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61. 发明申请

US20050277179A1 L-tyrosine-producing bacterium and a method for producing L-tyrosine 有权
标题翻译： L-酪氨酸生产菌和L-酪氨酸的生产方法
公开(公告)号：US20050277179A1
公开(公告)日：2005-12-15
申请号：US11149349
申请日：2005-06-10
申请人： Atsuko Takai , Ranko Nishi , Yuji Joe , Hisao Ito
发明人： Atsuko Takai , Ranko Nishi , Yuji Joe , Hisao Ito
IPC分类号： C12N1/21 , C12N9/02 , C12N9/90 , C12P13/08 , C12P13/22
CPC分类号： C12P13/225 , C12N9/001 , C12N9/90
摘要： The present invention describes the production of L-tyrosine by culturing in a medium an Escherichia bacterium which has L-tyrosine-producing ability and which carries a mutant prephenate dehydrogenase which is desensitized to feedback inhibition by L-tyrosine, producing and accumulating L-tyrosine in the medium or in the bacterial cells, and collecting L-tyrosine from the medium or the bacterial cells.
摘要翻译：本发明描述了通过在具有L-酪氨酸生产能力的大肠杆菌细菌培养基中培养L-酪氨酸，并携带脱敏的L-突变型预苯酸脱氢酶以产生和积累L-酪氨酸在培养基或细菌细胞中，并从培养基或细菌细胞中收集L-酪氨酸。

62. 发明申请

US20050260720A1 L-amino acid-producing bacterium and a method for producing L-amino acid 有权
标题翻译： L-氨基酸生产菌和L-氨基酸的生产方法
公开(公告)号：US20050260720A1
公开(公告)日：2005-11-24
申请号：US11113270
申请日：2005-04-25
申请人： Hisao Ito , Yuji Joe
发明人： Hisao Ito , Yuji Joe
IPC分类号： C12N1/20 , C12P13/08 , C12P13/12 , C12P13/14 , C12P13/22 , C12P13/24 , C12P13/04 , C12N1/21 , C12P13/20
CPC分类号： C12N1/20 , C12P13/08 , C12P13/12 , C12P13/14 , C12P13/22 , C12P13/24
摘要： An L-amino acid-producing strain of Escherichia coli is bred by modifying an Escherichia coli K12 strain or a derivative thereof so as to become resistant to L-valine and have an ability to produce one or more L-amino acids selected from the group consisting of L-tryptophan, L-phenylalanine, L-lysine, L-tyrosine, L-glutamic acid, L-histidine, L-cysteine, and L-proline.
摘要翻译：通过改变大肠杆菌K12菌株或其衍生物以使其变得对L-缬氨酸具有抗性并且具有产生一种或多种选自下组的L-氨基酸的能力来培育大肠杆菌的L-氨基酸生产菌株由L-色氨酸，L-苯丙氨酸，L-赖氨酸，L-酪氨酸，L-谷氨酸，L-组氨酸，L-半胱氨酸和L-脯氨酸组成。

63. 发明授权

US06962805B2 Method of constructing amino acid producing bacterial strains, and method of preparing amino acids by fermentation with the constructed amino acid producing bacterial strains 有权
标题翻译：构建产氨酸的细菌菌株的方法，以及用构建的产生氨基酸的菌株通过发酵制备氨基酸的方法
公开(公告)号：US06962805B2
公开(公告)日：2005-11-08
申请号：US09577005
申请日：2000-05-25
申请人： Yoko Asakura , Jun Nakamura , Sohei Kanno , Mikiko Suga , Eiichiro Kimura , Hisao Ito , Kazuhiko Matsui , Tsuyoshi Ohsumi , Tsuyoshi Nakamatsu , Osamu Kurahashi
发明人： Yoko Asakura , Jun Nakamura , Sohei Kanno , Mikiko Suga , Eiichiro Kimura , Hisao Ito , Kazuhiko Matsui , Tsuyoshi Ohsumi , Tsuyoshi Nakamatsu , Osamu Kurahashi
IPC分类号： C12N15/37 , C12N1/21 , C12N15/67 , C12P13/04 , C12P13/14 , C07H21/04 , C12N1/20 , C12N15/74 , C12Q1/32
CPC分类号： C12P13/14 , C12N15/67
摘要： A method of producing coryneform bacteria having improved amino acid or nucleic acid productivity comprising the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic acid-biosynthesizing genes on a chromosome of a coryneform bacterium to make it close to a consensus sequence, or introducing a change in a promoter sequence of amino acid- or nucleic acid-biosynthesizing genes on a chromosome of a coryneform bacterium by gene recombination to make it close to a consensus sequence, to obtain mutants of the coryneform amino acid- or nucleic acid-producing microorganism, culturing the mutants and selecting a mutant capable of producing the intended amino acid or nucleic acid in a large amount. This method allows the construction of a mutant capable of enriching or controlling the expression of an intended gene without using a plasmid and to promote production of amino acids in a high yield by recombination or mutation.
摘要翻译：制备具有改善的氨基酸或核酸生产力的棒状细菌的方法包括以下步骤：在棒状细菌染色体上的氨基酸或核酸 - 生物合成基因的启动子序列中引入突变，使其接近共有序列或通过基因重组在棒状细菌的染色体上引入氨基酸或核酸 - 生物合成基因的启动子序列的变化使其接近共有序列，以获得棒状细胞氨基酸或核酸的突变体培养微生物，培养突变体并选择能够大量产生所需氨基酸或核酸的突变体。该方法允许构建能够富集或控制预期基因的表达而不使用质粒的突变体，并通过重组或突变促进高产量的氨基酸的产生。

64. 发明授权

US5381794A Ultrasonic probe apparatus 失效
标题翻译：超声波探头设备
公开(公告)号：US5381794A
公开(公告)日：1995-01-17
申请号：US7346
申请日：1993-01-21
申请人： Chuwa Tei , Takashi Hosokawa , Tomoyuki Kato , Wataru Takekawa , Hisao Ito , Yoshihiro Yoshikawa
发明人： Chuwa Tei , Takashi Hosokawa , Tomoyuki Kato , Wataru Takekawa , Hisao Ito , Yoshihiro Yoshikawa
IPC分类号： A61B8/00 , G10K11/35
CPC分类号： A61B8/4281 , A61B8/4209 , A61B8/4236 , G10K11/35 , A61B8/0883 , A61B8/582
摘要： An ultrasonic probe apparatus suitable for use in stress echocardiography testing is disclosed. This ultrasonic probe apparatus comprises, an ultrasonic probe provided with a phased array transducer for transmitting and receiving ultrasonic waves; a supporting member for supporting the ultrasonic probe rotationally and pivotally; and a plurality of deformable holding legs provided on the supporting member and formed of a copper plate coated with plastic so as to be able to be easily deformed by hand and further maintain its deformed state for a long time. Therefore, the ultrasonic probe apparatus can hold the ultrasonic probe stably onto a body surface of a person to be examined for a long time by appropriately deforming or bending any of the holding legs and then attaching the legs on the body surface in such a manner that the probe is in contact with the body surface, even if the body surface has various shape and unevenness. Further, the apparatus comprises a first motor for rotating the probe and a plurality of second motors for pivotally inclining the probe, so that the contact angle and direction of the probe with respect to the body surface of the examined person in exercise can be adjustably corrected or changed by remote control when the probe is dislocated or a scanning plane is required to be changed during the stress echocardiography testing.
摘要翻译：公开了一种适用于压力超声心动图检测的超声探头装置。该超声波探头装置包括：超声波探头，其设置有用于发送和接收超声波的相控阵转换器; 支撑构件，其用于支撑所述超声波探头; 以及多个可变形的保持腿，其设置在支撑构件上并且由涂覆有塑料的铜板形成，以便能够用手容易地变形并且进一步长时间地保持其变形状态。因此，超声波探头装置可以通过适当地变形或弯曲任何保持腿，然后将腿部附接到身体表面上，将超声波探头稳定地保持在待检查人员的身体表面上，探针与身体表面接触，即使体表具有各种形状和不均匀性。此外，该装置包括用于旋转探针的第一电动机和用于使探针枢转倾斜的多个第二电动机，使得可以可调节地校正探针相对于被检查人员身体表面的接触角度和方向或者当应力超声心动图测试期间探头脱位或需要改变扫描平面时，由遥控器更改。

65. 发明授权

US4956471A Process for isolating and purifying amino acids 失效
标题翻译：分离和纯化氨基酸的方法
公开(公告)号：US4956471A
公开(公告)日：1990-09-11
申请号：US355821
申请日：1989-05-16
申请人： Hisao Ito , Akio Nishi , Masasi Miyazawa , Masayoshi Naruse
发明人： Hisao Ito , Akio Nishi , Masasi Miyazawa , Masayoshi Naruse
IPC分类号： B01D15/04 , C07D233/54 , C07D233/64
CPC分类号： C07D233/64
摘要： A process for isolating and purifying an amino acid, which comprises subjecting an aqueous solution of said amino acid containing impurities composed mainly of at least one member selected from the group consisting of acidic amino acids, lysine, ornithine, citrulline, histidine, PCA, sulfate ions, chloride ions and pigments to ion-exclusion chromatography using a strongly acidic cation exchange resin.
摘要翻译：一种用于分离和纯化氨基酸的方法，其包括使含有主要由选自酸性氨基酸，赖氨酸，鸟氨酸，瓜氨酸，组氨酸，PCA，硫酸盐中的至少一种的杂质组成的所述氨基酸水溶液离子，氯离子和颜料进行离子排阻色谱，使用强酸性阳离子交换树脂。

66. 发明授权

US4510589A System for securing combination radio and tape recorder 失效
标题翻译：用于固定组合无线电和磁带录音机的系统
公开(公告)号：US4510589A
公开(公告)日：1985-04-09
申请号：US336082
申请日：1981-12-31
申请人： Hisao Ito
发明人： Hisao Ito
IPC分类号： F16B1/02 , F16B21/08 , G11B25/06 , G11B31/00 , G11B33/02 , G11B33/06
CPC分类号： G11B31/003 , G11B25/063 , G11B33/02
摘要： A coupling/uncoupling device for use in a combination appliance including a main appliance combined with an auxiliary appliance. The device includes an accommodation recess for accommodating the auxiliary appliance in it, which is formed in the main appliance, a first locking member for locking the auxiliary appliance at its accommodating position, a supporting member for supporting the auxiliary appliance in the accommodation recess, a second locking member for locking the supporting member, and a lock releasing member for releasing the locking of the auxiliary appliance and that of the supporting member simultaneously.
摘要翻译：一种用于组合设备的耦合/解耦装置，包括与辅助设备结合的主要设备。该装置包括用于容纳其中的辅助装置的容纳凹部，其形成在主要装置中，用于将辅助装置锁定在其容纳位置的第一锁定构件，用于将辅助装置支撑在容纳凹部中的支撑构件，用于锁定支撑构件的第二锁定构件，以及用于同时释放辅助装置和支撑构件的锁定的锁定释放构件。

67. 发明授权

US08586334B2 Method for producing substance utilizing microorganism 有权
标题翻译：利用微生物生产物质的方法
公开(公告)号：US08586334B2
公开(公告)日：2013-11-19
申请号：US09897988
申请日：2001-07-05
申请人： Yuta Nakai , Kazuo Nakanishi , Yoshio Kawahara , Hisao Ito , Osamu Kurahashi
发明人： Yuta Nakai , Kazuo Nakanishi , Yoshio Kawahara , Hisao Ito , Osamu Kurahashi
IPC分类号： C12P13/04 , C12P13/08 , C12N1/21 , C12N9/00
CPC分类号： C12P13/222 , C12N9/0036 , C12N9/0038 , C12P13/08 , C12P13/22
摘要： In a method for producing a target substance utilizing a microorganism comprising culturing the microorganism in a medium to produce and cause accumulation of the target substance in the medium and collecting the target substance, there is used, as the microorganism, a mutant strain or a genetic recombinant strain constructed from a parent strain of the microorganism having a respiratory chain pathway of high energy efficiency and a respiratory chain pathway of low energy efficiency as respiratory chain pathways, and having either one or both of the following characteristics: (A) the respiratory chain pathway of high energy efficiency is enhanced, (B) the respiratory chain pathway of low energy efficiency is deficient.
摘要翻译：在利用微生物生产目标物质的方法中，包括在培养基中培养微生物以产生并引起目标物质在培养基中的积聚并收集目标物质，作为微生物使用突变菌株或遗传由具有高能量呼吸链途径和呼吸链途径的低能量呼吸链途径的微生物亲本菌株构建的重组菌株，具有以下特征中的一种或两种：（A）呼吸链提高能源效率的途径，（B）能源效率低下的呼吸链路径不足。

68. 发明申请

US20130008257A1 UNDERWATER WORK DEVICE AND UNDERWATER STRAIN GAUGE DEVICE 有权
标题翻译：水下工作装置和水下应变仪
公开(公告)号：US20130008257A1
公开(公告)日：2013-01-10
申请号：US13518597
申请日：2010-12-24
申请人： Hisao Ito , Eiichiro Araki , Kazuo Furuya
发明人： Hisao Ito , Eiichiro Araki , Kazuo Furuya
IPC分类号： G01B13/24
CPC分类号： G01B13/24
摘要： To easily change internal pressure of a container according to a change in external pressure.In a strain gauge device 100, a piston 54 attached to a tubular opening portion 53A provided at a housing part 53 slides in response to external pressure. Thereby varying the volumes of a regulator oil containing region 52 and a sensitive region 15 so as to achieve a balance with the external pressure, to change the internal pressure. Then, in the above-described strain gauge device, because the internal pressures of the regulator oil containing region 52 and the sensitive region 15 are changed according to a change in external pressure only by sliding of the piston 54, it is possible to easily perform regulation of the internal pressure. Further, because the above-described pressure balance mechanism 51 is achieved with a simple configuration, it is possible to easily perform regulation of the external pressure and the internal pressure even in a high-temperature/high-pressure environment.
摘要翻译：根据外部压力的变化容易地改变容器的内部压力。在应变计装置100中，附接到设置在壳体部53的管状开口部53A的活塞54响应于外部压力而滑动。从而改变调节器油容纳区域52和敏感区域15的体积，以实现与外部压力的平衡，以改变内部压力。而且，在上述的应变计装置中，由于调节器油容纳区域52和敏感区域15的内部压力仅通过活塞54的滑动而根据外部压力的变化而变化，因此能够容易地进行调节内压。此外，由于通过简单的结构实现了上述的压力平衡机构51，所以即使在高温高压环境下也能够容易地进行外部压力和内部压力的调节。

69. 发明申请

US20120319021A1 VALVE MECHANISM 审中-公开
标题翻译：阀门机构
公开(公告)号：US20120319021A1
公开(公告)日：2012-12-20
申请号：US13518638
申请日：2010-12-24
申请人： Hisao Ito , Eiichiro Araki , Kazuo Furuya
发明人： Hisao Ito , Eiichiro Araki , Kazuo Furuya
IPC分类号： F16K5/00
CPC分类号： F16K3/26 , G01V1/008
摘要： In the valve mechanism 60, when a valve sleeve 62 and a valve plunger 63 move in an inside of a valve holder 61 by driving of a power unit 65, to be at a predetermined position, a coupling port 63C provided in a flow path 63A of the valve plunger 63 and a slit 610 in the valve holder 61 are communicated with one another, thereby connecting a regulator oil containing region 52 and a sensitive region 15, and in the case where the internal pressures of the regulator oil containing region 52 and the sensitive region 15 are different from each other, the pressures fluctuate so as to equalize those. On the other hand, when those are at positions other than the predetermined position, the coupling port 63C and the slit 610 are not communicated with one another, thereby cutting off the connection between the regulator oil containing region and the sensitive region, and therefore, it is possible to easily perform a pressure regulation even in a high-temperature and high-pressure environment.
摘要翻译：在阀机构60中，当阀套62和阀柱塞63通过驱动动力单元65在阀保持器61的内部移动到预定位置时，设置在流路63A中的联接口63C 并且阀保持器61中的狭缝610彼此连通，从而连接调节器油容纳区域52和敏感区域15，并且在调节器油容纳区域52和敏感区域15彼此不同，所以压力波动，以使其均衡。另一方面，当它们处于除了预定位置之外的位置时，联接口63C和狭缝610彼此不连通，从而切断调节器油容纳区域和敏感区域之间的连接，因此，即使在高温高压环境下也可以容易地进行压力调节。

70. 发明授权

US08237327B2 Method for driving piezoelectric actuator, piezoelectric-actuator control circuit, and image-stabilization control circuit 有权
标题翻译：用于驱动压电致动器，压电致动器控制电路和图像稳定控制电路的方法
公开(公告)号：US08237327B2
公开(公告)日：2012-08-07
申请号：US12754030
申请日：2010-04-05
申请人： Tetsuya Tokoro , Yukihiko Shigeoka , Hisao Ito , Hideo Yoshida , Takezo Nagamitsu
发明人： Tetsuya Tokoro , Yukihiko Shigeoka , Hisao Ito , Hideo Yoshida , Takezo Nagamitsu
IPC分类号： H02N2/06
CPC分类号： G03B5/00 , H02N2/062
摘要： Abnormal noise generated while driving a piezoelectric actuator is prevented. A pulse-generation circuit is capable of selectively generating a displacement pulse and a stationary pulse as a drive pulse for application to a piezoelectric element, the displacement pulse having a duty ratio for causing a lens to be displaced by a predetermined step width, and the stationary pulse having a duty ratio for causing the lens to remain stationary in a current position. The pulse-generation circuit controls the production of the drive pulse continuously for a plurality of times within the servo control cycle, causes the displacement pulse to be produced when the remainder of a required amount of displacement is equal to or greater than a threshold value, and causes the stationary pulse to be continuously produced until the initiation of the next servo control cycle when the remainder is less than the threshold value.
摘要翻译：防止在驱动压电致动器时产生的异常噪声。脉冲发生电路能够选择性地产生位移脉冲和静止脉冲作为施加到压电元件的驱动脉冲，所述位移脉冲具有使透镜以预定的步长位移的占空比，并且具有使透镜在当前位置保持静止的占空比的固定脉冲。脉冲发生电路在伺服控制周期内连续地控制驱动脉冲的产生多次，当所需的位移量的余数等于或大于阈值时，产生位移脉冲，并且当余数小于阈值时，使得静止脉冲被连续地产生直到下一个伺服控制周期的开始。

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