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61. 发明授权

US06776888B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06776888B2
公开(公告)日：2004-08-17
申请号：US10089289
申请日：2002-03-26
申请人： Tomohiro Yamamoto , Miwa Hasegawa , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Tomohiro Yamamoto , Miwa Hasegawa , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/004 , G01N27/3272
摘要： The present invention provides a biosensor that enables highly-accurate measurement of a sample solution including a solid component like hemocytes and has a little variation in response. The biosensor includes: an insulating base plate, an electrode system having at least a working electrode and a counter electrode provided on the base plate, a cover member that is combined with the base plate to define a sample solution supply pathway for leading a sample solution from a sample supply unit to the electrode system, a reaction reagent system including at least an oxidation-reduction enzyme and an electron mediator, and a filter disposed between the electrode system and the sample supply unit in the sample solution supply pathway. The biosensor has a space that encircles surface of the filter in an area from one end of the filter close to the sample supply unit to the other end of the filter close to the electrode system. This arrangement effectively prevents the solid component like hemocytes from flowing into the electrode system without being filtered out by the filter.
摘要翻译：本发明提供一种生物传感器，其能够高精度地测量包含像血细胞这样的固体成分的样品溶液，并且响应性变化很小。生物传感器包括：绝缘基板，至少具有工作电极和设置在基板上的对电极的电极系统，与基板结合以限定用于引导样品溶液的样品溶液供给路径的盖构件从样品供给单元到电极系统，至少包含氧化还原酶和电子介体的反应试剂系统，以及设置在样品溶液供给路径中的电极系统和样品供给单元之间的过滤器。生物传感器具有在过滤器的一端靠近样品供给单元的一个区域中的过滤器的表面周围到靠近电极系统的过滤器的另一端的空间。这种布置有效地防止诸如血细胞的固体组分流入电极系统而不被过滤器过滤掉。

62. 发明授权

US06458258B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06458258B2
公开(公告)日：2002-10-01
申请号：US09748229
申请日：2000-12-27
申请人： Yuko Taniike , Shin Ikeda , Shiro Nankai
发明人： Yuko Taniike , Shin Ikeda , Shiro Nankai
IPC分类号： G01N2726
CPC分类号： C12Q1/004 , C12Q1/001
摘要： The present invention provides a biosensor having a high current response sensitivity, a low blank response and a high storage stability. This sensor comprises an electrode system including a working electrode and a counter electrode, for forming an electrochemical measurement system by coming in contact with a supplied solution; an insulating supporting member for supporting the electrode system; a first reagent layer formed on the working electrode; and a second reagent layer formed on the counter electrode, wherein the first reagent layer does not contain an enzyme, but it contains at least an electron mediator, and the second reagent layer does not contain an electron mediator, but it contains at least an enzyme.
摘要翻译：本发明提供具有高电流响应灵敏度，低空白响应和高储存稳定性的生物传感器。该传感器包括电极系统，其包括工作电极和对电极，用于通过与所提供的溶液接触形成电化学测量系统; 用于支撑电极系统的绝缘支撑构件; 形成在工作电极上的第一试剂层; 和形成在对电极上的第二试剂层，其中第一试剂层不含酶，但至少包含电子介体，第二试剂层不含电子介体，但至少含有酶。

63. 发明授权

US4376689A Coenzyme immobilized electrode 失效
标题翻译：辅酶固定电极
公开(公告)号：US4376689A
公开(公告)日：1983-03-15
申请号：US321326
申请日：1981-11-13
申请人： Kenichi Nakamura , Shiro Nankai , Takashi Iijima
发明人： Kenichi Nakamura , Shiro Nankai , Takashi Iijima
IPC分类号： C12Q1/00 , C12Q1/26
CPC分类号： C12Q1/005 , Y10S435/817
摘要： Improvements in a coenzyme electrode used to electrochemically measure the activity of enzyme or substrate concentration of the enzyme easily. The coenzyme is immobilized, without using a semipermeable membrane, on the electron collector directly with the chemical bond, particularly the covalent bond, whereby the activity of the oxide-reductase requiring the coenzyme can be measured. In addition, the oxide-reductase requiring the coenzyme is also immobilized together with such immobilized coenzyme to improve the characteristics of the conventional enzyme-coenzyme immobilized electrode.
摘要翻译：用于电化学测量酶活性或酶底物浓度的辅酶电极的改进容易。辅酶不用半透膜即可直接用化学键，特别是共价键直接固定在电子收集器上，从而可以测量需要辅酶的氧化还原酶的活性。此外，需要辅酶的氧化还原酶也与这样的固定化辅酶一起固定，以改善常规的酶 - 辅酶固定化电极的特性。

64. 发明授权

US06966977B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06966977B2
公开(公告)日：2005-11-22
申请号：US10350139
申请日：2003-01-24
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： C12Q1/00 , G01N33/487 , G01N33/49 , G01N33/543 , G01N27/327
CPC分类号： C12Q1/004 , G01N27/3272
摘要： A sensor including an insulating base plate; an electrode system, provided on the base plate, having a measuring electrode and a counter electrode; a reaction layer including at least an oxidoreductase and an electron mediator; a sample solution supply pathway including the electrode system and the reaction layer; and a sample supply unit, wherein the sensor is so structured that, between the sample supply unit and the sample solution supply pathway, there is provided a filter having a function to filter out hemocytes and having a cross-sectional area larger than an opening of the sample solution supply pathway, and that plasma of a blood with hemocytes thereof having been filtered out is sucked into the inside of the sample solution supply pathway owing to capillary phenomena.
摘要翻译：一种传感器，包括绝缘基板; 设置在基板上的具有测量电极和对电极的电极系统; 至少包含氧化还原酶和电子介体的反应层; 包括电极系统和反应层的样品溶液供给路径; 以及样本供应单元，其中所述传感器的结构使得在所述样品供应单元和所述样品溶液供应通道之间提供过滤器，所述过滤器具有过滤出血细胞并且具有大于所述样品供应单元的开口的横截面积样品溶液供给路径，由于毛细血管现象，血液中已经滤出血细胞的血浆被吸入到样品溶液供给路径的内部。

65. 发明申请

US20050203707A1 Data measuring device, healthcare data acquiring system, and healthcare data acquiring method 审中-公开
标题翻译：数据测量装置，保健数据采集系统，医疗数据采集方法
公开(公告)号：US20050203707A1
公开(公告)日：2005-09-15
申请号：US10509728
申请日：2003-08-08
申请人： Hiroshi Tsutsui , Yasuhiro Mori , Hirosi Yamamoto , Shiro Nankai , Nobuyuki Shigetoh , Tatsurou Kawamura
发明人： Hiroshi Tsutsui , Yasuhiro Mori , Hirosi Yamamoto , Shiro Nankai , Nobuyuki Shigetoh , Tatsurou Kawamura
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： G16H10/40 , A61B5/14532
摘要： The data measuring unit 11 measures a subject's blood and urine, and acquires numerical data (S501). The communication control unit 12 transmits the acquired numerical data to the data management apparatus 20 (S502). The overall control unit 14 receives the numerical data from the data measuring apparatus 10 (S503), and analyzes the content of the received numerical data (S504). The overall control unit 14 selects calibration curve data based on the above mentioned analysis result (S505), and calculates health care data (S506). Furthermore, the overall control unit 14 directs the communication control unit 13 to transmit the calculated health care data to the data measuring apparatus 10 (S507). The data measuring apparatus 10 receives the health care data from the data management apparatus 20 (S508).
摘要翻译：数据测量单元11测量受试者的血液和尿液，并获取数字数据（S 501）。通信控制单元12将获取的数字数据发送到数据管理装置20（步骤502）。总体控制单元14从数据测量装置10接收数字数据（S 503），并分析接收数字数据的内容（S 504）。总体控制单元14基于上述分析结果选择校准曲线数据（S 505），并计算保健数据（S 506）。此外，总体控制单元14引导通信控制单元13将计算出的医疗保健数据发送到数据测量装置10（S 507）。数据测量装置10从数据管理装置20接收保健数据（S 508）。

66. 发明授权

US06885196B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06885196B2
公开(公告)日：2005-04-26
申请号：US10220153
申请日：2001-07-17
申请人： Yuko Taniike , Shin Ikeda , Shiro Nankai
发明人： Yuko Taniike , Shin Ikeda , Shiro Nankai
IPC分类号： C12Q1/00 , A61B5/05
CPC分类号： G01N27/3272 , C12Q1/005 , C12Q1/006
摘要： A highly sensitive biosensor that uses a smaller amount of sample for measurement is described. The biosensor includes a first insulating base plate having a working electrode, a second insulating base plate having a counter electrode opposed to the working electrode, and a reagent layer containing at least an oxidoreductase. The biosensor further includes a sample supply pathway formed between the first and second insulating base plates, where the working electrode, counter electrode and reagent layer are exposed to an inside of the sample supply pathway, and the distance between the working electrode and the counter electrode is 150 μm or less.
摘要翻译：描述了使用较少量的样品进行测量的高灵敏度生物传感器。生物传感器包括具有工作电极的第一绝缘基板，具有与工作电极相对的反电极的第二绝缘基板和至少含有氧化还原酶的试剂层。生物传感器还包括形成在第一和第二绝缘基板之间的样品供给路径，其中工作电极，对电极和试剂层暴露于样品供应路径的内部，并且工作电极和对电极之间的距离是150mam以下。

67. 发明授权

US06740215B1 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06740215B1
公开(公告)日：2004-05-25
申请号：US09959571
申请日：2001-10-30
申请人： Takahiro Nakaminami , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Takahiro Nakaminami , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/005
摘要： A biosensor comprising an electrically insulating base plate, an electrode system containing a working electrode and a counter electrode disposed on the base plate, and a reagent system comprising at least an oxidoreductase, a hydrophilic polymer and an electron mediator, wherein the reagent system further comprises a substance having a function to convert an organic product generated by direct reaction of a substrate to be measured with the oxidoreductase to another compound.
摘要翻译：一种生物传感器，包括电绝缘基板，包含工作电极的电极系统和设置在基板上的对电极，以及至少包含氧化还原酶，亲水性聚合物和电子介体的试剂系统，其中所述试剂系统还包括具有将待测基质与氧化还原酶直接反应产生的有机产物转化为其他化合物的功能的物质。

68. 发明授权

US06719887B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06719887B2
公开(公告)日：2004-04-13
申请号：US10221990
申请日：2002-09-17
申请人： Miwa Hasegawa , Motokazu Watanabe , Tomohiro Yamamoto , Shin Ikeda , Shiro Nankai
发明人： Miwa Hasegawa , Motokazu Watanabe , Tomohiro Yamamoto , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： G01N33/92 , C12Q1/005 , G01N33/5438
摘要： A biosensor includes: an insulating base plate; an electrode system which is provided on the base plate and has a measurement electrode and a counter electrode; a reaction layer including at least oxidoreductase and an electron mediator; a sample solution supply pathway which includes the electrode system and the reaction layer and has an air aperture on the termination side thereof; a sample supply portion; and a filter which is disposed between the sample solution supply pathway and the sample supply portion and filters hemocytes, where plasma with the hemocytes therein filtered with the filter is sucked into the sample solution supply pathway due to capillarity, the central part of a secondary side portion of the filter is protruded into the sample solution supply pathway more than both the right and left ends thereof.
摘要翻译：生物传感器包括：绝缘基板; 电极系统，设置在基板上，具有测量电极和对电极; 至少包含氧化还原酶和电子介体的反应层; 样品溶液供给路径，其包括电极系统和反应层，并且在其终端侧具有空气孔; 样品供应部分; 以及过滤器，其设置在样品溶液供给路径和样品供给部之间，并且过滤血细胞，其中由过滤器过滤的血细胞的血浆由于毛细作用而被吸入样品溶液供给通道，次级侧的中心部分过滤器的一部分比其右端和左端都突出到样品溶液供给路径中。

69. 发明授权

US06599407B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06599407B2
公开(公告)日：2003-07-29
申请号：US09747975
申请日：2000-12-27
申请人： Yuko Taniike , Shin Ikeda , Shiro Nankai
发明人： Yuko Taniike , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/004
摘要： The present invention provides a biosensor having a favorable response characteristic up to a high concentration range, a low blank response and a high storage stability. This sensor comprises an electrode system including a working electrode and a counter electrode, for forming an electrochemical measurement system by coming in contact with a supplied solution; an electrically insulating supporting member for supporting the electrode system; a first reagent layer formed on the working electrode; and a second reagent layer formed on the counter electrode, wherein the first reagent layer comprises an enzyme as the main component, and the second reagent layer comprises an electron mediator as the main component.
摘要翻译：本发明提供一种生物传感器，其具有高浓度范围，低空白响应和高储存稳定性的良好响应特性。该传感器包括电极系统，其包括工作电极和对电极，用于通过与所提供的溶液接触形成电化学测量系统; 用于支撑电极系统的电绝缘支撑构件; 形成在工作电极上的第一试剂层; 以及形成在对电极上的第二试剂层，其中第一试剂层包含酶作为主要成分，第二试剂层包含电子介体作为主要成分。

70. 发明授权

US06451372B2 Biosensor and method of producing the same 失效
标题翻译：生物传感器及其生产方法
公开(公告)号：US06451372B2
公开(公告)日：2002-09-17
申请号：US09770946
申请日：2001-01-26
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： B05D300
CPC分类号： C12Q1/002
摘要： The present invention provides a biosensor that has a reaction reagent system easily dissolved even in a sample solution containing a high concentration of a substrate and ensures rapid and highly accurate measurement. The method of forming a target reaction layer according to the present invention dissolves a material constituting the target reaction layer in a solvent of a sublimable substance to prepare a solution, applies the solution in a desired area to form the target reaction layer, freezes the applied solution, and sublimates the solvent included in a solid matter of the frozen solution under reduced pressure for removal. The resultant reaction layer has a large surface area and is easily dissolved in the sample solution to enable rapid measurement.
摘要翻译：本发明提供了一种生物传感器，其具有即使在含有高浓度基板的样品溶液中也容易溶解的反应试剂体系，并且确保快速且高精度的测量。根据本发明的形成目标反应层的方法将构成目标反应层的材料溶解在可升华物质的溶剂中以制备溶液，将溶液施加到所需区域以形成目标反应层，冻结所施加的溶液，并在减压下升华包含在冷冻溶液的固体物质中的溶剂以除去。所得反应层的表面积大，容易溶解在样品溶液中，能够快速测定。

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