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61. 发明授权

US08036831B2 Ligand searching device, ligand searching method, program, and recording medium 失效
标题翻译：配体搜索装置，配体搜索方法，程序和记录介质
公开(公告)号：US08036831B2
公开(公告)日：2011-10-11
申请号：US10590116
申请日：2005-02-24
申请人： Hideaki Umeyama , Yoshiaki Watanabe , Ryoichi Arai
发明人： Hideaki Umeyama , Yoshiaki Watanabe , Ryoichi Arai
IPC分类号： G06F19/00 , G01N33/566
CPC分类号： C40B30/02 , G06F19/16 , G06F19/706
摘要： The present invention is directed to serve ligand screening apparatuses, ligand screening methods, programs and a recording medium for studying the binding analysis between a receptor including an induced-fit type receptor and a ligand. First, analysis and calculation of normal mode are conducted, and then fluctuation of a dihedral angle of a main chain in a steady state is calculated. Then by carrying out a molecular dynamic calculation while imposing constraint on each atom based on the fluctuation, a dynamic structure of the receptor is predicted more accurately. By using the dynamic structure obtained in the molecular dynamic calculation and an interaction function, receptor/ligand binding which is also applicable to an induced-fit type receptor is predicted with high accuracy.
摘要翻译：本发明涉及用于研究包括诱导配合型受体和配体的受体之间的结合分析的配体筛选装置，配体筛选方法，程序和记录介质。首先，进行正常模式的分析计算，然后计算主链在稳定状态下的二面角的波动。然后通过进行分子动力学计算，同时基于波动对每个原子施加约束，更准确地预测受体的动态结构。通过使用在分子动力学计算中获得的动态结构和相互作用功能，可以高精度地预测也适用于诱导拟合型受体的受体/配体结合。

62. 发明授权

US07879887B2 α-amino acid derivatives and medicaments containing the same as an active ingredient 有权
标题翻译： α-氨基酸衍生物和含有活性成分的药物
公开(公告)号：US07879887B2
公开(公告)日：2011-02-01
申请号：US12306901
申请日：2007-06-29
申请人： Kazuhiko Ohrai , Michiaki Adachi , Koji Toyama , Takanori Shimizu , Keishi Hayashi , Masataka Minami , Yoshiyuki Suzuki , Masakazu Sugiyama , Masateru Ohta , Shojiro Kadono , Takuya Shiraishi , Haruhiko Sato , Yoshiaki Watanabe , Nobuya Ishii , Masahiro Sakaitani , Masami Hasegawa
发明人： Kazuhiko Ohrai , Michiaki Adachi , Koji Toyama , Takanori Shimizu , Keishi Hayashi , Masataka Minami , Yoshiyuki Suzuki , Masakazu Sugiyama , Masateru Ohta , Shojiro Kadono , Takuya Shiraishi , Haruhiko Sato , Yoshiaki Watanabe , Nobuya Ishii , Masahiro Sakaitani , Masami Hasegawa
IPC分类号： C07D513/04 , A61K31/429
CPC分类号： C07D513/04
摘要： The present invention provides novel α-amino acid derivatives of formula (1): (wherein, R1, R2, R3, R4, X and Y are as defined in the claims) or pharmaceutically acceptable salts, prodrugs or solvates thereof. The derivatives of formula (1) have βARK1 inhibitory activity and are useful for preventing or treating heart failure. Moreover, the derivatives of formula (1) also have antitumor activity, particularly dual inhibitory activity on Aurora kinase and CDK, and are useful for cell proliferative diseases such as cancer.
摘要翻译：本发明提供新的式（1）的α-氨基酸衍生物：其中R1，R2，R3，R4，X和Y如权利要求中所定义）或其药学上可接受的盐，前药或溶剂合物。式（1）的衍生物具有ARK1抑制活性，可用于预防或治疗心力衰竭。此外，式（1）的衍生物还具有抗肿瘤活性，特别是对极光激酶和CDK的双重抑制活性，并且可用于细胞增殖性疾病如癌症。

63. 发明授权

US07684453B2 Surface light emitting semiconductor laser element 有权
标题翻译：表面发光半导体激光元件
公开(公告)号：US07684453B2
公开(公告)日：2010-03-23
申请号：US10847904
申请日：2004-05-18
申请人： Yoshiaki Watanabe , Hironobu Narui , Yuichi Kuromizu , Yoshinori Yamauchi , Yoshiyuki Tanaka
发明人： Yoshiaki Watanabe , Hironobu Narui , Yuichi Kuromizu , Yoshinori Yamauchi , Yoshiyuki Tanaka
IPC分类号： H01S5/00
CPC分类号： G02B6/4296 , H01S5/02284 , H01S5/02288 , H01S5/0425 , H01S5/18311 , H01S5/18388 , H01S5/18394 , H01S5/2214 , H01S5/32308 , H01S2301/18 , H01S2301/203
摘要： A surface light emitting semiconductor laser element, comprises a substrate, a lower reflector including a semiconductor multi-layer disposed on the substrate, an active layer disposed on the lower reflector, an upper reflector including a semiconductor multi-layer disposed on the active layer, a compound semiconductor layer having a first opening for exposing the upper reflector and extending over the upper reflector, and a metal film having a second opening for exposing the upper reflector disposed inside of the first opening and extending over the compound semiconductor layer, wherein the metal film and the compound semiconductor layer constitute a complex refractive index distribution structure where a complex refractive index is changed from the center of the second opening towards the outside. A method of emitting laser light in a single-peak transverse mode is also provided.
摘要翻译：一种表面发光半导体激光元件，包括基板，包括设置在基板上的半导体多层的下反射器，设置在下反射器上的有源层，包括设置在有源层上的半导体多层的上反射器，化合物半导体层，具有用于暴露上反射体并在上反射体上方延伸的第一开口，以及具有第二开口的金属膜，用于暴露设置在第一开口内部并在化合物半导体层上方延伸的上反射体，其中金属膜和化合物半导体层构成复合折射率分布结构，其中复数折射率从第二开口的中心朝向外部改变。还提供了以单峰横向模式发射激光的方法。

64. 发明授权

US07593661B2 Power-saving control method of image forming device, and image forming device 有权
标题翻译：图像形成装置的节电控制方法和图像形成装置
公开(公告)号：US07593661B2
公开(公告)日：2009-09-22
申请号：US11743309
申请日：2007-05-02
申请人： Yoshiaki Watanabe , Hiroshi Kobayashi
发明人： Yoshiaki Watanabe , Hiroshi Kobayashi
IPC分类号： G03G15/00 , G03G15/20
CPC分类号： G03G15/5004
摘要： In a power-saving control method of an image forming device, the image forming device is set in a power saving state when an input operation is not performed by a user over a predetermined time. The image forming device in the power saving state is shifted to a minimum power state. Prior to shifting of the image forming device to the minimum power state, a filtering unit is activated to detect communication between an external device and the image forming device in the minimum power state. When a detected communication signal indicates an image formation request from the external device, the image forming device is caused to return from the minimum power state through the power saving state to a standby state so that the image forming device is ready for performing image formation.
摘要翻译：在图像形成装置的省电控制方法中，当在预定时间内用户不执行输入操作时，图像形成装置被设置在省电状态。处于省电状态的图像形成装置转移到最小功率状态。在将图像形成装置移动到最小功率状态之前，启动滤波单元以在最小功率状态下检测外部装置与图像形成装置之间的通信。当检测到的通信信号表示来自外部设备的图像形成请求时，使图像形成装置从最小功率状态通过省电状态返回到待机状态，使得图像形成装置准备好进行图像形成。

65. 发明申请

US20080266622A1 SHEET PROCESSING APPARATUS 有权
标题翻译：板材加工设备
公开(公告)号：US20080266622A1
公开(公告)日：2008-10-30
申请号：US12107703
申请日：2008-04-22
申请人： Kenji Kawazoe , Haruo Uchida , Nozomu Nishiberi , Yoshiaki Watanabe , Yasuyuki Asai , Mitsuru Kondo
发明人： Kenji Kawazoe , Haruo Uchida , Nozomu Nishiberi , Yoshiaki Watanabe , Yasuyuki Asai , Mitsuru Kondo
IPC分类号： H04N1/04
CPC分类号： H04N1/00567 , H04N1/00578 , H04N1/00588 , H04N1/00591 , H04N1/00596 , H04N1/00602 , H04N1/0061 , H04N1/00612 , H04N1/00615 , H04N1/00623 , H04N1/00631 , Y10S271/902
摘要： A sheet processing apparatus includes a feeding portion that feeds an original or a recording medium, a reading portion that reads an original, and a recording portion that performs recording on a recording medium. The original or recording medium fed from the feeding portion can be selectively conveyed to the reading portion or the recording portion, thereby allowing for compactness of the apparatus as well as cost reduction.
摘要翻译：片材处理设备包括馈送原稿或记录介质的馈送部分，读取原稿的读取部分和在记录介质上执行记录的记录部分。从供给部供给的原稿或记录介质能够选择性地传送到读取部或记录部，从而允许装置的紧凑性以及成本降低。

66. 发明申请

US20080244134A1 Multiprocessor System and Method for Processing Memory Access 有权
标题翻译：用于处理存储器访问的多处理器系统和方法
公开(公告)号：US20080244134A1
公开(公告)日：2008-10-02
申请号：US10586153
申请日：2005-07-01
申请人： Takeo Hosomi , Yoshiaki Watanabe
发明人： Takeo Hosomi , Yoshiaki Watanabe
IPC分类号： G06F13/36
CPC分类号： G06F13/385 , G06F12/0808
摘要： When receiving a write message, an input/output controller issues a write request message to a home processor node that holds the corresponding data in a memory. A memory controller of the processor node having received the write request message performs a consistency processing based on the status of the corresponding data stored in a directory and controls a write permission message to reach the input/output controller having issued the write request message. The input/output controller of the input/output node having received the write permission message issues, as the write message, an update message to the home processor node. The memory controller of the processor node having received the update message updates the data in a main storage part. In the processing described above, when receiving a plurality of write messages from input/output devices, the input/output controller issues a write request message regardless of the progress of the preceding write message, and issues a write message after an issuance of the write message of the preceding write.
摘要翻译：当接收到写入消息时，输入/输出控制器向存储有相应数据的家庭处理器节点发出写入请求消息。已经接收到写请求消息的处理器节点的存储器控制器基于存储在目录中的对应数据的状态执行一致性处理，并且控制写许可消息以到达已发出写请求消息的输入/输出控制器。作为写入消息，已经接收到写许可消息的输入/输出节点的输入/输出控制器向家庭处理器节点发出更新消息。已经接收到更新消息的处理器节点的存储器控制器更新主存储部分中的数据。在上述处理中，当从输入/输出设备接收到多个写入消息时，输入/输出控制器发出写入请求消息，而不管先前的写入消息的进展如何，并且在发出写入之后发出写入消息上一次写的消息。

67. 发明申请

US20080128721A1 LIGHT EMITTING DEVICE AND METHOD OF MANUFACTURING THE SAME 有权
标题翻译：发光装置及其制造方法
公开(公告)号：US20080128721A1
公开(公告)日：2008-06-05
申请号：US11873763
申请日：2007-10-17
申请人： Yoshiaki Watanabe , Tomonori Hino , Nobukata Okano , Hisayoshi Kuramochi , Yuichiro Kikuchi , Tatsuo Ohashi
发明人： Yoshiaki Watanabe , Tomonori Hino , Nobukata Okano , Hisayoshi Kuramochi , Yuichiro Kikuchi , Tatsuo Ohashi
IPC分类号： H01L33/00
CPC分类号： H01L33/44 , H01L33/38
摘要： Herein disclosed a method of manufacturing a light emitting device, including the steps of: (A) sequentially forming a first compound semiconductor layer of a first conduction type, an active layer, and a second compound semiconductor layer of a second conduction type different from said first conduction type, over a substrate; and (B) exposing a part of said first compound semiconductor layer, forming a first electrode over said exposed part of said first compound semiconductor layer and forming a second electrode over said second compound semiconductor layer, wherein said method further includes, subsequent to said step (B), the step of: (C) covering at least said exposed part of said first compound semiconductor layer, an exposed part of said active layer, an exposed part of said second compound semiconductor layer, and a part of said second electrode with an SOG layer.
摘要翻译：本文公开了一种制造发光器件的方法，包括以下步骤：（A）顺序地形成第一导电类型的第一化合物半导体层，有源层和与所述第二导电类型不同的第二化合物半导体层第一导电类型，在基板上; 和（B）暴露所述第一化合物半导体层的一部分，在所述第一化合物半导体层的所述暴露部分上形成第一电极，并在所述第二化合物半导体层上形成第二电极，其中所述方法还包括，在所述步骤（B）中，步骤：（C）至少覆盖所述第一化合物半导体层的所述暴露部分，所述有源层的暴露部分，所述第二化合物半导体层的暴露部分和所述第二电极的一部分， SOG层。

68. 发明申请

US20070286630A1 POWER-SAVING CONTROL METHOD OF IMAGE FORMING DEVICE, AND IMAGE FORMING DEVICE 有权
标题翻译：图像形成装置的节电控制方法和图像形成装置
公开(公告)号：US20070286630A1
公开(公告)日：2007-12-13
申请号：US11743309
申请日：2007-05-02
申请人： Yoshiaki Watanabe , Hiroshi Kobayashi
发明人： Yoshiaki Watanabe , Hiroshi Kobayashi
IPC分类号： G03G13/00
CPC分类号： G03G15/5004
摘要： In a power-saving control method of an image forming device, the image forming device is set in a power saving state when an input operation is not performed by a user over a predetermined time. The image forming device in the power saving state is shifted to a minimum power state. Prior to shifting of the image forming device to the minimum power state, a filtering unit is activated to detect communication between an external device and the image forming device in the minimum power state. When a detected communication signal indicates an image formation request from the external device, the image forming device is caused to return from the minimum power state through the power saving state to a standby state so that the image forming device is ready for performing image formation.
摘要翻译：在图像形成装置的省电控制方法中，当在预定时间内用户不执行输入操作时，图像形成装置被设置在省电状态。处于省电状态的图像形成装置转移到最小功率状态。在将图像形成装置移动到最小功率状态之前，启动滤波单元以在最小功率状态下检测外部装置与图像形成装置之间的通信。当检测到的通信信号表示来自外部设备的图像形成请求时，使图像形成装置从最小功率状态通过省电状态返回到待机状态，使得图像形成装置准备好进行图像形成。

69. 发明申请

US20070166760A1 Ligand searching device, ligand searching method, program, and recording medium 失效
标题翻译：配体搜索装置，配体搜索方法，程序和记录介质
公开(公告)号：US20070166760A1
公开(公告)日：2007-07-19
申请号：US10590116
申请日：2005-02-24
申请人： Hideaki Umeyama , Yoshiaki Watanabe , Ryoichi Arai
发明人： Hideaki Umeyama , Yoshiaki Watanabe , Ryoichi Arai
IPC分类号： G06F19/00
CPC分类号： C40B30/02 , G06F19/16 , G06F19/706
摘要： The present invention is directed to serve ligand screening apparatuses, ligand screening methods, programs and recording medium for studying the binding analysis between a receptor including an induced-fit type receptor and a ligand. First, analysis and calculation of normal mode are conducted, and then fluctuation of dihedral angle of main chain in a steady state is calculated. Then by carrying out molecular dynamic calculation while imposing constraint on each atom based on the fluctuation, dynamic structure of the receptor is predicted more accurately. By using the dynamic structure obtained in the molecular dynamic calculation and an interaction function, receptor/ligand binding which is also applicable to an induced-fit type receptor is predicted with high accuracy.
摘要翻译：本发明涉及用于研究包括诱导拟合型受体和配体的受体之间的结合分析的配体筛选装置，配体筛选方法，程序和记录培养基。首先进行正常模式的分析和计算，然后计算主链在稳态下的二面角波动。然后通过进行分子动力学计算，同时基于波动对每个原子施加约束，从而更准确地预测受体的动态结构。通过使用在分子动力学计算中获得的动力学结构和相互作用功能，可以高精度地预测也适用于诱导拟合型受体的受体/配体结合。

70. 发明申请

US20060160525A1 Authentication system for mobile terminal having electronic money function 有权
标题翻译：具有电子货币功能的移动终端验证系统
公开(公告)号：US20060160525A1
公开(公告)日：2006-07-20
申请号：US11334358
申请日：2006-01-19
申请人： Yoshiaki Watanabe
发明人： Yoshiaki Watanabe
IPC分类号： H04M1/66
CPC分类号： G06Q20/425 , G06Q20/20 , G06Q20/32 , G06Q20/322 , G06Q20/3229 , G06Q20/4014 , G06Q20/42 , G07C9/00087 , G07G1/0036 , H04M17/02
摘要： A user of a mobile phone photographs himself/herself, and sends a password to an authentication server. After the authentication server authenticates the user, the mobile phone stores the photographed image of the user in a memory accessible only by authentication software. When the authentication software detects a billing apparatus at the time the user makes a purchase, the image is read from the memory and displayed while an indicator is on. A store clerk can confirm whether the person carrying the mobile phone is the legitimate user by judging whether the face image matches the person and whether the indicator is on at the same time.
摘要翻译：手机的用户自己拍摄，并向认证服务器发送密码。在认证服务器认证用户之后，移动电话将用户的拍摄图像存储在仅由认证软件访问的存储器中。当认证软件在用户进行购买时检测到记帐装置时，在存储器中读取图像并在指示器打开时显示。店员可以判断携带手机的人是否合法，通过判断脸部图像是否与人物相匹配，以及指示灯是否同时开启。

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