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    • 62. 发明授权
    • Semiconductor wafer
    • 半导体晶圆
    • US06469361B2
    • 2002-10-22
    • US09946390
    • 2001-09-04
    • Nan Zhang
    • Nan Zhang
    • H01L2900
    • H01L21/32139G03F7/095G03F7/16H01L21/0274H01L21/31144
    • Techniques for etching a wafer layer using multiple layers of the same photoresistant material and structures formed using such techniques are provided. In a method, first, multiple layers of the same photoresist material are formed over the wafer layer to form a composite photoresist layer. The composite photoresist layer is patterned and developed to form a patterned photoresist layer. Exposed portions of the wafer layer are then removed using the pattern photoresist layer. Each of the multiple layers of photoresist may, for example, be formed to a maximum rated thickness for the photoresist material. Structures formed using this process may have relatively small dimensions (e.g., widths of 5 microns or less or a spacing or pitch of 5 microns or less). In addition, structures may also have sidewalls which are relatively long, smooth, and/or vertical.
    • 提供了使用相同光致抗蚀剂材料的多层蚀刻晶片层的技术和使用这些技术形成的结构。 在一种方法中,首先在晶片层上形成多层相同的光致抗蚀剂材料以形成复合光致抗蚀剂层。 将复合光致抗蚀剂层图案化并显影以形成图案化的光致抗蚀剂层。 然后使用图案光致抗蚀剂层去除晶片层的暴露部分。 例如,可以将多层光致抗蚀剂中的每一层形成为光致抗蚀剂材料的最大额定厚度。 使用该方法形成的结构可以具有相对小的尺寸(例如,5微米或更小的宽度或5微米或更小的间距或间距)。 此外,结构还可以具有相对长,平滑和/或垂直的侧壁。
    • 64. 发明授权
    • Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents
    • 杂环芳基吡啶并喹唑啉酮衍生物作为抗癌剂
    • US5908840A
    • 1999-06-01
    • US965217
    • 1997-11-06
    • Michael P. TrovaNan Zhang
    • Michael P. TrovaNan Zhang
    • C07D471/04A61K31/505A61K31/55
    • C07D471/04
    • This invention provides a compound having the formula: ##STR1## wherein: (A) n=2-4;(B) R.sub.1 and R.sub.2 are the same or different and selected from the group consisting of H, (C.sub.1 -C.sub.3) alkyl, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 NH.sub.2, and --CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 or R.sub.1 and R.sub.2 are alkyl moieties which are taken together to form a 4- to 7- membered ring;(C) R.sub.3 is selected from the group consisting of H, --CH.sub.3, --CH.sub.2 CH.sub.3, and --CH.sub.2 CH.sub.2 NH.sub.2 ;(D) Y is a heterocyclic radical having 5-14 atoms, located at the 2- or 3- position of the pyridoquinazolinone nucleus, in which 1-3 of the heterocyclic ring atoms are independently nitrogen, oxygen, or sulfur; wherein Y may be optionally mono-, di-, or tri- substituted with --OR.sub.4, --NR.sub.5 R.sub.6, --CO.sub.2 H, --CO.sub.2 R.sub.4, or phenyl;R.sub.4 is H or (C.sub.1 -C.sub. 4) straight-chain alkyl;R.sub.5 and R.sub.6 are the same or different and are selected from the group consisting of H, (C.sub.1 -C.sub.4) straight-chain alkyl, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 NH.sub.2, and --CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 or R.sub.5 and R.sub.6 are alkyl moieties which are taken together to form a 4-7 membered ring;or a pharmaceutically acceptable salt thereof which is useful as an antineoplastic agent.
    • 本发明提供具有下式的化合物:其中:(A)n = 2-4; (B)R 1和R 2相同或不同,选自H,(C 1 -C 3)烷基,-CH 2 CH 2 OH,-CH 2 CH 2 NH 2和-CH 2 CH 2 N(CH 3)2或R 1和R 2为被取代的烷基部分 一起形成4-至7-元环; (C)R 3选自H,-CH 3,-CH 2 CH 3和-CH 2 CH 2 NH 2; (D)Y是位于吡啶并喹啉酮核的2-或3-位的具有5-14个原子的杂环基,其中1-3个杂环环原子独立地是氮,氧或硫; 其中Y可任选被-OR 4,-NR 5 R 6,-CO 2 H,-CO 2 R 4或苯基单,二或三取代; R4是H或(C1-C4)直链烷基; R5和R6相同或不同,选自H,(C1-C4)直链烷基,-CH2CH2OH,-CH2CH2NH2和-CH2CH2N(CH3)2或R5和R6是烷基部分,它们是 一起形成4-7元环; 或其药学上可接受的盐,其可用作抗肿瘤剂。
    • 66. 发明授权
    • Just-in-time analytics on large file systems and hidden databases
    • 大型文件系统和隐藏数据库的即时分析
    • US09244976B1
    • 2016-01-26
    • US13402764
    • 2012-02-22
    • Nan ZhangGautam Das
    • Nan ZhangGautam Das
    • G06F17/30
    • G06F17/30442
    • A just-in-time sampling-based system can, after consuming a small number of disk accesses or queries, produce extremely accurate answers for a broad class of aggregate and top-k queries over a file system or database without the requirement of prior knowledge. The system is efficient, accurate, and scalable. The system performs aggregate estimations of a hidden database through its web interface by employing techniques that use a small number of queries to produce unbiased estimates with small variance. It conducts domain discovery over a hidden database through its web interface by employing techniques which provide effective guarantees on the effectiveness of domain discovery. Systems and methods enhance forms used by mobile devices to access hidden databases. It employs data analytics to improve the usage of form fields, including providing context-sensitive auto-completion suggestions, highlighting selections in drop-down boxes and eliminating suggestions in drop-down boxes.
    • 基于时间抽样的系统可以在消耗少量磁盘访问或查询后,通过文件系统或数据库为广泛类型的聚合和顶级查询提供非常准确的答案,而无需事先知识 。 该系统是高效,准确和可扩展的。 系统通过使用少量查询的技术来生成具有小差异的无偏估计,通过其Web界面执行隐藏数据库的总体估计。 它通过其Web界面通过隐藏的数据库进行域发现,采用技术为域发现的有效性提供有效的保证。 系统和方法增强了移动设备访问隐藏数据库所使用的形式。 它采用数据分析来改进表单域的使用,包括提供上下文相关的自动完成建议,在下拉框中突出显示选择,并在下拉框中删除建议。
    • 68. 发明授权
    • Encoding for nuclear medical imaging block detectors
    • 核医学成像块检测器的编码
    • US09006664B2
    • 2015-04-14
    • US13115220
    • 2011-05-25
    • Nan ZhangNiraj K. DoshiMatthias J. Schmand
    • Nan ZhangNiraj K. DoshiMatthias J. Schmand
    • G01T1/20
    • G01T1/2018
    • Signals generated by radiation sensors can be encoded to reduce the number of cables needed to transport information from a nuclear imaging apparatus to a processor for reconstruction. For example, signals from 16 radiation sensors can be encoded into three signals: T (top), L (left), and E (energy). This method of encoding signals can be capable of substantially reducing the number of signals, thereby reducing costs. In addition, reducing the number of signals could improve system timing performance by eliminating cable time-skew and facilitate the filter design by downgrading the circuit accuracy requirements such as group-delay error and filter signal skews.
    • 可以编码由辐射传感器产生的信号以减少将信息从核成像设备传输到处理器以进行重建所需的电缆数量。 例如,来自16个辐射传感器的信号可以被编码成三个信号:T(上),L(左)和E(能量)。 这种编码信号的方法能够显着减少信号的数量,从而降低成本。 此外,减少信号数量可以通过消除电缆时间偏移来提高系统定时性能,并通过降低电路精度要求(如组延迟误差和滤波器信号偏移)来促进滤波器设计。
    • 70. 发明申请
    • Providing Variable Cell Density and Sizes in a Radiation Detector
    • 在辐射检测器中提供可变细胞密度和尺寸
    • US20130009267A1
    • 2013-01-10
    • US13540079
    • 2012-07-02
    • Debora HenselerRonald GraziosoNan Zhang
    • Debora HenselerRonald GraziosoNan Zhang
    • H01L27/146
    • G01T1/248H01L27/14658
    • An apparatus and method to decrease light saturation in a photosensor array and increase detection efficiency uses a light distribution profile from a scintillator-photodetector geometry to configure the photosensor array to have a non-uniform sensor cell pattern, with varying cell density and/or varying cell size and shape. A solid-state photosensor such as a SiPM sensor having such a non-uniform cell structure realizes improved energy resolution, higher efficiency and increased signal linearity. In addition the non-uniform sensor cell array can have improved timing resolution due to improvements in statistical fluctuations. A particular embodiment for such photosensors is in PET medical imaging.
    • 降低光传感器阵列中的光饱和度并提高检测效率的装置和方法使用来自闪烁体 - 光电检测器几何形状的光分布分布来配置光传感器阵列具有不均匀的传感器单元图案,具有变化的单元密度和/或变化 细胞大小和形状。 诸如具有这种非均匀单元结构的SiPM传感器的固态光电传感器实现了改进的能量分辨率,更高的效率和更高的信号线性度。 此外,由于统计波动的改善,非均匀传感器单元阵列可以改善时序分辨率。 这种感光器的特定实施例是在PET医学成像中。