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61. 发明授权

US08239798B1 Methods, systems, and apparatus for variation aware extracted timing models 有权
标题翻译：用于变异感知提取时序模型的方法，系统和装置
公开(公告)号：US08239798B1
公开(公告)日：2012-08-07
申请号：US12185072
申请日：2008-08-02
申请人： Ratnakar Goyal , Naresh Kumar , Harindranath Parmeswaran
发明人： Ratnakar Goyal , Naresh Kumar , Harindranath Parmeswaran
IPC分类号： G06F17/50
CPC分类号： G06F17/5031
摘要： In one embodiment of the invention, a method of analysis of a circuit design is disclosed to generate a statistical timing model. The method includes receiving a timing graph of a circuit including arcs with a statistical function of delay, slew, or arrival time; determining primary input ports and output ports of the circuit; identifying timing pins between the input ports and the output ports of the circuit; and evaluating the timing pins from input ports to output ports to reduce the timing graph to ease analysis of the reduced timing graph with a processor.
摘要翻译：在本发明的一个实施例中，公开了一种分析电路设计的方法以产生统计时序模型。该方法包括接收包括具有延迟，转换或到达时间的统计功能的电弧的电路的时序图; 确定电路的主输入端口和输出端口; 识别输入端口和电路的输出端口之间的定时引脚; 并且从输入端口到输出端口评估定时引脚以减少定时图，以便利用处理器来简化分析缩减的时序图。

62. 发明授权

US08010594B2 System and method for billing system interface failover resolution 有权
标题翻译：计费系统接口故障切换解决方案的系统和方法
公开(公告)号：US08010594B2
公开(公告)日：2011-08-30
申请号：US12141203
申请日：2008-06-18
申请人： Naresh Kumar , Robert Perry
发明人： Naresh Kumar , Robert Perry
IPC分类号： G06F15/16 , G06F15/173 , H04N7/16 , H04N7/173
CPC分类号： H04L12/14 , G06F11/2033 , G06F11/2038 , G06F11/2041 , H04L12/1403 , H04L69/40 , H04M15/70 , H04M15/74 , H04M2215/70 , H04M2215/709
摘要： A determination is made whether a first application server of a group of N application servers, N being at least two, is a coordinator of the group. Responsive to determining that the first application server is the coordinator of the group, a connection to a billing system is established, via a terminal server, by the first application server. A determination is made whether a second application server of the group of N application servers is the coordinator of the group. Responsive to determining that the second application server is not the coordinator of the group, a periodic check is made whether the second application server of the group of N application servers is the coordinator of the group. The second application server may later be determined to be the coordinator of the group, when the first server experiences difficulty. Once it is determined that the second application server now is the coordinator of the group, a connection is established to the billing system, via the terminal server, by the second application server.
摘要翻译：确定一组N个应用服务器的第一应用服务器是否为该组的协调器，N至少为两个。响应于确定第一应用服务器是该组的协调器，通过终端服务器由第一应用服务器建立与计费系统的连接。确定N个应用服务器组的第二应用服务器是否是该组的协调器。响应于确定第二应用服务器不是组的协调器，定期检查N个应用服务器组中的第二应用服务器是否是该组的协调器。当第一服务器遇到困难时，可以将第二应用服务器确定为该组的协调器。一旦确定第二应用服务器现在是组的协调器，则通过第二应用服务器经由终端服务器向计费系统建立连接。

63. 发明申请

US20110172201A1 PROCESS FOR PREPARING A CARBAPENEM ANTIBIOTIC COMPOSITION 审中-公开
标题翻译：制备抗生素组合物的方法
公开(公告)号：US20110172201A1
公开(公告)日：2011-07-14
申请号：US12997668
申请日：2009-06-12
申请人： Vinod George , Bhupendra Vashishta , Mohan Prasad , Naresh Kumar , Vinod Kumar Arora
发明人： Vinod George , Bhupendra Vashishta , Mohan Prasad , Naresh Kumar , Vinod Kumar Arora
IPC分类号： A61K31/407 , C07D477/20 , A61P31/04
CPC分类号： A61K9/0019 , A61K9/19 , A61K31/407 , C07D477/20
摘要： The present invention relates to a process for preparing a carbapenem antibiotic composition. The present invention further relates to a carbapenem antibiotic composition substantially free of degradation impurities. The present invention further relates to a polymorphic form of ertapenem mono sodium designated as Form D and its preparation.
摘要翻译：本发明涉及一种制备碳青霉烯类抗生素组合物的方法。本发明还涉及基本上不含降解杂质的碳青霉烯类抗生素组合物。本发明还涉及被称为D型的ertapenem单钠的多晶形式及其制备方法。

64. 发明授权

US07906660B2 Production of isoflavone derivatives 失效
标题翻译：异黄酮衍生物的生产
公开(公告)号：US07906660B2
公开(公告)日：2011-03-15
申请号：US11442369
申请日：2006-05-25
申请人： Andrew Heaton , Naresh Kumar
发明人： Andrew Heaton , Naresh Kumar
IPC分类号： C07D311/60
CPC分类号： C07D311/56 , C07D311/36 , C07D311/38
摘要： Methods for the hydrogenation of isoflavones are described which provide access to workable quantities of isoflavan-4-ols, isoflav-3-enes, and isoflavans. The isoflavone derivatives can be obtained in high purity and in near quantitative yields whilst employing pharmaceutically acceptable reagents and solvents.
摘要翻译：描述了异黄酮氢化方法，其提供了可使用量的异黄烷-4-醇，异氟烷-3-烯和异构体。异黄酮衍生物可以以高纯度和接近定量的产率获得，同时使用药学上可接受的试剂和溶剂。

65. 发明申请

US20100112106A1 SYNERGISTIC HERBAL OPHTHALMIC FORMULATION FOR LOWERING THE INTRA OCULAR PRESSURE IN CASE OF GLAUCOMA 有权
标题翻译：用于降低GLAUCOMA病例中内镜压力的协同草药眼用配方
公开(公告)号：US20100112106A1
公开(公告)日：2010-05-06
申请号：US12529015
申请日：2008-02-27
申请人： Suresh Kumar Gupta , Sunder Agrawal , Renu Agrawal , Sushma Srivastava , Ankita Nagpal , Naresh Kumar , Rohit Saxena , Sateesh Kumar , Deepak Bahri
发明人： Suresh Kumar Gupta , Sunder Agrawal , Renu Agrawal , Sushma Srivastava , Ankita Nagpal , Naresh Kumar , Rohit Saxena , Sateesh Kumar , Deepak Bahri
IPC分类号： A61K36/9066 , A61P27/06
CPC分类号： A61K36/53 , A61K36/81 , A61K36/889 , A61K36/9066
摘要： The present invention relates to a synergistic herbal composition for lowering the intra ocular pressure in different types of glaucoma and process for the preparation of the same in pharmaceutically acceptable dosage forms.
摘要翻译：本发明涉及用于降低不同类型青光眼的眼内压的协同草药组合物及其在药学上可接受的剂型中的制备方法。

66. 发明申请

US20090012116A1 Muscarinic Receptor Antagonists 审中-公开
标题翻译：毒蕈碱受体拮抗剂
公开(公告)号：US20090012116A1
公开(公告)日：2009-01-08
申请号：US11995376
申请日：2006-07-11
申请人： Naresh Kumar , Kirandeep Kaur , Sandeep Sinha , Suman Gupta , Venkata P. Palle , Anita Chugh
发明人： Naresh Kumar , Kirandeep Kaur , Sandeep Sinha , Suman Gupta , Venkata P. Palle , Anita Chugh
IPC分类号： A61K31/44 , C07D453/02 , A61K31/40 , C07D487/08
CPC分类号： C07D209/52 , C07D405/12 , C07D409/12 , C07D471/08
摘要： Provided are muscarinic receptor antagonists, which can be useful in treating various diseases of the respiratory, urinary or gastrointestinal system mediated through muscarinic receptors. Also provided are processes for preparing compounds described herein, pharmaceutical compositions comprising compounds described herein, and methods for treating diseases mediated through muscarinic receptors.
摘要翻译：提供毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿或胃肠系统的各种疾病。还提供了用于制备本文所述化合物的方法，包含本文所述化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

67. 发明授权

US07312344B2 Dimeric isoflavones 失效
标题翻译：二聚异黄酮
公开(公告)号：US07312344B2
公开(公告)日：2007-12-25
申请号：US10469957
申请日：2002-03-08
申请人： Andrew Heaton , Graham Edmund Kelly , Naresh Kumar
发明人： Andrew Heaton , Graham Edmund Kelly , Naresh Kumar
IPC分类号： C07D311/00
CPC分类号： C07D311/58 , C07D311/38
摘要： A compound of the general formula (I) or (II) wherein X is O, NR4 or S and R1-R8 are as defined in the specification
摘要翻译：通式（I）或（II）的化合物，其中X为O，NR 4或S且R 1 -R 8为如说明书中所定义

68. 发明授权

US06958145B2 Synthesis of cyclic compounds 失效
标题翻译：环状化合物的合成
公开(公告)号：US06958145B2
公开(公告)日：2005-10-25
申请号：US10312155
申请日：2001-06-28
申请人： Naresh Kumar , Roger Wayne Read
发明人： Naresh Kumar , Roger Wayne Read
IPC分类号： A61K31/365 , A61P31/04 , A61P31/10 , C07B61/00 , C07C59/21 , C07C59/347 , C07D307/58 , C07D307/60 , C08F34/00 , C08F224/00 , C07D307/33
CPC分类号： C07D307/58 , C07C59/347 , C07D307/60 , C08F224/00
摘要： A method for the preparation of a compound of formula (II) wherein R1 and R2 are independently H, alkyl, alkoxy, oxoalkyl, alkenyl, aryl or arylalkyl whether unsubstituted or substituted, optionally interrupted by one or more hetero atoms, straight chain or branched chain, hydrophilic, hydrophobic or fluorophilic; R3, R4, R5 and R6 are independently or all hydrogen or halogen; provided that at least two of the R3, R4, R5 and R6 are halogens.
摘要翻译：制备式（II）化合物的方法，其中R 1和R 2独立地是H，烷基，烷氧基，氧代烷基，烯基，芳基或芳基烷基，无论是未取代的或取代的，任选被一个或多个杂原子间隔的直链或支链，亲水的，疏水的或富含荧光的; R 3，R 4，R 5和R 6是独立地或全部是氢或卤素; 条件是R 3，R 4，R 5和R 6中的至少两个是卤素。

69. 发明授权

US5792874A Process for the manufacture of 8-chloro-6-(2-flourophenyl)-1-methyl-4H-imidazo�1,5A!�1,4!benzodiazepine (midazolam) 失效
标题翻译：制备8-氯-6-（2-氟苯基）-1-甲基-4H-咪唑并[1,5A] [1,4]苯并二氮杂（咪达唑仑）的方法
公开(公告)号：US5792874A
公开(公告)日：1998-08-11
申请号：US918393
申请日：1997-08-26
申请人： Jag Mohan Khanna , Naresh Kumar , Chandrahas Khanduri , Mukesh Kumar Sharma , Pankaj Sharma , Swargam Sathyanarayan , Girij Pal Singh
发明人： Jag Mohan Khanna , Naresh Kumar , Chandrahas Khanduri , Mukesh Kumar Sharma , Pankaj Sharma , Swargam Sathyanarayan , Girij Pal Singh
IPC分类号： A61K31/55 , A61P21/02 , A61P23/00 , A61P25/20 , C07D339/06 , C07D339/08 , C07D409/10 , C07D487/04 , C07D204/04
CPC分类号： C07D339/08 , C07D339/06 , C07D409/10 , C07D487/04
摘要： A multistep process for producing 8-chloro-6-(2-fluorophenyl)-1-methyl-4-H-imidazo�1,5a!�1,4!benzodiazepine (midazolam) comprises treating a compound of Formula II with a lower alkyl dithiol to produce a compound of Formula III, wherein n=2 or 3, converting the compound of Formula III to a compound of Formula VII, and then treating the compound of Formula VII with a deprotecting agent, thereby producing midazolam. Novel intermediate compounds are also disclosed.
摘要翻译：用于制备8-氯-6-（2-氟苯基）-1-甲基-4H-咪唑并[1,5a] [1,4]苯并二氮杂（咪达唑仑）的多步方法包括用较低的制备式III化合物，其中n = 2或3，将式III化合物转化为式VII化合物，然后用脱保护剂处理式VII化合物，从而产生咪达唑仑。还公开了新的中间体化合物。

70. 发明授权

US5621120A Process for the manufacture of form 1 ranitidine hydrochloride 失效
标题翻译：制备1型盐酸雷尼替丁的方法
公开(公告)号：US5621120A
公开(公告)日：1997-04-15
申请号：US265307
申请日：1994-06-24
申请人： Jag M. Khanna , Naresh Kumar , Brij Khera , Mahavir S. Khanna
发明人： Jag M. Khanna , Naresh Kumar , Brij Khera , Mahavir S. Khanna
IPC分类号： C07D307/52 , C07D307/02
CPC分类号： C07D307/52
摘要： A process for the manufacture of Form 1 ranitidine hydrochloride (N-[2-[[[5-(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl-N'-methyl-2-nitro-1,1-ethenediamine) hydrochloride, is described. A process to convert ranitidine hydrochloride Form 2 to Form 1 is also described.
摘要翻译：制备形式1盐酸雷尼替丁的方法（N- [2 - [[[5-（二甲基氨基）甲基] -2-呋喃基]甲基]硫基]乙基-N'-甲基-2-硝基-1,1- 乙烯二胺）盐酸盐。还描述了将盐酸雷尼替丁形式2转化为形式1的方法。

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