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61. 发明授权

US06239153B1 Pharmaceutical composition 有权
公开(公告)号：US06239153B1
公开(公告)日：2001-05-29
申请号：US09618636
申请日：2000-07-18
申请人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
IPC分类号： A61K3142
CPC分类号： A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/50 , A61K31/52 , A61K31/535 , A61K31/64 , A61K31/70 , A61K45/06 , Y10S514/866 , A61K2300/00 , A61K31/21 , A61K31/155 , A61K31/405 , A61K31/40 , A61K31/365 , A61K31/22
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

62. 发明授权

US06211205B1 Pharmaceutical composition 有权
公开(公告)号：US06211205B1
公开(公告)日：2001-04-03
申请号：US09606176
申请日：2000-06-29
申请人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
IPC分类号： C07D40102
CPC分类号： A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/50 , A61K31/52 , A61K31/535 , A61K31/64 , A61K31/70 , A61K45/06 , Y10S514/866 , A61K2300/00 , A61K31/21 , A61K31/155 , A61K31/405 , A61K31/40 , A61K31/365 , A61K31/22
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

63. 发明授权

US06174904B1 Pharmaceutical composition 有权
公开(公告)号：US06174904B1
公开(公告)日：2001-01-16
申请号：US09321095
申请日：1999-05-27
申请人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
IPC分类号： C07D40102
CPC分类号： A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/50 , A61K31/52 , A61K31/535 , A61K31/64 , A61K31/70 , A61K45/06 , Y10S514/866 , A61K2300/00 , A61K31/21 , A61K31/155 , A61K31/405 , A61K31/40 , A61K31/365 , A61K31/22
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

64. 发明授权

US6166043A Pharmaceutical composition 有权
公开(公告)号：US6166043A
公开(公告)日：2000-12-26
申请号：US303492
申请日：1999-04-30
申请人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
IPC分类号： A61K45/06 , A61K9/20 , A61K9/48 , A61K31/00 , A61K31/133 , A61K31/155 , A61K31/18 , A61K31/33 , A61K31/41 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/52 , A61K31/64 , A61K31/70 , A61K31/702 , A61P3/08 , A61P3/10 , A61P5/50 , A61P43/00 , C07D233/54 , C07D263/44 , C07D277/20 , C07D277/34 , A61K31/42 , C07D401/02
CPC分类号： A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/50 , A61K31/52 , A61K31/535 , A61K31/64 , A61K31/70 , A61K45/06 , Y10S514/866 , A61K2300/00 , A61K31/21 , A61K31/155 , A61K31/405 , A61K31/40 , A61K31/365 , A61K31/22
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

65. 发明授权

US6121295A Pharmaceutical composition 有权
公开(公告)号：US6121295A
公开(公告)日：2000-09-19
申请号：US303496
申请日：1999-04-30
申请人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
IPC分类号： A61K45/06 , A61K9/20 , A61K9/48 , A61K31/00 , A61K31/133 , A61K31/155 , A61K31/18 , A61K31/33 , A61K31/41 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/52 , A61K31/64 , A61K31/70 , A61K31/702 , A61P3/08 , A61P3/10 , A61P5/50 , A61P43/00 , C07D233/54 , C07D263/44 , C07D277/20 , C07D277/34 , A61K31/42 , C07D401/02
CPC分类号： A61K9/2018 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/52 , A61K31/64 , A61K31/70 , A61K45/06 , A61K9/2054 , A61K9/4858 , Y10S514/866
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

66. 发明授权

US5965589A Thiazolidinedione derivatives, their production and use 失效
标题翻译：噻唑烷二酮衍生物，其生产和使用
公开(公告)号：US5965589A
公开(公告)日：1999-10-12
申请号：US530115
申请日：1995-10-05
申请人： Takashi Sohda , Hiroyuki Odaka , Yu Momose
发明人： Takashi Sohda , Hiroyuki Odaka , Yu Momose
IPC分类号： C07D277/34 , C07D417/12 , C07D413/12 , A61K31/42
CPC分类号： C07D417/12 , C07D277/34
摘要： A 2,4-thiazolidinedione derivative of the formula (I): ##STR1## wherein R is an optionally substituted hydrocarbon group or heterocyclic group which may be attached through a hydrocarbon chain; n is 0 or 1; X is CH or N; Y is a bivalent hydrocarbon group; R.sup.1 and R.sup.2 are the same or different and are a hydrogen atom, a halogen atom, an optionally substituted hydroxyl group or an optionally substituted hydrocarbon group, and either R.sup.1 or R.sup.2 and a part of Y may be linked together to form a ring; and L and M are a hydrogen atom, or L and M are linked together to form a bond; or a salt thereof. A pharmaceutical composition comprising the compound (I) and a process for producing the compound (I) are also provided.
摘要翻译： PCT No.PCT / JP95 / 01579 Sec。 371日期1995年10月5日第 102（e）日期1995年10月5日PCT 1995年8月9日PCT PCT。公开号WO96 / 05186 日期：1996年2月22日A式（I）的2,4-噻唑烷二酮衍生物：其中R是可通过烃链连接的任选取代的烃基或杂环基; n为0或1; X是CH或N; Y为二价烃基; R 1和R 2相同或不同，为氢原子，卤素原子，任选取代的羟基或任选取代的烃基，R 1或R 2和Y的一部分可以连接在一起形成环; L和M是氢原子，或L和M连接在一起形成键; 或其盐。还提供了包含化合物（I）和制备化合物（I）的方法的药物组合物。

67. 发明授权

US5952356A Pharmaceutical composition 失效
公开(公告)号：US5952356A
公开(公告)日：1999-09-14
申请号：US667979
申请日：1996-06-19
申请人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
IPC分类号： A61K45/06 , A61K9/20 , A61K9/48 , A61K31/00 , A61K31/133 , A61K31/155 , A61K31/18 , A61K31/33 , A61K31/41 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/52 , A61K31/64 , A61K31/70 , A61K31/702 , A61P3/08 , A61P3/10 , A61P5/50 , A61P43/00 , C07D233/54 , C07D263/44 , C07D277/20 , C07D277/34 , C07D401/06
CPC分类号： A61K9/2018 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/52 , A61K31/64 , A61K31/70 , A61K45/06 , A61K9/2054 , A61K9/4858 , Y10S514/866
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

68. 发明授权

US5932601A Oxazolidinedione derivatives, their production and use 失效
标题翻译：恶唑二酮衍生物，其生产和使用
公开(公告)号：US5932601A
公开(公告)日：1999-08-03
申请号：US550289
申请日：1995-10-30
申请人： Takashi Sohda , Hiroyuki Odaka , Yu Momose , Mitsuru Kawada
发明人： Takashi Sohda , Hiroyuki Odaka , Yu Momose , Mitsuru Kawada
IPC分类号： A61K31/42 , C07D263/32 , C07D263/44 , C07D277/22 , C07D277/24 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号： C07D277/22 , C07D263/32 , C07D263/44 , C07D277/24 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12
摘要： 2,4-Oxazolidinedione derivative represented by the formula: ##STR1## wherein R stands for an optionally substituted hydrocarbon residue or heterocyclic group; Y stands for a group represented by --CO--, --CH(OH)-- or --NR.sup.3 -- (wherein R.sup.3 stands for an optionally substituted alkyl group); m is 0 or 1; n is 0, 1 or 2; A stands for a C.sub.1-7 divalent aliphatic hydrocarbon group; R.sup.1 stands for hydrogen or an alkyl group; ring E stands for a benzene ring having 1 or 2 substituents; L and M respectively stand for hydrogen, or L and M may optionally be combined with each other to form a bond; with a proviso that the partial formula: ##STR2## does not include the formula: ##STR3## wherein R' stands for an alkyl group; or a salt thereof, which has excellent actions of lowering blood sugar and lipid in blood.
摘要翻译：由下式表示的2,4-恶唑烷二酮衍生物：其中R表示任选取代的烃残基或杂环基; Y表示由-CO-，-CH（OH） - 或-NR 3 - （其中R 3表示任选取代的烷基）表示的基团; m为0或1; n为0,1或2; A代表C 1-7二价脂族烃基; R1代表氢或烷基; 环E代表具有1或2个取代基的苯环; L和M分别代表氢，或者L和M可以任选地彼此结合形成键; 条件是部分式：不包括下式：其中R'代表烷基; 或其盐，其具有降低血液中血糖和血脂的优异作用。

69. 发明授权

US5723479A Benzofuran compounds and their use 失效
标题翻译：苯并呋喃化合物及其用途
公开(公告)号：US5723479A
公开(公告)日：1998-03-03
申请号：US615084
申请日：1996-03-14
申请人： Takashi Sohda , Hiroyuki Odaka , Yu Momose
发明人： Takashi Sohda , Hiroyuki Odaka , Yu Momose
IPC分类号： C07D413/12 , C07D413/14 , C07D417/14 , C07D417/12 , A61K31/40
CPC分类号： C07D413/12 , C07D413/14 , C07D417/14
摘要： Benzofuran compound represented by the formula: ##STR1## wherein ##STR2## represents a group capable of releasing a cation in which ....... represents a single or double bond: R.sup.1 represents an optionally substituted heterocyclic residue which may be attached to the oxygen atom through a carbon chain; R.sup.2 represents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon residue, an optionally protected hydroxyl group or an optionally protected amino group; Y represents a di- or tri-valent aliphatic hydrocarbon residue having 1 to 8 carbon atoms; and the benzene ring of the benzofuran moiety may have further substituents; or a salt thereof, which has excellent hypoglycemic and hypolipidemic action.
摘要翻译：由下式表示的苯并呋喃化合物：其中表示能够释放阳离子的基团，其中+ E，ovs + EE表示单键或双键：R1表示任选取代的杂环可通过碳链连接到氧原子的残基; R 2表示氢原子，卤素原子，任选取代的烃残基，任选保护的羟基或任选保护的氨基; Y表示碳原子数为1〜8的二价或三元脂肪族烃残基; 并且苯并呋喃部分的苯环可以具有其它取代基; 或其盐，其具有优异的降血糖和降血脂作用。

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