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61. 发明授权

US08455234B2 Multiple mutation variants of serine protease 失效
标题翻译：丝氨酸蛋白酶的多重突变变体
公开(公告)号：US08455234B2
公开(公告)日：2013-06-04
申请号：US13162104
申请日：2011-06-16
申请人： Wolfgang Aehle , David A. Estell , Ronaldus W. J. Hommes , Brian E. Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran J. Poulose , Andrew Shaw , Wilhelmus A. H. van der Kley , Leonardus P. M. van Marrewijk
发明人： Wolfgang Aehle , David A. Estell , Ronaldus W. J. Hommes , Brian E. Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran J. Poulose , Andrew Shaw , Wilhelmus A. H. van der Kley , Leonardus P. M. van Marrewijk
IPC分类号： C12N9/48
CPC分类号： C12N9/52 , A23K20/189 , A23K50/75 , C11D3/386 , C12N9/96 , C12Y304/21 , D06M16/003
摘要： The present invention provides novel Micrococcineae spp serine proteases having multiple substitutions. In particular, the present invention provides serine proteases having multiple substitutions, DNA encoding these proteases, vectors comprising the DNA encoding the proteases, host cells transformed with the vector DNA, and enzymes produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising these serine protease variants. In particularly preferred embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These variant proteases also find use in numerous applications.
摘要翻译：本发明提供了具有多个取代的新型微球菌spp丝氨酸蛋白酶。特别地，本发明提供了具有多个取代的丝氨酸蛋白酶，编码这些蛋白酶的DNA，包含编码蛋白酶的DNA的载体，用载体DNA转化的宿主细胞和由宿主细胞产生的酶。本发明还提供了清洁组合物（例如洗涤剂组合物），动物饲料组合物以及包含这些丝氨酸蛋白酶变体的纺织和皮革加工组合物。在特别优选的实施方案中，本发明提供衍生自本文所述的野生型蛋白酶的突变体（即，变体）蛋白酶。这些变体蛋白酶也可用于许多应用。

62. 发明授权

US08438548B2 Consistency checking of source instruction to execute previously translated instructions between copy made upon occurrence of write operation to memory and current version 有权
标题翻译：一致性检查源指令，以便在写操作发生到存储器和当前版本之间执行复制之前执行之前转换的指令
公开(公告)号：US08438548B2
公开(公告)日：2013-05-07
申请号：US13021609
申请日：2011-02-04
申请人： John Banning , H. Peter Anvin , Robert Bedicheck , Guillermo J. Rozas , Andrew Shaw , Linus Torvalds , Jason Wilson
发明人： John Banning , H. Peter Anvin , Robert Bedicheck , Guillermo J. Rozas , Andrew Shaw , Linus Torvalds , Jason Wilson
IPC分类号： G06F9/455
CPC分类号： G06F9/3808 , G06F9/3812
摘要： In one embodiment, after translating a plurality of target instructions from a target memory location into a plurality of host instructions, a write operation to a target memory portion which includes said target memory location is detected. In response to the detecting, a copy of the target instructions is stored in a host memory. In response to an attempt to execute the host instructions, the copy is compared with a plurality of current target instructions presently stored in the target memory location. Further, in response to a mismatch based on the comparison, the host instructions are disabled.
摘要翻译：在一个实施例中，在将多个目标指令从目标存储器位置翻译成多个主机指令之后，检测到包括所述目标存储器位置的目标存储器部分的写入操作。响应于检测，将目标指令的副本存储在主机存储器中。响应于尝试执行主机指令，将该副本与当前存储在目标存储器位置中的多个当前目标指令进行比较。此外，响应于基于比较的不匹配，主机指令被禁用。

63. 发明申请

US20130076557A1 ELECTROMAGNETIC SENSOR 审中-公开
标题翻译：电磁传感器
公开(公告)号：US20130076557A1
公开(公告)日：2013-03-28
申请号：US13642271
申请日：2011-04-21
申请人： Andrew Shaw , Ahmed Al-Shamma'a
发明人： Andrew Shaw , Ahmed Al-Shamma'a
IPC分类号： F17D5/06 , G01S13/89
CPC分类号： F17D5/06 , G01S13/89
摘要： Disclosed is a probe for use in a fluid pipeline, comprising: a transmitter for transmitting an RF signal via an antenna (50); a receiver for receiving an RF signal via an antenna; a processor operable to compare the received signal with an expected signal. Also disclosed is a method of assessing the condition of a pipeline by means of a probe located inside the pipeline, comprising the steps of: transmitting an RF signal from the probe; receiving an RF signal at the probe; comparing the received and an expected signal and, based on the result of the comparison, indicating that the pipeline is acceptable or not.
摘要翻译：公开了一种用于流体管道的探针，包括：用于经由天线（50）发送RF信号的发射器; 用于经由天线接收RF信号的接收机; 处理器，其可操作以将所接收的信号与预期信号进行比较。还公开了一种通过位于管线内的探头来评估管道状况的方法，包括以下步骤：从探头发送RF信号; 在探头处接收RF信号; 比较接收的和预期的信号，并且基于比较的结果，指示管道是否可接受。

64. 发明申请

US20120315676A1 ENDOGLUCANASES 有权
公开(公告)号：US20120315676A1
公开(公告)日：2012-12-13
申请号：US13493795
申请日：2012-06-11
申请人： Jie YANG , Andrew Shaw , Ish Kumar Dhawan , Onorato Campopiano , Kripa Rao
发明人： Jie YANG , Andrew Shaw , Ish Kumar Dhawan , Onorato Campopiano , Kripa Rao
IPC分类号： C12N9/42 , C12N9/96 , C12N15/62 , C12N1/21 , C12P19/14 , C12N15/56 , C12N15/75
CPC分类号： C12N9/2437 , C07K2319/02 , C12N9/2445 , C12N15/75 , C12P7/10 , C12P19/14 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16
摘要： The present invention relates to variant endoglucanases and particularly endoglucanases having improved properties over wild-type endoglucanase.

65. 发明授权

US08309328B1 Compositions and methods for production of fermentable sugars 有权
公开(公告)号：US08309328B1
公开(公告)日：2012-11-13
申请号：US13539799
申请日：2012-07-02
申请人： Ish Kumar Dhawan , Dipnath Baidyaroy , Andrew Shaw , Oleh Tanchak , Christopher Hill , Chengsong Liu , Amala Chokshi , Brian R. Scott
发明人： Ish Kumar Dhawan , Dipnath Baidyaroy , Andrew Shaw , Oleh Tanchak , Christopher Hill , Chengsong Liu , Amala Chokshi , Brian R. Scott
IPC分类号： C12P19/00 , C12P19/12 , C12P19/02 , C12P21/06 , C12P21/04 , C12N9/02 , C12N9/04 , C12N9/00 , C12N15/00 , C12N1/20 , C12N1/14 , C12Q1/68 , C07H21/04
CPC分类号： C12P19/14 , C12N9/0006 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/12 , C12P2203/00 , C12Y101/99018 , C13K1/02 , Y02E50/16
摘要： The present application provides genetically modified fungal organisms that produce enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to glucose, enzyme mixtures produced by the genetically modified fungal organisms, and processes for producing glucose from cellulose using such enzyme mixtures.

66. 发明申请

US20120270298A1 NOVEL VARIANT HYPROCREA JECORINA CBH1 CELLULASES 失效
标题翻译：新型变异胶原蛋白CBH1细胞
公开(公告)号：US20120270298A1
公开(公告)日：2012-10-25
申请号：US13523800
申请日：2012-06-14
申请人： Anthony Day , Frits Goedegebuur , Peter Gualfetti , Colin Mitchinson , Paulien Neefe , Mats Sandgren , Andrew Shaw , Jerry Stahlberg
发明人： Anthony Day , Frits Goedegebuur , Peter Gualfetti , Colin Mitchinson , Paulien Neefe , Mats Sandgren , Andrew Shaw , Jerry Stahlberg
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C11D3/38645 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , D21C5/005 , Y02E50/16
摘要： Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
摘要翻译：本文描述的是H.jecorina CBH I，Cel7酶的变体。本发明提供了具有改善的热稳定性和可逆性的新型纤维二糖水解酶。

67. 发明授权

US08236551B2 Compositions and methods for production of fermentable sugars 有权
标题翻译：用于生产可发酵糖的组合物和方法
公开(公告)号：US08236551B2
公开(公告)日：2012-08-07
申请号：US13286972
申请日：2011-11-01
申请人： Ish Kumar Dhawan , Dipnath Baidyaroy , Andrew Shaw , Oleh Tanchak , Christopher Hill , Chengsong Liu , Amala Chokshi , Brian R. Scott
发明人： Ish Kumar Dhawan , Dipnath Baidyaroy , Andrew Shaw , Oleh Tanchak , Christopher Hill , Chengsong Liu , Amala Chokshi , Brian R. Scott
IPC分类号： C12N1/14 , C12N9/04 , C12N15/00 , C12N9/02 , C12N9/00 , C12Q1/68 , C07H21/04
CPC分类号： C12P19/14 , C12N9/0006 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/12 , C12P2203/00 , C12Y101/99018 , C13K1/02 , Y02E50/16
摘要： The present application provides genetically modified fungal organisms that produce enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to glucose, enzyme mixtures produced by the genetically modified fungal organisms, and processes for producing glucose from cellulose using such enzyme mixtures.
摘要翻译：本申请提供了经遗传修饰的真菌生物体，其产生显示纤维素材料对葡萄糖的增强水解，由遗传修饰的真菌生物体产生的酶混合物的酶混合物，以及使用这种酶混合物从纤维素生产葡萄糖的方法。

68. 发明申请

US20120156733A1 GEOBACILLUS STEAROTHERMOPHILUS ALPHA AMYLASE (AMYS) VARIANTS WITH IMPROVED PROPERTIES 审中-公开
标题翻译：具有改进性质的GEOBACILLUS STEAROTHERMOPHILUS ALPHA AMYLASE（AMYS）变种
公开(公告)号：US20120156733A1
公开(公告)日：2012-06-21
申请号：US13291938
申请日：2011-11-08
申请人： William A. Cuevas , Sang-Kyu Lee , Sandra W. Ramer , Andrew Shaw , Amr R. Toppozada , David A. Estell , Sura Hadi
发明人： William A. Cuevas , Sang-Kyu Lee , Sandra W. Ramer , Andrew Shaw , Amr R. Toppozada , David A. Estell , Sura Hadi
IPC分类号： C12P7/14 , C12P19/14
CPC分类号： D06M16/003 , C11D3/38609 , C11D3/38618 , C11D3/3869 , C12N9/2417 , C12Y302/01001 , D06L4/40
摘要： Described are variants of a parent α-amylase that exhibits an alteration in at least one of the following properties relative to said parent α-amylase: specific activity, substrate specificity, substrate binding, substrate cleavage, thermal stability, pH-dependent activity, pH-dependent stability, oxidative stability, Ca2+ dependency, pI, and wash performance. The variants are suitable for starch conversion, ethanol production, laundry washing, dish washing, hard surface cleaning, textile desizing, and/or sweetener production.
摘要翻译：描述了亲本α-淀粉酶的变体，其相对于所述亲本α-淀粉酶在至少一个以下性质中具有改变：比活性，底物特异性，底物结合，底物切割，热稳定性，pH依赖性活性，pH 依赖稳定性，氧化稳定性，Ca2 +依赖性，pI和洗涤性能。这些变体适用于淀粉转化，乙醇生产，洗衣，洗碗，硬表面清洗，纺织品退浆和/或甜味剂生产。

69. 发明授权

US08153412B2 Variants of Bacillus sp. TS-23 alpha-amylase with altered properties 有权
标题翻译：芽孢杆菌的变种具有改变性质的TS-23α-淀粉酶
公开(公告)号：US08153412B2
公开(公告)日：2012-04-10
申请号：US12264006
申请日：2008-11-03
申请人： Claudine Y. Chang , Clement Choy , Melodie Estabrook , Mansi Goyal , Thomas P. Graycar , Victoria E. Huang , Brian E. Jones , Marc Kolkman , Karsten M. Kragh , Chris Leeflang , Scott D. Power , Sandra W. Ramer , Andrew Shaw , Casper Vroemen , Walter Weyler
发明人： Claudine Y. Chang , Clement Choy , Melodie Estabrook , Mansi Goyal , Thomas P. Graycar , Victoria E. Huang , Brian E. Jones , Marc Kolkman , Karsten M. Kragh , Chris Leeflang , Scott D. Power , Sandra W. Ramer , Andrew Shaw , Casper Vroemen , Walter Weyler
IPC分类号： C12N9/28 , C12N9/26 , C12N9/24 , C12N1/20 , C12N15/00 , A23C17/00 , A23L1/28 , C11D3/02 , C12D3/00 , C12D3/386 , C07H21/04 , C07K1/00
CPC分类号： C11D3/386 , C11D3/38681 , C12N9/2417
摘要： Variants of Bacillus sp. TS-23 strain alpha-amylases exhibit improved enzymatic performance, including increased themostability, reduced calcium dependence, increased washing/cleaning performance, and baking ability. Compositions comprising these variants are useful in methods of starch processing, starch liquefaction, fermatation, starch saccharification, cleaning, laundrying, textile desizing, baking, and biofilm removal.
摘要翻译：芽孢杆菌的变种 TS-23菌株α-淀粉酶表现出改善的酶性能，包括增加其稳定性，降低钙依赖性，提高洗涤/清洁性能和烘烤能力。包含这些变体的组合物可用于淀粉加工，淀粉液化，粉化，淀粉糖化，清洗，洗衣，纺织品退浆，烘烤和生物膜除去的方法。

70. 发明授权

US07776576B2 Thermostable amylase polypeptides, nucleic acids encoding those polypeptides and uses thereof 有权
标题翻译：热稳定淀粉酶多肽，编码那些多肽的核酸及其用途
公开(公告)号：US07776576B2
公开(公告)日：2010-08-17
申请号：US10886905
申请日：2004-07-07
申请人： Karsten Matthias Kragh , Casper Tune Berg , Patrick M. F. Derkx , Anja H. Kellett-Smith , Charlotte Refdahl Thoudahl , Oene R. Veltman , Carol Fioresi , Wei Liu , Andrew Shaw , Gijsbert Gerritse
发明人： Karsten Matthias Kragh , Casper Tune Berg , Patrick M. F. Derkx , Anja H. Kellett-Smith , Charlotte Refdahl Thoudahl , Oene R. Veltman , Carol Fioresi , Wei Liu , Andrew Shaw , Gijsbert Gerritse
IPC分类号： C12N9/28 , C12N15/00 , C12N9/88 , C07H21/04
CPC分类号： C12N9/2417 , A21D8/042 , A23L29/06 , A23L29/35 , A23L33/17 , A23V2002/00 , A23V2300/21
摘要： This invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered thermostability.
摘要翻译：本发明涉及淀粉酶多肽和编码多肽的核酸及其用途。本发明的淀粉酶已被设计成具有更多的有益品质。具体地说，本发明的淀粉酶显示出改变的热稳定性。

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