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61. 发明授权

US08067546B2 Humanized anti-CD70 binding agents and uses thereof 有权
标题翻译：人源化抗CD70结合剂及其用途
公开(公告)号：US08067546B2
公开(公告)日：2011-11-29
申请号：US11912096
申请日：2006-04-19
申请人： Charlotte McDonagh , Paul Carter , Julie McEarchern , Che-Leung Law
发明人： Charlotte McDonagh , Paul Carter , Julie McEarchern , Che-Leung Law
IPC分类号： C12P21/08 , C07K16/00 , C07K17/00 , C07K17/14 , A61K39/00 , A61K39/395
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2317/92 , Y02A50/386
摘要： Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.
摘要翻译：公开了CD70结合剂，例如在表达CD70的细胞上发挥细胞毒性，细胞抑制或免疫调节的人源化抗CD70抗体和片段和衍生物，以及包含抗体，片段或衍生物的药物组合物和试剂盒。还公开了用于治疗表达CD70的癌症和免疫学疾病的方法，其包括对受试者施用CD70结合剂或药物组合物。

62. 发明申请

US20110166627A1 VARIABLE IMPEDANCE BYPASS PATHWAY FOR A TISSUE STIMULATING PROSTHESIS 失效
标题翻译：用于组织刺激预防的旁路途径的可变阻力
公开(公告)号：US20110166627A1
公开(公告)日：2011-07-07
申请号：US13062436
申请日：2009-09-04
申请人： Paul Carter
发明人： Paul Carter
IPC分类号： A61F11/04
CPC分类号： A61N1/0541 , A61N1/08 , A61N1/36036 , A61N1/3605 , H03K17/51
摘要： A method and apparatus for neural stimulation are disclosed. The principle is that a conventional current path is used to deliver the stimulus to neural structures, but an alternative current path is provided to bypass the neural structures during the opposite polarity part of the current flow. As a consequence, charge balance can be provided at the tissue/electrode interface, whilst delivering stimuli which are not charge balanced to the neural structures.
摘要翻译：公开了一种用于神经刺激的方法和装置。原理是使用传统的电流路径将刺激传递给神经结构，但提供替代的电流路径以在电流的相反极性部分旁路神经结构。因此，可以在组织/电极界面处提供电荷平衡，同时递送对神经结构不是电荷平衡的刺激。

63. 发明申请

US20110112462A1 PHARMACEUTICAL AGENT DELIVERY IN A STIMULATING MEDICAL DEVICE 审中-公开
标题翻译：刺激性医疗器械中的药物代理
公开(公告)号：US20110112462A1
公开(公告)日：2011-05-12
申请号：US12935909
申请日：2009-03-31
申请人： John Parker , James F. Patrick , Paul Carter
发明人： John Parker , James F. Patrick , Paul Carter
IPC分类号： A61F11/04 , A61N1/36 , A61M37/00
CPC分类号： H04R25/00 , A61M5/14276 , A61M2205/05 , A61M2210/0662 , H04R25/606 , H04R25/70 , H04R2460/13 , Y10T29/49572
摘要： A stimulating medical device comprising a stimulating assembly implantable proximate to nerve cells of a recipient having at least one agent delivery port and a plurality of electrical contacts; an electrical stimulation controller configured to generate electrical stimulation signals for application to a first population of the nerve cells via one or more of the plurality of electrical contacts; a pharmaceutical agent source configured to provide a pharmaceutical agent to the at least one delivery port for application to a second population of the nerve cells; and a pharmaceutical agent controller configured to control one or more of the pharmaceutical agent source and the at least one delivery port to cause selective application of the pharmaceutical agent to the second population of nerve cells.
摘要翻译：一种刺激性医疗装置，包括可接近于具有至少一个药剂输送口和多个电触头的受体的神经细胞植入的刺激组件; 电刺激控制器，被配置为产生电刺激信号，以经由多个电触点中的一个或多个施加到神经细胞的第一群体; 药剂源，被配置为向所述至少一个递送端口提供药剂以施用于所述神经细胞的第二群体; 以及药剂控制器，其被配置为控制所述药剂源和所述至少一个递送端口中的一个或多个，以引起所述药剂选择性施用于所述第二神经细胞群。

64. 发明授权

US07922066B2 Method of manufacturing a rotary sputtering target using a mold 有权
标题翻译：使用模具制造旋转溅射靶的方法
公开(公告)号：US07922066B2
公开(公告)日：2011-04-12
申请号：US11534205
申请日：2006-09-21
申请人： Al Nolette , Paul Carter , Dean Plaisted , Alan Plaisted
发明人： Al Nolette , Paul Carter , Dean Plaisted , Alan Plaisted
IPC分类号： B23K1/00 , B23K31/02 , C23C14/00
CPC分类号： C23C14/3407 , H01J37/34 , H01J37/342 , H01J37/3491
摘要： The process that is the subject of this invention is a method of making a rotary sputtering target having the steps of providing a cylinder of sputtering target material having an adhesion-wetting layer on its inside surface; providing a stainless steel sputtering target backing tube having an outside diameter smaller than the sputtering target material inside diameter, the backing tube having an adhesion-wetting layer on its outside surface; welding an upper and lower stainless steel retaining ring to the backing tube adjacent to the sputtering target material so that the target material is in compression and the backing tube in tension; and introducing molten bonding material into the annulus between the backing tube and the sputtering target material.The apparatus that is the subject of the present invention is a rotary sputtering target apparatus having a cylinder of sputtering target material; a backing tube having a smaller outside diameter than the inside diameter of the sputtering target material; and bonding material disposed between the target material and backing tube, the bonding material bonding them together.
摘要翻译：作为本发明的主题的方法是制造旋转溅射靶的方法，其具有以下步骤：在其内表面上设置具有粘附润湿层的溅射靶材料的圆筒; 提供具有小于溅射靶材料内径的外径的不锈钢溅射靶背衬管，所述背衬管在其外表面上具有粘附润湿层; 将上下不锈钢保持环焊接到与溅射靶材料相邻的背衬管上，使得目标材料处于压缩状态并使背衬管张紧; 并将熔融粘合材料引入到背衬管和溅射靶材料之间的环形空间中。作为本发明的主题的装置是具有溅射靶材料的圆筒的旋转溅射靶装置，具有比溅射靶材料的内径小的外径的背衬管; 以及设置在目标材料和背衬管之间的接合材料，所述粘合材料将它们结合在一起。

65. 发明申请

US20110004273A1 SOUND COMMAND TO STIMULATION CONVERTER 审中-公开
标题翻译：声音转换器的声音
公开(公告)号：US20110004273A1
公开(公告)日：2011-01-06
申请号：US12497335
申请日：2009-07-02
申请人： Koen Van den Heuvel , Paul Carter
发明人： Koen Van den Heuvel , Paul Carter
IPC分类号： H04R25/00 , A61N1/05
CPC分类号： A61N1/36036
摘要： A method and system for stimulating a tissue-stimulating prosthesis is disclosed. The method and system comprise receiving a sound command, such a MIDI command, and converting the sound to a stimulation signal. The stimulation signal is then used to provide stimulation to a recipient so that the recipient may perceive sound in accordance with the received sound command.
摘要翻译：公开了一种用于刺激组织刺激假体的方法和系统。该方法和系统包括接收声音命令，诸如MIDI命令，并将声音转换为刺激信号。刺激信号然后用于向接收者提供刺激，使得接收者可以根据收到的声音命令感知声音。

66. 发明申请

US20100239571A1 CD30 Binding Agents and Uses Thereof 有权
标题翻译： CD30结合剂及其用途
公开(公告)号：US20100239571A1
公开(公告)日：2010-09-23
申请号：US12438604
申请日：2007-08-24
申请人： Charlotte McDonagh , Paul Carter
发明人： Charlotte McDonagh , Paul Carter
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N5/10 , C12N5/16 , A61P37/06 , A61P35/00
CPC分类号： C07K16/2878 , A61K47/6811 , A61K47/6849 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： This invention relates to CD30 binding agents and methods of using such binding agents for treating disease characterized by expression of CD30 antigen.
摘要翻译：本发明涉及CD30结合剂和使用这种结合剂治疗特征在于表达CD30抗原的疾病的方法。

67. 发明申请

US20100212485A1 Arm Guards 审中-公开
标题翻译：护臂
公开(公告)号：US20100212485A1
公开(公告)日：2010-08-26
申请号：US12527477
申请日：2008-02-15
申请人： Paul Carter
发明人： Paul Carter
IPC分类号： F41H5/08
CPC分类号： F41H1/02
摘要： A ballistic arm guard is provided and includes a pliable outer shell or housing that encompasses inner ballistic cores which are housed or contained within an inner shell or housing. Secured to exterior portions of the ballistic arm guard are a series of attaching straps and buckles that facilitates the securing of the ballistic arm guard to the wearer's upper limb. Secured to and incorporated into an upper portion of the ballistic arm guard is a tourniquet. In one design, the interior ballistic cores comprise high performance fibers such as an aramid fiber, high molecular weight polyethylene, a combination of these, or other high performance fibers types.
摘要翻译：提供弹道防护罩，其包括柔韧的外壳或壳体，该外壳或外壳包围内部或外壳内部的弹道芯。固定在防弹手臂护罩的外部部分是一系列附着带和带扣，有利于将弹道防护罩固定在佩戴者的上肢上。止血带是安全的并结合到弹道防护罩的上部。在一种设计中，内部弹道芯包括高性能纤维，例如芳族聚酰胺纤维，高分子量聚乙烯，它们的组合或其它高性能纤维类型。

68. 发明申请

US20100126337A1 Vehicle Gunner's Protection Cuppola 审中-公开
标题翻译：车手保护玻璃杯
公开(公告)号：US20100126337A1
公开(公告)日：2010-05-27
申请号：US12529288
申请日：2008-03-07
申请人： Paul Carter
发明人： Paul Carter
IPC分类号： F41H5/20 , B23P17/04 , F41H5/00
CPC分类号： F41A23/24 , F41A27/18 , F41H5/18 , F41H5/20 , Y10T29/49826
摘要： An anti-ballistic guard is provided and includes a rigid frame that includes an outer portion of rigid ballistic material and an inner portion that includes a pliable outer shell or housing that encompasses an inner thermally resistant core which is housed or contained within an inner shell or housing and a inner ballistic core which is housed or contained within an inner shell or housing. Secured to exterior portions of the inner portion housing are pluralities of attachment points that facilitate the securement of the inner portion to the rigid frame. In one design, the inner portion outer cover comprises flame retardant, high performance fibers such as arimid, O-PAN, or a combination of these, and other high performance fibers.
摘要翻译：提供了防弹防护装置，并且包括刚性框架，该刚性框架包括刚性防弹材料的外部部分和内部部分，该内部部分包括柔软的外壳或外壳，所述内壳或外壳包围容纳或容纳在内壳内的内部耐热芯体，壳体和内部弹道芯，其被容纳或容纳在内壳或壳体内。固定到内部部分壳体的外部部分是多个附接点，其有助于将内部部分固定到刚性框架。在一个设计中，内部部分的外盖包括阻燃的高性能纤维，例如芳族聚酰胺，O-PAN或它们的组合，以及其它高性能纤维。

69. 发明申请

US20100088799A1 Load Bearing Tactical Vest 审中-公开
标题翻译：负载轴承战术背心
公开(公告)号：US20100088799A1
公开(公告)日：2010-04-15
申请号：US12559076
申请日：2009-09-14
申请人： Paul Carter
发明人： Paul Carter
IPC分类号： F41H1/02
CPC分类号： F41H1/02
摘要： A load-bearing vest comprising a yoke, a core, attached to the yoke and comprising a telescoping assembly, and a waist belt, attached to the core.
摘要翻译：一种负载背心，包括轭，芯，附接到轭并且包括伸缩组件和连接到芯的腰带。

70. 发明申请

US20080305044A1 Engineered Antibodies and Immunoconjugates 审中-公开
标题翻译：工程抗体和免疫缀合物
公开(公告)号：US20080305044A1
公开(公告)日：2008-12-11
申请号：US11720244
申请日：2005-11-29
申请人： Charlotte McDonagh , Paul Carter
发明人： Charlotte McDonagh , Paul Carter
IPC分类号： A61K49/00 , C07K16/00 , C12N9/00 , C12P21/04 , A61P35/04 , A61K39/44 , C12N5/02
CPC分类号： C07K16/2878 , A61K47/6803 , A61K47/6849
摘要： Antibody drug conjugates with predetermined sites and stoichiometries of drug attachment are provided. Also provided are methods of using antibody drug conjugates.
摘要翻译：提供了具有预定位点和药物附着化学计量的抗体药物偶联物。还提供了使用抗体药物偶联物的方法。

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