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61. 发明申请

US20050101609A1 Quinazoline derivatives as kinase inhibitors 失效
标题翻译：喹唑啉衍生物作为激酶抑制剂
公开(公告)号：US20050101609A1
公开(公告)日：2005-05-12
申请号：US10344736
申请日：2001-08-17
申请人： Anjali Pandey , Robert Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A61K31/517 , A61K31/5377 , A61K31/541 , A61P9/08 , A61P9/10 , A61P13/12 , A61P35/00 , A61P43/00 , C07D239/94 , C07D401/12 , C07D403/12 , C07D43/04 , C07D43/14
CPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method ol inhibiling kinascs and tre ating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention prtvides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及一种通过抑制激酶的磷酸化来抑制哺乳动物抑制哺乳动物的疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化阻碍异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及用于预防或治疗细胞增殖性疾病如动脉硬化的方法，血管重构，癌症和肾小球硬化症。

62. 发明授权

US06846211B2 Cover joining structure for outboard engine unit 有权
标题翻译：舷外发动机单元盖接合结构
公开(公告)号：US06846211B2
公开(公告)日：2005-01-25
申请号：US10621473
申请日：2003-07-17
申请人： Toyoshi Yasuda , Makoto Yazaki , Shinichi Ide
发明人： Toyoshi Yasuda , Makoto Yazaki , Shinichi Ide
IPC分类号： B63H20/32 , F02B61/04
CPC分类号： B63H20/32 , F02B61/045
摘要： Fixedly joining sections are provided on opposed joining edges of left and right undercover members defining part of an engine space of an outboard engine unit. The opposed joining edges are abutted against each other with the joining sections of the left and right undercover members overlapped in face-to-face relation with each other in a front-and-rear direction of the outboard engine unit. Fasteners, such as bolts, fasten together the overlapped joining sections in the front-and-rear direction, to thereby join together the left and right undercover members. The joining sections may be provided on frame members integrally secured to the respective inner side surfaces of resin-made outer wall sections of the left and right undercover members.
摘要翻译：固定接合部分设置在限定舷外发动机单元的发动机空间的一部分的左和右底盖构件的相对的接合边缘上。相对的接合边缘彼此抵接，并且左右的底盖部件的接合部分在外侧发动机单元的前后方向上以面对面的关系重叠。诸如螺栓的紧固件将重叠的连接部分在前后方向上固定在一起，从而将左和右卧底部件接合在一起。接合部可以设置在一体地固定在左右卧底部件的树脂制外壁部的内侧面的框架部件上。

63. 发明授权

US06750218B2 Nitrogen-containing heterocyclic compounds 失效
标题翻译：含氮杂环化合物
公开(公告)号：US06750218B2
公开(公告)日：2004-06-15
申请号：US10227302
申请日：2002-08-26
申请人： Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shigeki Fujiwara , Shinichi Ide , Eiji Tsukuda , Junko Irie , Shoji Oda
发明人： Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shigeki Fujiwara , Shinichi Ide , Eiji Tsukuda , Junko Irie , Shoji Oda
IPC分类号： C07D48704
CPC分类号： C07D401/12 , A61K31/496 , A61K31/502 , A61K31/517 , C07D215/46 , C07D217/22 , C07D237/34 , C07D239/94 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D487/04
摘要： 1,3 Diazines according to formula: and pharmaceutically acceptable salts thereof inhibit phosphorylation of platelet-derived growth factor receptor and thereby hinder abnormal cell growth and cell wandering.
摘要翻译： 1,3根据式的二嗪类及其药学上可接受的盐抑制血小板衍生生长因子受体的磷酸化，从而阻碍异常细胞生长和细胞游动。

64. 发明授权

US06207667B1 1,3 diazines with platelet-derived growth factor receptor inhibitory activity 失效
标题翻译：与苯结合的吡啶与血小板衍生
公开(公告)号：US06207667B1
公开(公告)日：2001-03-27
申请号：US09481544
申请日：2000-01-12
申请人： Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shigeki Fujiwara , Shinichi Ide , Eiji Tsukuda , Junko Irie , Shoji Oda
发明人： Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shigeki Fujiwara , Shinichi Ide , Eiji Tsukuda , Junko Irie , Shoji Oda
IPC分类号： A61K31535
CPC分类号： C07D401/12 , A61K31/496 , A61K31/502 , A61K31/517 , C07D215/46 , C07D217/22 , C07D237/34 , C07D239/94 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D487/04
摘要： 1,3 Diazines according to formula (I): and pharmaceutically acceptable salts thereof inhibit phosphorylation of platelet-derived growth factor receptor and thereby hinder abnormal cell growth and cell wandering. The compounds may be used to treat or prevent cell-proliferative disorders such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译： 1,3根据式（I）的二嗪类及其药学上可接受的盐抑制血小板衍生生长因子受体的磷酸化，从而阻碍异常细胞生长和细胞游动。该化合物可用于治疗或预防细胞增殖性疾病如动脉硬化，血管重构，癌症和肾小球硬化。

65. 发明授权

US06169088A 1,3 diazines with platelet-derived growth factor receptor inhibitory activity 失效
标题翻译： 1,3二嗪与血小板衍生生长因子受体的抑制活性
公开(公告)号：US06169088A
公开(公告)日：2001-01-02
申请号：US09088199
申请日：1998-06-01
申请人： Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shigeki Fujiwara , Shinichi Ide , Eiji Tsukuda , Junko Irie , Shoji Oda
发明人： Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shigeki Fujiwara , Shinichi Ide , Eiji Tsukuda , Junko Irie , Shoji Oda
IPC分类号： A61K31495
CPC分类号： C07D401/12 , A61K31/496 , A61K31/502 , A61K31/517 , C07D215/46 , C07D217/22 , C07D237/34 , C07D239/94 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D487/04
摘要： 1,3 Diazines and pharmaceutically acceptable salts thereof inhibit phosphorylation of platelet-derived growth factor receptor and thereby hinder abnormal cell growth and cell wandering. The compounds may be used to treat or prevent cell-proliferative disorders such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译： 1,3二嗪及其药学上可接受的盐抑制血小板衍生生长因子受体的磷酸化，从而阻碍异常细胞生长和细胞游动。该化合物可用于治疗或预防细胞增殖性疾病如动脉硬化，血管重构，癌症和肾小球硬化。

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