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61. 发明授权

US07669880B2 Strap for snowboard boots or bindings 失效
公开(公告)号：US07669880B2
公开(公告)日：2010-03-02
申请号：US11215727
申请日：2005-08-29
申请人： Christopher Doyle , Ryan Larson , Gregory Dean , Florian Lang
发明人： Christopher Doyle , Ryan Larson , Gregory Dean , Florian Lang
IPC分类号： A63C9/18
CPC分类号： A43C11/146 , A63C10/06 , A63C10/24
摘要： A binding or boot strap is provided that allows a rider to easily, rapidly and/or effectively tighten and/or loosen the strap about his or her boot. The strap includes a boot-engaging strap portion that engages with an engagement strap coupleable to the boot, as may be the case with boots used for step-in bindings, or to the binding, as may be the case with strap-type bindings. An arrangement for facilitating tightening/loosening of the two strap pieces so that a rider can slip his or her foot into or out from the boot or fasten the boot to or loosen it from a snowboard binding is also provided. In one embodiment, this arrangement includes a tightening element, such as for example a cord, lace or strap, suitably coupled to one or both strap portions such that a rider can pull on the tightening element to move the strap pieces relative to each other and tighten the strap. The tightening arrangement may be configured with a mechanical advantage whereby the force applied to the tightening element results in a greater force applied to the strap. To take up any excess amount of tightening element after the strap has been tightened, a retraction device, such as a self-winding spool, may be utilized. To separate the strap from the boot or binding, a hook and catch arrangement may be employed.

62. 发明申请

US20090194972A1 FOOTBED FOR GLIDING BOARD BINDING 有权
标题翻译：冰盖板绑定
公开(公告)号：US20090194972A1
公开(公告)日：2009-08-06
申请号：US12398949
申请日：2009-03-05
申请人： Kahlil Zaloom , Christopher C. Cunningham , Florian Lang , Matt Windt , Christopher M. Doyle , Richard William Wagner, JR. , Ryan Larson , Gregory Aaron Dean , Greg Reagan
发明人： Kahlil Zaloom , Christopher C. Cunningham , Florian Lang , Matt Windt , Christopher M. Doyle , Richard William Wagner, JR. , Ryan Larson , Gregory Aaron Dean , Greg Reagan
IPC分类号： A63C9/00
CPC分类号： A63C10/285 , A63C5/03 , A63C5/128 , A63C10/04 , A63C10/18 , A63C10/20 , A63C10/22 , A63C10/24 , A63C10/26
摘要： A method and apparatus for providing a gliding board binding, such as a snowboard binding. The binding may include an adjustment indicator that allows for determination of a longitudinal position of the base relative to a gliding board, heel-to-toe position of the base relative to a gliding board and/or an angular position of the base relative to a gliding board when the base is secured to the gliding board. The adjustment indicator may be included with a footbed that is removable from a binding base, e.g., that includes a foot engagement member to secure a rider's foot to the binding and board. A removable footbed may include a toe portion that is adjustable in position relative to a heel portion of the footbed. A gliding board may include a channel for mounting a binding that is arranged in the board core so that no portion of the board core is located on top or bottom sides of the channel, and instead so the top and bottom reinforcement layers are located above and below the channel.
摘要翻译：一种用于提供滑行板结合的方法和装置，例如滑雪板结合。装订可以包括调整指示器，其允许确定基座相对于滑板的纵向位置，基座相对于滑板的脚跟到脚趾位置和/或基座相对于滑动板的角位置当基座固定在滑板上时滑翔板。调节指示器可以包括可从装订基座移除的脚部，例如包括脚部接合构件以将骑手的脚固定到装订和板上。可移除的脚垫可以包括相对于脚踏板的脚跟部分可调节的脚趾部分。滑动板可以包括用于安装布置在板芯中的装订的通道，使得板芯的任何部分不位于通道的顶侧或底侧，而是顶部和底部加强层位于上方和/ 在频道下方

63. 发明授权

US07401423B2 Lace system for footwear 有权
公开(公告)号：US07401423B2
公开(公告)日：2008-07-22
申请号：US11286956
申请日：2005-11-23
申请人： Greg Reagan , Christopher M. Doyle , Florian Lang , Maurizio Molin
发明人： Greg Reagan , Christopher M. Doyle , Florian Lang , Maurizio Molin
IPC分类号： A43C11/00 , A43B5/04
CPC分类号： A43C1/003 , A43B3/0031 , A43B11/00 , A43C1/06 , A43C3/00 , A43C7/00 , A43C11/008 , A43C11/14
摘要： A boot incorporating techniques for making the process of tightening and loosening the laces of a boot more convenient for the wearer is disclosed. The boot may be provided with at least two independent lacing zones, the tensions of which are separately adjustable by the wearer. The zones may be secured by pulling on two laces, each of which tightens one of the two independent lacing zones. This arrangement allows the wearer to simultaneously tighten each zone, providing the wearer with the “feel” as though he or she is tightening a conventional single lacing zone boot. The laces may be simultaneously, yet independently secured by a lace lock at the upper and/or forward region of the boot. Slack may be created to facilitate loosening of the boot and easy removal of a foot from the boot by unhooking the lace from the lace guide without a corresponding distance of lace traveling through the lace lock. A release strap, graspable by the wearer, facilitates unhooking the lace.

64. 发明申请

US20080030001A1 Footbed for gliding board binding 有权
标题翻译：脚踏板滑板固定
公开(公告)号：US20080030001A1
公开(公告)日：2008-02-07
申请号：US11825658
申请日：2007-07-06
申请人： Kahlil Zaloom , Christopher Cunningham , Florian Lang , Matt Windt , Christopher Doyle , Richard Wagner , Ryan Larson , Gregory Dean , Greg Reagan
发明人： Kahlil Zaloom , Christopher Cunningham , Florian Lang , Matt Windt , Christopher Doyle , Richard Wagner , Ryan Larson , Gregory Dean , Greg Reagan
IPC分类号： A63C9/086
CPC分类号： A63C10/285 , A63C5/03 , A63C5/128 , A63C10/04 , A63C10/18 , A63C10/20 , A63C10/22 , A63C10/24 , A63C10/26
摘要： A method and apparatus for providing a gliding board binding, such as a snowboard binding. The binding may include an adjustment indicator that allows for determination of a longitudinal position of the base relative to a gliding board, heel-to-toe position of the base relative to a gliding board and/or an angular position of the base relative to a gliding board when the base is secured to the gliding board. The adjustment indicator may be included with a footbed that is removable from a binding base, e.g., that includes a foot engagement member to secure a rider's foot to the binding and board. A removable footbed may include a toe portion that is adjustable in position relative to a heel portion of the footbed. A gliding board may include a channel for mounting a binding that is arranged in the board core so that no portion of the board core is located on top or bottom sides of the channel, and instead so the top and bottom reinforcement layers are located above and below the channel.
摘要翻译：一种用于提供滑行板结合的方法和装置，例如滑雪板结合。装订可以包括调整指示器，其允许确定基座相对于滑板的纵向位置，基座相对于滑板的脚跟到脚趾位置和/或基座相对于滑动板的角位置当基座固定在滑板上时滑翔板。调节指示器可以包括可从装订基座移除的脚部，例如包括脚部接合构件以将骑手的脚固定到装订和板上。可移除的脚垫可以包括相对于脚踏板的跟部可调节的脚趾部分。滑板可以包括用于安装布置在板芯中的装订的通道，使得板芯的任何部分不位于通道的顶侧或底侧，而是顶部和底部加强层位于上方和在频道下方

65. 发明申请

US20080030000A1 Footbed for gliding board binding 有权
公开(公告)号：US20080030000A1
公开(公告)日：2008-02-07
申请号：US11825652
申请日：2007-07-06
申请人： Kahlil Zaloom , Christopher Cunningham , Florian Lang , Matt Windt , Christopher Doyle , Richard Wagner , Ryan Larson , Gregory Dean , Greg Reagan
发明人： Kahlil Zaloom , Christopher Cunningham , Florian Lang , Matt Windt , Christopher Doyle , Richard Wagner , Ryan Larson , Gregory Dean , Greg Reagan
IPC分类号： A63C9/086
CPC分类号： A63C10/285 , A63C5/03 , A63C5/128 , A63C10/04 , A63C10/18 , A63C10/20 , A63C10/22 , A63C10/24 , A63C10/26
摘要： A method and apparatus for providing a gliding board binding, such as a snowboard binding. The binding may include an adjustment indicator that allows for determination of a longitudinal position of the base relative to a gliding board, heel-to-toe position of the base relative to a gliding board and/or an angular position of the base relative to a gliding board when the base is secured to the gliding board. The adjustment indicator may be included with a footbed that is removable from a binding base, e.g., that includes a foot engagement member to secure a rider's foot to the binding and board. A removable footbed may include a toe portion that is adjustable in position relative to a heel portion of the footbed. A gliding board may include a channel for mounting a binding that is arranged in the board core so that no portion of the board core is located on top or bottom sides of the channel, and instead so the top and bottom reinforcement layers are located above and below the channel.

66. 发明申请

US20080015141A1 Use of a Novel Polymorphism in the Hsgk1 Gene in the Diagnosis of Hypertonia an Use of the Sgk Gene Family in the Diagnosis and Therapy of the Long Qt Syndrome 审中-公开
标题翻译：在高血压诊断中使用Hsgk1基因中的新型多态性使用Sgk基因家族进行长Qt综合征的诊断和治疗
公开(公告)号：US20080015141A1
公开(公告)日：2008-01-17
申请号：US10544576
申请日：2004-02-05
申请人： Florian Lang , Andreas Busjahn
发明人： Florian Lang , Andreas Busjahn
IPC分类号： A61K38/16 , A61K31/56 , C12Q1/68 , G01N33/00
CPC分类号： A61K31/573 , A61K31/56 , A61K38/1841 , C12Q1/6883 , C12Q2600/156 , G01N33/573 , G01N33/6893 , G01N2333/9121
摘要： The invention relates to the use of a single-stranded or double-stranded nucleic acid comprising a fragment of hsgk for diagnosing hypertension, with said fragment being at least 10 nucleotides/base pairs in length and with said fragment furthermore comprising a polymorphism with ensues from the presence or absence of an insertion of the nucleotide G at position 732/733 in intron 2 of the hsgk1 gene. The invention furthermore relates to the use of the direct correlation between the overexpression or the functional molecular modification of human homologues of the sgk family and the length of the Q/T interval for diagnosing the long Q/T syndrome, and also to the use for the nucleic acid of a human homologue of the sgk gene family or of one of its fragments for diagnosing the long Q/T syndrome. In particular, polymorphisms of individual nucleotides (single nucleotide polymorphisms=SNP) in the human homologues of the sgk gene family can also, in the present case, be used for diagnosing a genetically determined predisposition for the long Q/T syndrome. In a further aspect, the invention relates to the use of a functional activator or transcription factor which increases the expression of the genes of the sgk family for producing a pharmaceutical for the therapy and/or prophylaxis of the long Q/T syndrome.
摘要翻译：本发明涉及包含hsgk片段的单链或双链核酸用于诊断高血压的用途，所述片段长度为至少10个核苷酸/碱基对，并且所述片段还包含多态性，随后来自存在或不存在hsgk1基因的内含子2中位置732/733处的核苷酸G的插入。本发明还涉及使用sgk家族的人类同源物的过表达或功能性分子修饰与用于诊断长Q / T综合征的Q / T间期的长度之间的直接相关性，以及用于用于诊断长Q / T综合征的sgk基因家族的人类同源物的核酸或其片段之一的核酸。特别地，在sgk基因家族的人类同源物中，单个核苷酸的多态性（ single 核苷酸多态性= SNP）在这种情况下，用于诊断长期Q / T综合征的遗传决定性倾向。在另一方面，本发明涉及功能活化剂或转录因子的用途，其增加sgk家族的基因的表达以产生用于治疗和/或预防长Q / T综合征的药物。

67. 发明申请

US20070203085A1 Methods For Interfering With Fibrosis 审中-公开
标题翻译：干扰纤维化的方法
公开(公告)号：US20070203085A1
公开(公告)日：2007-08-30
申请号：US10592111
申请日：2005-02-08
申请人： Florian Lang
发明人： Florian Lang
IPC分类号： A61K48/00 , A61K31/56
CPC分类号： A61K31/00 , A61K31/165 , A61K31/519
摘要： Modulation of the of glucocorticoid inducible kinases to restore Connective tissue growth factor activity. Also disclosed are methods and compounds useful for the detection and treatment of fibroproliferative disorders.
摘要翻译：调节糖皮质激素诱导型激酶恢复结缔组织生长因子活性。还公开了可用于检测和治疗纤维增生性疾病的方法和化合物。

68. 发明申请

US20050084485A1 Clckb mutation as a diagnostic and therapeutical target 失效
标题翻译： Clckb突变作为诊断和治疗靶点
公开(公告)号：US20050084485A1
公开(公告)日：2005-04-21
申请号：US10687523
申请日：2003-10-15
申请人： Florian Lang , Siegfried Waldegger , Philipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
发明人： Florian Lang , Siegfried Waldegger , Philipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
IPC分类号： C12Q1/68 , A61K38/48 , C07H21/04 , C12N9/12
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a method for diagnosing hypertension, and/or allergy, and/or hair loss, and/or liabilty for infection, of a human being, or a predisposition therefor; to a nucleic acid molecule coding for a human ClCKb protein comprising a genetic alteration at amino acid position 481 compared to the wild type, as well as for corresponding segments thereof; to a nucleic acid molecule which binds to the before-mentioned nucleic acid molecule under stringent conditions, as well as to a nucleic acid molecule which binds to that nucleic acid molecule; to a (poly)peptide encoded by the afore-mentioned nucleic acid molecules; to a method for identifying substances modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to a substance for modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to methods for preparing a pharmaceutical composition for treatment of hypertension, and/or allergy, and/or hair loss, and/or liability for infection; to pharmaceutical compositions; and to a method for treating a human being affected by hypertension, and/or allergy and/or hair loss, and/or liability for infection.
摘要翻译：本发明涉及一种用于诊断人类或其易感性的高血压，/或过敏和/或脱发，和/或感染的可能性的方法; 涉及编码人类ClCKb蛋白质的核酸分子，其包含与野生型相比在氨基酸位置481处的遗传改变，以及其对应的片段; 涉及在严格条件下与前述核酸分子结合的核酸分子，以及与该核酸分子结合的核酸分子; 涉及由上述核酸分子编码的（多）肽; 涉及一种用于鉴定与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽调节活性的物质的方法; 涉及调节与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽的活性的物质; 制备用于治疗高血压和/或过敏和/或脱发的药物组合物和/或感染责任的方法; 至药物组合物; 以及治疗受高血压，/或过敏和/或脱发影响的人的方法和/或感染责任。

69. 发明授权

US06326181B1 Cell volume-regulated human kinase h-sgk 失效
标题翻译：细胞体积调节人激酶h-sgk
公开(公告)号：US06326181B1
公开(公告)日：2001-12-04
申请号：US09031295
申请日：1998-02-26
申请人： Florian Lang , Siegfried Waldegger
发明人： Florian Lang , Siegfried Waldegger
IPC分类号： C12N912
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention relates to the cloning and characterization of a human serine/threonine kinase (h-sgk: serum and glucocorticoid dependent kinase). The invention furthermore relates to reagents for diagnosing conditions associated with a change in cell volume and/or in “macromolecular crowding” in the body, such as, for example, hypernatremia, hyponatremia, diabetes mellitus, renal failure, hypercatabolism, hepatic encephalopathy, inflammation and microbial or viral infections. The present invention additionally relates to pharmaceuticals comprising the h-sgk, nucleic acids which code for the h-sgk, or receptors, in particular antibodies, which specifically bind to the h-sgk.
摘要翻译：本发明涉及人丝氨酸/苏氨酸激酶（h-sgk：血清和糖皮质激素依赖性激酶）的克隆和表征。本发明还涉及用于诊断与细胞体积变化和/或体内“大分子拥挤”相关的病症的试剂，例如高钠血症，低钠血症，糖尿病，肾功能衰竭，高分泌症，肝性脑病，炎症和微生物或病毒感染。本发明还涉及包含h-sgk，编码h-sgk的核酸或特异性结合h-sgk的受体，特别是抗体的药物。

70. 发明授权

US09491646B2 Measuring device and a method for measuring a signal with several component signals 有权
标题翻译：测量装置以及用多个分量信号测量信号的方法
公开(公告)号：US09491646B2
公开(公告)日：2016-11-08
申请号：US14123092
申请日：2012-06-05
申请人： Jens Franke , Florian Lang , Michael Simon , Bjoern Coenen , Markus Niedl , Ronald Tonn , Johannes Steffens
发明人： Jens Franke , Florian Lang , Michael Simon , Bjoern Coenen , Markus Niedl , Ronald Tonn , Johannes Steffens
IPC分类号： H04B1/30 , H04W24/08 , G01R13/02 , G01R23/16 , G01R23/18 , H04L1/24 , H04W84/04
CPC分类号： H04W24/08 , G01R13/0236 , G01R23/16 , G01R23/18 , H04L1/242 , H04W84/042
摘要： A measuring device for measuring a signal with a first component signal and at least one second component signal comprises a high-frequency processing device, which is embodied to mix the signal in order to form an intermediate-frequency signal and to digitize the latter in order to form a digital composite signal. The measuring device further comprises a digital mixer, which is embodied to generate a first digital composite test signal and a second digital composite test signal subject to a displacement of the frequency of the digital composite signal. Moreover, the measuring device comprises a digital filter, which is embodied to filter the first digital composite test signal in order to form a first digital test signal and to filter the second digital composite test signal in order to form a second digital test signal.
摘要翻译：用于测量具有第一分量信号和至少一个第二分量信号的信号的测量装置包括高频处理装置，其被实施为混合信号以形成中频信号并按顺序数字化后者以形成数字复合信号。该测量装置还包括数字混合器，其被实现为产生第一数字复合测试信号和经受数字复合信号的频率位移的第二数字复合测试信号。此外，测量装置包括数字滤波器，其被实施为滤波第一数字复合测试信号以便形成第一数字测试信号并且滤波第二数字复合测试信号以便形成第二数字测试信号。

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