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61. 发明申请

US20060116316A1 Heterocyclic inhibitors of IRES-mediated translation and methods of use thereof 审中-公开
标题翻译： IRES介导的翻译的杂环抑制剂及其使用方法
公开(公告)号：US20060116316A1
公开(公告)日：2006-06-01
申请号：US11251268
申请日：2005-10-14
申请人： Todd Kinsella , Donald Payan
发明人： Todd Kinsella , Donald Payan
IPC分类号： A61K38/12 , A61K31/407 , C07K5/12
CPC分类号： C07H21/04 , A61K38/00 , C07K5/123 , C07K5/126
摘要： The present invention provides heterocyclic compounds that exhibits IRES-inhibitory activity. The heterocyclic compounds generally a nine-membered ring of three repeating C—C—N subunits covalently bound through amide bonds, and variable side groups linked to a central carbon of each subunit. Formulations and kits containing the subject compounds are also provided.
摘要翻译：本发明提供表现出IRES抑制活性的杂环化合物。杂环化合物通常是通过酰胺键共价结合的三个重复C-C-N亚基的九元环，以及连接到每个亚基的中心碳的可变侧基。还提供了含有本发明化合物的制剂和试剂盒。

62. 发明授权

US07034145B2 Directionally cloned random cDNA expression vector libraries, compositions and methods of use 有权
公开(公告)号：US07034145B2
公开(公告)日：2006-04-25
申请号：US10933855
申请日：2004-09-03
申请人： Mary Shen , Simon Yu , Xian Wu , Donald Payan
发明人： Mary Shen , Simon Yu , Xian Wu , Donald Payan
IPC分类号： C07H21/04
CPC分类号： C12N15/86 , C12N15/66 , C12N2740/13043 , C12N2800/70 , C12Q1/6855 , C12Q2525/185
摘要： The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense orientation. Also provided are random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in antisense orientation. Methods for producing these libraries through directional cloning of random cDNAs are also provided. Also provided herein are methods of using these libraries to screen for agents capable of modulating cell phenotype in desirable ways.

63. 发明申请

US20050032110A1 Directionally cloned random cDNA expression vector libraries, compositions and methods of use 有权
标题翻译：定向克隆的随机cDNA表达载体文库，组合物和使用方法
公开(公告)号：US20050032110A1
公开(公告)日：2005-02-10
申请号：US10933855
申请日：2004-09-03
申请人： Mary Shen , Simon Yu , Xian Wu , Donald Payan
发明人： Mary Shen , Simon Yu , Xian Wu , Donald Payan
IPC分类号： C12N15/66 , C12N15/867 , C12Q1/68
CPC分类号： C12N15/86 , C12N15/66 , C12N2740/13043 , C12N2800/70 , C12Q1/6855 , C12Q2525/185
摘要： The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense orientation. Also provided are random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in antisense orientation. Methods for producing these libraries through directional cloning of random cDNAs are also provided. Also provided herein are methods of using these libraries to screen for agents capable of modulating cell phenotype in desirable ways.
摘要翻译：本发明提供随机cDNA表达载体文库，其包含表达载体，其包含位于正义取向的随机cDNA。还提供了随机cDNA表达载体文库，其包含表达载体，其包含以反义方向定位的随机cDNA。还提供了通过定向克隆随机cDNA产生这些文库的方法。本文还提供了使用这些文库筛选能够以期望的方式调节细胞表型的试剂的方法。

64. 发明授权

US6114111A Mammalian protein interaction cloning system 失效
标题翻译：哺乳动物蛋白质相互作用克隆系统
公开(公告)号：US6114111A
公开(公告)日：2000-09-05
申请号：US50863
申请日：1998-03-30
申请人： Ying Luo , Betty Huang , Donald Payan
发明人： Ying Luo , Betty Huang , Donald Payan
IPC分类号： C12N15/10 , C12N15/12 , C12Q1/70
CPC分类号： C12N15/1055 , C12Q2565/201
摘要： The present invention is directed to compositions and methods for a genetic system of detecting protein--protein interactions in a mammalian host cell. Two fusion proteins are made in the host cell. The first fusion protein contains a DNA binding domain which is fused to a so-called bait protein. The second fusion protein consists of a transcriptional activation domain fused to a so-called test protein. The transcriptional activation domain is recruited to the promoter through the functional interaction between the bait protein and the test protein. Subsequently the transcriptional activation domain interacts with the basal transcription machinery to activate expression of one or more reporter genes which can be identified and characterized. The individual compositions are useful for analyzing protein--protein interactions between known proteins and to isolate, clone and characterize unknown proteins. The individual compositions can be used to express the fusion proteins either transiently or stably.
摘要翻译：本发明涉及用于在哺乳动物宿主细胞中检测蛋白质 - 蛋白质相互作用的遗传系统的组合物和方法。在宿主细胞中制备两种融合蛋白。第一个融合蛋白含有与所谓诱饵蛋白融合的DNA结合结构域。第二种融合蛋白由与所谓的测试蛋白融合的转录激活结构域组成。通过诱饵蛋白质和测试蛋白质之间的功能相互作用将转录激活结构域引入启动子。随后，转录激活结构域与基础转录机制相互作用以激活一种或多种可鉴定和表征的报告基因的表达。单独的组合物可用于分析已知蛋白质之间的蛋白质 - 蛋白质相互作用并分离，克隆和表征未知蛋白质。单独的组合物可用于瞬时或稳定地表达融合蛋白。

65. 发明授权

US08796254B2 Methods for using carboxamide, sulfonamide and amine compounds 有权
标题翻译：使用羧酰胺，磺酰胺和胺化合物的方法
公开(公告)号：US08796254B2
公开(公告)日：2014-08-05
申请号：US13077539
申请日：2011-03-31
申请人： Donald Payan , Yasumichi Hitoshi , Todd Kinsella
发明人： Donald Payan , Yasumichi Hitoshi , Todd Kinsella
IPC分类号： A61K31/5377 , A61K31/4545 , A61K31/506 , A61K31/454 , A61K31/496 , A61P29/00 , A61P35/00 , A61P11/00 , A61P11/06 , A61P9/10 , A61P25/00 , A61P39/06
CPC分类号： A61K31/437 , A61K31/4427 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377
摘要： Disclosed are uses of carboxamide, sulfonamide and amine compounds for the treatment and amelioration of disorders and conditions related to oxidative stress, mitochondrial dysfunction, free radical damage and metabolic inefficiency, among others. Also described are methods for increasing exercise endurance, exercise efficiency and aerobic workload using the compounds described herein.
摘要翻译：公开了羧酰胺，磺酰胺和胺化合物用于治疗和改善与氧化应激，线粒体功能障碍，自由基损伤和代谢低效等相关的病症和病症的用途。还描述了使用本文所述化合物增加运动耐力，运动效率和有氧工作量的方法。

66. 发明申请

US20110245222A1 Methods for Using Carboxamide, Sulfonamide and Amine Compounds 有权
标题翻译：使用羧酰胺，磺酰胺和胺化合物的方法
公开(公告)号：US20110245222A1
公开(公告)日：2011-10-06
申请号：US13077539
申请日：2011-03-31
申请人： Donald Payan , Yasumichi Hitoshi , Todd Kinsella
发明人： Donald Payan , Yasumichi Hitoshi , Todd Kinsella
IPC分类号： A61K31/5377 , A61K31/4545 , A61K31/506 , A61K31/454 , A61K31/496 , A61P21/00 , A61P29/00 , A61P35/00 , A61P11/00 , A61P11/06 , A61P9/10 , A61P25/00 , A61P9/04 , A61P7/04 , A61P3/00 , A61P9/00 , A61P39/06 , A61P25/08
CPC分类号： A61K31/437 , A61K31/4427 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377
摘要： Disclosed are uses of carboxamide, sulfonamide and amine compounds for the treatment and amelioration of disorders and conditions related to oxidative stress, mitochondrial dysfunction, free radical damage and metabolic inefficiency, among others. Also described are methods for increasing exercise endurance, exercise efficiency and aerobic workload using the compounds described herein.
摘要翻译：公开了羧酰胺，磺酰胺和胺化合物用于治疗和改善与氧化应激，线粒体功能障碍，自由基损伤和代谢低效等相关的病症和病症的用途。还描述了使用本文所述化合物增加运动耐力，运动效率和有氧工作量的方法。

67. 发明申请

US20070172818A1 Multiparameter FACS assays to detect alterations in cellular parameters and to screen small molecule libraries 审中-公开
标题翻译：多参数FACS测定法检测细胞参数的变化并筛选小分子文库
公开(公告)号：US20070172818A1
公开(公告)日：2007-07-26
申请号：US11636405
申请日：2006-12-07
申请人： Joseph Fisher , James Lorens , Donald Payan , Alexander Rossi
发明人： Joseph Fisher , James Lorens , Donald Payan , Alexander Rossi
IPC分类号： C40B30/06 , C40B40/02 , C40B40/10
CPC分类号： G01N33/5008 , G01N15/147 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/5044 , G01N2015/1477 , G01N2015/149
摘要： The invention relates to novel methods of detecting alterations in cell cycle regulation in a cell or a cell population and screening for agents capable of modulating cell cycle regulation through the use of multiparameter assays and a fluorescence-activated cell sorter (FACS) machine.
摘要翻译：本发明涉及检测细胞或细胞群体中细胞周期调节变化的新方法，并且通过使用多参数测定法和荧光激活细胞分选仪（FACS）机器筛选能够调节细胞周期调节的试剂。

68. 发明申请

US20060276459A1 Methods of treating cell proliferative disorders 有权
公开(公告)号：US20060276459A1
公开(公告)日：2006-12-07
申请号：US11407233
申请日：2006-04-18
申请人： Esteban Masuda , Donald Payan , Elliott Grossbard
发明人： Esteban Masuda , Donald Payan , Elliott Grossbard
IPC分类号： A61K31/542 , A61K31/5383 , A61K31/505
CPC分类号： A61K31/505 , A61K31/5383 , A61K31/542
摘要： The present disclosure provides methods for the treatment of cell proliferative disorders by administration of a Syk kinase or Syk/Flt-3 kinase inhibitor. Cell proliferative disorders treatable by the methods include, hematopoietic neoplasms and virally associated tumors. The compounds are also directed to therapeutic or prophylactic inhibition of tumor metastasis.

69. 发明授权

US06897031B1 Multiparameter FACS assays to detect alterations in exocytosis 失效
标题翻译：多参数FACS测定以检测胞吐的变化
公开(公告)号：US06897031B1
公开(公告)日：2005-05-24
申请号：US09062330
申请日：1998-04-17
申请人： Joseph Fisher , James Lorens , Donald Payan , Alexander Rossi
发明人： Joseph Fisher , James Lorens , Donald Payan , Alexander Rossi
IPC分类号： G01N33/50 , G01N33/569 , G01N33/567
CPC分类号： G01N33/5011 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5047 , G01N33/56966 , G01N2333/43595 , G01N2333/4718
摘要： Described is a method for screening for alterations in exocytosis of a population of cells. The cells are sorted by a FACS machine by assaying for alterations in at least three of the properties selected from the group consisting of light scattering, fluorescent dye uptake, fluorescent dye release, annexin granule binding, surface granule enzyme activity, and the quantity of granule specific proteins. Methods for screening for bioactive agents capable of modulating exocytosis in a cell are also described. The methods provide for reduced background and increased specificity without increasing the time or steps involved in assaying for exocytosis.
摘要翻译：描述了筛选细胞群的胞吐作用的方法。细胞由FACS机通过测定至少三种选自光散射，荧光染料摄取，荧光染料释放，膜联蛋白颗粒结合，表面颗粒酶活性和颗粒数量的性质的变化进行分选特异性蛋白质。还描述了筛选能够调节细胞中胞吐作用的生物活性剂的方法。所述方法提供降低的背景和增加的特异性，而不增加测定胞吐的时间或步骤。

70. 发明授权

US06737240B1 Methods of screening for a multi-drug resistance conferring peptide 有权
标题翻译：筛选多药耐药性肽的方法
公开(公告)号：US06737240B1
公开(公告)日：2004-05-18
申请号：US09578030
申请日：2000-05-24
申请人： Ziang Xu , Donald Payan
发明人： Ziang Xu , Donald Payan
IPC分类号： G01N3353
CPC分类号： G01N33/5011 , C12N15/1034
摘要： The invention relates generally to methods of screening for drugs which bind to and/or regulate cellular proteins involved in drug resistance, particularly resistance of tumor cells to chemotherapeutic agents.
摘要翻译：本发明一般涉及筛选结合和/或调节参与耐药性的细胞蛋白质的药物的方法，特别是肿瘤细胞对化学治疗剂的抗性。

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