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61. 发明授权

US07612137B2 Surface-modified silica gels 失效
标题翻译：表面改性硅胶
公开(公告)号：US07612137B2
公开(公告)日：2009-11-03
申请号：US11132293
申请日：2005-05-19
申请人： Ulrich Brinkmann , Christian Götz , Hans-Dieter Christian
发明人： Ulrich Brinkmann , Christian Götz , Hans-Dieter Christian
IPC分类号： C08K3/34
CPC分类号： C09C1/3081 , C01P2004/51 , C01P2006/11 , C01P2006/12 , C01P2006/14 , C01P2006/19 , C01P2006/22 , C01P2006/40 , C08K3/36 , C08K9/06 , C09D5/04 , C09D7/42 , C09D7/62 , C09D7/68 , C09D7/69
摘要： The invention relates to surface-modified silica gels, to a process for preparing them, and to their use as matting agents in coating materials. As a result of the nature of the surface modification, the viscosity of 2-component coating materials is increased only slightly, or not at all, after the matting agent has been added.
摘要翻译：本发明涉及表面改性硅胶，其制备方法及其作为涂料中消光剂的用途。由于表面改性的性质，在添加消光剂后，双组分涂料的粘度仅略微增加，或根本不增加。

62. 发明申请

US20070248972A1 Page-4, an X-linked gage-like gene expressed in normal and neoplastic prostate, testis and uterus, and uses therefor 审中-公开
标题翻译：第4页，在正常和肿瘤前列腺，睾丸和子宫中表达的X连接的量规样基因，并用于其
公开(公告)号：US20070248972A1
公开(公告)日：2007-10-25
申请号：US11704714
申请日：2007-02-09
申请人： Ira Pastan , Ulrich Brinkmann , George Vasmatzis , Byungkook Lee
发明人： Ira Pastan , Ulrich Brinkmann , George Vasmatzis , Byungkook Lee
IPC分类号： C12Q1/68 , C07H21/00 , C12N1/00 , C12N1/21 , C12N15/00 , C12N5/00
CPC分类号： C07K14/4748 , A61K39/00
摘要： PAGE-4 is a gene preferentially expressed in normal male and female reproductive tissues, prostate, testis, fallopian tube, uterus and placenta, as well as in prostate cancer, testicular cancer and uterine cancer. This expression pattern makes it a target for diagnosis and for vaccine based therapy of neoplasms of prostate, testis and uterus. The invention provides immunogenic compositions comprising PAGE-4 protein or immunogenic peptides thereof, methods of inhibiting the growth of malignant cells expressing PAGE-4, and methods of inducing an enhanced immune response to PAGE-4-expressing cancers.
摘要翻译： PAGE-4是在正常男性和女性生殖组织，前列腺，睾丸，输卵管，子宫和胎盘以及前列腺癌，睾丸癌和子宫癌中优先表达的基因。这种表达模式使其成为诊断和基于疫苗的前列腺，睾丸和子宫肿瘤的治疗的目标。本发明提供包含PAGE-4蛋白或其免疫原性肽的免疫原性组合物，抑制表达PAGE-4的恶性细胞生长的方法，以及诱导对表达PAGE-4的癌症增强的免疫应答的方法。

63. 发明申请

US20060172291A1 Polymorphisms in the human gene for cytochrome p450 polypeptide 2c8 and their use in diagnostic and therapeutic applications 有权
标题翻译：细胞色素p450多肽2c8的人基因多态性及其在诊断和治疗应用中的应用
公开(公告)号：US20060172291A1
公开(公告)日：2006-08-03
申请号：US10479225
申请日：2002-05-31
申请人： Anja Penger , Reimund Sprenger , Ulrich Brinkmann
发明人： Anja Penger , Reimund Sprenger , Ulrich Brinkmann
IPC分类号： C12Q1/68
CPC分类号： C12N9/0077 , A01K2217/05 , C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a polymorphic CYP2C8-polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a prodrug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit.
摘要翻译：本发明涉及多态CYP2C8-多核苷酸。此外，本发明涉及包含本发明的多核苷酸的基因或载体，并涉及用本发明的多核苷酸或基因进行遗传工程改造的宿主细胞。此外，本发明涉及用于产生分子变体多肽或其片段的方法，用于产生能够表达分子变体多肽的细胞的方法及其由本发明的多核苷酸或基因编码的多肽或其片段，或可由方法或由本发明方法生产的细胞。此外，本发明涉及特异性结合本发明多肽的抗体。此外，本发明涉及转基因非人动物。本发明还涉及包含一种或多种上述多核苷酸，基因，载体，多肽，抗体或宿主细胞的固体支持物。此外，鉴定多态性，鉴定和获得前药或药物或抑制剂的方法也包括在本发明中。此外，本发明涉及制备药物组合物的方法和诊断疾病的方法。此外，本发明涉及本发明的多核苷酸的检测方法。此外，本发明包括诊断和药物组合物。更进一步地，本发明涉及本发明的多核苷酸，基因，载体，多肽或抗体的用途。最后，本发明涉及诊断试剂盒。

64. 外观设计

USD481344S1 Front face of a vehicle wheel 失效
公开(公告)号：USD481344S1
公开(公告)日：2003-10-28
申请号：US29150782
申请日：2001-11-30
申请人： Stephen Mattin , Ulrich Brinkmann
设计人： Stephen Mattin , Ulrich Brinkmann

65. 发明授权

US06558672B1 Methods of making recombinant disulfide-stabilized polypeptide fragments having binding specificity 有权
标题翻译：制备具有结合特异性的重组二硫键稳定的多肽片段的方法
公开(公告)号：US06558672B1
公开(公告)日：2003-05-06
申请号：US09657274
申请日：2000-09-07
申请人： Ira H. Pastan , Byungkook Lee , Sun-Hee Jung , Ulrich Brinkmann
发明人： Ira H. Pastan , Byungkook Lee , Sun-Hee Jung , Ulrich Brinkmann
IPC分类号： A61K3900
CPC分类号： C07K14/7051 , A61K38/00 , A61K47/6829 , A61K47/6835 , C07K16/00 , C07K2319/00 , C07K2319/33 , C07K2319/55 , Y10S530/866 , Y10S530/867
摘要： The present invention relates to disulfide-stabilized recombinant polypeptide molecules which have the binding ability and specificity for another peptide, such as the variable region of an antibody molecule. Methods of producing these molecules and nucleic acid sequences encoding these molecules are also described. In particular, the invention discloses Fv antibody fragments stabilized by a disulfide bond connecting the VH and VL regions of the Fv fragment. The &agr; and &bgr; chains of T cell receptors may be similarly stabilized by means described in the invention.
摘要翻译：本发明涉及对另一种肽（例如抗体分子的可变区）具有结合能力和特异性的二硫键稳定的重组多肽分子。还描述了生产这些分子的方法和编码这些分子的核酸序列。特别地，本发明公开了通过连接Fv片段的VH和VL区的二硫键稳定的Fv抗体片段。 T细胞受体的α链和β链可以通过本发明所述的手段相似地稳定。

66. 发明授权

US06232086B1 Method for detecting cancer cells 失效
标题翻译：癌细胞检测方法
公开(公告)号：US06232086B1
公开(公告)日：2001-05-15
申请号：US09234232
申请日：1999-01-20
申请人： Ira Pastan , Ulrich Brinkmann
发明人： Ira Pastan , Ulrich Brinkmann
IPC分类号： A61K39395
CPC分类号： C07K16/18 , A61K38/00 , C07K14/4747 , Y10S435/81
摘要： The cDNA and amino acid sequences for a cellular apoptosis susceptibility (CAS) protein are used to detect expression and amplification of the CAS gene in normal and cancer cells. An antisense CAS gene sequence introduced into living cells inhibits CAS protein activity and thus prevents or inhibits apoptosis in the cells.
摘要翻译：用于细胞凋亡敏感性（CAS）蛋白的cDNA和氨基酸序列用于检测正常和癌细胞中CAS基因的表达和扩增。引入活细胞的反义CAS基因序列抑制CAS蛋白活性，从而阻止或抑制细胞凋亡。

67. 外观设计

USD417857S Surface configuration of a front panel for a vehicle 失效
公开(公告)号：USD417857S
公开(公告)日：1999-12-21
申请号：US93110
申请日：1998-09-03
申请人： Bruno Sacco , Peter Pfeiffer , Hans-Dieter Futschik , Ulrich Brinkmann
设计人： Bruno Sacco , Peter Pfeiffer , Hans-Dieter Futschik , Ulrich Brinkmann

68. 发明授权

US5990296A Single chain B3 antibody fusion proteins and their uses 失效
标题翻译：单链B3抗体融合蛋白及其用途
公开(公告)号：US5990296A
公开(公告)日：1999-11-23
申请号：US759804
申请日：1996-12-03
申请人： Ira Pastan , Mark Willingham , David Fitzgerald , Ulrich Brinkmann , Lee Pai
发明人： Ira Pastan , Mark Willingham , David Fitzgerald , Ulrich Brinkmann , Lee Pai
IPC分类号： A61K38/00 , A61K47/48 , A61P35/00 , C07K14/21 , C07K16/18 , C07K16/30 , C07K16/34 , C07K19/00 , G01N33/574 , C07H21/04
CPC分类号： A61K47/48569 , C07K14/21 , C07K16/18 , C07K16/30 , C07K16/34 , C07K19/00 , G01N33/57419 , G01N33/57446 , G01N33/57449 , G01N33/57492 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/622 , C07K2319/00 , Y10S530/866 , Y10S530/867
摘要： This invention provides for recombinant single chain antibodies capable of specifically binding to a Lewis.sup.Y -related carbohydrate antigen and fusion proteins comprising these antibodies. More particularly, the invention provides for single chain Fv regions of the monoclonal antibody B3. The invention also provides for a method of improving the binding affinity of antibodies lacking a serine at position 95 of the V.sub.H region that involves mutating position 95 to a serine.
摘要翻译：本发明提供能够特异性结合LewisY相关糖类抗原的重组单链抗体和包含这些抗体的融合蛋白。更具体地，本发明提供单克隆抗体B3的单链Fv区。本发明还提供了一种方法，其将VH区域的95位缺失丝氨酸的抗体与包含突变位置95的丝氨酸相结合。

69. 外观设计

USD416222S Surface configuration of a rear panel for a vehicle 失效
公开(公告)号：USD416222S
公开(公告)日：1999-11-09
申请号：US93215
申请日：1998-09-03
申请人： Bruno Sacco , Peter Pfeiffer , Hans-Dieter Futschik , Ulrich Brinkmann
设计人： Bruno Sacco , Peter Pfeiffer , Hans-Dieter Futschik , Ulrich Brinkmann

70. 发明授权

US5759782A Cellular apoptosis susceptibility protein (CSP) and antisense CSP 失效
标题翻译：细胞凋亡敏感性蛋白（CSP）和反义CSP
公开(公告)号：US5759782A
公开(公告)日：1998-06-02
申请号：US480662
申请日：1995-06-07
申请人： Ira Pastan , Ulrich Brinkmann
发明人： Ira Pastan , Ulrich Brinkmann
IPC分类号： A61K38/00 , C07K14/47 , C07K16/18 , C07H21/00 , C07H21/04 , C12N15/09 , C12N15/63
CPC分类号： C07K16/18 , C07K14/4747 , A61K38/00 , Y10S435/81
摘要： The cDNA and amino acid sequences for a cellular apoptosis susceptibility (CAS) protein are used to detect expression and amplification of the CAS gene in normal and cancer cells. An antisense CAS gene sequence introduced into living cells inhibits CAS protein activity and thus prevents or inhibits apoptosis in the cells.
摘要翻译：用于细胞凋亡敏感性（CAS）蛋白的cDNA和氨基酸序列用于检测正常和癌细胞中CAS基因的表达和扩增。引入活细胞的反义CAS基因序列抑制CAS蛋白活性，从而阻止或抑制细胞凋亡。

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