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61. 发明申请

US20130023502A1 SUBSTITUTED PYRIDINYL-PYRIMIDINES AND THEIR USE AS MEDICAMENTS 有权
标题翻译：取代的吡啶并吡啶并作为药物使用
公开(公告)号：US20130023502A1
公开(公告)日：2013-01-24
申请号：US13357734
申请日：2012-01-25
申请人： Georg Dahmann , Dennis Fiegen , Martin Fleck , Matthias Hoffmann , Jasna Klicic , Stephen Peter East , Spencer Charles R. Napier , John Scott
发明人： Georg Dahmann , Dennis Fiegen , Martin Fleck , Matthias Hoffmann , Jasna Klicic , Stephen Peter East , Spencer Charles R. Napier , John Scott
IPC分类号： A61K31/506 , C07D409/14 , C07D401/14 , C07D413/14 , A61K31/5377 , A61K31/551 , C07D498/10 , A61K31/5386 , C07D401/04 , C07D471/04 , A61K31/553 , C07D417/14 , A61K31/541 , C07D487/04 , A61K31/56 , A61P11/02 , A61P37/08 , A61P11/06 , A61P11/00 , A61P17/00 , A61P29/00 , A61P7/06 , A61P1/04 , A61P1/16 , A61P37/00 , A61P19/02 , A61P25/00 , A61P21/04 , A61P19/10 , A61P17/06 , C07D405/14
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10
摘要： The invention relates to new substituted pyridinyl-pyrimidines of formula 1 wherein ring A is a five-membered saturated or unsaturated carbocyclic ring which optionally comprises one, two or three heteroatoms each independently from each other selected from the group N, S and O, wherein R1, R2, R4, R3, R5 and R6 are defined as in claim 1 and wherein ring A is further optionally substituted by one or two further substituents and the pharmaceutically acceptable salts, diastereomers, enantiomers, racemates, hydrates and solvates of the aforementioned compounds.
摘要翻译：本发明涉及式1的新的取代的吡啶基 - 嘧啶，其中环A是五元饱和或不饱和碳环，任选地包含一个，两个或三个彼此独立地选自N，S和O的杂原子，其中 R 1，R 2，R 4，R 3，R 5和R 6如权利要求1中所定义，并且其中环A进一步任选被一个或两个其它取代基取代，并且上述化合物的药学上可接受的盐，非对映异构体，对映异构体，外消旋物，水合物和溶剂合物。

62. 发明授权

US08153660B2 Piperidyl-propane-thiol CCR3 modulators 有权
标题翻译：哌啶基 - 丙烷 - 硫醇CCR3调节剂
公开(公告)号：US08153660B2
公开(公告)日：2012-04-10
申请号：US12445993
申请日：2007-10-25
申请人： Domnic Martyres , Matthias Hoffmann , Peter Seither , Thierry Bouyssou
发明人： Domnic Martyres , Matthias Hoffmann , Peter Seither , Thierry Bouyssou
IPC分类号： A61K31/445 , C07D401/00
CPC分类号： C07D401/04 , C07D401/14
摘要： One object of the present invention are novel substituted piperidyl-propane-thiols of the formula (1), wherein R1, R2, R3 and R4 are defined as below. Another object of the present invention is to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明的一个目的是式（1）的新的取代的哌啶基 - 丙烷 - 硫醇，其中R1，R2，R3和R4定义如下。本发明的另一个目的是提供CCR-3的激动剂或拮抗剂或其药学上可接受的盐，更具体地提供药物组合物，其包含药学上可接受的载体和治疗有效量的至少一种本发明的化合物或其药学上可接受的盐。

63. 发明申请

US20110263549A1 4-DIMETHYLAMINO-PHENYL-SUBSTITUTED NAPHTHYRIDINES, AND USE THEREOF AS MEDICAMENTS 有权
标题翻译： 4-二甲基苯胺基 - 取代的萘啶，并作为药物使用
公开(公告)号：US20110263549A1
公开(公告)日：2011-10-27
申请号：US13057330
申请日：2009-07-23
申请人： Dennis Fiegen , Sandra Handschuh , Silke Hobbie , Matthias Hoffmann , Takeshi Kono , Yayoi Sato , Andreas Schnapp , Annette Schuler-Metz
发明人： Dennis Fiegen , Sandra Handschuh , Silke Hobbie , Matthias Hoffmann , Takeshi Kono , Yayoi Sato , Andreas Schnapp , Annette Schuler-Metz
IPC分类号： A61K31/573 , A61K31/4375 , A61P11/00 , A61P19/10 , A61P1/04 , A61P31/14 , A61P7/06 , A61P25/00 , C07D471/04 , A61P19/02
CPC分类号： C07D471/04 , C07D519/00
摘要： The invention relates to novel substituted naphthyridines of formula 1 as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof. In formula 1, R1 can represent a group A selected from among the group comprising —O—R3, —NR3 R4, —CR3R4R5, -(ethyne)-R3, —S—R3, —SO—R3, and SO2—R3, or R1 represents a group B selected from among the group comprising: —C6-10-aryl;—a five-membered to ten-membered, monocyclic or bicyclic heteroaryl containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heteroaryl is linked to the structure according to formula 1 via a C atom or an N atom;—a three-membered to ten-membered, monocyclic or bicyclic, saturated or partially saturated heterocycle containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heterocycle is linked to the structure according to formula 1 via a C atom or an N atom; and—a 5-membered to 11-membered spiro group which can optionally contain 1, 2, or 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said spiro group is linked to the structure according to formula 1 via a C atom or an N atom, wherein said group B can be optionally substituted as described in claims 1, and R3,R4,R5,R6, and m can have the meanings indicated in claim 1. The invention also relates to pharmaceutical compositions containing said compounds.
摘要翻译：本发明涉及式1的新型取代萘啶以及其药理学上可接受的盐，非对映异构体，对映异构体，外消旋物，水合物或溶剂合物。在式1中，R 1可以表示选自-O-R 3，-NR 3 R 4，-CR 3 R 4 R 5， - （乙炔）-R 3，-S-R 3，-SO-R 3和SO 2 -R 3的基团A，或R 1表示选自包括以下基团的基团：-C 6-10 - 芳基; - 含有1至3个独立地选自以下的杂原子的五元至十元单环或双环杂芳基：N，O，和S，其中所述杂芳基通过C原子或N原子连接到根据式1的结构; - 含有1至3个独立选择的杂原子的三元至十元单环或双环饱和或部分饱和的杂环包括N，O和S的基团，其中所述杂环通过C原子或N原子连接到根据式1的结构; 和可以任选地含有1,2或3个独立地选自包括N，O和S的基团的杂原子的5元至11元螺环，其中所述螺环与根据式1的结构连接通过C原子或N原子，其中所述基团B可以如权利要求1所述任选被取代，并且R 3，R 4，R 5，R 6和m可以具有权利要求1中所示的含义。本发明还涉及药物组合物含有所述化合物。

64. 发明申请

US20100317634A1 PIPERIDYL-PROPANE-THIOL CCR3 MODULATORS 有权
标题翻译： PIPERIDYL-PROPANE-THIOL CCR3调节剂
公开(公告)号：US20100317634A1
公开(公告)日：2010-12-16
申请号：US12445993
申请日：2007-10-25
申请人： Domnic Martyres , Matthias Hoffmann , Peter Seither , Thierry Bouyssou
发明人： Domnic Martyres , Matthias Hoffmann , Peter Seither , Thierry Bouyssou
IPC分类号： A61K31/573 , C07D401/04 , C07D401/14 , A61K31/454 , A61P11/06 , A61P37/08 , A61P11/00 , A61P31/00 , A61P29/00 , A61P9/10
CPC分类号： C07D401/04 , C07D401/14
摘要： One object of the present invention are novel substituted piperidyl-propane-thiols of the formula (1), wherein R1, R2, R3 and R4 are defined as below. Another object of the present invention is to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明的一个目的是式（1）的新的取代的哌啶基 - 丙烷 - 硫醇，其中R1，R2，R3和R4定义如下。本发明的另一个目的是提供CCR-3的激动剂或拮抗剂或其药学上可接受的盐，更具体地提供药物组合物，其包含药学上可接受的载体和治疗有效量的至少一种本发明的化合物或其药学上可接受的盐。

65. 发明申请

US20090134680A1 MOTOR VEHICLE SEAT BACK STRUCTURE FOR A MOTOR VEHICLE SEAT 有权
标题翻译：电动车辆座椅的电动车座椅背部结构
公开(公告)号：US20090134680A1
公开(公告)日：2009-05-28
申请号：US12360772
申请日：2009-01-27
申请人： Markus Fischer , Matthias Hoffmann , Andrea Bauersachs , Michael Forkel , Jochen Hofmann , Alwin Macht , Georg Scheck
发明人： Markus Fischer , Matthias Hoffmann , Andrea Bauersachs , Michael Forkel , Jochen Hofmann , Alwin Macht , Georg Scheck
IPC分类号： B60N2/66 , A47C7/46 , B60N2/64
CPC分类号： B60N2/0232 , B60N2/66 , B60N2/6673
摘要： A motor vehicle seat back structure comprising a backrest support frame which consists of a surface turned towards the seat user's back, a lordosis support which is arranged on the front part of the backrest support frame for supporting the user's back and an adjusting device for vertically adjusting the lordosis support position with respect to the extension plane of said backrest support frame. The adjusting device comprises at least one adjusting element operably connected to the lordosis support and at least one sliding element which is displaceable with respect to said adjusting element and interacts therewith in such a way that when the sliding element moves, the adjusting element is displaced with a directional component perpendicularly to the displacement direction of the sliding element and performs an action on said lordosis support in the direction.
摘要翻译：一种机动车辆座椅靠背结构，包括靠近座椅使用者背部的表面构成的靠背支撑框架，布置在靠背支撑框架的前部用于支撑使用者背部的前凸支撑件和用于垂直调节的调节装置相对于所述靠背支撑框架的延伸平面的脊柱前凸支撑位置。调节装置包括可操作地连接到脊柱前凸支撑件的至少一个调节元件和可相对于所述调节元件移动的至少一个滑动元件，并且与滑动元件相互作用，使得当滑动元件移动时，调节元件以垂直于滑动元件的位移方向的方向分量，并对该方向上的所述脊柱前凸支撑起作用。

66. 发明授权

US07488039B2 Motor vehicle seat back structure for a motor vehicle seat 有权
标题翻译：机动车座椅后部结构
公开(公告)号：US07488039B2
公开(公告)日：2009-02-10
申请号：US10570636
申请日：2004-08-25
申请人： Markus Fischer , Matthias Hoffmann , Andrea Bauersachs , Michael Forkel , Jochen Hofmann , Alwin Macht , Georg Scheck
发明人： Markus Fischer , Matthias Hoffmann , Andrea Bauersachs , Michael Forkel , Jochen Hofmann , Alwin Macht , Georg Scheck
IPC分类号： A47C7/44 , A47C7/46
CPC分类号： B60N2/0232 , B60N2/66 , B60N2/6673
摘要： A motor vehicle seat back structure comprising a backrest support frame which consists of a surface turned towards the seat user's back, a lordosis support which is arranged on the front part of the backrest support frame for supporting the user's back and an adjusting device for vertically adjusting the lordosis support position with respect to the extension plane of said backrest support frame. The adjusting device comprises at least one adjusting element operably connected to the lordosis support and at least one sliding element which is displaceable with respect to said adjusting element and interacts therewith in such a way that when the sliding element moves, the adjusting element is displaced with a directional component perpendicularly to the displacement direction of the sliding element and performs an action on said lordosis support in the direction.
摘要翻译：一种机动车辆座椅靠背结构，包括靠近座椅使用者背部的表面构成的靠背支撑框架，布置在靠背支撑框架的前部用于支撑使用者背部的前凸支撑件和用于垂直调节的调节装置相对于所述靠背支撑框架的延伸平面的脊柱前凸支撑位置。调节装置包括可操作地连接到脊柱前凸支撑件的至少一个调节元件和可相对于所述调节元件移动的至少一个滑动元件，并且与滑动元件相互作用，使得当滑动元件移动时，调节元件以垂直于滑动元件的位移方向的方向分量，并对该方向上的所述脊柱前凸支撑起作用。

67. 发明申请

US20060082232A1 Drive unit 失效
标题翻译：驱动单元
公开(公告)号：US20060082232A1
公开(公告)日：2006-04-20
申请号：US11292222
申请日：2005-11-30
申请人： Helmut Sesselmann , Matthias Hoffmann , Markus Schultz
发明人： Helmut Sesselmann , Matthias Hoffmann , Markus Schultz
IPC分类号： H02K7/10 , H02K1/22
CPC分类号： F16H49/001 , E05F11/483 , E05F11/505 , E05F15/60 , E05F15/697 , E05Y2201/72 , E05Y2800/12 , E05Y2900/55 , F16H2001/2881 , H02K7/116 , H02K11/33 , H02K21/24 , Y10T74/2186
摘要： A driving unit especially adapted to adjusting devices for motor vehicles having an electric motor, a gear box and an electronic control device. At least one element of the electric motor, for example, at the driving shaft, the magnetic short-circuit or the motor side crankcase casing, additionally provides a gear box mechanical feature and/or a mechanical member, for example, a gear box side crankcase casing, provides an electric motor or electronic control device feature.
摘要翻译：一种驱动装置，特别适用于具有电动马达，齿轮箱和电子控制装置的机动车辆的调节装置。电动机的至少一个元件例如在驱动轴，磁短路或电动机侧曲轴箱外壳上另外提供齿轮箱机械特征和/或机械构件，例如齿轮箱侧曲轴箱外壳，提供电动机或电子控制装置的特点。

68. 发明授权

US06458568B1 Method for the production of baccatin-III by enzymatic synthesis 失效
标题翻译：通过酶合成制备浆果赤霉素Ⅲ的方法
公开(公告)号：US06458568B1
公开(公告)日：2002-10-01
申请号：US09311084
申请日：1999-05-13
申请人： Konrad Glund , Matthias Hoffmann , Wolfram Weckwerth , Rainer Zocher
发明人： Konrad Glund , Matthias Hoffmann , Wolfram Weckwerth , Rainer Zocher
IPC分类号： C12P1702
CPC分类号： C12P17/02
摘要： A method for the continuous synthesis of baccatin-III is performed by means of the enzymatic acetylations of 10-deacetyl baccatin-III (10-DAB) in an enzyme reactor. This objective is accomplished by a method, for which an aqueous reaction batch is used, which contains a partially purified or a very pure acetyl transferase from a Taxus species and synthesis components, especially 10-DAB, acetyl compounds or optionally an acetyl coenzyme A, which can be regenerated, a protective colloid and optionally a buffer substance in solution. The solution is separated by a semipermeable membrane from an organic solvent, which serves as extraction agent for baccatin-III, the reaction batch being regenerated at regular intervals in an aqueous buffer system and the solvent continuously being exchanged. By conducting the reaction, the product can be removed continuously from the reaction batch for the partial synthesis of taxol and taxoter. By the above method, achievable yields are increased significantly.
摘要翻译：通过酶反应器中10-脱乙酰浆果赤霉素III（10-DAB）的酶促乙酰化进行浆果赤霉素III的连续合成方法。该目的通过一种使用含水反应批料的方法来实现，该方法含有来自紫杉属物种和合成成分，特别是10-DAB，乙酰化合物或任选的乙酰辅酶A的部分纯化或非常纯的乙酰转移酶，其可以再生，保护胶体和任选的溶液中的缓冲物质。将溶液由半透膜与有机溶剂分离，其用作浆果赤霉素III的提取剂，反应批次在水性缓冲体系中以规则的间隔再生，溶剂连续交换。通过进行反应，可以从反应批料中连续除去产物以部分合成紫杉醇和紫杉醇。通过上述方法，可实现的产率显着增加。

69. 发明授权

US09096579B2 Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments 有权
标题翻译：氨基 - 吲哚基取代的咪唑基 - 嘧啶及其作为药物的用途
公开(公告)号：US09096579B2
公开(公告)日：2015-08-04
申请号：US13864394
申请日：2013-04-17
申请人： Georg Dahmann , Horst Dollinger , Christian Gnamm , Dennis Fiegen , Matthias Hoffmann , Jasna Klicic , David James Lamb , Andreas Schnapp
发明人： Georg Dahmann , Horst Dollinger , Christian Gnamm , Dennis Fiegen , Matthias Hoffmann , Jasna Klicic , David James Lamb , Andreas Schnapp
IPC分类号： A61K31/506 , A61K31/551 , A61K31/553 , A61K31/5386 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D498/10 , C07D209/42 , C07D403/06 , C07D487/04 , C07D409/14 , C07D403/14 , C07D405/14 , C07D401/14 , C07D413/14 , A61K45/06 , C07D417/14 , C07D471/04 , C07D487/10 , C07D498/04 , C07D513/04
CPC分类号： C07D403/14 , A61K31/506 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/553 , A61K45/06 , C07D209/42 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D498/04 , C07D498/10 , C07D513/04
摘要： The invention relates to new amino-indole-substituted imidazolyl-pyrimidines of formula 1 wherein R1, R2, R3, R4 and R5 are defined as in claim 1 and pharmaceutically acceptable salts thereof and the use of these compounds for the preparation of a medicament for treating a disease selected from asthma, COPD, rheumatoid arthritis, specific lymphomas and specific diseases of the nervous system.
摘要翻译：本发明涉及式1的新的氨基 - 吲哚取代的咪唑基 - 嘧啶，其中R 1，R 2，R 3，R 4和R 5如权利要求1所定义，及其药学上可接受的盐，以及这些化合物用于制备治疗选自哮喘，COPD，类风湿性关节炎，特异性淋巴瘤和神经系统的特定疾病的疾病。

70. 发明授权

US08969568B2 Substituted naphthyridines and their use as medicaments 有权
标题翻译：取代的萘啶并用作药物
公开(公告)号：US08969568B2
公开(公告)日：2015-03-03
申请号：US13013973
申请日：2011-01-26
申请人： Matthias Hoffmann , Georg Dahmann , Dennis Fiegen , Sandra Handschuh , Jasna Klicic , Guenter Linz , Gerhard Schaenzle , Andreas Schnapp , Stephen Peter East , Michael Philip Mazanetz , Robert John Scott , Edward Walker
发明人： Matthias Hoffmann , Georg Dahmann , Dennis Fiegen , Sandra Handschuh , Jasna Klicic , Guenter Linz , Gerhard Schaenzle , Andreas Schnapp , Stephen Peter East , Michael Philip Mazanetz , Robert John Scott , Edward Walker
IPC分类号： C07D471/02 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D498/04 , C07D519/00
摘要： The invention relates to new substituted naphthyridines of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1 is selected from among —O—R3 or —NR3R4, R3 is C1-6-alkyl which is substituted by R5 and R6, R5 is selected from hydrogen, branched or linear C1-6-alkyl, C2-6-alkenyl, —C1-6-alkylen-O—C1-3-alkyl, C1-3-haloalkyl, R6 is ring X wherein n is either 0 or 1, and is a either a single or a double bond and wherein A, B, D and E are each independently from one another selected from CH2, CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, —C1-3-alkyl, —C1-3-haloalkyl, —O—C1-3-alkyl, —C1-3-alkanol and halogen, and wherein R4, R2, R7, R8, R9, R10, R11 and Q may have the meanings as given in claim 1, as well as pharmaceutical compositions containing these compounds.
摘要翻译：本发明涉及式1的新取代的萘啶，以及其药学上可接受的盐，非对映异构体，对映异构体，外消旋体，水合物或溶剂合物，其中R 1选自-O-R 3或-NR 3 R 4，R 3是C 1-6 - 烷基其被R5和R6取代，R5选自氢，支链或直链C 1-6 - 烷基，C 2-6 - 烯基，-C 1-6 - 亚烷基-O-C 1-3 - 烷基，C 1-3 - 卤代烷基， R6是环X，其中n是0或1，并且是单键或双键，并且其中A，B，D和E各自独立地选自CH 2，CH，C，N，NH，O 或S，并且其中环X通过位置A，B，D或E连接到分子，其中所述环X可任选地被一个，两个或三个残基进一步取代，每个残基各自独立地选自氧基，羟基，-C 1-3 - 烷基，-C 1-3 - 卤代烷基，-O-C 1-3 - 烷基，-C 1-3 - 链烷醇和卤素，其中R4，R2，R7，R8，R9，R10，R11和Q 可能具有的含义权利要求1中给出，以及含有这些化合物的药物组合物。

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