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61. 发明授权

US08486062B2 Curved ablation catheter 有权
标题翻译：弯曲消融导管
公开(公告)号：US08486062B2
公开(公告)日：2013-07-16
申请号：US11550302
申请日：2006-10-17
申请人： Kedar Ravindra Belhe , Saurav Paul , Hong Cao , John Avi Roop
发明人： Kedar Ravindra Belhe , Saurav Paul , Hong Cao , John Avi Roop
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00351 , A61B2018/143 , A61B2018/1475 , A61B2018/1497
摘要： A curved ablation catheter imparts ablative energy to target tissue, for example, along a trabecular slope, e.g., in the right atrium along the isthmus between the ostium of the inferior vena cava and the tricuspid valve. The catheter is formed with a preset curvature that, when deployed, both translates linearly and increases in radius to aid in the formation of spot or continuous linear lesions. A method of treating atrial flutter employs the curved ablation catheter.
摘要翻译：弯曲的消融导管向靶组织提供消融能量，例如沿着小梁斜面，例如沿着下腔静脉的口和三尖瓣之间的峡谷的右心房。导管形成有预设曲率，当展开时，两者均线性地平移并且半径增加以帮助形成斑点或连续的线性损伤。治疗心房扑动的方法采用弯曲消融导管。

62. 发明申请

US20110022045A1 Ablation electrodes with capacitive sensors for resolving magnitude and direction of forces imparted to a distal portion of a cardiac catheter 审中-公开
标题翻译：具有电容传感器的消融电极，用于分辨施加到心脏导管的远端部分的力的大小和方向
公开(公告)号：US20110022045A1
公开(公告)日：2011-01-27
申请号：US12893707
申请日：2010-09-29
申请人： Hong Cao , Riki Thao , Saurav Paul
发明人： Hong Cao , Riki Thao , Saurav Paul
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B5/6852 , A61B5/6885 , A61B2090/065
摘要： A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. In an exemplary embodiment the assembly includes a catheter shaft and a trio of pressure sensitive capacitive members each of whose electrical resistance varies with a pressure vector applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive capacitive members. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive capacitors.
摘要翻译：公开了一种用于评估导管组件和组织之间的接触的导管组件。在示例性实施例中，组件包括导管轴和三个压敏电容构件，每个电阻构件的电阻随着施加到导管组件的压力矢量而变化。组件还包括至少一个测量端子，以允许测量压敏电容构件的电特性的变化。组件可以可选地包括测量电阻，阻抗和/或其他电特性的测量装置。组件可以利用固定到患者组织的参考电极，其允许测量装置测量参考电极和至少一个测量终端之间的变化。可选地，组件可以包括导电外层。还公开了传感器组件，接触传感器，接触感测方法以及与使用压敏电容器有关的制造方法。

63. 发明申请

US20050267460A1 Ablation catheter with suspension system incorporating rigid and flexible components 失效
标题翻译：消融导管与悬挂系统结合刚性和柔性组件
公开(公告)号：US20050267460A1
公开(公告)日：2005-12-01
申请号：US10856544
申请日：2004-05-27
申请人： John Roop , Kedar Belhe , Hong Cao , Saurav Paul
发明人： John Roop , Kedar Belhe , Hong Cao , Saurav Paul
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00867 , A61B2018/00351 , A61B2018/143 , C08L2201/12
摘要： A curved ablation catheter imparts ablative energy to target tissue, for example, along a trabecular slope, e.g., in the right atrium along the isthmus between the ostium of the inferior vena cava and the tricuspid valve. The catheter is formed with a preset curvature that, when deployed, both translates linearly and increases in radius to aid in the formation of spot or continuous linear lesions. A method of treating atrial flutter employs the curved ablation catheter.
摘要翻译：弯曲的消融导管向靶组织提供消融能量，例如沿着小梁斜面，例如沿着下腔静脉的口和三尖瓣之间的峡谷的右心房。导管形成有预设曲率，当展开时，两者均线性地平移并且半径增加以帮助形成斑点或连续的线性损伤。治疗心房扑动的方法采用弯曲消融导管。

64. 发明授权

US10555685B2 Method and apparatus for determining tissue morphology based on phase angle 有权
公开(公告)号：US10555685B2
公开(公告)日：2020-02-11
申请号：US13584368
申请日：2012-08-13
申请人： Hong Cao , Saurav Paul
发明人： Hong Cao , Saurav Paul
IPC分类号： A61B5/00 , A61B5/053
摘要： A compensation circuit has a predetermined, known complex impedance and is located in a handle of a catheter or in a distal end of a cable that connects to the catheter. The compensation circuit is probed with a pilot signal produced by a compensation control. The compensation control measures the complex impedance, which is the combination of the circuit's known impedance as well as that of the cable and then determines the difference between the measured and the known complex impedances which represents that which is attributable to the cable, and is used to cancel out such cable-related contributions to complex impedance in other electrical connections in the same cable. In another aspect, an unknown tissue is identified as one of a plurality of possible tissue types such as regular myocardium, scar and fat based on the measured phase angle of the complex impedance of the unknown tissue.

65. 发明授权

US09949792B2 Pressure-sensitive flexible polymer bipolar electrode 有权
公开(公告)号：US09949792B2
公开(公告)日：2018-04-24
申请号：US13555929
申请日：2012-07-23
申请人： Saurav Paul , Harry A. Puryear , Riki Thao , Hong Cao
发明人： Saurav Paul , Harry A. Puryear , Riki Thao , Hong Cao
IPC分类号： A61B18/14 , A61B18/12 , A61B18/00
CPC分类号： A61B18/1492 , A61B18/1206 , A61B2018/00023 , A61B2018/00577 , A61B2018/00875
摘要： The present invention is directed to bipolar ablation systems. A bipolar electrode system for ablation therapy is disclosed, including a pressure-sensitive conducting composite layer and a pair of electrodes in electrical conductive contact or communication with the pressure-sensitive conducting composite layer. Energy (e.g., ablation energy) is delivered via the pressure-sensitive conductive composition when sufficient pressure is applied to transform the pressure-sensitive conductive composite to an electrical conductor. An electrically insulative flexible layer, which may include a passageway for a fill material is also disclosed. In some embodiments, the systems can also be used for targeted delivery of compounds, such as drugs, using a bipolar electrode.

66. 发明授权

US08369922B2 Method for displaying catheter electrode-tissue contact in electro-anatomic mapping and navigation system 有权
标题翻译：在电解剖映射和导航系统中显示导管电极组织接触的方法
公开(公告)号：US08369922B2
公开(公告)日：2013-02-05
申请号：US12096066
申请日：2006-12-06
申请人： Saurav Paul , Hong Cao
发明人： Saurav Paul , Hong Cao
IPC分类号： A61B5/04 , A61B5/05 , A61N1/00
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode coupling output system associated with an electrode catheter that provides indication to the physician via the navigation system, concerning the electrical coupling of an electrode, such as an ablative or mapping electrode, with a patient. The indication may be provided by changing the color or other display characteristics of the electrode on the navigation system display or by way of providing a waveform indicating the electrode coupling. In this manner, electrode coupling information is provided to a physician in a manner that minimizes physician distraction.
摘要翻译：与电极导管相关联的电极耦合输出系统，其通过导航系统向医生提供关于电极（例如烧蚀或映射电极）与患者的电耦合的指示。可以通过改变导航系统显示器上的电极的颜色或其他显示特性或通过提供指示电极耦合的波形来提供指示。以这种方式，电极耦合信息以最小化医师分心的方式提供给医师。

67. 发明授权

US07331959B2 Catheter electrode and rail system for cardiac ablation 有权
标题翻译：导管电极和轨道系统用于心脏消融
公开(公告)号：US07331959B2
公开(公告)日：2008-02-19
申请号：US10857421
申请日：2004-05-27
申请人： Hong Cao , John Avi Roop , Kedar Ravindra Belhe , Saurav Paul
发明人： Hong Cao , John Avi Roop , Kedar Ravindra Belhe , Saurav Paul
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00867 , A61B2018/00351 , A61B2018/143 , C08L2201/12
摘要： The instant invention is directed toward an ablation catheter and sheath incorporating wire rail system. The catheter may have a combination of rigid and flexible components to orient an ablation electrode at the distal tip toward the target tissue. The wire rail acts to guide an ablation tip along the tissue to aid in the formation of spot or continuous linear lesions on a trabecular surface, e.g., in the right atrium along the isthmus between the ostium of the inferior vena cava and the tricuspid valve.
摘要翻译：本发明涉及一种包含线轨系统的消融导管和护套。导管可以具有刚性和柔性部件的组合，以将远端处的消融电极朝向靶组织定向。线轨用于沿着组织引导消融尖端以帮助在小梁表面上形成斑点或连续的线性损伤，例如沿着下腔静脉的口和三尖瓣之间的峡部的右心房。

68. 发明申请

US20070088349A1 Curved ablation catheter 有权
标题翻译：弯曲消融导管
公开(公告)号：US20070088349A1
公开(公告)日：2007-04-19
申请号：US11550302
申请日：2006-10-17
申请人： Kedar Belhe , Saurav Paul , Hong Cao , John Roop
发明人： Kedar Belhe , Saurav Paul , Hong Cao , John Roop
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00351 , A61B2018/143 , A61B2018/1475 , A61B2018/1497
摘要： A curved ablation catheter imparts ablative energy to target tissue, for example, along a trabecular slope, e.g., in the right atrium along the isthmus between the ostium of the inferior vena cava and the tricuspid valve. The catheter is formed with a preset curvature that, when deployed, both translates linearly and increases in radius to aid in the formation of spot or continuous linear lesions. A method of treating atrial flutter employs the curved ablation catheter.
摘要翻译：弯曲的消融导管向靶组织提供消融能量，例如沿着小梁斜面，例如沿着下腔静脉的口和三尖瓣之间的峡谷的右心房。导管形成有预设曲率，当展开时，两者均线性地平移并且半径增加以帮助形成斑点或连续的线性损伤。治疗心房扑动的方法采用弯曲消融导管。

69. 发明授权

US08702690B2 Device and method for real-time lesion estimation during ablation 有权
标题翻译：消融期间实时病变评估的装置和方法
公开(公告)号：US08702690B2
公开(公告)日：2014-04-22
申请号：US12742485
申请日：2008-11-17
申请人： Saurav Paul , Hong Cao
发明人： Saurav Paul , Hong Cao
IPC分类号： A61B18/14
CPC分类号： A61B18/1233 , A61B18/1206 , A61B18/1492 , A61B2018/00678 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2018/00827 , A61B2018/00869 , A61B2018/00892 , A61B2090/065
摘要： Disclosed herein are ablation systems and methods for providing feedback on lesion formation in real-time. The methods and systems assess absorptivity of tissue based on a degree of electric coupling or contact between an ablation electrode and the tissue. The absorptivity can then be used, along with other information, including, power levels and activation times, to provide real-time feedback on the lesions being created. Feedback may be provided, for example, in the form of estimated lesion volumes and other lesion characteristics. The methods and systems can provide estimated treatment times to achieve a desired lesion characteristic for a given degree of contact, as well as depth of a lesion being created. The degree of contact may be measured using different techniques, including the phase angle techniques and a coupling index.
摘要翻译：本文公开了用于实时提供病变形成反馈的消融系统和方法。方法和系统基于消融电极和组织之间的电偶联或接触程度来评估组织的吸收性。然后可以使用吸收率以及其他信息，包括功率水平和激活时间，为正在创建的病变提供实时反馈。可以例如以估计的病变体积和其他病变特征的形式提供反馈。方法和系统可以提供估计的治疗时间以达到给定程度的接触所需的病变特征，以及所产生的病变的深度。可以使用不同的技术来测量接触程度，包括相位角技术和耦合指数。

70. 发明申请

US20130190754A1 Pressure-sensitive flexible polymer bipolar electrode 有权
标题翻译：压敏柔性聚合物双极电极
公开(公告)号：US20130190754A1
公开(公告)日：2013-07-25
申请号：US13555929
申请日：2012-07-23
申请人： Saurav Paul , Harry A. Puryear , Riki Thao , Hong Cao
发明人： Saurav Paul , Harry A. Puryear , Riki Thao , Hong Cao
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/1206 , A61B2018/00023 , A61B2018/00577 , A61B2018/00875
摘要： The present invention is directed to bipolar ablation systems. A bipolar electrode system for ablation therapy is disclosed, including a pressure-sensitive conducting composite layer and a pair of electrodes in electrical conductive contact or communication with the pressure-sensitive conducting composite layer. Energy (e.g., ablation energy) is delivered via the pressure-sensitive conductive composition when sufficient pressure is applied to transform the pressure-sensitive conductive composite to an electrical conductor. An electrically insulative flexible layer, which may include a passageway for a fill material is also disclosed. In some embodiments, the systems can also be used for targeted delivery of compounds, such as drugs, using a bipolar electrode.
摘要翻译：本发明涉及双相消融系统。公开了一种用于消融治疗的双极电极系统，包括压敏导电复合层和一对导电接触或与压敏导电复合层连通的电极。当施加足够的压力以将压敏导电复合材料转化为电导体时，经由压敏导电组合物递送能量（例如，消融能量）。还公开了可以包括用于填充材料的通道的电绝缘柔性层。在一些实施方案中，所述系统也可用于使用双极电极靶向递送化合物，例如药物。

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