2
公开(公告)日：2017-08-15
申请号：US14621362
申请日：2015-02-12
申请人： Min Hu
发明人： Min Hu
IPC分类号： A61M1/06 , A61F7/00
CPC分类号： A61M1/062 , A61F7/007 , A61F2007/0021 , A61F2007/0088 , A61M1/064 , A61M2205/3633 , A61M2205/3653 , A61M2205/8206
摘要： A breast pump including a container, a host unit disposed above and communicating with the container, an electric heating cup disposed at the front end of the host unit and communicating with the container, an electric heating element, and heat insulation. The electric heating cup includes an inner cover and an outer cover which are integrated. The electric heating element and the heat insulation are disposed between the inner cover and the outer cover. The heat insulation is disposed between the electric heating element and the outer cover. Positive and negative electrodes of the electric heating element are connected to conducting plates disposed in the inner side of the outer cover via connection wires. The conducting plates extend to the outer side of the outer cover and are in electric connection to contact chips disposed at the lower front end of the host unit.

68. 发明授权

US08663445B2 Electrochemical desalination system and method 有权
标题翻译：电化学脱盐系统及方法
公开(公告)号：US08663445B2
公开(公告)日：2014-03-04
申请号：US12570227
申请日：2009-09-30
申请人： Ran Niu , Hai Yang , John H. Barber , Min Hu , Rihua Xiong , Wei Cai , Xin Gao , Yufeng Liu
发明人： Ran Niu , Hai Yang , John H. Barber , Min Hu , Rihua Xiong , Wei Cai , Xin Gao , Yufeng Liu
IPC分类号： B01D57/00
CPC分类号： C02F1/4691 , C02F2103/08 , C02F2201/46135 , C02F2201/4614 , C02F2209/005
摘要： An electrochemical desalination system includes a first and a second electrochemical device and a controller. The first and second electrochemical devices each comprises a electrochemical desalination module comprising at least one pair of electrodes and a compartment between each pair of electrodes for receiving an electrolyte solution. Each of the first and second electrochemical desalination devices comprises a plurality of successive operation cycles. Each cycle comprises a charging mode of operation for charging each pair of electrodes and for adsorbing ions in the electrolyte solution on the electrodes, and a discharging mode of operation for discharging the pair of electrodes and for desorbing ions from the pair of electrodes. The controller is configured to control the system that the first and second electrochemical desalination devices have interleaved charging and discharging modes of operation. One of the first and second electrochemical desalination devices is in a discharging mode and the at least one pair of electrodes release electrical current, while the other of the first and second electrochemical desalination devices is in a charging mode of operation and receives the electrical current released from said one of the first and second electrochemical desalination device.
摘要翻译：电化学脱盐系统包括第一和第二电化学装置和控制器。第一和第二电化学装置各自包括电化学脱盐模块，其包括至少一对电极和用于接收电解质溶液的每对电极之间的隔室。第一和第二电化学脱盐装置中的每一个包括多个连续的操作循环。每个循环包括用于对每对电极进行充电并用于将电解质中的离子吸附在电极上的充电操作模式，以及用于对该电极放电和用于从一对电极解吸离子的放电模式。控制器被配置为控制系统，第一和第二电化学脱盐装置具有交错的充放电操作模式。第一和第二电化学脱盐装置之一处于放电模式，并且至少一对电极释放电流，而第一和第二电化学脱盐装置中的另一个处于充电操作模式并且接收释放的电流从所述第一和第二电化学脱盐装置中的一个。

69. 发明申请

US20130206673A1 TUBULAR FIBER MEMBRANE WITH NANOPOROUS SKIN 有权
标题翻译：管状纤维膜与纳米皮肤
公开(公告)号：US20130206673A1
公开(公告)日：2013-08-15
申请号：US13881705
申请日：2010-10-25
申请人： Jackie Y. Ying , Rensheng Deng , Min Hu , Ming Ni
发明人： Jackie Y. Ying , Rensheng Deng , Min Hu , Ming Ni
IPC分类号： B01D63/02 , D01D5/06 , D01D5/247
CPC分类号： B01D63/02 , A61M1/1621 , A61M1/1625 , A61M1/3689 , B01D63/06 , B01D67/0088 , B01D69/085 , B01D69/087 , B01D71/68 , B01D2313/44 , D01D5/06 , D01D5/247
摘要： A wet spinning process for forming a tubular fiber membrane is provided. The tubular fiber membrane has a nanoporous skin layer and a microporous lumen layer. The skin layer defines an outer surface of the fiber membrane and the lumen layer defines a lumen surface of the fiber membrane. The pores in the skin layer may have an average pore size of less than about 7 nm, and pores in the lumen layer may have an average pore size of from about 0.5 to about 3 μm. The fiber membranes may be used in artificial renal proximal tubules, artificial kidneys, bioreactors, or fiber cartridges.
摘要翻译：提供了一种用于形成管状纤维膜的湿式纺丝方法。管状纤维膜具有纳米孔表皮层和微孔腔层。表皮层限定纤维膜的外表面，内腔层限定纤维膜的内表面。皮肤层中的孔可以具有小于约7nm的平均孔径，并且内腔层中的孔可具有约0.5至约3μm的平均孔径。纤维膜可以用于人造肾近端小管，人造肾，生物反应器或纤维筒。

70. 发明申请

US20120274559A1 Diffusing light of a laser 有权
标题翻译：扩散激光的光
公开(公告)号：US20120274559A1
公开(公告)日：2012-11-01
申请号：US13066994
申请日：2011-04-29
申请人： Sagi Varghese Mathai , Min Hu , Huel Pel Kuo
发明人： Sagi Varghese Mathai , Min Hu , Huel Pel Kuo
IPC分类号： G06F3/033 , F21V8/00 , G02B27/20 , F21V7/00
CPC分类号： G02B27/20 , G02B5/0278 , G02B6/04 , G06F3/0421
摘要： Embodiments disclosed herein relate to diffusing light of a multi-mode laser. In one embodiment, the multi-mode laser projects a plurality of modes of light and a diffuser reflects the plurality of modes of light to output a single lobe of light.
摘要翻译：本文公开的实施例涉及漫射多模激光器的光。在一个实施例中，多模激光器投射多种模式的光，扩散器反射多种模式的光以输出单个光。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式