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61. 发明授权

US08190250B2 System and method for estimating volume of activation in tissue 有权
标题翻译：用于估计组织中活化体积的系统和方法
公开(公告)号：US08190250B2
公开(公告)日：2012-05-29
申请号：US12904967
申请日：2010-10-14
申请人： Michael A. Moffitt
发明人： Michael A. Moffitt
IPC分类号： A61N1/05
CPC分类号： A61N1/372 , A61N1/36185
摘要： A system for a neurostimulation device comprises at least one processor configured for estimating at a plurality of spatial points a respective plurality of electrical field vectors resulting from a stimulation lead operating in accordance with a set of stimulation parameters, determining an amplitude of each electrical field vector and an angle between each electrical field vector and a vector aligned with an axis of the stimulation lead, and estimating a tissue of volume activation about the stimulation lead based on the determined amplitude and angle of each electrical field vector.
摘要翻译：用于神经刺激装置的系统包括至少一个处理器，其被配置用于在多个空间点处估计由根据一组刺激参数操作的刺激引线产生的相应多个电场矢量，确定每个电场矢量的幅度以及每个电场矢量与与刺激引线的轴对准的矢量之间的角度，以及基于确定的每个电场矢量的幅度和角度来估计关于刺激引线的体积激活的组织。

62. 发明申请

US20110319967A1 SYSTEM AND METHOD FOR COMPUTATIONALLY DETERMINING MIGRATION OF NEUROSTIMULATION LEADS 有权
标题翻译：用于计算神经元导联移动的系统和方法
公开(公告)号：US20110319967A1
公开(公告)日：2011-12-29
申请号：US13219269
申请日：2011-08-26
申请人： Michael A. Moffitt
发明人： Michael A. Moffitt
IPC分类号： A61N1/08
CPC分类号： A61N1/36128 , A61N1/0551 , A61N1/08 , A61N1/36071 , A61N1/36185
摘要： A tissue stimulation system and computer software and method of monitoring a neurostimulation lead having a plurality of electrodes implanted within a patient (e.g., adjacent the spinal cord) is provided. Neurostimulation lead models are provided, each of which includes estimated electrical parameter data (e.g., electrical field potential data) corresponding to a predetermined position of the neurostimulation lead. Electrical energy is transmitted to or from the electrodes, and electrical parameter data (e.g., electrical field potential data) is measured in response to the transmitted electrical energy. The measured electrical parameter data is compared with the estimated electrical parameter data of each of the neurostimulation lead models, and a position of the neurostimulation lead is determined based on the comparison.
摘要翻译：提供了一种组织刺激系统和计算机软件以及监测具有植入患者体内的多个电极（例如，与脊髓相邻）的神经刺激引线的方法。提供神经刺激引导模型，每个模型包括对应于神经刺激引线的预定位置的估计电参数数据（例如，电场势数据）。电能传输到电极或从电极传输，并且响应于所传输的电能测量电参数数据（例如，电场势数据）。将测量的电参数数据与每个神经刺激引导模型的估计电参数数据进行比较，并且基于该比较来确定神经刺激引线的位置。

63. 发明授权

US08019427B2 System and method for computationally determining migration of neurostimulation leads 有权
标题翻译：用于计算确定神经刺激导联迁移的系统和方法
公开(公告)号：US08019427B2
公开(公告)日：2011-09-13
申请号：US12899139
申请日：2010-10-06
申请人： Michael A. Moffitt
发明人： Michael A. Moffitt
IPC分类号： A61N1/08
CPC分类号： A61N1/36128 , A61N1/0551 , A61N1/08 , A61N1/36071 , A61N1/36185
摘要： A tissue stimulation system and computer software and method of monitoring a neurostimulation lead having a plurality of electrodes implanted within a patient (e.g., adjacent the spinal cord) is provided. Neurostimulation lead models are provided, each of which includes estimated electrical parameter data (e.g., electrical field potential data) corresponding to a predetermined position of the neurostimulation lead. Electrical energy is transmitted to or from the electrodes, and electrical parameter data (e.g., electrical field potential data) is measured in response to the transmitted electrical energy. The measured electrical parameter data is compared with the estimated electrical parameter data of each of the neurostimulation lead models, and a position of the neurostimulation lead is determined based on the comparison.
摘要翻译：提供了一种组织刺激系统和计算机软件以及监测具有植入患者体内的多个电极（例如，与脊髓相邻）的神经刺激引线的方法。提供神经刺激引导模型，每个模型包括对应于神经刺激引线的预定位置的估计电参数数据（例如，电场势数据）。电能传输到电极或从电极传输，并且响应于所传输的电能测量电参数数据（例如，电场势数据）。将测量的电参数数据与每个神经刺激引导模型的估计电参数数据进行比较，并且基于该比较来确定神经刺激引线的位置。

64. 发明申请

US20100305631A1 APPARATUS AND METHOD FOR DETERMINING THE RELATIVE POSITION AND ORIENTATION OF NEUROSTIMULATION LEADS 审中-公开
标题翻译：用于确定相对位置和神经细胞导向方位的装置和方法
公开(公告)号：US20100305631A1
公开(公告)日：2010-12-02
申请号：US12856905
申请日：2010-08-16
申请人： Kerry Bradley , James R. Thacker , Michael A. Moffitt
发明人： Kerry Bradley , James R. Thacker , Michael A. Moffitt
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61B5/053 , A61N1/0551 , A61N1/3605 , A61N1/37247
摘要： A method for determining whether the relative position of electrodes used by a neurostimulation system has changed within a patient comprises determining the amplitude of a field potential at each of at least one of the electrodes, determining if a change in each of the determined electric field amplitudes has occurred, and analyzing the change in each of the determined electric field amplitudes to determine whether a change in the relative position of the electrodes has occurred. Another method comprises measuring a first monopolar impedance between a first electrode and a reference electrode, measuring a second monopolar impedance between second electrode and the reference electrode, measuring a bipolar impedance between the first and second electrodes, and estimating an amplitude of a field potential at the second electrode based on the first and second monopolar impedances and the bipolar impedance.
摘要翻译：一种用于确定神经刺激系统使用的电极的相对位置是否在患者内已经改变的方法包括确定每个电极中的每个电极处的场电位的幅度，确定每个确定的电场幅度是否发生变化并且分析每个确定的电场幅度的变化，以确定是否发生了电极的相对位置的变化。另一种方法包括测量第一电极和参考电极之间的第一单极阻抗，测量第二电极和参考电极之间的第二单极阻抗，测量第一和第二电极之间的双极性阻抗，以及估计第一和第二电极之间的场电位的振幅基于第一和第二单极阻抗的第二电极和双极性阻抗。

65. 发明授权

US07742819B2 System and method for uniformly displacing a region of neural stimulation 有权
标题翻译：用于均匀置换神经刺激区域的系统和方法
公开(公告)号：US07742819B2
公开(公告)日：2010-06-22
申请号：US11557477
申请日：2006-11-07
申请人： Michael A. Moffitt
发明人： Michael A. Moffitt
IPC分类号： A61N1/18
CPC分类号： A61N1/0553 , A61N1/36071
摘要： A tissue stimulation system and computer software and method of operating the system is provided. An array of electrodes is placed contact with tissue of a patient (e.g., neural tissue), and electrical current is conveyed within the electrode array, thereby creating a stimulation region in the tissue. Electrical current is shifted between cathodes of the electrode array in incremental steps over a range, thereby causing displacement of the stimulation region at substantially uniform distances over the incremental steps. The electrical current may be shifted between the cathodes in accordance with a sigmoid-like function of a position of the stimulation region. A navigation table containing a series of states and corresponding gradually and non-uniformly changing electrical current values can be accessed, in which case, the electrical current may be shifted between the cathodes by incrementing through the states of the navigation table.
摘要翻译：提供组织刺激系统和操作该系统的计算机软件和方法。电极阵列与患者的组织（例如，神经组织）放置接触，并且在电极阵列内传送电流，由此在组织中产生刺激区域。电流在电极阵列的阴极之间以一定范围内的增量步长移动，从而导致刺激区域在增量步骤上基本上均匀距离的位移。根据刺激区域的位置的类似S形功能，电流可以在阴极之间移动。可以访问包含一系列状态和对应的逐渐和不均匀改变的电流值的导航表，在这种情况下，可以通过递增导航表的状态在阴极之间移动电流。

66. 发明授权

US07742810B2 Short duration pre-pulsing to reduce stimulation-evoked side-effects 有权
标题翻译：短脉冲预脉冲以减少刺激诱发的副作用
公开(公告)号：US07742810B2
公开(公告)日：2010-06-22
申请号：US11752895
申请日：2007-05-23
申请人： Michael A. Moffitt , David K. L. Peterson
发明人： Michael A. Moffitt , David K. L. Peterson
IPC分类号： A61N1/05
CPC分类号： A61N1/36128 , A61N1/0553 , A61N1/36017 , A61N1/36071 , A61N1/36164 , A61N1/36167
摘要： A method and neurostimulation system of providing therapy to a patient is provided. At least one electrode is placed in contact with tissue of a patient. A sub-threshold, hyperpolarizing, conditioning pre-pulse (e.g., an anodic pulse) is conveyed from the electrode(s) to render a first region of the tissue (e.g., dorsal root fibers) less excitable to stimulation, and a depolarizing stimulation pulse (e.g., a cathodic pulse) is conveyed from the electrode(s) to stimulate a second different region of the tissue (e.g., dorsal column fibers). The conditioning pre-pulse has a relatively short duration (e.g., less than 200 μs).
摘要翻译：提供了向患者提供治疗的方法和神经刺激系统。将至少一个电极放置成与患者的组织接触。从电极传送亚阈值超极化调理预脉冲（例如阳极脉冲），以使得组织的第一区域（例如，背根根纤维）对刺激不太兴奋，并且去极化刺激脉冲（例如，阴极脉冲）从电极传送以刺激组织的第二不同区域（例如，背部柱状纤维）。调节预脉冲具有相对短的持续时间（例如，小于200μs）。

67. 发明申请

US20100137962A1 IMPLANTABLE NEUROSTIMULATORS HAVING REDUCED POCKET STIMULATION 审中-公开
公开(公告)号：US20100137962A1
公开(公告)日：2010-06-03
申请号：US12630633
申请日：2009-12-03
申请人： Michael A. Moffitt , Dongchul Lee
发明人： Michael A. Moffitt , Dongchul Lee
IPC分类号： A61N1/00
CPC分类号： A61N1/36175 , A61N1/08 , A61N1/36185 , A61N1/372 , A61N1/37205 , A61N1/3756
摘要： Neurostimulators and methods of using neurostimulators are provided. The neurostimulator is implanted within a tissue pocket of a patient, and electrical energy is conveyed from the neurostimulator to stimulate a target tissue site remote from the tissue pocket. The neurostimulator has a case with which one or more electrodes are associated. The electrical energy is returned to the electrode(s) in a manner that prevents, or at least reduces, pocket stimulation that may otherwise occur due to the return of electrical energy to the case of the neurostimulator.

68. 发明申请

US20100137960A1 IMPLANTABLE NEUROSTIMULATORS HAVING REDUCED POCKET STIMULATION 审中-公开
标题翻译：具有减少口袋刺激的可植入神经细胞
公开(公告)号：US20100137960A1
公开(公告)日：2010-06-03
申请号：US12629814
申请日：2009-12-02
申请人： Michael A. Moffitt , Dongchul Lee , Kerry Bradley
发明人： Michael A. Moffitt , Dongchul Lee , Kerry Bradley
IPC分类号： A61N1/00
CPC分类号： A61N1/36175 , A61N1/08 , A61N1/36185 , A61N1/372 , A61N1/37205 , A61N1/3756
摘要： Neurostimulators and methods of using neurostimulators are provided. The neurostimulator is implanted within a tissue pocket of a patient, and electrical energy is conveyed from the neurostimulator to stimulate a target tissue site remote from the tissue pocket. The neurostimulator has a case with which one or more electrodes are associated. The electrical energy is returned to the electrode(s) in a manner that prevents, or at least reduces, pocket stimulation that may otherwise occur due to the return of electrical energy to the case of the neurostimulator.
摘要翻译：提供神经刺激器和使用神经刺激器的方法。将神经刺激器植入患者的组织袋中，并且电能从神经刺激器传送以刺激远离组织袋的靶组织部位。神经刺激器具有与一个或多个电极相关联的情况。电能以防止或至少减少由于电能返回到神经刺激器的情况而可能发生的口袋刺激的方式返回到电极。

69. 发明申请

US20080125833A1 APPARATUS AND METHOD FOR DETERMINING THE RELATIVE POSITION AND ORIENTATION OF NEUROSTIMULATION LEADS 有权
标题翻译：用于确定相对位置和神经细胞导向方位的装置和方法
公开(公告)号：US20080125833A1
公开(公告)日：2008-05-29
申请号：US11938490
申请日：2007-11-12
申请人： Kerry Bradley , James R. Thacker , Michael A. Moffitt
发明人： Kerry Bradley , James R. Thacker , Michael A. Moffitt
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61B5/053 , A61N1/0551 , A61N1/3605 , A61N1/37247
摘要： A method for determining whether the relative position of electrodes used by a neurostimulation system has changed within a patient comprises determining the amplitude of a field potential at each of at least one of the electrodes, determining if a change in each of the determined electric field amplitudes has occurred, and analyzing the change in each of the determined electric field amplitudes to determine whether a change in the relative position of the electrodes has occurred. Another method comprises measuring a first monopolar impedance between a first electrode and a reference electrode, measuring a second monopolar impedance between second electrode and the reference electrode, measuring a bipolar impedance between the first and second electrodes, and estimating an amplitude of a field potential at the second electrode based on the first and second monopolar impedances and the bipolar impedance.
摘要翻译：一种用于确定神经刺激系统使用的电极的相对位置是否在患者内已经改变的方法包括确定每个电极中的每个电极处的场电位的幅度，确定每个确定的电场幅度是否发生变化并且分析每个确定的电场幅度的变化，以确定是否发生了电极的相对位置的变化。另一种方法包括测量第一电极和参考电极之间的第一单极阻抗，测量第二电极和参考电极之间的第二单极阻抗，测量第一和第二电极之间的双极性阻抗，以及估计第一和第二电极之间的场电位的振幅基于第一和第二单极阻抗的第二电极和双极性阻抗。

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